ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 0287 • ACR Convergence 2020

    RNA Externalized by Neutrophil Extracellular Traps Promotes Inflammatory Pathways in Endothelial Cells

    Xinghao Wang1, Philip Carlucci2, Jorge Romo-Tena1, Jose Torres-Ruiz1, Hong-Wei Sun1, Markus Hafner1, Mariana Kaplan3 and Luz Blanco4, 1NIAMS, National Institute of Health, Bethesda, 2New York University School of Medicine, New York, NY, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centreville

    Background/Purpose: Neutrophil extracellular traps (NETs) are extracellular lattices composed of nucleic material bound to neutrophil granule proteins. NETs may play pathogenic roles in development and…
  • Abstract Number: 0461 • ACR Convergence 2020

    High-Throughput Single-Cell Analysis Reveals Unique Lung Cellular Subsets in a Murine Model of Rheumatoid Arthritis-Inflammatory Lung Disease

    Rohit Gaurav1, Ted Mikuls1, Geoffrey Thiele1, Amy Nelson1, Meng Niu1, Chittibabu Guda1, James Eudy1, Austin Barry1, Debra Romberger1, Michael Duryee1, Bryant England1 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA)-associated inflammatory lung disease is an extra-articular manifestation of RA associated with increased morbidity and mortality, whose precise molecular mechanisms remain undetermined.…
  • Abstract Number: 0462 • ACR Convergence 2020

    Lupus-like Autoimmunity and Increased Interferon Response in Patients with STAT3-deficient Hyper-IgE Syndrome

    Brian Dizon1, Rishi Goel2, Shuichiro Nakabo2, Amanda Urban2, Meryl Waldman2, Lilian Howard2, Dirk Darnell2, Munir Buhaya2, Sarfaraz Hasni3, Mariana Kaplan4, Alexandra Freeman2 and Sarthak Gupta1, 1National Institutes of Health, BETHESDA, MD, 2National Institutes of Health, Bethesda, 3Lupus Clinical Trials Unit, NIAMS/NIH, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD

    Background/Purpose: Autosomal dominant hyper-IgE syndrome (AD-HIES), also known as Job’s syndrome, is a rare primary immunodeficiency caused by dominant-negative loss-of-function (LOF) mutations in signal transducer…
  • Abstract Number: 0463 • ACR Convergence 2020

    Molecular Diagnosis of Childhood Immunodysregulation, Endocrinopathy and Enteropathy X-linked (IPEX)-Like Syndrome and Implications for Clinical Management

    Sarah Baxter1, Tom Walsh1, Silvia Casadei1, Suleyman Gulsuner1, Eric Allenspach2, David Hagin3, Gesmar Segundo4, Troy Torgerson5 and Mary-Claire King1, 1University of Washington, Seattle, 2Seattle Children's Research Institute, Seattle, 3Tel Aviv Medical Center, Tel Aviv, Israel, 4Universidade Federal de Uberlandia, Uberlandia, Brazil, 5Allen Institute, Seattle

    Background/Purpose: Patients with early-onset immunodysregulation, endocrinopathy and enteropathy but without identified mutations in FOXP3 are termed “IPEX-like,” and undergo trial-and-error immunosuppressive treatment with highly variable…
  • Abstract Number: 0469 • ACR Convergence 2020

    IFNγ Is Essential for Alveolar Macrophage Driven Lung Inflammation in Macrophage Activation Syndrome

    Denny Gao1, Maggie Henderlight1, Christopher Woods1, Alexei Grom1, Sherry Thornton1, Michael Jordan1, Katheryn Wikenheiser-Brokamp1 and Grant Schulert2, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Macrophage activation syndrome (MAS) is a life-threatening cytokine storm syndrome frequently complicating systemic juvenile idiopathic arthritis (SJIA) and driven by IFNγ. MAS is also…
  • Abstract Number: 159 • 2020 Pediatric Rheumatology Symposium

    Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide Appropriate Therapeutic Strategy in Chronic Arthritic Systemic Juvenile Idiopathic Arthritis

    Takako Miyamae1, Yumi Tani 1, Manabu Kawamoto 2, Takayuki Kishi 3 and Masayoshi Harigai 2, 1Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, TOKYO, Japan, 3Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes into adulthood.…
  • Abstract Number: 800 • 2019 ACR/ARP Annual Meeting

