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Abstracts tagged "Knee and osteoarthritis"

  • Abstract Number: 2082 • ACR/ARP Annual Meeting 2019

    Activity in Work and Life: The Association Between Physical Activity and Employment Status with Future Slow Walking in Knee Osteoarthritis

    Jason Jakiela1, Louise Thoma 2, Hiral Master 3, Dana Voinier 1, Meredith Christiansen 1, Lauren Neely 1 and Daniel White 3, 1University of Delaware, Newark, 2University of North Carolina at Chapel Hill, Newark, 3University of Delaware, Newark, DE

    Background/Purpose: Knee osteoarthritis (OA) is the leading cause of functional limitation in older adults, e.g., slow walking. Physical activity (PA) is beneficial for those with…
  • Abstract Number: 453 • ACR/ARHP Annual Meeting 2018

    Profound Changes in the NaV1.8 Nociceptive Innervation of the Murine Knee Joint after Destabilization of the Medial Meniscus

    Alia Obeidat1, Richard J. Miller2, Rachel E. Miller3 and Anne-Marie Malfait4, 1Rush University Medical Center, Chicago, IL, 2Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, 3Biochemistry, Rush University Medical Center, Chicago, IL, 4Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: We aimed to compare the nociceptive innervation of healthy and osteoarthritic mouse knees. Methods: Destabilization of the medial meniscus (DMM) or sham surgery was…
  • Abstract Number: 945 • ACR/ARHP Annual Meeting 2018

    Pain, Functional Limitations and Physical Activity Participation Trajectories in Patients with Symptomatic Knee and Hip Osteoarthritis: A Multi-Trajectory Analysis

    Maud Wieczorek1, Christine Rotonda1, Francis Guillemin1,2 and Anne-Christine Rat1,3, 1Université de Lorraine, EA4360, APEMAC, Nancy, France, 2Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, 3Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France

    Background/Purpose: The aims of this study were to identify homogeneous subgroups of knee and/or hip osteoarthritis (OA) patients with distinct trajectories of the combination of…
  • Abstract Number: 1056 • ACR/ARHP Annual Meeting 2017

    Evolution of Health Care Consumption in the Knee and Hip Osteoarthritis Long Term Assessment Cohort, a French Population Based Cohort of Symptomatic Knee and/or Hip OA Patients

    Anne-Christine Rat1,2,3, Jean-Hugues Salmon4, Willy Ngueyon Sime5, Maud Wieczorek6, Alain Saraux7, Claudine Gard8, Francis Guillemin9 and Bruno Fautrel10, 1Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, 2Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, 3Université de Lorraine, EA4360, APEMAC, Nancy, France, 4Rheumatology, Rheumatology Department CHU Teaching Hospital Reims, Reims, France, 5CIC 1433 Epidémiologie clinique, Inserm, Nancy, France, 6Université de Lorraine EA 4360 APEMAC, Nancy, France, 7Rheumatology Department, Rheumatology Department, CHU de la Cavale Blanche, Brest, France, Brest Cedex, France, 8Pitié Salpetrière hospital, Paris, France, 9CHRU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, 10UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France

    -      Background/Purpose:  in hip and knee OA, one of the leading causes of global disability, recent population-based data of health care practices and utilization are scarce.…
  • Abstract Number: 1191 • ACR/ARHP Annual Meeting 2017

    Efficacy and Safety of Cntx-4975 in Subjects with Moderate to Severe Osteoarthritis Knee Pain: 24-Week, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study

    Randall Stevens1, Dena Petersen2, John Ervin3, Jennifer Nezzer4, Yeni Nieves4, James Campbell1, Kimberly Guedes1, Robin Burges1 and Peter Hanson1, 1Centrexion Therapeutics, Boston, MA, 2Noble Clinical Research, Tucson, AZ, 3Center for Pharmaceutical Research, Kansas City, MO, 4Premier Research, Durham, NC

    Background/Purpose: CNTX-4975, a highly purified, synthetic trans-capsaicin, targets transient receptor potential vanilloid 1, producing analgesia via reversible desensitization of end terminals of primary afferent pain…
  • Abstract Number: 2177 • ACR/ARHP Annual Meeting 2017

    The Medial Shift of the Tibial Articular Surface Is One Factor of Medial Osteoarthritis of the Knee

    Ryuji Nagamine, Artificial joint and rheumatism, Fukuoka Tokushukai Medical Center, Kasuga, Japan

    Background/Purpose: Varus alignment is one factor of medial osteoarthritis (OA) of the knee. According to the concept of the constitutional varus, the bone growth disturbance…
  • Abstract Number: 2200 • ACR/ARHP Annual Meeting 2017

    History of Walking for Exercise Is Not Associated with More Symptomatic Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    Grace H. Lo1, Jeffrey B. Driban2, Andrea Kriska3, Timothy E. McAlindon4, Richard Souza5, Nancy J. Petersen6, Bonny Jane Rockette-Wagner7, Charles Eaton8, Marc Hochberg9, Rebecca D. Jackson10, C. Kent Kwoh11, Michael C. Nevitt12 and Maria Suarez-Almazor13, 1Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 2Rheumatology, Tufts Medical Center, Boston, MA, 3University of Pittsburgh, Pittsburgh, PA, 4Division of Rheumatology, Tufts Medical Center, Boston, MA, 5University of California, San Francisco, San Francisco, CA, 6Medicine, Baylor College of Medicine, Houston, TX, 7University of Pittsburgh Medical Center, Pittsburgh, PA, 8Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, 9Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 10Ohio State University, Columbus, OH, 11University of Arizona, Tucson, AZ, 12Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 13Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, Houston, TX

    Background/Purpose: Walking is recommended for those with knee OA (KOA). However, few studies have explored the association between walking and symptomatic OA, and conflicting data…
  • Abstract Number: 979 • ACR/ARHP Annual Meeting 2017

    What Have We Learned from Trajectory Analysis of Clinical Outcomes in Osteoarthritis?

