Abstracts tagged "interstitial lung disease"

Abstract Number: 1382 • ACR Convergence 2020
Changes in Imaging Markers in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) Treated with Nintedanib: Sub-Study of the SENSCIS Trial
Stephen Humphries¹, Eric Hachulla², Mark Hamblin³, Takashi Ogura⁴, Dag Wormanns⁵, Carina Ittrich⁶, Frank Risse⁶, Margarida Alves⁷, Martina Gahlemann⁸ and David Lynch⁹, ¹National Jewish Health, Denver, Colorado, USA, Denver, CO, ²Department of Internal Medicine and Clinical Immunology, Université de Lille, Lille, France, Lille, France, ³University of Kansas Hospital, Kansas City, Kansas, USA, Kansas City, KS, ⁴Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Centre, Yokohama, Japan, Yokohama, Japan, ⁵Evangelische Lungenklinik, Berlin, Germany, Berlin, Germany, ⁶Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Biberach an der Riss, Germany, ⁷Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, ⁸Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, ⁹National Jewish Health, Denver, Colorado, USA, Denver
Background/Purpose: In the SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks by…
Abstract Number: 0927 • ACR Convergence 2020
Care Gap in Patients with Systemic Sclerosis with CXR Findings Suggestive of Fibrosis
Sandeep Dhillon¹, Jessica Kapralik², Curtis Sobchak³, Nader Khalidi⁴, Martin Kolb⁵, Nathan Hambly², Gerard Cox², Karen Beattie⁴ and Maggie Larche⁴, ¹McMaster University, Burlington, ON, Canada, ²McMaster University, Hamilton, ³McMaster University, St. Catharines, ON, Canada, ⁴McMaster University, Hamilton, ON, Canada, ⁵McMaster University and Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamliton, ON, Canada
Background/Purpose: Lung involvement, including interstitial lung disease (ILD), is the leading cause of death in patients with systemic sclerosis (SSc). High resolution CT (HRCT) is…
Abstract Number: 1078 • ACR Convergence 2020
Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis
Antonella Notarnicola¹, Charlotta Preger², Susanna L. Lundström², Nuria Renard², Edvard Wigren², Eveline Van Gompel², Angeles S. Galindo-Feria², Helena Persson³, Maryam Fathi⁴, Johan Grunewald², Per-Johan Jakobsson², Susanne Gräslund², Ingrid Lundberg⁵ and Cátia Fernandes-Cerqueira², ¹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²Karolinska Institutet, stockholm, Sweden, ³Science for Life Laboratories, KTH, Stockholm, Sweden, ⁴Karolinska University Hospital, stockholm, Sweden, ⁵Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden
Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
Abstract Number: 1383 • ACR Convergence 2020
Tocilizumab Shows Potential in Preserving Lung Function in Systemic Sclerosis with Positive anti-topoisomerase-1 (Scl-70): A Single Centre Cohort Study
Yasir Suleman¹, Kristina Clark², Svetlana Nihtyanova³, Voon Ong⁴ and Christopher Denton², ¹Royal Free Hospital London NHS Trust, London, United Kingdom, ²University College London, London, United Kingdom, ³Centre for Rheumatology, Royal Free Campus, UCL Division of Medicine, UK, London, United Kingdom, ⁴UCL, London, United Kingdom
Background/Purpose: Recent Phase II (faSScinate) and Phase III (focuSSced) clinical trials of tocilizumab versus placebo in early dcSSc highlighted the potential impact of tocilizumab on…
Abstract Number: 0929 • ACR Convergence 2020
The Effect of Mycophenolate Mofetil on Pulmonary Function Tests in Patients with Systemic Sclerosis-associated Interstitial Lung Disease, and the Difference Between the African Americans versus Non-African Americans
