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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 0769 • ACR Convergence 2021

    Renal Outcomes in 1528 Childhood-onset Systemic Lupus Erythematosus Patients: A Brazilian Multicenter Study

    Ana Paula Sakamoto1, Clovis Silva2, Aline Islabão3, Glaucia Novak2, Beatriz Molinari2, Rosa Pereira4, Claudia Saad-Magalhães5, Gleice Clemente6, Daniela Petry Pioto7, Nadia Aikawa4, Ana Pita2, Vitor Trindade2, Simone Appenzeller8, Luciana Carvalho9, Carlos Rabelo-Junior10, Adriana Fonseca11, Flavio Sztajnbok12, Maria Santos13, Blanca Elena Rios Gomes Bica14, Evaldo Sena15, Ana Moraes16, Melissa Fraga6, Teresa Robazzi17, Paulo Spelling18, Iloite Scheibel19, Andre Cavalcanti20, Erica Matos21, Luciano Guimarães22, Flavia Santos23, Licia Maria Henrique Mota24, Eloisa Bonfá4 and Maria Terreri25, 1Federal University of So Paulo (UNIFESP), São Paulo, Brazil, 2Pediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 3Pediatric Rheumatology Unit, Hospital da Criança de Brasília Jose Alencar, Brasilia, DF, Brazil, 4Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Pediatric Rheumatology Division, São Paulo State University (UNESP) – Faculdade de Medicina de Botucatu, Botucatu, Botucatu, Brazil, 6Universidade Federal de São Paulo, São Paulo, Brazil, 7Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, SP, Brazil, 8Hospital das Clínicas da Universidade Estadual de Campinas, Campinas, Brazil, 9Pediatric Rheumatology Unit, Ribeirão Preto Medical School – University of São Paulo, Ribeirão Preto, SP, Brazil, 10Pediatric Rheumatology Unit, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil, 11Pediatric Rheumatology Unit, Rio de Janeiro Federal University (IPPMG-UFRJ), Rio de Janeiro, RJ, Brazil, 12UFRJ/UERJ, Rio de Janeiro, Brazil, 13Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil, 14Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 15Pediatric Rheumatology Unit, Lauro Vanderley University Hospital, João Pessoa, PB, Brazil, 16Pediatric Rheumatology Unit, Federal University of Pará, Belém, PA, Brazil, 17Pediatric Rheumatology Unit, Federal University of Bahia, Salvador, BA, Brazil, 18Pediatric Rheumatology Unit, Hospital Evangélico de Curitiba, Curitiba, PR, Brazil, 19Pediatric Rheumatology Unit, Hospital Criança Conceição, Porto Alegre, RS, Brazil, 20Pediatric Rheumatology Unit, Federal University of Pernambuco, Recife, PE, Brazil, 21Pediatric Rheumatology Unit, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil, 22Pediatric Rheumatology Unit, University of Brasília, Brasilia, DF, Brazil, 23Pediatric Rheumatology Unit, Federal University of Minas Gerais, Belo Horizonte, Belo Horizonte, MG, Brazil, 24Universidade de Brasília, Brasilia, Brazil, 25UNIFESP, São Paulo, Brazil

    Background/Purpose: Lupus nephritis is a frequent manifestation in childhood-onset systemic lupus erythematosus (cSLE) and has a great potential for chronic kidney disease (CKD), requiring dialysis…
  • Abstract Number: 1460 • ACR Convergence 2021

    Lupus Nephritis Renal Responses in Relation to Treatment and Demographics: Observations from a Multi-racial/ethnic Cohort of 159 Patients in the NYU Lupus Registry

    Mayce Haj-Ali1, Kristina Deonaraine2, Alexis Engel3, Yingzhi Qian1, Amit Saxena4, Peter Izmirly2, Jill Buyon4 and H. Michael Belmont4, 1NYU Grossman School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3NYU Langone Health, New Yok, NY, 4NYU School of Medicine, New York, NY

    Background/Purpose: Lupus nephritis (LN) disproportionately affects racial and ethnic populations. Contreras reported African-American (AA) and Hispanic patients had worse outcomes as compared to patients of…
  • Abstract Number: 1754 • ACR Convergence 2021

    Effect of Belimumab on Autoantibodies, Complement, and B-Cell Subsets in Patients with Lupus Nephritis

