ACR Meeting Abstracts

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Abstracts tagged "interferon"

  • Abstract Number: 1805 • ACR Convergence 2020

    Longitudinal Analysis of IFN Status and Disease Characteristics in SLE

    Melissa Northcott1, Alberta Hoi2, Rachel Koelmeyer3 and Eric Morand4, 1Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia, 2Monash University, Melbourne, Victoria, Australia, 3Monash University, Clayton, Victoria, Australia, 4Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

    Background/Purpose: The type 1 interferon (IFN) cytokine family is key to the pathogenesis of SLE, evidenced by the expression of IFN stimulated genes (ISGs) in…
  • Abstract Number: 0035 • ACR Convergence 2020

    Distinct Biological Pathways in Both Blood and Kidney Further Define Molecular Profiles Across Diverse Nephritides

    Loqmane Seridi1, Matteo Cesaroni1, Qingxuan Song2, Ashley Orillion1, Frédéric Baribaud1, Tatiana Ort1, Sheng Gao2, Tomas Parker3, James Chevalier3, Dan Levine3, Alan Perlman3 and Jarrat Jordan1, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 3The Rogosin Institute, New York Presbyterian Hospital-Weill Medical College of Cornell University New York, NY, USA., New York, NY

    Background/Purpose: Approximately 40% of SLE patients will develop Lupus Nephritis (LN), of which 10-30 % will progress to end-stage renal disease. To further understand LN…
  • Abstract Number: 0935 • ACR Convergence 2020

    Efficacy and Safety Results from a Phase 2, Randomized, Double-Blind Trial of BIIB059, an Anti-Blood Dendritic Cell Antigen 2 Antibody, in SLE

    Richard Furie1, Ronald van Vollenhoven2, Kenneth Kalunian3, Sandra Navarra4, Juanita Romero-Díaz5, Victoria Werth6, Xiaobi Huang7, Hua Carroll8, Adam Meyers7, Cristina Musselli7, Catherine Barbey9 and Nathalie Franchimont7, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 2Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 3University of California San Diego, La Jolla, CA, 4University of Santo Tomas, Manila, Philippines, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 6University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 7Biogen, Cambridge, MA, 8Biogen, Cambridge, 9Biogen, Baar, Switzerland

    Background/Purpose: Type I interferons (IFN-I), inflammatory mediators principally produced by plasmacytoid dendritic cells (pDCs), components of the innate immune system, have been implicated in the…
  • Abstract Number: 1806 • ACR Convergence 2020

    The Association of Interferon-α with Kynurenine/Tryptophan Pathway Activation in Systemic Lupus Erythematosus

    Erik Anderson1, Ying Jin2, Sara Goodwin2, Julien Roeser3, Richard Furie4, Cynthia Aranow5, Bruce Volpe5, Betty Diamond6 and Meggan Mackay7, 1Feinstein Institutes for Medical Research, New York, NY, 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 3Charles River Laboratories, South San Francisco, CA, 4Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 5Feinstein Institutes for Medical Research, Manhasset, NY, 6Northwell Health, Manhasset, NY, 7Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Type I IFN contributes to SLE pathogenesis and stimulates the kynurenine/tryptophan (KYN/TRP) pathway, producing elevated quinolinic acid (QA) levels relative to kynurenic acid (KA)…
  • Abstract Number: 0068 • ACR Convergence 2020

    Single Cell RNA-seq to Characterize Monocyte Subtypes in the Autoinflammatory Interferonopathy, SAVI and the Inflammasomopathy, NOMID

    Ying Zhang1, Bernadette Marrero2, Adriana de Jesus3, Sara Alehashemi4, Jinguo Chen5, Rongye Shi6, Huizhi Zhou6, Clifton Dalgard7, Manfred Boehm8 and Raphaela Goldbach-Mansky9, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 2Computational Systems Biology Section/NIAID/NIH, Bethesda, MD, 3Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 5Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 6Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, 7Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, 8Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: Monocytes are pivotal producers of key inflammatory cytokines that drive autoinflammatory diseases. In SAVI, constitutive STING activation causes chronic activation with increased type-I IFN…
  • Abstract Number: 0946 • ACR Convergence 2020

