ACR Meeting Abstracts

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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 0656 • ACR Convergence 2023

    Concordance and Prognostic Relevance of Different Definitions of Systemic Sclerosis Interstitial Lung Disease Progression

    enrico De Lorenzis1, Francesco Del Galdo2, gerlando Natalello1, Stefano Di Donato2, lucrezia verardi1, Vishal Kakkar2, pier giacomo Cerasuolo1, Francesco Varone3, Luca Richeldi3, Maria Antonietta D'Agostino1 and Silvia Bosello1, 1Division of Rheumatology - Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy, 2University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom, 3Division of Pulmonology - Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

    Background/Purpose: Interstitial Lung Disease (ILD) in systemic sclerosis (SSc) is a common complication that has varied progression rate and prognosis. Different progression definitions include minimal…
  • Abstract Number: 1042 • ACR Convergence 2023

    B-line of Lung Ultrasound Reflects Different Morphological Features on Chest HRCT Between Interstitial Lung Disease Associated with Systemic Sclerosis and Myositis

    Shinji Watanabe1, Keina Yomono2, Shintaro Yamamoto1, Mikito Suzuki3, Takahisa Gono4 and Masataka Kuwana4, 1Nippon Medical School, Tokyo, Japan, 2Nippon Medical School University, Tokyo, Japan, 3Nippon Medical School Hospital, Tokyo, Japan, 4Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Lung ultrasound (LUS) is a non-invasive imaging tool to evaluate distribution and severity of interstitial lung disease (ILD). Utility of LUS has been examined…
  • Abstract Number: 1322 • ACR Convergence 2023

    Efzofitimod, a First-in Class NRP2-targeting Immunomodulator, Ameliorates Rheumatoid Arthritis and Associated Lung Fibrosis in Preclinical Models

    Christoph Burkart, Clara Polizzi, Lisa Eide, Max Pastenes, David Siefker and Leslie Nangle, aTyr Pharma, San Diego, CA

    Background/Purpose: Efzofitimod, a novel immunomodulator, has shown clinical proof-of-concept in a Phase 1b/2a clinical trial in patients with pulmonary sarcoidosis and is currently enrolling a…
  • Abstract Number: 1771 • ACR Convergence 2023

    Role of Periostin in the Pathophysiology and Accurate Diagnosis of Interstitial Lung Disease Associated with Autoimmune Diseases

    Verónica Pulito-Cueto1, David Iturbe-Fernández2, Victor Mora-Cuesta2, Joao Carlos Batista-Liz1, Belén Atienza-Mateo3, María Sebastián-Mora1, Virginia Portilla1, Alfonso Corrales1, Miguel A Gonzalez-Gay4, Jose Cifrian5, Ricardo Blanco1 and Raquel López-Mejías1, 1Rheumatology Department, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, 2Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVAL; Department of Pneumology, Marqués de Valdecilla University Hospital, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 4IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain, 5Immunopathology Group, Marqués de Valdecilla University Hospital-IDIVAL; Department of Pneumology, Marqués de Valdecilla University Hospital; School of Medicine, Cantabria University, Santander, Spain

    Background/Purpose: Periostin is an extracellular matrix protein that contributes to the development and repair of lung tissue [1]. Previous works have described periostin as a…
  • Abstract Number: 2174 • ACR Convergence 2023

    JAK Inhibitors in Rheumatoid Arthritis-Interstitial Lung Disease. National Multicenter Study of 73 Patients, 55 of Baricitinib

