Abstracts tagged "Knee"

Abstract Number: 2201 • 2017 ACR/ARHP Annual Meeting
Baseline Periarticular Tibial Knee Bone Mineral Density Is Associated with Change in Static Alignment
Grace H. Lo¹, Jeffrey B. Driban², Michael T. Strayhorn³, Lori Lyn Price⁴, Charles Eaton⁵ and Timothy E. McAlindon⁶, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Rheumatology, Tufts Medical Center, Boston, MA, ³VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁴Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁵Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Relative local knee periarticular bone mineral density (paBMD) as measured by dual x-ray absorptiometry (DXA) has been associated with static alignment cross-sectionally, but not…
Abstract Number: 932 • 2017 ACR/ARHP Annual Meeting
Association of Varus Knee Thrust during Walking to Worsening Knee Pain over Two Years
Alexandra Wink¹, K. Douglas Gross², Carrie Brown³, Michael C. Nevitt⁴, Cora E. Lewis⁵, James Torner⁶, Leena Sharma⁷ and David T. Felson⁸, ¹Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, ²Clinical Epidem Rsrch, Boston University School Medicine, Boston, MA, ³Boston University School of Public Health, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA, ⁷Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Varus knee thrust is an abrupt change in frontal plane tibiofemoral alignment observed during gait. Thrust has been linked to radiographic knee OA progression…
Abstract Number: 1201 • 2017 ACR/ARHP Annual Meeting
Reducing Heterogeneity in OA Clinical Trials: Data from a Phase 2 Study of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor in Knee Osteoarthritis
Philip G. Conaghan¹, Anita DiFrancesco², Christopher J. Swearingen², Sarah Kennedy², Ismail Simsek², Jeymi Tambiah² and Yusuf Yazici², ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Samumed, LLC, San Diego, CA
Background/Purpose: Kellgren-Lawrence [KL] radiographic grading is used to classify knee osteoarthritis (OA), but may not accurately reflect disease progression. Classifying subjects by baseline medial joint…
Abstract Number: 2204 • 2017 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report
Ece Kaptanoglu¹, Ozlem Şahin², Tiraje Tuncer³, Sami Hizmetli¹, Lale Altan⁴, Figen Ayhan⁵, Ajda Bal⁶, Meral Bilgilisoy⁷, Gulnur Bozbas⁸, Lale Cerrahoglu⁹, Remzi Cevik¹⁰, Tuncay Duruoz¹¹, Deniz Dulgeroglu⁶, Gulcan Gurer¹², Savas Gursoy¹³, Simin Hepguler¹⁴, Cahit Kacar¹⁵, Taciser Kaya¹⁶, Meltem Melikoglu¹⁷, Kemal Nas¹⁸, Suheda Ozcakir¹⁹, Senay Ozdolap²⁰, merih Saridogan²¹, Selda Sarikaya²⁰, Dilsad Sindel²², Omer F Şendur⁸, Canan Tikiz²³ and Hatice Ugurlu²⁴, ¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, ²Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey, ³Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey, ⁴Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Uludag University School of Medicine, Bursa, Turkey, ⁵Department of Physical Medicine and Rehabilitation, University of Health Ankara Training and Research Hospital, Ankara, Turkey, ⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, ⁷Department of Physical Medicine and Rehabilitation, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey, ⁸Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁹Department of Physical Medicine and Rehabilitation, Celal Bayar University School of Medicine, Manisa, Turkey, ¹⁰Department of Physical Medicine and Rehabilitation, Dicle University School of Medicine, Diyarbakir, Turkey, ¹¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ¹²Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydin, Turkey, ¹³Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹⁴Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey, ¹⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences İzmir Bozyaka Training and Research Hospital, Izmir, Turkey, ¹⁷Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, ¹⁸Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey, ¹⁹Department of Physical Medicine and Rehabilitation, Uludag University School of Medicine, Bursa, Turkey, ²⁰Department of Physical Medicine and Rehabilitation, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, ²¹Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, ²²Department of Physical Medicine and Rehabilitation, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey, ²³Celal Bayar University School of Medicine, Manisa, Turkey, ²⁴Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
Background/Purpose: Neuropathic pain (NP) was accused for increased pain and reduced functional capacity in knee osteoarthritis (KO). Here we aimed to find out the prevalence…
Abstract Number: 933 • 2017 ACR/ARHP Annual Meeting
Longitudinal Association between Sleep Quality and Knee Pain in the Multicenter Osteoarthritis Study
Zhaoli (Joy) Dai¹, Carrie Brown², Tuhina Neogi³ and David T. Felson³, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Sleep and pain have been shown to be reciprocally related. Studies have suggested a stronger effect of sleep impairment on chronic pain such as…
Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial
E.A.M. Mahler¹, M.J.M Minten¹, M.M. Leseman-Hoogenboom², P.M.P. Poortmans², S.S. Boks³, J.W.J. Bijlsma⁴, F.H.J. van den Hoogen^1,5, A.A. Den Broeder^1,5 and C.H.M. van den Ende^1,5, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, ³Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁵Rheumatology, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
Abstract Number: 2205 • 2017 ACR/ARHP Annual Meeting
Trajectories of Knee Bone Shape Change Are Associated with Sex and Osteoarthritis
Barton L Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Nevada, Reno, Reno, NV, ⁶Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA
Background/Purpose: Knee osteoarthritis (OA) is more common in women than men; however, the biological mechanisms for sex difference in knee OA are not well understood.…
Abstract Number: 934 • 2017 ACR/ARHP Annual Meeting
Effectiveness of FX006 Intra-Articular Injection in Patients with Knee Osteoarthritis Who Present with and without Clinical Inflammation at Baseline: A Pooled Analysis of Data from 3 Double-Blind, Randomized, Parallel-Group Clinical Trials
Herbert S. B. Baraf¹, Christian Lattermann², Deryk G. Jones³, Philip G. Conaghan⁴, Joelle Lufkin⁵, James Johnson⁶, Scott Kelley⁵ and Neil Bodick⁵, ¹Center for Rheumatology and Bone Research, Wheaton, MD, ²University of Kentucky, Orthopaedic Surgery and Sports Medicine, Lexington, KY, ³Ochsner Sports Medicine Institute, New Orleans, LA, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Flexion Therapeutics, Inc., Burlington, MA, ⁶Summit Analytical, Denver, CO
Background/Purpose: Inflammation is a key contributor to osteoarthritis (OA).1 OA pain is mediated by interactions between inflammatory cytokines and other features including local tissue damage,…
Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting
Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders
J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium
Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
Abstract Number: 2217 • 2017 ACR/ARHP Annual Meeting
Combined Impacts of Lifestyle Factors on Knee Osteoarthritis in the Osteoarthritis Initiative
Zhaoli (Joy) Dai¹, Carrie Brown², Yuqing Zhang³ and David T. Felson⁴, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Body mass index (BMI), healthy diet or components, physical activity, and tobacco smoking have been examined independently with risk of knee osteoarthritis (OA). Sleep…
Abstract Number: 110 • 2016 ACR/ARHP Annual Meeting
Patient Decisions Related to Hip and Knee Arthroplasty and the Factors Influencing Them
W. Benjamin Nowell¹, Shilpa Venkatachalam¹, Erik Harden¹ and Thomas Concannon^2,3, ¹Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ²The RAND Corporation, Boston, MA, ³Tufts University School of Medicine, Boston, MA
Background/Purpose: Patient-engaged research can improve the safety and satisfaction outcomes of hip and knee arthroplasty (joint replacement surgery). Patients are able to identify the decisions…
Abstract Number: 1020 • 2016 ACR/ARHP Annual Meeting
Risk Factors Can Classify Individuals Who Develop Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Timothy E. McAlindon², Mamta Amin³, Lori Lyn Price⁴, Charles B. Eaton⁵, Julie Davis⁶, Bing Lu⁷, Grace H. Lo⁸, Jeffrey Duryea⁹ and Mary Barbe¹⁰, ¹Tufts Medical Center, Boston, MA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁶Rheumatology, Tufts Medical Center, Boston, MA, ⁷Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁸Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁹Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁰Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Accelerated knee osteoarthritis (KOA) is a painful disorder and associated with several risk factors: greater age, greater body mass index (BMI), static knee alignment,…
Abstract Number: 2356 • 2016 ACR/ARHP Annual Meeting
Comparison of Spa Therapy with or without Physical Rehabilitation for Knee Osteoarthritis: A Randomized Controlled Trial
Anne-Christine Rat^1,2, Damien Loeuille³, Emmanuel Spitz⁴, Alexandra Desvignes⁵, Michel Boulange⁶, Jean Paysant⁷, Francis Guillemin⁸ and Isabelle Chary-Valckenaere⁹, ¹Université de Lorraine, Apemac EA4360, Nancy, Nancy, France, ²Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, ³Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁴Rheumatology Strasbourg, Strasbourg, France, ⁵rheumatology, Hopital Simone Veil, Eaubonne, Eaubonne, France, ⁶Hydrologie et Climatologie Médicale, CHRU Nancy, Nancy, France, ⁷Institut de rééducaption et réadapattion Louis Pierquin, Nancy, France, ⁸CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, ⁹CHRU Nancy, Nancy, France
Background/Purpose: To demonstrate the non-inferiority of “Active” compared to “Standard” spa therapy at 6 months in symptomatic knee osteoarthritis (KOA) care. Methods: Prospective, randomized, monocenter,…
Abstract Number: 153 • 2016 ACR/ARHP Annual Meeting
Synovial Immunophenotype and Ultrasonography: A Contemporaneous Study of Different Compartments of the Knee Joint
Aurélie Najm^1,2, Carl Orr³, Benoît Le Goff MD PhD¹, Ursula Fearon⁴ and Douglas J. Veale⁵, ¹Rheumatology, Nantes University Hospital, Nantes, France, ²Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁴Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, ⁵Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland
Background/Purpose: Histological analysis of synovial tissue, despite being a reliable and accurate assessment for synovitis, is not routinely performed. Ultrasonography (US) is a fast, available…
Abstract Number: 1021 • 2016 ACR/ARHP Annual Meeting
Maintaining Sufficient Serum Vitamin D Levels over 2 Years Is Associated with Reduced Knee Structural and Symptomatic Changes in Patients with Knee Osteoarthritis
Shuang Zheng¹, Xingzhong Jin¹, Flavia M Cicuttini², Xia Wang¹, Zhaohua Zhu¹, Anita E Wluka³, Weiyu Han¹, Tania Winzenberg¹, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding⁴, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia, ³Australia, Armadale, Australia, ⁴Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: To examine whether those maintaining sufficient serum vitamin D levels have reduced knee structural changes and symptomatic improvement compared with those not maintaining sufficient…

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