ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Intervention"

  • Abstract Number: 0063 • ACR Convergence 2022

    Implementability of a SLE Medication Adherence Intervention

    Kai Sun1, Nneka Molokwu2, Amy Corneli1, Kathryn Pollak1, Alexandria Bennion2, Jennifer L Rogers3, Rebecca Sadun2, Lisa Criscione-Schreiber1, Jayanth Doss2, Amanda Eudy4, Hayden Bosworth1 and Megan Clowse2, 1Duke University School of Medicine, Durham, NC, 2Duke University, Durham, NC, 3Duke University School of Medicine, Division of Rheumatology & Immunology, Durham, NC, 4Duke University, Raleigh, NC

    Background/Purpose: Medication nonadherence in SLE is common and negatively impacts patient outcomes. Yet, little is known about how to improve medication adherence in patients with…
  • Abstract Number: 0126 • ACR Convergence 2022

    Should Arthrocentesis Be Attempted in the Symptomatic but Non-Effusive Knee?

    Rosemina Patel1, Angie Ariza-hutchinson1, Ahsan Iqbal1, Matthew McElwee1, N. Suzanne Emil1, Sharon Nunez1, maheshwari muruganandam1, frank O'Sullivan1, Roderick Fields1, Yvonne Waters2 and Wilmer Sibbitt1, 1University of New Mexico, Albuquerque, NM, 2University of New Mexico Hospital, Corrales, NM

    Background/Purpose: Arthrocentesis of the painful but non-effusive knee is usually not undertaken due to a high arthrocentesis failure rate. We hypothesized that compression-assisted arthrocentesis of…
  • Abstract Number: 0173 • ACR Convergence 2022

    Cutaneous Manifestations, Clinical Trials, Safety Efficacy and Safety of Lenabasum in the Phase 3 DeterMine Trial in Dermatomyositis

    Victoria Werth1, Barbara White2, Josef Concha3, Josh Dan1, Nancy Dgetluck2, Kathleen Hally2, Scott Constantine2, Rohit Aggarwal4, David Fiorentino5, Ingrid Lundberg6 and Chester Oddis7, 1Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 2Corbus Pharmaceuticals, Norwood, MA, 3Universiity of Pennsylvania/Dermatology, Philadelphia, PA, 4University of Pittsburgh, Division of Rheumatology, Pittsburgh, PA, 5Stanford university/Department of Dermatology, Palo Alto, CA, 6Karolinska Institute, Stockholm, Sweden, 7University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Safe and effective treatments are of significant unmet need in DM. Lenabasum, a CB2 agonist that activates resolution of inflammation, improved skin disease, patient-reported…
  • Abstract Number: 0201 • ACR Convergence 2022

    Real-World Evidence from Social Media Provides Insights into Patient Mental Health Outcomes in the Management of Gout

    Maurice Flurie1, Joseph Coe2, Monica Converse1, Kristina Davidson3, Colton Flowers1, Kelly Gavigan4, Daniel Hernandez5, Helen Hernandez1, Gary Ho6, Brian LaMoreaux3, Christopher Parker6, E. Robert Wassman1, Christopher DeFelice1 and Maria Picone1, 1TREND Community, Philadelphia, 2Global Healthy Living Foundation, Upper Nyack, 3Horizon Therapeutics, Chicago, IL, 4Global Healthy Living Foundation, Upper Nyack, NY, 5Global Healthy Living Foundation, Nyack, NY, 6Gout Support Group of America, Austin, TX

    Background/Purpose: The ability to actively listen to and interpret the patient experience is vital to effectively address the needs of individuals within a particular community.…
  • Abstract Number: 0571 • ACR Convergence 2022

    National Rollout of a Medication Safety Dashboard to Improve Testing for Latent Infections Among Biologic/targeted Synthetic DMARD Users Within the Veterans Health Administration: Initial Results

    Anna Montgomery1, Gary Tarasovsky2, Mary Whooley2, Jennifer Barton3, Karla Miller4, Holly Mitchell5, Jo Dana2, Kimberly Reiter6, Elizabeth Wahl7, Karine Rozenberg-Ben-Dror8, Jing Li9 and Gabriela Schmajuk10, 1University of California San Francisco, Reno, NV, 2San Francisco VA Medical Center, San Francisco, CA, 3VA Portland Health Care System/OHSU, Portland, OR, 4University of Utah Division of Rheumatology/VA Salt Lake City Health Care, Salt Lake City, UT, 5Ralph H. Johnson VA Hospital, Mount Pleasant, SC, 6Albuquerque VA Medical Center, Albuquerque, NM, 7VA Puget Sound Healthcare System, Seattle, WA, 8Greater Lakes Region/VISN 12 Dept Veterans Affairs, Hines, IL, 9University of California, San Francisco, San Francisco, CA, 10UCSF / SFVA, San Francisco, CA