Afroditi Boulougoura¹, Shannon Lance², Duncan Moore³, Haijun Wang⁴, Julio Huapaya⁵ and Virginia Steen³, ¹Department of Internal Medicine, Medstar Georgetown University Hospital, Washington, DC, USA., Washington, DC, ²Department of Internal Medicine, Medstar Georgetown University Hospital, Washington, DC, USA., Washington, ³Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ⁴MedStar Health Research Institute, Washington, DC, USA, Washington, ⁵Department of Critical Care Medicine, National Institutes of Health, Bethesda, MD, USA., Bethesda
Background/Purpose: Scleroderma-related interstitial lung disease (SSc-ILD) is a pulmonary fibrosing disorder characterized by systemic inflammation and progressive scarring of the lungs that leads to respiratory…
Abstract Number: 1082 • ACR Convergence 2020
The Presence of Anti-Jo1, anti-PL7, And/or anti-MDA5 Antibodies in Idiopathic Inflammatory Myopathy Confers an Increased Risk of a Significant Restrictive Pulmonary Defect
Dmitriy Cherny¹ and Carrie Richardson¹, ¹Rush University Medical Center, Chicago, IL
Background/Purpose: A subset of patients with idiopathic inflammatory myopathy develop significant restrictive lung disease, although risk factors for this are poorly defined. Autoantibodies may be…
Abstract Number: 1431 • ACR Convergence 2020
Interstitial Lung Disease in Patients with ANCA Associated Vasculitis – a Prospective Single Centre Study
Alojzija Hocevar¹, Katja Perdan Pirkmajer¹, Matija Tomsic¹ and Ziga Rotar¹, ¹University Medical Center Ljubljana, LJUBLJANA, Slovenia
Background/Purpose: Recently, an association between anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and interstitial lung disease (ILD) has been uncovered. We aimed to determine the rate…
Abstract Number: 0995 • ACR Convergence 2020
Jo-1-Binding B Cells Undergo Limited Class-Switching but Are Biased Towards Autoreactive-Prone and Memory B Cell Subsets in Anti-histidyl-tRNA Synthetase Syndrome
Jennifer Young-Glazer¹, Alberto Cisneros², Erin Wilfong¹, Scott Smith¹, Leslie J. Crofford¹ and Rachel Bonami¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbit University Medical Center, Nashville, TN
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases traditionally classified as dermatomyositis or polymyositis, but these disorders are increasingly defined by the presence of…
Abstract Number: 1091 • ACR Convergence 2020
A Computer-Aided Diagnostic System for Quantitative Scoring of Extent of Interstitial Lung Disease (ILD) in Dermatomyositis/Polymyositis Associated ILD
Sangmee Bae¹, Andrea Oh², Grace Kim³, Jonathan Goldin³ and Christina Charles-Schoeman⁴, ¹University of California Los Angeles, Los Angeles, CA, ²National Jewish Health, Denver, CO, ³University of California, Los Angeles, Los Angeles, ⁴University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Interstitial lung disease (ILD) occurs in up to 80% of patients with dermatomyositis (DM) and polymyositis (PM), and is a leading cause of morbidity…
Abstract Number: 1446 • ACR Convergence 2020
Pregnancy Outcomes in Patients with Interstitial Lung Disease
Aardra Rajendran¹, Stephanie Giattino², Amanda Eudy³, Aparna Swaminathan⁴ and Megan Clowse⁵, ¹Duke University, Lewisville, NC, ²Duke University, Media, PA, ³Duke University, Durham, NC, ⁴Duke University, Durham, ⁵Duke University, Chapel Hill, NC
Background/Purpose: Patients with interstitial lung disease (ILD) are often recommended to avoid conception or terminate pregnancy despite limited data on pregnancy outcomes and complications. Studies…
Abstract Number: 1046 • ACR Convergence 2020
Risk Factors Associated with Interstitial Lung Disease in Patients with RA: Findings from a Retrospective Healthcare Database Analysis
