Abstracts tagged "innate immunity"

Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages
Trudy McGarry¹, Megan M. Hanlon², Clare C. Cunningham³, Douglas J. Veale⁴ and Ursula Fearon⁵, ¹St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ²Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ³Molecular Rheumatology, Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁴Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁵Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…
Abstract Number: 1026 • 2018 ACR/ARHP Annual Meeting
Autoinflammatory Diseases, Particularly SAVI and Candle, Are Driven By Chronically Active Type I Interferons
Bernadette Marrero¹, Katherine R. Calvo², Yin Liu³, Angelique Biancotto⁴, Yan Huang¹ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, ³Scientific Review Branch, NIAMS/NIH, Bethesda, MD, ⁴Center for Human Immunology Autoimmunity and Inflammation (CHI), NIAID, NIH, Bethesda, MD
Background/Purpose: STING Associated Vasculopathy with onset in Infancy (SAVI)is caused by gain-of-function mutations in TMEM173/STING and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature…
Abstract Number: 1833 • 2018 ACR/ARHP Annual Meeting
The Vδ2 Subset of Γδt-Cells Are Present at Healthy Human Enthesis and Have Transcriptional and Functional Characteristics Consistent with a Capacity for IL- 17A Production in Response to IL-23
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Charlie Bridgewood¹, Robert Dunsmuir², Abdulla Watad³, Abhay Rao², Almas Khan², Helena Marzo-Ortega⁴, Darren Newton⁵ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³Department of Internal Medicine 'B', Sheba Medical Center, Ramat Gan, Ramat Gan, Israel, ⁴NIHR LBRC, LTHT and LIRMM, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Background/Purpose: Recent mouse studies of SpA pathogenesis have suggested that γδT-cells accumulate at entheseal regions in an IL-23 overexpression model and that these cells are…
Abstract Number: 2039 • 2018 ACR/ARHP Annual Meeting
A Survey of Blood and Synovial Tissue Myeloid Cells in RA Patients By Transcriptional Profiling
Shurui Bian¹, Arthur M. Mandelin II², Salina Dominguez³, Philip J. Homan⁴, Gaurav Gadhvi¹, Hiam Abdala-Valencia¹, Alexander Misharin⁵, Eric M. Ruderman⁶, Carla M. Cuda³, Richard M. Pope⁶, Harris Perlman³ and Deborah R. Winter³, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Myeloid cells – including dendritic cells (DCs), monocytes, and macrophages – are critical to the pathogenesis of rheumatoid arthritis (RA) through production of pro-inflammatory…
Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus
Goh Murayama¹, Asako Chiba², Atsushi Nomura³, Hirofumi Amano¹, Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake^4,5, ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Juntendo Univ Sch of Med, Juntendo University School of Medicine, Tokyo, Japan, ³JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan, ⁴Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ⁵Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
Abstract Number: 2854 • 2018 ACR/ARHP Annual Meeting
Majeed Syndrome Causing LPIN2 mutations May Prevent Bone “Healing” By Rendering M2 Macrophage Proinflammatory
Farzana Bhuyan¹, Adriana Almeida de Jesus¹, Rachel VanTries¹, Ronit Herzog², Karen Onel³, Bernadette Marrero¹, Yan Huang¹, Katherine R. Calvo⁴, Gina A. Montealegre Sanchez¹, Polly Ferguson⁵ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²NYU Langone Medical Center, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Department of Laboratory Medicine, Hematology Section, National Institutes of Health Clinical Center, Bethesda, MD, ⁵Pediatrics, University of Iowa, Iowa City, IA
Background/Purpose: To study the mechanism that leads to bone inflammation in a 4-year old patient of mixed Puerto Rican and African-American background who presented with…
Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting
Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Kimberly Samson², Paige Snow³, Shimon Sakaguchi⁴ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ⁴Osaka University, Osaka, Japan
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
Abstract Number: 94 • 2018 ACR/ARHP Annual Meeting
Circulating Soluble MICA Is Associated to Lupus Nephritis and to a TLR/IFN-I Signature in T Cells in a Cohort of Adult SLE Patients
Maria Perez-Ferro¹, Fredeswinda I. Romero-Bueno¹, Cristina Serrano del Castillo², Raquel Largo³, Gabriel Herrero-Beaumont³ and Olga Sanchez-Pernaute⁴, ¹Section for Autoimmune Diseases, Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ²Immunology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ³Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, ⁴Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: The MHC class I-related chain A (MICA) is a major ligand for the NKG2D receptor of NK and CD8 T cells. MICA expression at…
Abstract Number: 97 • 2018 ACR/ARHP Annual Meeting
Enhanced IFN-α Production By Plasmacytoid Dendritic Cells Is Associated with Increased Toll-like Receptor 7 Retention in the Lysosomes and Exosure to Type I IFN in Systemic Lupus Erythematosus