    Background/Purpose: Guidelines recommend testing for latent hepatitis B virus (HBV), hepatitis C virus (HCV), and tuberculosis (TB) infection prior to initiating biologics or targeted synthetic…
  • Abstract Number: 1269 • ACR Convergence 2022

    Implementing RAPID-3 Using Electronic Patient Portal and Point of Care Entry

    Sancia Ferguson1, Lori Zemlicka2, Amanda Weber2, Abdul Halabi3, Jon Arnason4 and Christie Bartels5, 1University of Wisconsin School of Medicine & Public Health, Madison, WI, 2UW Health, Madison, WI, 3University of Wisconsin, Madison, WI, 4University of Wisconsin Hospitals and Clinics, Madison, WI, 5University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: The treat-to-target approach endorsed by the ACR for rheumatoid arthritis requires frequent monitoring of disease activity using validated instruments, with changes to the treatment…
  • Abstract Number: 1809 • ACR Convergence 2022

    Impact of Colchicine Prophylaxis on Cardiovascular Outcome Among Gout Patients: A Secondary Analysis of CARES Trial

    Keigo Hayashi1, yuqing zhang2, Hyon Choi3 and Kazuki Yoshida4, 1Brigham and Women's Hospital, Okayama, Japan, 2Massachusetts General Hospital, Quincy, MA, 3MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, 4Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Low-dose colchicine has been demonstrated to reduce cardiovascular (CV) events in two recent large cardiovascular trials. Gout patients, for whom colchicine is a highly relevant…
  • Abstract Number: 2003 • ACR Convergence 2022

    Anti-rheumatic Treatment Modulates Expression of the Glycolytic Enzyme PFKFB3 in CD14+ Monocytes of Patients with Rheumatoid Arthritis, Which Contributes to Dissimilarities of the IFN Signature

    Malin Erlandsson1, Karin Andersson1, Sofia Töyrä Silfverswärd2, Rille pullerits2 and Maria Bokarewa2, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Combination of IFN-stimulated genes known as IFN signature, helps to predict disease activity and treatment response in several autoimmune diseases, including rheumatoid arthritis (RA).…
  • Abstract Number: 2263 • ACR Convergence 2022

    Nanotherapeutic Approaches for the Treatment of Post-traumatic Osteoarthritis

    Luke Springer1, Kelsey Collins2, Huimin Yan2, Ying Hu3, Farshid Guilak2, Samuel Wickline4, Hua Pan2 and Christine Pham2, 1Washington University School of Medicine, St. Louis, MO, 2Washington University School of Medicine, Saint Louis, MO, 3Washington University, Saint Louis, MO, 4University of South Florida, Tampa, FL

    Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and is a major cause of morbidity in the aging population. Post-traumatic OA (PTOA) is…
  • Abstract Number: L02 • ACR Convergence 2021

    COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases

    Ines Colmegna1, Mariana Useche1, Emmanouil Rampakakis2, Nathalie Amiable3, Emmanuelle Rollet-Labelle3, Louis Bessette4, Jo-Anne Costa4, Marc Dionne4, Mary-Ann Fitzcharles2, Elizabeth Hazel2, Deirdre McCormack2, Laetitia Michou4, Pantelis Panopalis2, Marc-Andre Langlois5, Sasha Bernatsky6 and Paul R. Fortin7, 1The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Centre de Recherche du CHU de Quebec, Quebec, Canada, 4Universite Laval, Quebec, QC, Canada, 5University of Ottawa, Ottawa, ON, Canada, 6McGill University, Montreal, QC, Canada, 7CHU de Quebec - Universite Laval, Quebec, Canada

    Background/Purpose: Immunocompromised conditions and/or a history of autoimmune disease were exclusion criteria of the initial SARS-CoV-2 vaccines clinical trials. We assessed the safety and immunogenicity…
  • Abstract Number: 0462 • ACR Convergence 2021

    Remotely Delivered Cognitive Behavioural and Personalised Exercise Interventions Reduce Fatigue Severity and Impact in Inflammatory Rheumatic Diseases: Results from a Multi-centre Randomised Controlled Parallel Group Trial

