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Abstracts tagged "insulin resistance"

  • Abstract Number: 0578 • ACR Convergence 2021

    Hyperinsulinemic Diet and Increased Risk of Female Gout: 2 Prospective Cohort Studies of US Women over 30 Years

    Natalie McCormick1, Chio Yokose2, Na Lu3, Amit Joshi1 and Hyon K. Choi4, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout and the metabolic (insulin resistance) syndrome frequently coexist. Intravenous insulin has been shown to raise serum urate (SU) levels in physiologic studies1 and…
  • Abstract Number: 704 • 2018 ACR/ARHP Annual Meeting

    Metabolomics Analysis of Insulin Resistance in Mild/Inactive Non-Diabetic Systemic Lupus Erythematosus Women

    Claudia Mendoza Pinto1, Mario García-Carrasco2, Gerardo Díaz-Merino3, Pamela Soto-Santillan4, Rossy Mejia-Ocampo5, Pamela Munguía-Realpozo3 and Alejandro Ruiz-Arguelles5, 1Systemic Autoimmune Diseases Research Unit,, UMAE, HE CMN Manuel Ávila Camacho-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, 2Systemic Autoimmune Diseases Research Unit, HGR 36-CIBIOR Instituto Mexicano del Seguro Social, Puebla, Mexico, 3Systemic Autoimmune Diseases Research Unit,, Hospital de Especialidades UMAE CMN, Instituto Mexicano del Seguro Social, Puebla, Mexico, 4Systemic Autoimmune Diseases Research Unit, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico, 5Laboratorios Clínicos de Puebla, Puebla, Mexico

    Background/Purpose: SLE patients present a higher prevalence of insulin resistance (IR) and metabolic syndrome (MetS) than age- and sex-matched healthy controls. Advances in technology are…
  • Abstract Number: 391 • 2017 ACR/ARHP Annual Meeting

    Defective Glucose and Lipid Metabolism in Rheumatoid Arthritis Is Determined By Chronic Inflammation in Metabolic Tissues

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Sergio Rodriguez-Cuenca3, Yolanda Jiménez-Gómez1, Patricia Ruiz-Limon2, Carlos Perez-Sanchez1, Maria Carmen Abalos-Aguilera2, Irene Cecchi2, Rafaela Ortega-Castro1, Jerusalem Calvo-Gutierrez1, Rocio Guzman-Ruiz4, Maria del Mar Malagon5, Eduardo Collantes-Estévez1, Antonio Vidal-Puig3, Alejandro Escudero-Contreras2 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, 4Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, 5Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain

    Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
  • Abstract Number: 392 • 2017 ACR/ARHP Annual Meeting

    Effects of Synthetic Dmards on the Insulin Resistance and Obesity Associated with Rheumatoid Arthritis: An Obese Mouse Model of Arthritis

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Miriam Ruiz-Ponce1, Sergio Rodriguez-Cuenca3, Maria Carmen Abalos-Aguilera2, Yolanda Jiménez-Gómez1, Patricia Ruiz-Limon2, Carlos Perez-Sanchez1, Eduardo Collantes-Estévez1, Antonio Vidal-Puig3, Alejandro Escudero-Contreras2 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Numerous studies have demonstrated the closely association between rheumatoid arthritis (RA) and metabolic complications such as obesity and insulin resistance (IR). Thus, there is…
  • Abstract Number: 1434 • 2016 ACR/ARHP Annual Meeting

    Effect of Systemic and Local Inflammation on the Insulin Resistance and Glucose/Lipid Metabolism in Rheumatoid Arthritis: Humans and CIA Mouse Model

    Nuria Barbarroja1, IVÁN ARIAS DE LA ROSA1, Manuel Peña1, Sergio Rodriguez-Cuenca2, Yolanda Jiménez-Gómez1, Patricia Ruiz-Limon3, Carlos Perez-Sanchez1, Maria Carmen Abalos-Aguilera3, Jerusalem Calvo-Gutierrez1, Eduardo Collantes-Estévez1, Antonio Vidal-Puig2, Chary Lopez-Pedrera1 and Alejandro Escudero-Contreras1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose:  Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
  • Abstract Number: 3170 • 2016 ACR/ARHP Annual Meeting

