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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 2160 • 2017 ACR/ARHP Annual Meeting

    Clinical Significance of Anti-Aminoacyl tRNA Synthetase Antibodies Which Are Positive By ELISA but Not By Immunoprecipitation – the Variations of Antigen Recognition and the Association with Interstitial Lung Diseases but Not Myositis –

    Yuki Ishikawa1,2, Ran Nakashima1, Takaki Nojima3,4, Takuya Isayama5, Nobuo Kuramoto1, Kosaku Murakami1, Hajime Yoshifuji1, Koichiro Ohmura1 and Tsuneyo Mimori1, 1Clinical Immunology and Rheumatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2One Joslin Place, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 3Clinical Immunology and Rheumatolog, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Nojima Internal Medicine Clinic, Hiroshima, Japan, 5Medical & Biological Laboratories CO.,LTD., Nagoya, Japan

    Background/Purpose: Anti-aminoacyl tRNA synthetase (ARS) antibodies are associated with common clinical characters, which are fever, polyarthritis, interstitial lung disease (ILD), Raynaud’s phenomenon, mechanic’s hand and…
  • Abstract Number: 2173 • 2017 ACR/ARHP Annual Meeting

    Characteristics Unique to MDA5 and Anti-Ro/SSA-52 Kda Dual Antibody Positive Patients with Inflammatory Myopathies

    Juan J Maya, Olga Pinkston, Florentina Berianu, Benjamin Wang and Andy Abril, Rheumatology, Mayo Clinic Florida, Jacksonville, FL

    Background/Purpose: The anti-melanoma differentiation-associated gene 5 antibody (MDA5) was recently classified as a myositis-specific antibody (MSA), and has been associated with rapidly progressive interstitial lung…
  • Abstract Number: 98 • 2017 ACR/ARHP Annual Meeting

    Impact of a Lung Ultrasound Course for Rheumatology Specialist (IMPACT-2)

    Christopher Gasho1, Karina Torralba2, David Chooljian3, Cong-Bin Wang4 and Vi Dinh4, 1Pulmonary and Critical Care Medicine, Loma Linda Medical Center, 12354 Anderson St, CA, 2Division of Rheumatology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA, 3Loma Linda Veteran Affairs Hospital, Loma Linda, CA, 4Loma Linda University Medical Center, Loma Linda, CA

                Background/Purpose: Although much emphasis is focused on lung ultrasonography(US) within the critical care field, there is a growing interest in the use of lung…
  • Abstract Number: 2392 • 2017 ACR/ARHP Annual Meeting

    Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Namrata Singh1, Jimmy Varghese2, Bryant R. England3, Joshua J. Solomon4, Kaleb Michaud5, Ted R. Mikuls6 and Marin Schweizer7, 1Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, 2Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 3Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 5University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Internal Medicine, Iowa City VA, Iowa City, IA

    ABSTRACT Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A systematic review and meta-analysis Background/Purpose: Interstitial lung disease affects 10-15%…
  • Abstract Number: 257 • 2017 ACR/ARHP Annual Meeting

    The Use of Positron Emission Tomography (PET)-Scan for the Quantitative Assessment of Interstitial Lung Disease in Systemic Sclerosis

    Daphne Peelen1, Ben Zwezerijnen2, Esther Nossent1, Lilian Meijboom1, Otto Hoekstra3, Conny van der Laken4 and Alexandre Voskuyl4, 1VUmc, Amsterdam, Netherlands, 2Nuclear Medicine, VUmc, Amsterdam, Netherlands, 3Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 4Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) in systemic sclerosis is treated by immunosuppressive drugs (e.g. cyclophosphamide), aimed at reduction of inflammatory response . Differentiation between inflamed…
  • Abstract Number: 2402 • 2017 ACR/ARHP Annual Meeting

    Rituximab in Rheumatoid Arthritis with Interstitial Lung Disease: A Multicenter Study of 32 Patients