    ENPP1 Regulates UV Light Triggered Type I Interferon Response in the Skin

    Sladjana Skopelja-Gardner1, Joyce Tai2, Xizhang Sun2 and Keith Elkon2, 1University of Washington, Seattle, WA, 2University of Washington, Seattle

    Background/Purpose: Systemic lupus erythematosus (SLE) patients have a prominent type I interferon (IFN-I) signature in both the lesional and non-lesional skin. We recently showed that…
  • Abstract Number: 1818 • ACR Convergence 2020

    IgG and IgA Autoantibodies Against L1 ORF1p Expressed in Granulocytes Correlate with Granulocyte Consumption and Disease Activity in Pediatric Systemic Lupus Erythematosus

    Kennedy Ukadike1, Kathryn Ni1, Victoria Carter1, Martin Taylor2, John LaCava3, Lauren Pachman4, Xiaoxing Wang1, Mary Eckert5, Anne Stevens1, Christian Lood1 and Tomas Mustelin1, 1University of Washington, Seattle, WA, 2Massachusetts General Hospital, Boston, MA, 3Rockefeller University, New York, NY, 4Department of Pediatrics, Northwestern University Feinberg School of Medicine; The Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Rheumatology; The CureJM Center of Excellence in Juvenile Myositis Research and Care, The Stanley Manne Children's Research Center of Chicago, Lake Forest, IL, 5Seattle Children's Hospital, Seattle, WA

    Background/Purpose: To quantitate autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement, expression of p40 itself, and markers of neutrophil death in…
  • Abstract Number: 0074 • ACR Convergence 2020

    The Intracellular DNA Sensor STING Protects Against Bone Loss Through Regulation of Type I Interferons

    Susan MacLauchlan1, Catherine Manning2, Sijia Chen3, Katherine Fitzgerald4, Shruti Sharma5 and Ellen Gravallese1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, 3Brigham and Women's Hospital, Boston, 4University of Massachusetts medical school, Worcester, MA, 5Tufts University, Boston, MA

    Background/Purpose: The intracellular DNA sensor Stimulator of Interferon Genes (STING) is essential for detection of viral and bacterial pathogen DNA. As with other pathways in…
  • Abstract Number: 0957 • ACR Convergence 2020

    Mitochondrial ROS as a Regulator of Calcinosis in Juvenile Dermatomyositis

    Bhargavi Duvvuri1, Lauren Pachman2, Richard Moore1, Stephen Doty3 and Christian Lood1, 1University of Washington, Seattle, WA, 2Department of Pediatrics, Northwestern University Feinberg School of Medicine; The Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Pediatric Rheumatology; The CureJM Center of Excellence in Juvenile Myositis Research and Care, The Stanley Manne Children's Research Center of Chicago, Lake Forest, IL, 3The Hospital for Special Surgery, New York

    Background/Purpose: Calcinosis, the accumulation of calcium crystals in soft tissues, is often a locus of infection and a debilitating manifestation of chronic juvenile dermatomyositis (JDM),…
  • Abstract Number: 1827 • ACR Convergence 2020

    Flare Reduction and Oral Corticosteroid Taper in Patients with Active SLE Treated with Anifrolumab in 2 Phase 3 Trials

    Richard Furie1, Eric Morand2, Anca Askanase3, Ed Vital4, Joan Merrill5, Rubana Kalyani6, Gabriel Abreu7, Lilia Pineda6 and Raj Tummala6, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, 2Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 3Columbia University College of Physicians and Surgeons, New York, 4University of Leeds; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5Oklahoma Medical Research Foundation, Oklahoma City, 6BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, 7BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

    Background/Purpose: Objectives of long-term SLE management are not only to reduce disease activity, but also to prevent flares and minimize exposure to oral corticosteroids (OCS),…
  • Abstract Number: 009 • 2020 Pediatric Rheumatology Symposium