    Cryopyrin-Associated Periodic Syndrome in Korea: 19 Years of Experience

    Young Ho Kim1, Bongjik Kim 2, Byung Yoon Choi 2, Haeng Jin Lee 3, Dae-Chul Jeong 4, Jinhee Han 2, Hye-Rim Park 2, Jayoung Oh 2, Seungmin Lee 2, Dooyi Oh 5 and Soyoung Lee 1, 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Kyonggi-do, Republic of Korea, 3Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea, 4Department of Pediatrics, The Catholic University of Korea, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 5Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Kyonggi-do, Republic of Korea

    Background/Purpose: Cryopyrin-associated periodic syndrome (CAPS) is rare auto-inflammatory disorder characterized by recurrent episodes fever with variable manifestation of systemic inflammation such as urticarial skin rash,…
  • Abstract Number: 1020 • 2019 ACR/ARP Annual Meeting

    NLRP12 Regulates Interferon-α Expression and Is a Biomarker for Disease Activity of Systemic Lupus Erythematosus

    Ming-Han Chen1, Yen-Po Tsao 1 and Szu-Ting Chen 2, 1Division of Allergy, Immunology & Rheumatology/Taipei Veterans General Hospital, Taipei, Taiwan (Republic of China), 2Institutes of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (Republic of China)

    Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune disease with diverse etiological factors. It was well recognized that interferon (IFN) signature did the perpetration…
  • Abstract Number: 2736 • 2019 ACR/ARP Annual Meeting

    Mucosal-associated Invariant T Cells Can Be Therapeutically Targeted in Lupus

    Goh Murayama1, Asako Chiba 2, Tomohiro Mizuno 3, Atsushi Nomura 2, Taiga Kuga 4, HIrofumi Amano 4, Ken Yamaji 4, Naoto Tamura 4 and Sachiko Miyake 2, 1Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, 4Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
  • Abstract Number: 2807 • 2019 ACR/ARP Annual Meeting

    Activation of the STING Pathway Is a Shared Feature of Salivary Gland and Lung Inflammation in Sjogren’s Syndrome

    Joanna Papinska 1, Grzegorz Gmyrek 2, Umesh Deshmukh1 and Harini Bagavant 1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City

    Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disorder characterized by an increased type 1 interferon gene signature. The engagement of stimulator of interferon genes (STING)…
  • Abstract Number: 75 • 2019 ACR/ARP Annual Meeting

    Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Elise Mike 2, Chaim Putterman 3, Deborah Winter 4 and Carla Cuda 5, 1Northwestern University, Chicago, IL, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine, New York, NY, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…
  • Abstract Number: 76 • 2019 ACR/ARP Annual Meeting

    Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Chirag Raparia 2, Anne Davidson 2 and Carla Cuda 3, 1Northwestern University, Chicago, IL, 2Feinstein Institutes for Medical Research, Manhasset, 3Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 79 • 2019 ACR/ARP Annual Meeting

    Unique Primed Status of Microglia Under the Systemic Autoimmune Condition of Lupus-Prone Mice

    Atsushi Nomura1, Daisuke Noto 2, Goh Murayama 3, Asako Chiba 1 and Sachiko Miyake 1, 1Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 2Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the…
  • Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting

    Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice

    Ruth Napier1, Ellen Lee1, Emily Vance1, Kimberly Samson2, Paige Snow3, Shimon Sakaguchi4 and Holly Rosenzweig1, 1Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 2Oregon Health & Science University, Portland, OR, 3Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, 4Osaka University, Osaka, Japan

    Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…
  • Abstract Number: 94 • 2018 ACR/ARHP Annual Meeting

    Circulating Soluble MICA Is Associated to Lupus Nephritis and to a TLR/IFN-I Signature in T Cells in a Cohort of Adult SLE Patients

    Maria Perez-Ferro1, Fredeswinda I. Romero-Bueno1, Cristina Serrano del Castillo2, Raquel Largo3, Gabriel Herrero-Beaumont3 and Olga Sanchez-Pernaute4, 1Section for Autoimmune Diseases, Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 2Immunology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 3Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 4Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

    Background/Purpose: The MHC class I-related chain A (MICA) is a major ligand for the NKG2D receptor of NK and CD8 T cells. MICA expression at…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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