    Carlos Fernández-Díaz1, Delia Reina2, Paula Rubio-Muñoz3, Ana Urruticoechea-Arana4, María Carrasco-cubero5, María Martín-López6, Jose A. Miranda-Filloy7, Ignacio Villa-Blanco8, Ana Milena Millan9, Ivan Castellví10, Olga Maiz-Alonso11, Antonio Juan12, Fátima Álvarez Reyes13, José Luis Martín-Varillas1, Nuria Vegas-Revenga1, Ricardo Blanco1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 3Rheumatology,, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 4Rheumatology Department. Hospital Can Misses, IBIZA, Spain, 5Hospital Infanta Cristina, Badajoz, Spain, 6Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 7Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 8Hospital de Sierrallana, Sierrallana, Spain, 9Unitat de Reumatologia. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, 12Hospital Universitario Son Llàtzer. Rheumatology, Palma de Mallorca, Spain, 13Rheumatology, University Hospital Ntra. Sra. de La Candelaria, Santa Cruz de Tenerife, Spain

    Background/Purpose: Anti-TNFα drugs and several conventional disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate (MTX) have been involved in the development of Interstitial Lung Disease (ILD).…
  • Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting

    Mast Cells Are Involved in the Pathogenesis of Sjögren  Syndrome By Inducing Tissue Fibrosis

    Shinjiro Kaieda1, Kyoko Fujimoto2, Masaki Okamoto3, Masaki Tominaga2, Tomoaki Hoshino4 and Hiroaki Ida5, 1Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, 2Kurume University School of Medicine, Kurume, Japan, 3Medicine, Kurume University School of Medicine, Kurume, Japan, 4Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, 5Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…
  • Abstract Number: 2412 • 2017 ACR/ARHP Annual Meeting

    Mortality and Clinical Features in Rheumatoid Arthritis and Interstitial Lung Disease

    Cristina Vadillo Font1, Maria Asunción Nieto2, Leticia Leon3, Luis Rodriguez-Rodriguez4, Judit Font Urgelles1, Esperanza Pato Cour1, Juan Angel Jover5 and Lydia A Alcazar6, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Pneumology. Hospital Clínico San Carlos, MD PhD, Madrid, Spain, 3Rheumatology, Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 4Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 5Rheumatology. Hospital Clínico San Carlos, MD PhD, Madrid, Spain, 6Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain

    Background/Purpose: Interstitial lung disease (ILD) is the most common extra-articular manifestation in Rheumatoid Arthritis (RA) generating higher mortality in these patients. The objective is to…
  • Abstract Number: 1559 • 2016 ACR/ARHP Annual Meeting

    Shared Genetic Predisposition in Rheumatoid Arthritis–Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: A Genetic Association Study