    Emapalumab (Anti-Interferon-Gamma Monoclonal Antibody) in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (sJIA)

    Fabrizio De Benedetti1, Paul Brogan 2, Claudia Bracaglia 1, Manuela Pardeo 1, Giulia Marucci 1, Emanuela Sacco 1, Despina Eleftheriou 3, Charalampia Papadopoulou 3, Alexei Grom 4, Pierre Quartier 5, Rayfel Schneider 6, Philippe Jacqmin 7, Rikke Frederiksen 8, Maria Ballabio 9 and Cristina de Min 8, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 2UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 3UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Section Head Infection, Immunology, and Rheumatology, London, United Kingdom, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5Paris-Descartes University, IMAGINE Institute, RAISE reference centre, Pediatric Immuno-Hematology and Rheumatology Unit, Necker hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, 6The Hospital for Sick Children, Toronto, Canada, 7MnS Modelling and Simulation, Dinant, Belgium, 8Swedish Orphan Biovitrum AG (Sobi), Basel, Basel-Stadt, Switzerland, 9Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland

    Background/Purpose: MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies…
  • Abstract Number: 5 • 2019 ACR/ARP Annual Meeting

    Interferon Kappa Promotes the Development of Psoriasis

    Mehrnaz Gharaee-Kermani1, Shannon Estadt 1, Sonya Wolf-Fortune 1, Johann Gudjonsson 1 and J. Michelle Kahlenberg 1, 1University of Michigan, Ann Arbor, MI

    Background/Purpose: Psoriasis is a one of the most common chronic inflammatory autoimmune skin diseases characterized by hyperproliferation and abnormal differentiation of keratinocytes and infiltration of…
  • Abstract Number: 1021 • 2019 ACR/ARP Annual Meeting

    Anti-IFNAR Treatment Does Not Reverse Neuropsychiatric Disease in MRL/lpr Lupus Mice

    Michelle Huang1, Ariel Stock 2, Elise Mike 2, Roland Kolbeck 3 and Chaim Putterman 4, 1Albert Einstein College of Medicine, Bronx, 2Albert Einstein College of Medicine, Bronx, NY, 3MedImmune, Gaithersburg, MD, 4Albert Einstein College of Medicine, New York, NY

    Background/Purpose: Many systemic lupus erythematosus patients display a type I interferon (IFN) signature, and IFNα levels and gene signatures have been positively correlated with disease…
  • Abstract Number: 1059 • 2019 ACR/ARP Annual Meeting

    BDCA2 Targeting of Human Plasmacytoid Dendritic Cells via CBS004 Reverts Dependent IFN Activation and Tissue Fibrosis in vitro and in vivo

    Rebecca Ross1, Clarissa Corinaldesi 2, Gemma Migneco 3, Yasser El-Sherbiny 4, Steve Holmes 5, Jörg Distler 6, Clive McKimmie 7 and Francesco Del Galdo 8, 1Univesristy of Leeds, Leeds, England, United Kingdom, 2University of Leeds, Leeds, England, United Kingdom, 3University of Leeds, Leeds, United Arab Emirates, 4University of Nottingham, Nottingham, United Kingdom, 5Capella Bioscience, london, United Kingdom, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 7University of Leeds, Leeds, United Kingdom, 8University of Leeds and LTHT NIHR Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
  • Abstract Number: 1765 • 2019 ACR/ARP Annual Meeting

    Interferon-gamma Supports Transcriptional Activity of BIRC5 in CD4+ T Cells in Established Rheumatoid Arthritis

    Malin Erlandsson 1, Karin Andersson 1, Nisha Nair 2, Anastasius Damdimopoulos 3, Sofia Silfverswärd 1, Rille Pullerits 1, Anne Barton 2 and Maria Bokarewa1, 1Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, 2Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK, Manchester, United Kingdom, 3Department of Biosciences and Nutrition, Karolinska Institute, Solna, Sweden, Stockholm, Sweden

    Background/Purpose: It is known that rheumatoid arthritis (RA) should be treated early and a delay in treatment increases the rate of treatment non-response, joint damage,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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