    Brad Rovin1, Richard Furie2, Ana Malvar3, Cynthia Aranow4, Jose M Pego-Reigosa5, Elena Zakharova6, Andreas Schwarting7, Angela Jones-Leone8, Anuradha Madan8, Jennifer Gilbride9, David Roth8, Yulia Green9 and André van Maurik10, 1Ohio State University Wexner Medical Center, Columbus, OH, 2Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 3Hospital Fernandez, Buenos Aires, Argentina, 4Feinstein Institutes for Medical Research, Manhasset, NY, 5Complexo Hospitalario Universitario de Vigo, Hospital Meixoeiro, Galicia Sur Health Research Institute, Rheumatology Department and IRIDIS (Investigation in Rheumatology and Immune-Mediated Diseases) Group, Vigo, Spain, 6Moscow City Clinical Hospital n.a. S.P. Botkin, Moscow, Russia, 7University Center of Autoimmunity, Mainz, Germany, 8GlaxoSmithKline, Collegeville, PA, 9GlaxoSmithKline, Brentford, United Kingdom, 10GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom

    Background/Purpose: Lupus nephritis (LN) is a complication affecting ~40% of patients with systemic lupus erythematosus (SLE). Belimumab (BEL), an anti–B-lymphocyte stimulator therapy, was approved in…
  • Abstract Number: 0326 • ACR Convergence 2021

    Apolipoprotein L1 (APOL1) in African-American SLE: Frequency and Clinical Associations

    Michelle Petri1, Romy Kallas2, Jessica Li3, Laurence Magder4 and Daniel Goldman1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Lankenau Medical Center, Lankenau, PA, 3Johns Hopkins University, Baltimore, MD, 4University of Maryland, Baltimore, Baltimore, MD

    Background/Purpose: The APOL1 gene is implicated in induction of TLR3 agonists and interferons as well as in autophagy. Two genetic variants, G1 (2 single nucleotide…
  • Abstract Number: 0784 • ACR Convergence 2021

    Use of EuroLupus Cyclophosphamide Dosing for the Treatment of Lupus Nephritis in Childhood-Onset Systemic Lupus Erythematosus in North America

    Laura Cannon1, Scott Wenderfer2, Laura Lewandowski3, Jennifer Cooper4, Beatrice Goilav5, Andrea Knight6, Aimee Hersh7, Stacy Ardoin8 and Rebecca Sadun1, 1Duke University, Durham, NC, 2Baylor College of Medicine, Houston, TX, 3NIAMS, NIH, Rockville, MD, 4University of Colorado/Children's Hospital Colorado, Denver, CO, 5Children's Hospital at Montefiore, Bronx, NY, 6Hospital for Sick Children, Toronto, ON, Canada, 7University of Utah, Salt Lake City, UT, 8Nationwide Children's Hospital, Columbus, OH

    Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) has higher rates of lupus nephritis (LN) than adult-onset SLE, often requiring intensive immunosuppression. This study examined North American…
  • Abstract Number: 1461 • ACR Convergence 2021

    Belimumab Improves Renal Responses in Patients with or Without Steroid Pulses During Induction Therapy for Lupus Nephritis

    Richard Furie1, Frédéric Houssiau2, Liz Lightstone3, Xueqing Yu4, Julia Weinmann-Menke5, Yoshiya Tanaka6, Angela Jones-Leone7, Tania Gonzalez-Rivera7, Jennifer Gilbride8, Anuradha Madan7, Yulia Green8 and David Roth7, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 2Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium, 3Department of Immunology and Inflammation, Imperial College, London, United Kingdom, 4Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China (People's Republic), 5University Hospital Mainz, Mainz, Germany, 6University of Occupational and Environmental Health, Kitakyushu, Japan, 7GlaxoSmithKline, Collegeville, PA, 8GlaxoSmithKline, Brentford, United Kingdom

    Background/Purpose: In the BLISS-LN trial (GSK Study BEL114054; NCT01639339), the administration of belimumab (BEL), a B-lymphocyte stimulator antagonist, resulted in improved renal outcomes in patients…
  • Abstract Number: 1756 • ACR Convergence 2021

    Class V Systemic Lupus Erythematosus Nephritis Patients Are Undertreated and Face Similar Adverse Renal Outcomes as Class III/IV Patients

    April Barnado and Alex Camai, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Few studies have investigated treatment patterns and renal outcomes in class V systemic lupus erythematosus (SLE) nephritis patients compared to class III/IV patients. Prior…
  • Abstract Number: 0328 • ACR Convergence 2021

    Natural Language Processing to Identify Lupus Nephritis Phenotype in Electronic Health Records

    Yu Deng1, Jennifer Pacheco1, Anh Chung1, Chengsheng Mao1, Joshua Smith2, juan zhao1, Wei-Qi Wei2, April Barnado3, Chunhua Weng4, Cong Liu4, Adam Gordon1, Jingzhi Yu1, Yacob Tedla1, Abel Kho1, Rosalind Ramsey-Goldman1, Theresa Walunas1 and Yuan Luo1, 1Northwestern University, Chicago, IL, 2Vanderbilt Universty Medical Center, Nashville, TN, 3Vanderbilt University Medical Center, Nashville, TN, 4Columbia University, New York, NY