    Association Between Insulin Resistance, Subclinical Artheriosclerosis and Activity/Damage Status in Systemic Lupus Erythematosus Patients

    Hiurma Sanchez-Perez1, Beatriz Tejera2 and Ivan Ferraz-Amaro3, 1Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, 2Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 3Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain

    Background/Purpose:  Insulin resistance (IR) may contribute to an increase in cardiovascular risk. The aim of this study was to examine the association between IR and…
  • Abstract Number: 1602 • 2015 ACR/ARHP Annual Meeting

    Beta Cells Function and Insulin Resistance during Tocilizumab Treatment in Non-Diabetic RA Patients: Results from a Single-Center Study

    Gorica Ristic1, Vesna Subota2, Petar Ristic3, Dejana Stanisavljevic4, Arsen Ristic5, Branislava Glisic1, Milan Petronijevic1 and Dusan Stefanovic1, 1Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, 2Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, 3Department of Endocrinology, Military Medical Academy, Belgrade, Serbia, 4Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia, 5Department of Cardiology, Clinical Center of Serbia & Belgrade University School of Medicine, Belgrade, Serbia

    Background/Purpose: Insulin resistance (IR) is increased and β-cell function impaired in rheumatoid arthritis (RA). The aim of this study was to evaluate whether treatment with…
  • Abstract Number: 1808 • 2015 ACR/ARHP Annual Meeting

    Exercise Is Associated with Improved Cardiometabolic Risk Factors in Patients with SLE

    Michelle J. Ormseth1, Annette M. Oeser2 and C Michael Stein3, 1Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Vanderbilt University, Nashville, TN

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased prevalence of insulin resistance and the metabolic syndrome. Exercise has been shown to improve insulin…
  • Abstract Number: 2128 • 2015 ACR/ARHP Annual Meeting

    The Role of Insulin Resistance in the Development of Premature Atherosclerosis in Patients with Rheumatoid Arthritis

    Gorica Ristic1, Vesna Subota2, Toplica Lepic3, Dejana Stanisavljevic4, Branislava Glisic1, Milan Petronijevic1, Arsen Ristic5 and Dusan Stefanovic1, 1Department of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Serbia, 2Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia, 3Department of Neurology, Military Medical Academy, Belgrade, Serbia, 4Institute of Medical Statistics, Belgrade University School of Medicine, Belgrade, Serbia, 5Department of Cardiology, Clinical Center of Serbia & Belgrade University School of Medicine, Belgrade, Serbia

    Background/Purpose: Accelerated atherosclerosis in rheumatoid arthritis (RA) is well established but the role of insulin resistance in RA pts without diabetes or metabolic syndrome remains…
  • Abstract Number: 2658 • 2015 ACR/ARHP Annual Meeting

    Low Disease Activity Is Associated with Higher HDL and a Trend to Lower Insulin Resistance in Rheumatoid Arthritis Patients

    Androniki Bili1, Debra Webb1, Cynthia Matzko2, Andrea Berger3, Eric Newman4, Thomas Olenginski4, H. Lester Kirchner3, Jon Giles5 and Mary Chester M. Wasko6, 1Rheumatology, Geisinger Medical Center, Danville, PA, 2Rheumatology MC 13-41, Geisinger Medical Center, Danville, PA, 3Biostatistics, Geisinger Center for Health Research, Danville, PA, 4Department of Rheumatology, Geisinger Medical Center, Danville, PA, 5Columbia University Medical Center, New York, NY, 6West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA

    Background/Purpose: Treat to target (T2T) trials in RA to date have focused on the effect of T2T on articular disease without directly addressing cardiovascular risk.…
  • Abstract Number: 2699 • 2015 ACR/ARHP Annual Meeting

    Muscle Inflammation Relates to Disease Activity and Disability but Not Insulin Resistance in Rheumatoid Arthritis

    Ryan Jessee1, Rachel Narowski2, Monica Hubal3, Janet Huebner4, Virginia Kraus5, William Kraus6 and Kim Huffman2,7, 1Internal Medicine, Duke University Medical Center, Durham, NC, 2Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 3Research and Education, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Duke Molecular Physiology Institute,, Duke University Medical Center, Durham, NC, 5Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 6Division of Cardiology, Duke University Medical Center, Durham, NC, 7Durham Veterans Affairs Medical Center, Durham, NC