    Pierre-Antoine Juge1, Raphaël Borie2, Caroline Kannengiesser3, Steven Gazal3, Patrick Revy4, Lidwine Wemeau-Stervinou5, Marie-Pierre Debray6, Sébastien Ottaviani7, Sylvain Adam-Marchand8, Nadia Nathan9, Gabriel Thabut10, Christophe Richez11, Hilario Nunes12, Isabelle Callebaut13, Aurélien Justet2, Nicolas Leulliot14, Amélie Bonnefond15, David Salgado16, Pascal Richette17, Jean-Pierre Desvignes16, Huguette Lioté18, Philippe Froguel15, Yannick Allanore19, Olivier Sand15, Claire Dromer20, René-Marc Flipo21, Annick Clément9, Christophe Béroud22, Jean Sibilia23, Baptiste Coustet1,24, Vincent Cottin25, Marie-Christophe Boissier26, Benoit Wallaert27, Thierry Schaeverbeke28, Florence Dasto le Moal29, Aline Frazier17, Christelle Ménard30, Martin Soubrier31, Nathalie Saidenberg29, Dominique Valeyre32, Serge Amselem9, Catherine Boileau3, Bruno Crestani2 and Philippe Dieudé1, 1Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, 2Pneumologie A, Hôpital Bichat - Claude Bernard, Paris, France, 3Génétique, Hôpital Bichat - Claude Bernard, Paris, France, 4Laboratory of Genome Dynamics in the Immune System, Institut Imagine, Paris, France, 5Pneumologie, CHRU de Lille, Lille, France, 6Université Paris-Diderot, Paris, France, 7Rheumatologie, Hôpital Bichat - Claude Bernard, Paris, France, 8Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 9Pneumologie pédiatrique, Hôpital Trousseau, Paris, France, 10Pneumologie B, Hôpital Bichat - Claude Bernard, Paris, France, 11Rhumatologie, Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, 12Pneumologie B, Hôpital Avicenne, Paris, France, 13CNRS UMR_7590, Paris, France, 14Laboratoire de cristallographie et RMN biologiques, UMR CNRS 8015, Paris, France, 15CNRS UMR_8199, Lille, France, 16UMR_S 910, Marseille, France, 17Rhumatologie, Hôpital Lariboisière, Paris, France, 18Pneumologie A, Hôpital Tenon, Paris, France, 19Rhumatologie A, Hôpital Cochin, Paris, France, 20Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, 21Rhumatologie, CHU Lille, Lille, France, 22INSERM UMR_S 910, Marseille, France, 23Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 24Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, 25Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, 26Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 27Pneumology, CHRU, Lille CEDEX, France, 28Rheumatology, CHU Bordeaux, Bordeaux, France, 29Rhumatologie, Hôpital Avicenne, Paris, France, 30Pneumologie Pédiatrique, Hôpital Trousseau, Paris, France, 31Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, 32Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality for rheumatoid arthritis (RA) patients. Despite its high prevalence and mortality, little…
  • Abstract Number: 30 • 2016 ACR/ARHP Annual Meeting

    Impact of Interstitial Lung Disease on Mortality of Patients with Rheumatoid Arthritis

    Dam Kim1, Soo-Kyung Cho2, Chan-Bum Choi3, Jung-Yoon Choe4, Won Tae Chung5, Seung-Jae Hong6, Young Ok Jung7, Tae-Hwan Kim8, Tae-Jong Kim9, Hye-Soon Lee10, Joo Hyun Lee11, Jisoo Lee12, Shin-Seok Lee13, Dae-Hyun Yoo14, Bo Young Yoon15, Jin Woo Song16, Sang-Cheol Bae17 and Yoon-Kyoung Sung1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, 3Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 4Medicine, Catholic university of Daegu School of medicine, Daegu, Korea, The Republic of, 5Rheumatology, Dong-A University Hospital, Busan, South Korea, 6Dept. of Rheumatology, #1 Hoeg, KyungHee University Medical Center, SEOUL, South Korea, 7Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, 8Department of Rheumatology, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 9Chonnam Nat`l University Medical School&Hospital, Chonnam, South Korea, 10Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 11Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 12Int Medicine, Ewha Woman's Univ Schl of Med, Seoul, Korea, Republic of, 13Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, The Republic of, 14Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 15Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, The Republic of, 16Department of pulmonary and critical care of medicine, Asan medical center, University of Ulsan, College of Medicine, Seoul, Korea, The Republic of, 17Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, Korea, The Republic of

    Background/Purpose:   Some studies have supported ethnicity-related differences in the prevalence of ILD and ILD in RA; however, these results have not yet been conclusive.…
  • Abstract Number: 1780 • 2016 ACR/ARHP Annual Meeting

    Pulmonary Disease in Late Versus Early Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

    Jennifer Medlin1, Karen Hansen2, Sara McCoy3 and Christie M. Bartels4, 1Internal Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, 2Department of Medicine, Division of Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI, 4Medicine, Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Phenotypes often differ in late-onset systemic lupus erythematosus (SLE) compared to SLE features in early-onset patients. Prior studies have suggested that there may be…
  • Abstract Number: 274 • 2016 ACR/ARHP Annual Meeting

    Splicing Factor Proline/Glutamine-Rich Is a Novel Autoantigen of Dermatomyositis and Associated with Anti-Melanoma Differentiation-Associated Gene 5 Antibody.