    Background/Purpose: Lupus nephritis (LN) is a major disease manifestation of Systemic lupus erythematosus (SLE) leading to organ damage and increased mortality. Accurately identifying lupus nephritis…
  • Abstract Number: 0874 • ACR Convergence 2021

    Serum Galectin-9 and CXCL-10 but Not Their Urinary Levels Reflect Lupus Activity

    Pankti Mehta, Pratibha Singh and Amita Aggarwal, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: SLE is characterized by increased type I IFN signature in the blood and immune cells. Traditionally, type I IFN signature is measured by gene…
  • Abstract Number: 1482 • ACR Convergence 2021

    LN Urinary Proteomics Reveals Common Biological Pathways Identified by Distinct Disease Measures

    Paul Newcombe1, Madhu Ramaswamy2, Dominic Sinibaldi2, Catharina Lindholm3, Frederick Jones1, Ahmad Akhgar2, Philip Brohawn2, Raj Tummala2 and Wendy White2, 1BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 2BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 3BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

    Background/Purpose: LN is a severe consequence of SLE and there is a huge unmet need for discovery of urine protein biomarkers that provide non-invasive surrogates…
  • Abstract Number: 1766 • ACR Convergence 2021

    Itolizumab-induced Modulation of Cell Surface CD6 Is a Pharmacodynamic Marker of Drug Activity in SLE Patients

    Dalena Chu1, Leslie Chinn2, Jeanette Ampudia1, Krishna Polu1, Joel Rothman1, Maple Fung3, Dolca Thomas4, Chaim Putterman5, Cherie Ng1 and Stephen Connelly1, 1Equillium, Inc., La Jolla, CA, 2Equillium, Inc., South San Francisco, CA, 3Equillium, Inc., San Diego, CA, 4Equillium, Inc., Brooklyn, NY, 5Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Itolizumab (ITO) is a novel first-in-class monoclonal antibody (IgG1-k) specific for CD6, a co-stimulatory receptor that is highly expressed on T cells that plays…
  • Abstract Number: 0340 • ACR Convergence 2021

    Urinary L-selectin Predicts Disease Activity and Histological Changes in Lupus Nephritis

    Huihua Ding1, Yiwei Shen1, Min Dai1, Chandra Mohan2 and Nan Shen3, 1Shanghai JiaoTong University School of Medicine, Shanghai, China (People's Republic), 2University of Houston, Houston, TX, 3Shanghai Jiang Tong University School of Medicine, Shanghai, China (People's Republic)

    Background/Purpose: There remains unmet needs of non-invasive markers of disease activity, damage, prognosis, and treatment response in lupus nephritis patients. Here, we aim to validate…
  • Abstract Number: 0888 • ACR Convergence 2021

    Disease Flares in Lupus Are Concordant with Ruminococcus Blautia Gnavus Blooms Within Unstable Gut Microbiota Communities

    Doua Azzouz1, Ze Chen1, Zhi Li1, Jing Deng1, Peter Izmirly1, David Fenyo1, Jill Buyon1, Alexander Alekseyenko2 and Gregg Silverman1, 1NYU Grossman School of Medicine, New York, NY, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic Lupus Erythematosus is the archetypic systemic autoimmune disease in which dysbiosis in the gut microbiome has been postulated to contribute to disease development…
  • Abstract Number: 1484 • ACR Convergence 2021

    B Cell Intracellular IFNβ as a Unique Cellular Marker for the Development of Lupus Nephritis

    Fatima Alduraibi1, Huma Fatima1, Winn Chatham2, Hui-Chen Hsu1 and John Mountz1, 1University of Alabama Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Our laboratory previously demonstrated a strong association of B cell intracellular interferon beta (IFNβ) with the development of anti-Smith/ribonuclear protein (Sm/RNP), anti-DNA, and lupus…
  • Abstract Number: 1936 • ACR Convergence 2021

    A Neutrophil Degranulation Signature Identifies Proliferative Lupus Nephritis

    Andrea Fava1, Jessica Li1, Daniel Goldman2, Brendan Antiochos1, Jose Monroy-Trujillo1, Derek Fine1, Mohamed G. Atta1, Jill Buyon3, Joel Guthridge4, Judith James4, Michelle Petri2 and Accelerating Medicines Partership (AMP) RA/SLE Network5, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3NYU School of Medicine, New York, NY, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Brigham and Women's Hospital, Everett, MA

    Background/Purpose: The identification of intrarenal pathological processes is key to develop better diagnostic and treatment strategies in lupus nephritis (LN). But the direct comprehensive study…
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