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease, insulin resistance, and disability. Our objectives were to analyze levels of skeletal muscle inflammatory cytokines…
  • Abstract Number: 2974 • 2015 ACR/ARHP Annual Meeting

    Insulin Resistance Is Associated with the Digital Ulcer in Patients with Systemic Sclerosis

    Seung-Geun Lee1, Eun-Kyoung Park2, Dong-Wan Koo2, Geun-Tae Kim3, Hee-Sang Tag3 and Joung-Wook Lee4, 1Division of Rheumatology, Department of Internal Medicine, Busan National University School of Medicine, Busan, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, 4Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea

    Background/Purpose: Growing evidence supports the view that systemic sclerosis (SSc) is a vascular disease mediated by autoimmunity and evolving into progressive tissue fibrosis. Several vascular…
  • Abstract Number: 1395 • 2014 ACR/ARHP Annual Meeting

    Disease Activity Is Associated with Insulin Resistance in Early Rheumatoid Arthritis

    Androniki Bili1, Debra Webb2, Cynthia Matzko3, Andrea Berger4, Eric D. Newman5, Thomas P. Olenginski6, David M. Pugliese7, Maria Butterwick8, Lisa L. Schroeder1, Thomas M. Harrington6, Jonida Cote1, Lyudmila Kirillova1, Susan Mathew1, Tarun Sharma1, H. Lester Kirchner9, Jon Giles10 and Mary Chester M. Wasko11, 1Rheumatology, Geisinger Health System, Danville, PA, 2Rheumatology, Geisinger Medical Center, Danville, PA, 3Rheumatology MC 13-41, Geisinger Medical Center, Danville, PA, 4Center for Health Research, Geisinger Health System, Danville, PA, 5Department of Rheumatology, Geisinger Health System, Danville, PA, 6Dept of Rheumatology, Geisinger Health System, Danville, PA, 7Rheumatology, Geisinger Health System, Wilkes-Barre, PA, 8Rheumatology, Geisinger Specialty Group, Wilkes-Barre, PA, 9Geisinger Center for Health Research, Geisinger Health System, Danville, PA, 10Columbia University Medical Center, New York, NY, 11West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic disease that manifests mainly with articular symptoms, but the main cause of death is cardiovascular disease (CVD). Chronic…
  • Abstract Number: 1387 • 2013 ACR/ARHP Annual Meeting

    Reversing Vascular Dysfunction In Rheumatoid Arthritis: Peroxisome Proliferator-Activated Receptor Gamma Agonist Therapy Improves Augmentation Index But Not Endothelial Function

    Michelle J. Ormseth1, Aihua Bian2, Annette M. Oeser2, Andrew Cunningham2, Ayumi Shintani2, S. Bobo Tanner3 and C. Michael Stein4, 1Rheumatology, Vanderbilt Medical Center, Nashville, TN, 2Vanderbilt Medical Center, Nashville, TN, 3Div of Rheumatology & Allergy, Vanderbilt Medical Center, Nashville, TN, 4School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: Rheumatoid arthritis (RA) is associated with insulin resistance and increased cardiovascular (CV) risk. Impaired vascular function, including arterial stiffness and endothelial dysfunction, is associated…
  • Abstract Number: 1261 • 2012 ACR/ARHP Annual Meeting

    Epicardial Adipose Tissue Is Associated with Cardiometabolic Risk and the Metabolic Syndrome in Patients with Rheumatoid Arthritis

    Michelle J. Ormseth1, Aliza Lipson2, Nikolaos Alexopoulos3, Gregory R. Hartlage3, Annette M. Oeser4, Aihua Bian4, Tebeb Gebretsadik5, Ayumi Shintani4, Paolo Raggi6 and C. Michael Stein7, 1Rheumatology, Vanderbilt Medical Center, Nashville, TN, 2Rheumatology, Emory University, Atlanta, GA, 3Emory University, Atlanta, GA, 4Vanderbilt Medical Center, Nashville, TN, 5Biostatistics, Vanderbilt University, Nashville, TN, 6University of Alberta, Edmonton, AB, Canada, 7School of Medicine, Division of Clinical Pharmacology, Vanderbilt Medical Center, Nashville, TN

    Background/Purpose: Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis and this may be related to their increased prevalence of visceral adiposity, insulin resistance, and…
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