    Yuji Hosono1, Ran Nakashima1, Kosaku Murakami1, Yoshitaka Imura1, Satoshi Serada2, Minoru Fujimoto3, Hajime Yoshifuji1, Koichiro Ohmura4, Tetsuji Naka5 and Tsuneyo Mimori4, 1Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 3Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 4Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Laboratory for immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan

    Background/Purpose:   Anti- melanoma differentiation-associated gene 5 (MDA5) antibody positive dermatomyositis (DM) and clinically amyopathic DM (CADM) often develop rapidly progressive interstitial lung disesase (RP-ILD),…
  • Abstract Number: 1880 • 2016 ACR/ARHP Annual Meeting

    A Large Proportion of Patients in an Early Systemic Sclerosis-Associated Interstitial Lung Disease Cohort Have Coexisting Pulmonary Hypertension

    Amber Young1, Caitlyn Fisher1, Rajaie Namas2, Holly Wilhalme3 and Dinesh Khanna4, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 4University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic Sclerosis (SSc) is a multi-organ system disease manifested by fibrosis, vascular damage and dysregulation of the immune system. The leading causes of death…
  • Abstract Number: 823 • 2016 ACR/ARHP Annual Meeting

    A Phase 2 Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness in Subjects with Systemic Sclerosis with Interstitial Lung Disease

    Vivien Hsu1, Christopher P.Denton2, Robyn T. Domsic3, Daniel E. Furst4, Maureen Rischmueller5, Marina Stanislav6, Virginia D. Steen7, Douglas Hough8, Shimon Korish9, Alyse Cooper10, Peter H. Schafer11 and Suktae Choi12, 1Rheumatology, RWJ Med Schl Scleroderma Prog, New Brunswick, NJ, 2Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 3Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4David Geffen School of Medicine at UCLA, Los Angeles, CA, 5University of Adelaide, Adelaide, Australia, 6Research Rheumatology Institute n. a. V.A. Nassonova, Moscow, Russia, 7Rheumatology, Georgetown University Medical Center, Washington, DC, 8Clinical Research, Celgene Corporation, Warren, NJ, 933 Technology Drive, Celgene Corporation, Warren, NJ, 10Immunology & Inflammation, Clinical Research, Celgene Corporation, Summit, NJ, 11Department of Translational Development, Celgene Corporation, Summit, NJ, 12Biostatistics, Celgene Corporation, Summit, NJ

    Background/Purpose:  Pomalidomide (POM) is an IMiD compound, structurally similar to thalidomide. POM binds to cereblon and facilitates Ikaros and Aiolos degradation, resulting in immunomodulation of…
  • Abstract Number: 1884 • 2016 ACR/ARHP Annual Meeting

    Esophageal Dilation and Interstitial Lung Disease Incidence and Progression in Systemic Sclerosis

    Kimberly Showalter1, Aileen Hoffmann2, Carrie Richardson3,4, Julia (Jungwha) Lee5, David Aaby6, Rishi Agrawal7, Jane Dematte8, Rowland W. Chang9 and Monique Hinchcliff10, 1Internal Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, 4Department of Rheumatology, Johns Hopkins University, Baltimore, MD, 5Preventive Medicine/Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 6Northwestern University Feinberg School of Medicine, Chicago, IL, 7Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 8Pulmonology, Northwestern University Feinberg School of Medicine, Chicago, IL, 9Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 10Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL

    Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in systemic sclerosis (SSc). Esophageal dysfunction and aspiration may play a role in SSc-ILD.…
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