ACR Meeting Abstracts

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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 0090 • ACR Convergence 2024

    Parenchymal and Hematopoietic IFNγ Signaling Exhibits Dichotomous Effects in Murine Lupus

    Minjung Kim1, Anthony Marinov2, Haylee Cosgrove3, Xiaoyan Gong3, Mark Shlomchik3 and Jeremy Tilstra3, 1University of Illinois College of Medicine at Chicago, Chicago, IL, 2University of Pittsburgh, Homestead, PA, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Lupus nephritis is the most common life-threatening end-organ complication of SLE, and response rates to current interventions remain poor. Notably, PD-L1 and other interferon-responsive…
  • Abstract Number: 0650 • ACR Convergence 2024

    Tubulointerstitial Inflammation Predicts Tubular Atrophy, Fibrosis, and Renal Function Loss in Lupus Nephritis

    Yevgeniya Gartshteyn1, Laura Geraldino2, Shuwei Wang3, Vivette D'Agati1 and Robert Winchester1, 1Columbia University Irving School of Medicine, New York, NY, 2Division of Rheumatology, Department of Medicine, Columbia University, New York, NY, 3Rutgers New Jersey Medical School, Newark, NJ

    Background/Purpose:     Current classification criteria of lupus nephritis (LN) emphasize glomerular pathology, however tubular atrophy and interstitial fibrosis (TAIF) are better predictors of poor…
  • Abstract Number: 0905 • ACR Convergence 2024

    High-Throughput Proteomic Profiling of Sera as a Non-Invasive Method for Identifying Lupus Nephritis Subtypes

    Rufei Lu1, Andrea Fava2, Benjamin Jones3, Peter Izmirly4, Jennifer Anolik5, Chaim Putterman6, David Wofsy7, Matthias Kretzler8, Celine Berthier9, E. Steve Woodle10, Michael Weisman11, Mariko Ishimori12, The Accelerating medicines Partnership: RA/SLE Network13, Betty Diamond14, Jill Buyon15, Michelle Petri16, Richard Furie17, Judith James13 and Joel Guthridge13, 1University of California San Francisco, San Bruno, CA, 2Divison of Rheumatology, Johns Hopkins University, Baltimore, MD, 3Oklahoma State University, Oklahoma City, OK, 4New York University Grossman School of Medicine, New York, NY, 5University of Rochester Medical Center, Rochester, NY, 6Albert Einstein College of Medicine, Safed, Israel, 7University of California San Francisco, SF, CA, 8University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, 9University of Michigan, Ann Arbor, MI, 10University of Cincinnati College of Medicine, Cincinnati, OH, USA, Cinncinnati, OH, 11Stanford University, Los Angeles, CA, 12Cedars-Sinai Health System, Los Angeles, CA, 13Oklahoma Medical Research Foundation, Oklahoma City, OK, 14The Feinstein Institutes for Medical Research, Manhasset, NY, 15NYU Grossman School of Medicine, New York, NY, 16Johns Hopkins University School of Medicine, Timonium, MD, 17Northwell Health, Manhasset, NY

    Background/Purpose: Lupus nephritis (LN) treatment decisions are typically informed using histopathological classification based on the International Society of Nephrology/Renal Pathology Society (ISN/RPS) and NIH activity…
  • Abstract Number: 1546 • ACR Convergence 2024

    Characteristics and Treatment Patterns of Patients with Lupus Nephritis: A Retrospective Claims Database Study in the USA

    Anisha M. Patel1, Carmen Ng1, Lisa Lindsay1, Zhiyu Xia2, William F. Pendergraft III3 and Maria Dall'Era4, 1Genentech, Inc., South San Francisco, 2Genentech, Inc., Sou, 3Genentech, Inc., Chapel Hill, NC, 4UCSF, Corte Madera, CA

    Background/Purpose: Accounting for the integration of new immunosuppressive treatment options (belimumab and voclosporin) since 2021, we aimed to describe real-world treatment patterns in patients with…
  • Abstract Number: 2159 • ACR Convergence 2024

    Reaching Those in Need: Understanding the Reach of a Digital Program for Lupus Self-Management Education

    Katherine Carpenter1, Melissa French2, Sara Johnson3, Janet Johnson3, Ashley Holden4, Joy Buie1, Melicent Miller1 and Mary Crimmings1, 1Lupus Foundation of America, Washington, DC, 2Lupus Foundation of America, Alexandria, VA, 3ProChange Behavior Solutions, South Kingstown, RI, 4Lupus Foundation of America, Bossier City, LA

    Background/Purpose: As part of a 5-year cooperative agreement with the Centers for Disease Control and Prevention, The Lupus Foundation of America (LFA) has implemented the…
  • Abstract Number: 2601 • ACR Convergence 2024

    Platelets Specifically Interact with Remigrating Neutrophils and Promote Immunogenic Cellular Death in Systemic Lupus