    Ana Serrano-Combarro1, Belén Atienza-Mateo2, Jesus Alejandro Valero-Jaimes3, Marta Pastor-Mena4, Rafael Benito Melero-Gonzalez5, David Castro-Corredor6, Maria Martin-Lopez7, Santos Castañeda8, Jesus Loarce-Martos9, Natalia Mena Vazquez10, Carmen carrasco-Cubero11, Carolina Diez-Morrondo12, andrea Garcia-Valle13, Gema Bonilla14, Juan Maria Blanco-Madrigal15, Natividad del Val del Amo16, Nuria Vegas Revenga17, Lorena Perez-Albadalejo18, Rafaela Ortega Castro19, Deseada Palma-Sanchez20, Ana Maria fernandez-Ortiz21, Patricia Lopez-Viejo22, Maria Lopez-Lasanta23, Marta Garijo Bufort24, Ivette Casafont-Sole25, Olga Maiz-Alonso26, Juan Moreno-Morales27, Ana Urruticoechea28, Carolina Perez-Garcia29, Jose Rosas30, Virginia Ruiz-Esquide31, Delia Fernández-Lozano32, Ignacio Brana Abascal33, Evelin Cecilia Cervantes-Perez34, Julia Fernandez-Melon35, Cristina Fernandez36, Bryan Josue Flores Robles37, Diego Ferrer38 and Ricardo Blanco39, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Bidasoa, Irún, Spain, 4Hospital de Jerez de la Frontera, Cádiz, Spain, 5CHU Vigo, O Carballino, Spain, 6General University Hospital of Ciudad Real, Santa Cruz de Mudela (Ciudad Real), Spain, 7Hospital 12 de Octubre, Madrid, Spain, 8Hospital Universitario de la Princesa, Madrid, Spain, 9Ramón y Cajal University Hospital, Madrid, Spain, 10IBIMA, Málaga, Spain, 11Department of Rheumatology, Hospital Universitario de Badajoz, Badajoz, Spain, 12Division of Rheumatology, Hospital de León, León, Spain, 13Division of Rheumatology, Complejo Asistencial Universitario de Palencia, Palencia, Spain, 14Department of Rheumatology, Hospital Clínico Universitario La Paz, Madrid, Spain, 15Division of Rheumatology, H. Universitario de Basurto, Bilbao, Spain, 16Complejo Hospitalario de Navarra, Pamplona, Spain, 17Hospital Galdakao- Usansolo, Galdakao, Spain, 18Division of Rheumatology, Hospital Universitario de Jaén, Jaén, Spain, 19Hospital Reina Sofía, Cordoba, Spain, 20Hospital Rafael Mendez, Lorca, Spain, 21CHU Badajoz, Badajoz, Spain, 22Division of Rheumatology, Hospital Severo Ochoa, Leganéz, Spain, 23Hospital Universitari Vall d'Hebron, Rheumatology, Barcelona, Spain, 24H. de Sagunto, Valencia, Italy, 25Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 26University Hospital Donostia, San Sebastian, Spain, 27Hospital Universitario Santa Lucia Cartagena, Cartagena, Spain, 28Hospital Can Misses, Ibiza, Spain, 29Hospital del Mar, Barcelona, Spain, 30Hospital Marina Baixa, Alicante, Spain, 31Hospital Clinic, Rheumatology, Barcelona, Spain, 32Hospital de Mérida, Merida, Spain, 33Division of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, 34Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain, 35Division of Rheumatology, Hospital Universitario Son Espases, Palma de Mallorca, Spain, 36Hospital Universitario San Juan de Alicante, Alicante, Spain, 37Hospital Universitario San Pedro, Logroño, Spain, 38Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 39Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). Abatacept and Rituximab are the recommended drugs. JAK inhibitors (JAKi) have…
  • Abstract Number: 0363 • ACR Convergence 2023

    Allogenic Hematopoietic Stem Cell Transplant for Children with Refractory Systemic Juvenile Idiopathic Arthritis and sJIA-Associated Lung Disease: 6-month Post-Transplant Outcomes from an International Cohort

