Date: Sunday, October 21, 2018
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: SLE patients present a higher prevalence of insulin resistance (IR) and metabolic syndrome (
Methods: SLE patients were consecutively enrolled in a cross-sectional study. A metabolomic approach using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) was developed in serum samples from non-diabetic SLE women. Activity (SLEDAI-2K) and damage (SLICC) index scores, as well as carotid intima-media thickness (IMT), were determined in SLE patients. Patients with a Quantose IR score of ≥ 63 were defined as IR.
Results: We enrolled 70 SLE patients with a mean ± SD age of 39.3±10.6 years and median disease duration of 11 years (IQR: 8-14).
Conclusion: In non-diabetic SLE women, the prevalence of IR based on Quantose IR was 64.2% using UHPLC-HRMS.
To cite this abstract in AMA style:Mendoza Pinto C, García-Carrasco M, Díaz-Merino G, Soto-Santillan P, Mejia-Ocampo R, Munguía-Realpozo P, Ruiz-Arguelles A. Metabolomics Analysis of Insulin Resistance in Mild/Inactive Non-Diabetic Systemic Lupus Erythematosus Women [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/metabolomics-analysis-of-insulin-resistance-in-mild-inactive-non-diabetic-systemic-lupus-erythematosus-women/. Accessed September 20, 2020.
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