Joe Zhuo¹, Qisu Zhang², Keith Knapp³, Yuexi Wang⁴, Cynthia Gutierrez⁴, Ding He⁴, Lin Xie⁴, Sonie Lama¹ and Gary Craig⁵, ¹Bristol-Myers Squibb Company, Princeton, NJ, ²STATinMED Research (at time of analysis), Ann Arbor, MI, ³Discus Analytics LLC, Spokane, WA, ⁴STATinMED Research, Ann Arbor, MI, ⁵Arthritis Northwest, PLLC, Spokane, WA
Background/Purpose: Interstitial lung disease (ILD) is a frequent complication of RA and is associated with increased morbidity and mortality.1 Previous studies have shown variability in…
Abstract Number: 1096 • ACR Convergence 2020
Assessing Interstitial Lung Disease in a Racially Diverse Population with Idiopathic Inflammatory Myositis
Jammie Law¹, Ana Valle², Katherine Mullins³ and Shereen Mahmood⁴, ¹Montefiore Medical Center, Bronx, NY, ²Albert Einstein College of Medicine, New York, NY, ³Montefiore Medical Center, BROOKLYN, NY, ⁴Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY
Background/Purpose: Interstitial lung disease (ILD) is a common extra-muscular manifestation of Idiopathic Inflammatory Myositis (IIM) and increases risk of mortality. Prior studies and registries have focused on either smaller cohorts or predominantly Caucasian/European populations. Our aim was to better characterize the…
Abstract Number: 1523 • ACR Convergence 2020
Pulmonary Cytokine, Chemokine and Growth Factor Profiles of Distinct Radiographic Patterns of Interstitial Lung Disease in Systemic Sclerosis
Elizabeth Volkmann¹, Donald Tashkin², Ning Li², Mei Leng², Grace Kim², Jonathan Goldin², Airi Harui² and Michael Roth², ¹University of California, Los Angeles, Los Angeles, CA, ²University of California, Los Angeles, Los Angeles
Background/Purpose: The radiological hallmarks of systemic sclerosis-related interstitial lung disease (SSc-ILD) include interstitial inflammation (ground glass opacity) with reticular changes (fibrosis). The precise pathobiology of…
Abstract Number: 0041 • ACR Convergence 2020
Association of the RPA3-UMAD1 Locus with Interstitial Lung Diseases Complicated with Rheumatoid Arthritis in Japanese
Yuya Shirai¹, Suguru Honda², Katsunori Ikari³, Masahiro Kanai⁴, Yoshito Takeda⁵, Yoichiro Kamatani⁶, Takayuki Morisaki⁷, Eiichi Tanaka⁸, Atsushi Kumanogoh⁹, Masayoshi Harigai¹⁰ and Yukinori Okada¹¹, ¹Osaka university, Suita, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Tokyo Women's Medical University, Shinjuku, Japan, ⁴Harvard Medical School, Boston, ⁵Osaka university, Osaka, ⁶Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan, ⁷The institute of Medical Science, the University of Tokyo, Tokyo, Japan, ⁸Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, ⁹Osaka university, Osaka, Japan, ¹⁰Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan, ¹¹Osaka University Graduate School of Medicine, Osaka, Japan
Background/Purpose: The genetic background of rheumatoid arthritis-interstitial lung disease (RA-ILD) has been evaluated in Europeans, but little knowledge has been obtained in non-Europeans. In particular,…
Abstract Number: 1047 • ACR Convergence 2020
Prospective Analysis of a Cohort of Patients with Interstitial Lung Disease Associated with Connective Tissue Disease and Their Response to Immunosuppression with Mycophenolate Mofetil and Rituximab
Yan Li¹, Hassan Baig², Carlos Rojas², Justin Stowell², Elizabeth Lesser², Shalmali Borkar², Andy Abril¹ and Isabel Mira-Avendano¹, ¹Mayo Clinic, Ponte Vedra Beach, FL, ²Mayo Clinic, Jacksonville, FL
Background/Purpose: Connective tissue diseases (CTDs) are commonly identified causes for interstitial lung disease (ILD). Compared with idiopathic interstitial pneumonias, patients with CTD-ILD and interstitial pneumonia…

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