    Michael Matt1, Daniel Drozdov1, Rolla Abu-Arja2, Shanmuganathan Chandrakasan3, Kyla Driest2, Elvira Cannizzaro Schneider4, Despina Moshous5, Benedicte Neven5, Karen Onel6, Sampath Prahalad7, Susan Prockop8, Pierre Quartier5, Johannes Roth9, Donna Wall10, Ulrike Zeilhofer11, Scott Canna12, Alexei Grom1, Grant Schulert1 and Rebecca Marsh1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Nationwide Children's Hospital, Columbus, OH, 3Emory University School of Medicine, Atlanta, GA, 4Universitaetskinderspital Zurich, Zurich, Switzerland, 5Paris Cité Université and Necker Hospital, Paris, France, 6Hospital for Special Surgery, New York, NY, 7Emory University School of Medicine, Children's Pediatric Institute, Atlanta, GA, 8Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA, 9University of Ottawa, Ottawa, ON, Canada, 10The Hospital for Sick Children, Toronto, ON, Canada, 11Children's Hospital of Zurich, Zurich, Switzerland, 12Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Refractory systemic juvenile idiopathic arthritis (sJIA) in children can be complicated by repeated episodes of macrophage activation syndrome (MAS) or sJIA-related lung disease (sJIA-LD).…
  • Abstract Number: 0662 • ACR Convergence 2023

    Changes in Treatment Patterns and Their Influence on the Outcome of Systemic Sclerosis-interstitial Lung Disease (SSc-ILD) Patients: An EUSTAR Analysis

    Corrado Campochiaro1, Marie-Elise Truchetet2, Madelon Vonk3, Giovanna Cuomo4, Lidia P Ananieva5, Eric Hachulla6, Vanessa Smith7, Ana Maria Gheorghiu8, Radim Becvar9, Nicolas Hunzelmann10, Daniel Furst11, Vera Ortiz-Santamaria12, Patricia Carreira13, Francesco Del Galdo14, marco Matucci Cerinic15 and Anna Maria Hoffmann-Vold16, 1IRCCS San Raffaele Hospital, Unit of Immunology, Rheumatology, Allergy and Rare Disease. Vita-Salute San Raffaele University, Milan, Italy, 2Bordeaux University Hospital, Bordeaux, France, 3Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4Department of Precision Medicine, “Luigi Vanvitelli” University of Campania, Naples, Italy, 5V.A. Nasonova Research Institute Of Rheumatology Russian Federation, Moscow, Russia, 6University of Lille, Lille, France, 7Ghent University Hospital, Gent, Belgium, 8Department of Internal Medicine and Rheumatology, Ion Cantacuzino Clinical Hospital, Bucharest, Romania, 9Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Praha, Czech Republic, 10University of Kšln, Kšln, Germany, 11University of California Los Angeles, Los Angeles, CA, 12University of Granollers, Granollers, Spain, 13Hospital Universitario 12 de Octubre, Madrid, Spain, 14University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom, 15Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, 16Oslo University Hospital, Department of Rheumatology, Oslo, Norway

    Background/Purpose: The treatment armamentarium with immunosuppressive treatments (ISTs) for interstitial lung disease (ILD) in systemic sclerosis (SSc) has greatly expanded. It is to date unclear…
  • Abstract Number: 1050 • ACR Convergence 2023

    Diagnostic Accuracy of Lung Ultrasound for Detecting Interstitial Lung Disease Among Patients with Systemic Sclerosis: A Comparative Study of Two Scanning Protocols

    Fabian Carranza Enriquez1, Carina Soto-Fajardo1, Sinthia Solorzano Flores1, Abish Angeles-Acuña1, Mayra Mejia-Avila2, Amyrari Vázquez-Ortega3, Paola Flores-Ordoñez2, Karina Arias Callejas2, Alejandra Enriquez-Luna4, Graciliano Ramon-Diaz4, Brenda Bravo-Zarate2, Tatiana Sofía Rodríguez-Reyna3 and Carlos Pineda4, 1Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico, 2Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Instituto Nacional de Rehabilitacion, Mexico City, Mexico

    Background/Purpose: Lung ultrasound (LUS) has proven useful to detect interstitial lung disease (ILD) among patients with SSc when compared to high-resolution computerized tomography (HRCT) as…
  • Abstract Number: 1374 • ACR Convergence 2023

    Interstitial Lung Disease Is Frequent in Primary Sjögren’s Syndrome and Is Associated with Reduced Survival