    Maud Wieczorek1, Anne-Christine Rat1,2,3, Francis Guillemin1,2 and Christine Rotonda1, 1Université de Lorraine, EA4360, APEMAC, Nancy, France, 2Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, 3Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France

    Background/Purpose: The aims of this review were to summarize the literature on the trajectories of clinical outcomes in knee and hip OA, to describe the…
  • Abstract Number: 296 • ACR/ARHP Annual Meeting 2016

    Knee Osteoarthritis As Risk for Hip Osteoarthritis

    Chan Kim1, Shanshan Sheehy2, Cara Lewis3, Mary M Clancy4,5,6, Michael C. Nevitt7, James Torner8, Cora E. Lewis9, Ali Guermazi10 and David T. Felson11, 1Rheumatology and Clinical Epidemiology, Boston University School of Medicine, Boston, MA, 2Clinical Epidemiology Research & Training Unit, Boston University, Boston, MA, 3Physical Therapy and Athletic Training, Boston University, Boston, MA, 4Clinical Epidemiology, BUSM, Boston, MA, 5Clinical Epidemiology, Boston University School Medical, Boston, MA, 6Clinical Epidemiology, Boston University Sch Med, Boston, MA, 7Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 8University of Iowa, UIowa, Iowa City, IA, 9University of Alabama Birmingham, Birmingham, AL, 10Boston University School of Medicine, Boston, MA, 11Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA

    Knee osteoarthritis as risk factor for hip osteoarthritis Background/Purpose: While the hip and knee are linked biomechanically, the risk of hip osteoarthritis (OA) in persons…
  • Abstract Number: 317 • ACR/ARHP Annual Meeting 2016

    Leg Muscle Imbalance Is Associated with Radiographic Grade or Pain in Knee Osteoarthritis

    Ji Yeon Lee1, Kyungdo Han2, Yong Gyu Park2 and Sung-Hwan Park3, 1International Healthcare Center, Seoul St Mary's Hosiptal, Seoul, Korea, Republic of, 2Department of Biostatistics, Catholic University of Korea, Seoul, South Korea, Seoul, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Osteoarthritis(OA) has been recognized as a progressive disease resulting from stress in synovial joint tissues including periarticular muscles. In knee OA, quadriceps muscle mass…
  • Abstract Number: 1296 • ACR/ARHP Annual Meeting 2016

    Quantitative Measurements of Cartilage, Osteophyte, and Bone Marrow Lesion Volume in Knee Osteoarthritis

    Lena Franziska Schaefer1, Ming Yin1, Meera Sury2, Scott Jamieson1, Jamie E. Collins3, Stacy Smith4 and Jeffrey Duryea1, 1Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, 2Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, 3Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, 4Radiology/Division of Musculoskeletal Imaging & Intervention, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA

    Quantitative Measurements of Cartilage, Osteophyte, and Bone Marrow Lesion volume in Knee Osteoarthritis Schaefer L.F., Yin M., Sury, M., Jamieson S., Collins J., Smith S.,…
  • Abstract Number: 2028 • ACR/ARHP Annual Meeting 2016

    Relationship of Limb Length Inequality and Incident and Progressive Knee and Hip Radiographic Osteoarthritis and Symptoms

    Yvonne M. Golightly1, Carolina Alvarez2, Kelli Allen3, Jordan B. Renner4 and Joanne M. Jordan5, 1Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Thurston Arthritis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina at Chapel Hill and Durham VA Medical Center, Chapel Hill, NC, 4Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose:  Limb length inequality (LLI) is a condition in which one limb is longer than the other. Previous reports of a link between LLI and…
  • Abstract Number: 318 • ACR/ARHP Annual Meeting 2015

    Dual Variable Domain-Immunoglobulin (Dvd-Ig™) Abt-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Αlpha and -1 Βeta in Subjects with Knee Osteoarthritis

    Susanne X. Wang1, Ralf Loebbert2, Erik Sampson3, Mary Saltarelli1, Jeroen Medema1 and Feng Hong3, 1AbbVie Inc., North Chicago, IL, 2AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 3AbbVie Inc., Worcester, MA

    Background/Purpose: ABT-981 is a novel human Dual-Variable Domain Immunoglobulin (DVD-Ig™) that inhibits interleukin (IL)-1α and IL-1β. The purpose of this study is to evaluate IL-1α…
  • Abstract Number: 319 • ACR/ARHP Annual Meeting 2015

    Phase 1 Studies of Anti-Interleukin-1 Dual-Variable Domain Immunoglobulin in Healthy Subjects and Patients with Osteoarthritis

    Susanne X. Wang1, Wei Liu1, Ping Jiang1, Martin Okun1, Richard Preston2, Carlos J. Lozada2, David Carter1 and Jeroen Medema1, 1AbbVie Inc., North Chicago, IL, 2University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose: Interleukin (IL)-1 is a catabolic cytokine that plays an important role in pathogenesis and progression of osteoarthritis (OA). Two phase 1 clinical trials investigated…
  • Abstract Number: 1088 • ACR/ARHP Annual Meeting 2015

    Effect of Training on Knee Torsional Stiffness and Its Relationship to Tibial Compressive and Anterior Shear Forces in Recreational Female Runners

    Bhushan Thakkar1 and D. S. Blaise Williams III2, 1PHYSICAL THERAPY, VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA, 2Physical Therapy, Virginia Commonwealth University, Richmond, VA

    Background/Purpose: 42 million Americans participate annually in running. In 2014, the half marathon was the most popular distance with a total of 61% females (1.2…
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