    Marie nansion1, Eloi Schmauch2, Pierre Vacher3, Jean Sibilia4, Nathan Broussaudier1, Adeline Bruchon1, Pierre Grenot1, Anne-Sophie Korganow5, Thierry Martin5, Sophie Caillard6, Anna Duval6, Jacques-Eric Gottenberg7, Raphaël Carapito1, Séiamak Bahram1, Patrick Blanco8 and Marc Scherlinger9, 1UMR_INSERM 1109, Strasbourg, France, 2Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boston, MA, 3Inserm U1045, Bordeaux, France, 4Strasbourg University Hospital, National reference center for autoimmune disease, Rheumatology, Strasbourg, France, 5Strasbourg University Hospital, National reference center for autoimmune disease, Clinical Immunology, Strasbourg, France, 6Nephrology department, HUS, Strasbourg, France, 7Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 8UMR_CNRS 5164 Immunoconcept, BORDEAUX CEDEX, France, 9Strasbourg University Hospital; INSERM 1109, Strasbourg, France

    Background/Purpose: In SLE, platelet activation (express P-selectin+) follows the disease activity, which plays a role in thrombosis as well as in inflammation (1). Neutrophils express high levels of PSGL-1,…
  • Abstract Number: 0091 • ACR Convergence 2024

    Targeting Endothelial Dysfunction in Lupus Nephritis: Effect of Sepiapterin, a Drug That Restores Endothelial Nitric Oxide Synthase Function, in a Murine Model of Lupus Nephritis

    Dayvia Russell1, Sandra Mungaray2, Soroush Moradi2 and Jim Oates2, 1Ralph H. Johnson VA, Charleston, SC, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Lupus nephritis (LN) is characterized by chronic endothelial cell dysfunction (ECD), which occurs when endothelial nitric oxide synthase (eNOS) becomes uncoupled, producing harmful reactive…
  • Abstract Number: 0651 • ACR Convergence 2024

    Renal Survival and Mortality in Patients with Proliferative and Membranous Lupus Nephritis

    Jung-Min Shin1, Jiyoung Lee2, Hye-Soon Lee3, Sang-Cheol Bae3 and So-Young Bang3, 1Department of Rheumatology, Nowon Eulji Medical Center, Seoul, Republic of Korea, 2Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea

    Background/Purpose: Lupus nephritis (LN) affects approximately 50% of patients and is a major determinant in the survival and prognosis of patients with systemic lupus erythematosus…
  • Abstract Number: 1040 • ACR Convergence 2024

    Clinic Personnel Perceptions Were Favorable for the Implementation of a Patient Decision-Aid for a Diverse Systemic Lupus Erythematosus Population: A Study in 15 U.S. Rheumatology Clinics

    Jasvinder Singh1, Larry Hearld2, Walter Chatham3, Sonali Narain4, Narender Annapureddy5, Diane Kamen6, Kimberly Trotter7, vikas Majithia8, Cathy Lee Ching9, Zineb Aouhab10, Swamy Venuturupalli11, Daniel Wallace12, rosalind Ramsey-Goldman13, Alfred Kim14, Maureen McMahon15, S. Sam Lim16, Kalpana Bhairavarasu17, Alexa Meara18 and Kenneth Kalunian19, 1Baylor College of Medicine, Birmingham, AL, 2University of Alabama at Birmingham (UAB), Birmingham, AL, 3University of Nevada, Las Vegas, Las Vegas, NV, 4Northwell Health, Great Neck, NY, 5Vanderbilt University Medical Center, Nashville, TN, 6Medical University of South Carolina, Charleston, SC, 7University of Chicago, Chicago, IL, 8University of Missisippi Medical Center (UMC), Jackson, MS, 9UMMC, Jackson, MS, 10Loyola University Medical Center, Oak Brook, IL, 11Attune Health, Beverly Hills, CA, 12Cedars Sinai Medical Center, Studio City, CA, 13Northwestern University, Chicago, IL, 14Washington University School of Medicine, Division of Rheumatology, Department of Medicine, St Louis, MO, 15UCLA David Geffen School of Medicine, Los Angeles, CA, 16Emory University, Atlanta, GA, 17Baylor College of Medicine, Sugar Land, TX, 18The Ohio State University Wexner Medical Center, COLUMBUS, OH, 19University of California San Diego, La Jolla, CA

    Background/Purpose: To understand clinic personnel feedback regarding the implementation of a self-administered patient decision-aid (PtDA) for lupus in regular, outpatient rheumatology clinics.Methods: We provided self-administered…
  • Abstract Number: 1642 • ACR Convergence 2024

    A Urinary Biomarker Panel to Predict the Probability of Histologically Active Lupus Nephritis