    Marco Sprecher1, Florine Weber2, Kastriot Kastrati3, Helmut Prosch4, Natasha Moe5, Emily Langballe6, Cosimo Bruni7, Oyvind Molberg8, Phuong Phuong Diep9, Christian Clarenbach10, Paul Studenic11, Helena Andersson8, Oyvind Midtvedt12, Torhild Garen8, Karoline Lerang13, Thomas Frauenfelder14, Helga Radner15, Oliver Distler7 and Anna Maria Hoffmann-Vold16, 1Dept of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 2Dept of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 3Dept of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna (Austria), Vienna, Austria, 4Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5Dept of Radiology, University Hospital Oslo, Oslo, Norway, 6Universitetet i Oslo, Oslo, Norway, 7Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 8Dept of Rheumatology, University Hospital Oslo, Oslo, Norway, 9Dept of Respiratory diseases, University Hospital Oslo, Oslo, Norway, 10Dept of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 11Medical University of Vienna and Karolinska Institutet (sweden), Vienna, Austria, 12Oslo University Hospital, Oslo, Norway, 13Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 14Dept of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 15Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 16Oslo University Hospital, Department of Rheumatology, Oslo, Norway

    Background/Purpose: Interstitial lung disease (ILD) has been reported to be present in 10-15% of patients with primary Sjögren's syndrome (pSS). Knowledge on risk factors predicting…
  • Abstract Number: 1774 • ACR Convergence 2023

    Gut Microbiota and Permeability Biomarkers for Diagnosis and Prognosis in Rheumatoid Arthritis Associated Interstitial Lung Disease

    José Lisbona-Montañez1, Patricia Ruiz-Limon2, Arkaitz Mucientes3, Natalia Mena Vazquez4, Isabel Moreno-Indias3, SARA MANRIQUE5, Laura Cano-García6, Rocío Redondo-Rodríguez6, Francisco J tinahones3 and Antonio Fernandez-Nebro7, 1Universidad de Málaga, Departamento de Medicina y Dermatología, Moclinejo, Spain, 2IBIMA Plataforma BIONAND, Cordoba, Spain, 3IBIMA Plataforma BIONAND, Málaga, Spain, 4IBIMA, Málaga, Spain, 5Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, 6Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, 7Hospital Regional Universitario de Málaga, Malaga, Spain

    Background/Purpose: Gut microbiota has been related to rheumatoid arthritis (RA), inflammation, and it's severity. Interstitial lung disease (ILD) is the most frequent non-pleural pulmonary manifestation…
  • Abstract Number: 2188 • ACR Convergence 2023

    Lung Cysts in Primary SS: New Findings on an Allegedly Innocuous Iiagnosis

    Regis Sewa Marques, Maria Fernanda Zacarin, Pamela Bellini, Raissa Dudienas D Pereira, Aloma Guinami Scabora, Zoraida Sachetto, Manoel Bertolo and ALISSON PUGLIESI, Universidade Estadual de Campinas, Campinas, Brazil

    Background/Purpose: Lung cysts are a frequent finding in patients with SS, with previous data indicating a prevalence of approximately 30% on chest CT scans. In…
  • Abstract Number: 0393 • ACR Convergence 2023

    Pulmonary Involvement in Patients with Seropositive and ACPA Positive Rheumatoid Arthritis (RA-ILD) – Novel Screening Protocol for Early Detection of Pulmonary Involvement

    Florian Popp1, Martin Hoffmann2, Johannes von Kempis3, Martin Welcker1, Werner von Wulffen2 and Frank Reichenberger2, 1Medizinisches Versorgungszentrum für Rheumatologie Dr. M. Welcker GmbH, Planegg, Germany, 2Augustinum Klinik München, Department of pneumology, Munich, Germany, 3Kantonsspital St. Gallen, Division of rheumatology and immunology, St. Gallen, Switzerland

    Background/Purpose: Seropositive and ACPA positive Rheumatoid Arthritis (RA) is associated with significant cardiovascular and pulmonary comorbidity. However, screening for early detection of pulmonary involvement especially…
  • Abstract Number: 0748 • ACR Convergence 2023

    Assessment of Myositis-related Interstitial Lung Disease by ⁶⁸ Ga-DATA.SA.FAPi PET/CT