    Eva-Maria Bachmair1, Kathryn Martin Remmes1, Lorna Aucott1, Emma Dures2, Richard Emsley3, Stuart Gray4, Elizabeth Kidd5, Vinod Kumar6, Karina Lovell7, Graeme MacLennan1, Paul McNamee1, John Norrie8, Lorna Paul9, Jon Packham10, Stuart Ralston11, Stefan Siebert4, Alison Wearden7, Gary Macfarlane12 and Neil Basu4, 1University of Aberdeen, Aberdeen, United Kingdom, 2University of West of England, Bristol, United Kingdom, 3King's College London, London, United Kingdom, 4University of Glasgow, Glasgow, United Kingdom, 5Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom, 6NHS Tayside, Dundee, United Kingdom, 7University of Manchester, Manchester, United Kingdom, 8Usher Institute – University of Edinburgh, Edinburgh, United Kingdom, 9Glasgow Caledonian University, Glasgow, Scotland, United Kingdom, 10Midlands Partnership NHS Foundation Trust, Stoke-on-Trent, United Kingdom, 11University of Edinburgh, Edinburgh, Scotland, United Kingdom, 12Epidemiology Group, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom

    Background/Purpose: Inflammatory rheumatic disease (IRD) related fatigue is pervasive and disabling, even in otherwise stable disease. Although cognitive-behavioural approaches (CBAs) and personalised exercise programmes (PEP)…
  • Abstract Number: 0488 • ACR Convergence 2021

    Efficacy and Safety of Brepocitinib (Tyrosine Kinase 2/Janus Kinase 1 Inhibitor) for the Treatment of Active Psoriatic Arthritis: Results from a Phase 2b Randomized Controlled Trial

    Philip Mease1, Philip S Helliwell2, Paula Silwinska-Stanczyk3, Malgorzata Miakisz4, Andrew Ostor5, Elena Peeva6, Michael Vincent6, Vanja Sikirica7, Randall Winnette8, Ruolun Qiu6, Gang Li7, Gang Feng6, Jean Beebe6 and David Martin6, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3REUMATIKA – Centrum Reumatologii NZOZ, Warsaw, Poland, 4Twoja Przychodnia Centrum Medyczne Nowa Sol, Nowa Sol, Poland, 5Monash University, Cabrini Hospital & Emeritus Research, Melbourne, Australia, 6Pfizer Inc, Cambridge, MA, 7Pfizer Inc, Collegeville, PA, 8Pfizer Inc, New York, NY

    Background/Purpose: Brepocitinib is a small-molecule tyrosine kinase 2/Janus kinase 1 inhibitor that has shown promising results in an oral formulation for plaque psoriasis and alopecia…
  • Abstract Number: 0623 • ACR Convergence 2021

    Intervention to Improve SLE Medication Adherence

    Kai Sun1, Amanda Eudy2, Jennifer Rogers1, Rebecca Sadun2, Lisa Criscione-Schreiber1, Jayanth Doss2, Mithu Maheswaranathan1, Ann Barr2, Lena Eder3, Amy Corneli1, Hayden Bosworth2 and Megan Clowse4, 1Duke University School of Medicine, Durham, NC, 2Duke University, Durham, NC, 3Duke University Medical Center, Durham, NC, 4Duke University, Chapel Hill, NC

    Background/Purpose: Medication nonadherence is as high as 80% among SLE patients and leads to higher morbidity, mortality, and healthcare costs. Both the under-recognition of nonadherence…
  • Abstract Number: 0773 • ACR Convergence 2021

    Janus Kinase (JAK) Inhibition with Baricitinib: Dosing and Patient-Reported Outcomes in Refractory Juvenile Dermatomyositis

    Hanna Kim1, Ly-Lan Bergeron2, Samantha Dill2, MIchelle O'Brien2, Xiaobai Li3, Jomy George3, April Brundidge2, Michelle Millwood2, Lisa Rider4 and Robert Colbert5, 1Juvenile Myositis Pathogenesis and Therapeutics Unit, NIAMS, National Institutes of Health, Bethesda, MD, 2Office of Clinical Director, NIAMS, National Institutes of Health, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4NIEHS, NIH, Garrett Park, MD, 5NIH/NIAMS, Bethesda, MD

    Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature. Treatment often requires prolonged high-dose steroids and other immunosuppressive medications.…
  • Abstract Number: 1746 • ACR Convergence 2021

    Baricitinib Decreases Anti-dsDNA and IgG Antibodies in Adults with Systemic Lupus Erythematosus from a Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial

    Thomas Dörner1, Ronald Van Vollenhaven2, Andrea Doria3, Bochao Jia4, Damiano Fantini4, Jorge Ross Terres4, Maria Silk5, Stephanie de Bono4, Peter Fischer6 and Daniel Wallace7, 1Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany, 2University Medical Center, Amsterdam, Netherlands, 3University of Padova, Padova, Italy, 4Eli Lilly and Company, Indianapolis, IN, 5Eli Lilly and Company, Carmel, IN, 6Eli Lilly and Company, North Easton, MA, 7Cedars-Sinai, Los Angeles, CA

    Background/Purpose: Baricitinib (BARI), an oral, selective Janus kinase (JAK)1 and JAK2 inhibitor, improved disease activity in adults with systemic lupus erythematosus (SLE) receiving standard background…
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