Goh Murayama¹, Asako Chiba², Ayako Makiyama², Ken Yamaji¹, Naoto Tamura¹ and Sachiko Miyake², ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Immunology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Type I interferon(IFN) appears to contribute to the development of systemic lupus erythematosus (SLE). Overexpression of type I IFN regulated genes has been reported…
Abstract Number: 104 • 2018 ACR/ARHP Annual Meeting
Identification of a Gut Pathobiont Immunostimulatory Lipoglycan Antigen Linked to Lupus Nephritis
Gregg Silverman¹, Nicolas Gisch², Aidana Omarbekova³ and Doua F. Azzouz⁴, ¹Department of Medicine, New York University School of Medicine, New York, NY, ²Research Center Borstel, Schleswig-Holstein, Germany, ³New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: A transmissible agent has long been suspected in SLE. In a discovery cohort we found that,compared with healthy subjects, Lupus patients had a five-fold…
Abstract Number: 1062 • 2017 ACR/ARHP Annual Meeting
Ptpn22 Regulates Synovial Slam Family Receptor Expression during Toll-like Receptor-Driven Suppression of Inflammatory Arthritis
David Ewart¹, Juan Abrahante Lloréns² and Erik J. Peterson³, ¹Rheumatology, University of Minnesota, Minneapolis, MN, ²Informatics Institute (UMII), University of Minnesota, Minneapolis, MN, ³Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: Genetic factors contribute strongly to Rheumatoid arthritis (RA) risk. Protein tyrosine phosphatase non-receptor 22 [PTPN22] encodes the hematopoietic-specific Lymphoid Phosphatase [“Lyp”]. A PTPN22 coding…
Abstract Number: 1065 • 2017 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus Is Realted to an Intrinsic Defect in the Ca2+/Calcineurin/NFAT1 Signaling Pathway
Yong-Wook Park¹, Young-Nan Cho², Hye-Mi Jin¹, Tae-Jong Kim³ and Seung-Jung Kee⁴, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ²Rheumatology, Chonnam National University Hospital and Medical School, Gwangju, MN, Korea, Republic of (South), ³Chonnam Nat`l University Medical School&Hospital, Chonnam, Korea, Republic of (South), ⁴Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)
Background/Purpose: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of…
Abstract Number: 1068 • 2017 ACR/ARHP Annual Meeting
Impact of TNF Antagonist Treatment on the Gut Microbiome In Vivo
Odile Gabay¹, Jonathan Vicenty², Grant Wunderlin³, Linda Tiffany², Wells Wu⁴, Vahan Simonyan⁵ and Kathleen A Clouse⁶, ¹Office of Biotechnology Products /Center for Drug Evaluation and Research DBRRI, U.S. Food and Drug Administration, Silver Spring, MD, ²Office of Biotechnology Products, Center for Drug Evaluation and Research, DBRRI, U.S. Food and Drug Administration, Silver Spring, MD, ³Center for Drug Evaluation and Research CDER DBRRI, U.S. Food and Drug Administration, Silver Spring, MD, ⁴Center for Biologic Evaluation and Research OMPT, U.S. Food and Drug Administration, Silver Spring, MD, ⁵Center for Biologic Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, ⁶Office of Biotechnology Products /Center for Drug Evaluation and Research,DBRRI, U.S. Food and Drug Administration, Silver Spring, MD
Background/Purpose: Auto-immune diseases are in constant progression in the US. Biologic therapeutics have been used successfully to treat these diseases, but have presented some unique…
Abstract Number: 1077 • 2017 ACR/ARHP Annual Meeting
The Lectin Pathway of the Complement System Is Activated in Patients with Systemic Lupus Erythematosus
Anne Troldborg^1,2, Steffen Thiel³, Marten Trendelenburg⁴, Justa Friebus-Kardash⁵, Josephine Nehring⁵, Rudi Steffensen⁶, Søren Werner Karlskov Hansen⁷, Magdalena Janina Laska¹, Bent Deleuran⁸, Jens Christian Jensenius¹, Anne Voss⁹ and Kristian Stengaard-Pedersen¹⁰, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²clinical medicine, Aarhus University, Aarhus, Denmark, ³Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark, ⁴Department of Biomedicine, Division of Internal Medicine, Basel, Switzerland, ⁵University Hospital Basel, Division of Internal Medicine, Basel, Switzerland, ⁶Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ⁷Department of Cancer and Inflammation Research, University of Souther Denmark, Odense, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁹Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of Systemic Lupus Erythematosus (SLE) involves complement activation. It is well established that activation of complement through the classical pathway (CP) and…
Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting
Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis
Antonia Puchner¹, Victoria Saferding¹, Michael Bonelli², Harald Leiss³, Gerhard Krönke⁴, René Pfeifle⁵, Josef S. Smolen⁶, Kurt Redlich⁷ and Stephan Blüml⁶, ¹Medical University of Vienna, Austria, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Rheumatology, Medical University Vienna, Vienna, Austria, ⁴Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Austria, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, ⁷Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…

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