    Kastriot Kastrati1, Thomas S Nakuz2, Oana C Kulterer2, Stephan Blüml3, Michael Bonelli3, Irina Gessl4, Hans-Peter Kiener3, Werner Langsteger2, Daniel Mrak3, Florian Prayer5, Helmut Prosch5, Elisabeth Simader3, Tatjana Traub-Weidinger2, Daniel Aletaha6, Helga Radner7, Marcus Hacker2 and Peter Mandl3, 1Dept of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna (Austria), Vienna, Austria, 2Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 4Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 6Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, Wien, Austria, 7Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Interstitial lung disease (ILD) is a common manifestation of idiopathic inflammatory myopathies (IIM) ranging up to 78% in IIM and is a key contributor…
  • Abstract Number: 1137 • ACR Convergence 2023

    Association Between Nailfold Videocapillaroscopy Findings and sKL-6 Levels in Patients with Idiopathic Inflammatory Myopathies–Related Interstitial Lung Disease

    Cristiana Sieiro Santos1, Jose Luis Tandaipan2, Diego Castillo2, Laura Martínez Martínez2, Helena Codes2, Luis Sainz-Comas2, Berta Paula Magallares-Lopez3, Patricia Moya2, Anais Mariscal2, Hye Sang Park2, Ana Milena Millán Arciniegas2, César Díaz-Torné2, Ana Laíz Alonso2, Sandra Ros2, Susana Fernández2, Hector Corominas4, Elvira Díez Álvarez5 and Iván Castellvi2, 1Complejo Asistencial Universitario de León, León, Spain, 2Hospital de Santa Creu i Sant Pau, Barcelona, Spain, 3Department of Rheumatology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain, 4Hospital Universitario Sant Pau, Rheumatology, Barcelona, Spain, 5CAULE, León, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a frequent pulmonary manifestation in idiopathic inflammatory myopathies (IIM) (IIM-ILD) and considerably influences morbidity and mortality. Krebs von den…
  • Abstract Number: 1377 • ACR Convergence 2023

    Characterization of Pulmonary Manifestations of Sjögren Syndrome: A Multicenter Retrospective Study

    Loïc Meudec1, Cindy Marques2, Pierre-Antoine Juge3, Robin Dhote4, Anne-Laure Fauchais5, Emanuelle Dernis6, Olivier Vittecoq7, Alain SARAUX8, Jacques-Eric Gottenberg9, Eric Hachulla10, Véronique Le Guern11, Philippe Dieudé12, Marie-Pierre Debray13, Antoine Beurnier14, Raphaele Seror15, Xavier Mariette16 and Gaetane Nocturne17, 1CHU Kremlin-Bicêtre, Rheumatology, Le Kremlin-Bicêtre, France, 2CHU Pitié Salpétrière, Internal Medicine 1, Paris, France, 3Division of Rheumatology, Inflammation, and Immunity Brigham & Women’s Hospital, Boston, MA, 4Department of Internal Medicine, Centre Hospitalier Avicenne, Bobigny, France, 5Dupuytren Hospital, Limoges, France, 6CH Le Mans, Le Mans, France, 7CHU Rouen, Rheumatology, Rouen, France, 8CHU Brest, Brest, France, 9Rheumatology Department, Strasbourg University Hospital, Strasbourg, France, 10CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France, 11APHP Hôpital Cochin, Paris, France, 12Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, INSERM UMR1152, University de Paris Cité, Department of Rheumatology, Paris, France, 13CHU Bichat, Radiology, Paris, France, 14CHU Kremlin-Bicêtre, Functional Explorations, Le Kremlin-Bicêtre, France, 15University Hospital Paris Saclay, Le Kremlin-Bicêtre, France, 16Université Paris-Saclay, Le Kremlin-Bicêtre, France, 17APHP, Le Kremlin-Bicêtre, France

    Background/Purpose: Sjögren disease (Sjo) is a systemic immune-related disease with pulmonary manifestations occurring in up to 16% of patients [1], including interstitial lung disease (SS-ILD)…
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