    Andrea Fava1, Andrew Concoff2, Tyler O'Malley3, Sepehr Taghavi4, Touba Warsi4, Sudha Kumar4, Christine Schleif4 and Michelle Petri5, 1Divison of Rheumatology, Johns Hopkins University, Baltimore, MD, 2Exagen, Inc., Los Angeles, CA, 3Exagen, Vista, CA, 4Exagen, Carlsbad, CA, 5Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Achieving an NIH Activity Index of < 2 upon treatment is associated with less LN flare and thus better long-term kidney survival. Here, we…
  • Abstract Number: 2371 • ACR Convergence 2024

    The Role of Intracytoplasmic Toll- Like Receptors (TLR) and MyD88 in B Cell Subsets as Renal Response Predictors in Patients with Lupus Nephritis

    Fabiola Cassiano-Quezada1, José Jiram Torres-Ruiz2, Jennifer Balderas Miranda3, José Luis Maravillas-Montero4, Karina Santana-de Anda2, Beatriz Alcalá-Carmona5, Nancy R Mejía-Domínguez5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Guillermo Juarez-Vega4 and Diana Gomez-martin6, 1Department of Internal Medicine. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, 2Departament of Immunology and Rheumatology. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, 3Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 4Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: Recently, a gain of-function mutation within TLR7 was identified to induce SLE in a murine model and increased the survival of activated B lymphocytes,…
  • Abstract Number: 2658 • ACR Convergence 2024

    Hypovitaminosis D in Lupus Nephitis

    Alicia Yupe1, Emma Puron Gonzalez2, Esteban Salatino3, Jessica Santana4, Montserrat Ochoa4, Rosa Elena Cervantes-Ramirez5, Eli Marisol Saldaña6, gabriel Calderon7, Brissia Ceniceros8, Ulices de la Cruz9, Monica Meza10 and Sergio Cerpa Cruz6, 1Facultad de Ciencias Médicas, Universidad de San Carlos de Guatemala., Guatemala, Guatemala, 2UDEM/ITESM, San Pedro Garza Garcia, Mexico, 3Faculty of Medical Sciences, Universidad de San Carlos de Guatemala., Guatemala, GU, 4Hospital Civil "Fray Antonio Alcalde", Guadalajara, Mexico, 5Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico, Distrito Federal, Mexico, 6Hospital Civil de Guadalajara, Guadalajara, Mexico, 7Hospital Civil de Guadalajara, Monterrey, Mexico, 8Hospital Civil de Guadalajara, Torreón, Coahuila de Zaragoza, Mexico, 9Hospital Civil "Fray Antonio Alcalde", Guadalajara, 10Centro Universitario de Ciencias de la SAlud, Guadalajara

    Background/Purpose: The prevalence of vitamin D deficiency is higher in patients with systemic lupus erythematosus (SLE) compared to the healthy population, and recent studies have…
  • Abstract Number: 0168 • ACR Convergence 2024

    Real-world Glucocorticoid Prescription Patterns in Patients with Lupus Nephritis: A Retrospective Study Using a Healthcare Insurance Claims Database

    Tatsuya Atsumi1, Hironari Hanaoka2, Nobuo Nishijima3, Kohji Murakami4, Mariko Nio3, Tsutomu Urakawa3, Takaaki Fujimura3 and Hiroki Hayashi5, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Chugai Pharmaceutical Co., Ltd., Tokyo, Japan, 4Nippon Shinyaku Co., Ltd., Tokyo, Japan, 5Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    Background/Purpose: Lupus nephritis (LN) is one of the most frequent organ manifestations of systemic lupus erythematosus (SLE), affecting morbidity and mortality in SLE. LN is…
  • Abstract Number: 0652 • ACR Convergence 2024

    Analysis of Relapses in a Single Center Cohort of Patients with Lupus Nephritis

    Gamze Kemec1, Sibel Varelci2, Erdem Gurel2, Isın Kılıcaslan3, Yasemın özlük3, Yasemın Yalcınkaya4, Ahmet Gul5, Murat Inanc6 and bahar Artım Esen4, 1Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul, Turkey, 3Department of Pathology Istanbul Faculty of Medicine, Istanbul, Turkey, 4Division of Rheumatology, Department of Internal Medicine, Istanbul, Turkey, 5Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, Istanbul, Turkey, 6Istanbul University, Istanbul Faculty of Medicine, Division of Rheumatology, Istanbul, Turkey

    Background/Purpose: Relapses are correlated with increased hospitalizations, poor renal outcomes, morbidity and mortality. We aim to investigate the incidence, predictive factors and outcomes related to…
  • Abstract Number: 1068 • ACR Convergence 2024

    Improving Health Numeracy Literacy in Pediatric Patients with SLE

    Nicole Salach1, Sarah Rogal1, Jessica Simpson1, Sangeeta Sule2, Abigail Bosk3 and Catherine Park1, 1Children's National Hospital, Washington DC, DC, 2Children's National Hospital, Washington, DC, 3Children's National Hospital, Bethesda, DC

    Background/Purpose: Health literacy is key to better patient outcomes. One aspect of health literacy that warrants additional investigation in patients who have systemic lupus erythematosus…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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