ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "innate immunity"

  • Abstract Number: L01 • ACR Convergence 2024

    Targeted Exosite Inhibition of STING Activation of TBK1 Selectively Blocks Type I Interferon and NFκB Responses for Treatment of Autoimmune Diseases

    Matthew Martin1, Erik Wilker1, Diana Gikunju1, Usha Narayanan1, Unnati Pandya1, Vijetha Prakash1, Ashley Edwards1, Sameer Kawatkar1, Tenghui Chen1, Ragunath Chandran1, Sai Sunder1, Sumathi Biradar1, Joerg Distler2, Alexandra Joseph1, Stephanos Ioannidis1 and Bhavatarini Vangamudi1, 1Exo Therapeutics, Cambridge, MA, 2Exo Therapeutics, Düsseldorf, Germany

    Background/Purpose: The cGAS-TBK1-STING pathway senses nucleic acids for innate immunity. Aberrant activation of the pathway is linked to autoimmune diseases including Systemic and Cutaneous Lupus…
  • Abstract Number: 1793 • ACR Convergence 2024

    SLE Patient Serum and SLE-associated Danger Signals Impair Efferocytosis in Human Macrophages

    Jessica Shannon and Rafael de Queiroz Prado, AstraZeneca, Gaithersburg, MD

    Background/Purpose: Efficient clearance of apoptotic cells, known as efferocytosis, plays a pivotal role in maintaining self-tolerance. Dysfunction in efferocytosis is implicated in the pathogenesis of…
  • Abstract Number: 1796 • ACR Convergence 2024

    Kidney Hematopoietic Stem and Progenitor Cells Contribute to Immune Cell Development and Pathology in Lupus Nephritis

    Hansol Yi1, Seyoung Jung2, Mi-Ra Cho3, Yong-Gil Kim1, Chang-Keun Lee1, Bin Yoo1, Jeongseok Lee2 and Seokchan Hong1, 1Asan medical center, Seoul, Republic of Korea, 2Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 3Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Hematopoiesis primarily occurs in the bone marrow (BM), where hematopoietic stem and progenitor cells (HSPCs) originate. However, non-lymphoid tissues outside the BM can contribute…
  • Abstract Number: 0040 • ACR Convergence 2024

    Targeting Complement Factor B (CFB) via a Novel siRNA Therapy (AZD6912) to Treat Inflammatory Arthritis

    Gary Sims1, Mia Collins2, Natalie Pursell3, Teneema Kuriakose1, Fanyi Jiang4, Kristi Moore5, Lucie Bertrand5, Melissa Lasaro5, Jessica Neisen6, Scott Manetz7, Gabriel Wong8, Patrick Riley5, Iain McInnes9, Kyriakos Konstantinidis10 and David Close8, 1Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 2Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 3Dicerna, Lexington, 4Translation and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 5Alexion, AstraZeneca Rare Disease, New Haven, CT, 6Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 7Clinical Pharmacology and Safety Science, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 8Early Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom, 9University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 10Projects, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: New precision medicine guided therapies targeting alternate disease driving processes are required to improve clinical outcomes in RA. The complement pathway has long been…
  • Abstract Number: 1816 • ACR Convergence 2024

    Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages

    Emily Morris1, Helen Jarnagin2, Heetaek Yang3, Alexandra Turnquist2, Michael Whitfield4 and Patricia Pioli5, 1Dartmouth College, Enfield, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth College, West Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
  • Abstract Number: 0046 • ACR Convergence 2024

    Impaired Neutrophil Extracellular Trap (NET) Degradation in Rheumatoid Arthritis (RA) and Pre-clinical RA Is Mediated by Anti-NET Antibodies

    Jeba Atkia Maisha1, Alina Sememenko2, Jun Kim2, Mario Navarrete2, XIAOBO MENG1, Hani El-Gabalawy1 and Liam O'Neil1, 1University of Manitoba, Winnipeg, MB, Canada, 2University of Manitoba, Winnipeg, Canada

    Background/Purpose: Rheumatoid Arthritis (RA) begins after a prolonged preclinical phase which is marked by the development of RA antibodies, typically against citrullinated proteins (ACPA). The…
  • Abstract Number: 1824 • ACR Convergence 2024

    Skin Macrophage Subtypes and Impact of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis: Results from Single-cell Analyses of an Observational Data Set and a Phase I/II Randomized Controlled Trial

    Juliette Ferrant1, Alain Lescoat2, Valérie Lecureur3, Marie Lelong3, John Varga4, Robert Lafyatis5, Johann Gudjonsson4 and Dinesh Khanna4, 1CHU Rennes, Rennes, France, 2CHU Rennes - University Rennes 1, Rennes, France, 3Rennes University, Rennes, France, 4University of Michigan, Ann Arbor, MI, 5University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Macrophages play a major role in dcSSc-related skin fibrosis, with a mixed M1-M2 activation profile relying on the activation of JAK/STAT. Tofacitinib, a pan-JAK…
  • Abstract Number: 0072 • ACR Convergence 2024

    The Association Between Activation of Inflammasome and HLA-B27 in Dendritic Cells of Patients with Axial Spondyloarthritis

    Jina Yeo1, Min-Gang Kim2, Hye Eun Lee3, Yeonsoo Yang2, Mi Ryoung Seo1, Hyo-Jin Choi1, Eun Young Lee4, Dae Ho Lee3 and Han Joo Baek5, 1Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea, 3Division of Endocrinology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, 43Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea, 5Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Inchon, South Africa

    Background/Purpose: Axial spondyloarthritis (axSpA) exhibits a predominant involvement of the innate immune system, marked by abnormal functions of innate immune cell such as dendritic cells…
  • Abstract Number: 1863 • ACR Convergence 2024

    Human Endogenous Retroviruses Promote the Aberrant T Cell Differentiation in Systemic Lupus Erythematosus

    Xiaoli Min1, Jiali Wu2, Yaqin Yu3, Qianjin Lu4 and Ming Zhao4, 1Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China (People's Republic), 2Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic), 3Central South University, Changsha, China (People's Republic), 4Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China (People's Republic)

    Background/Purpose: Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs and systems. The complex pathogenesis of SLE involved the abnormal activation of CD4+T cells and DNA hypomethylation modification. Human endogenous retroviruses (HERVs)…
  • Abstract Number: 0305 • ACR Convergence 2024

    Inflammatory T Cell Expansion in Yao Syndrome

    Danielle Xie1, Rimanpreet Kaur2, Richard Kew2, Qingping Yao3 and Charles Vorkas2, 1Stony Brook University, East Setauket, 2Stony Brook University, Stony Brook, 3Stony Brook University, Stony Brook, NY

    Background/Purpose: Yao syndrome (YAOS, #OMIM 617321), formerly known as nucleotide-binding oligomerization protein containing 2 (NOD2)-associated autoinflammatory disease, is associated with specific NOD2 mutations and affects…
  • Abstract Number: 2199 • ACR Convergence 2024

    Mycobacterial Infection and Renal and Bladder Malignancy in 2 IFNopathy Patients on High Doses of JAK Inhibitors

    Sara Alehashemi1, Kader Cetin Gedik2, Cassandra Calabrese3, Sherry Nguyen4, Alexi Baumgardner4, Katsiaryna Uss4, Kip Friend4, Ariane Soldatos5, Adriana Almeida de Jesus6 and Raphaela Goldbach-Mansky7, 1NIH/NIAID/TADS, Potomac, MD, 2Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Pittsburgh, PA, 3Cleveland Clinic Foundation, Cleveland Heights, OH, 4Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Bethesda, MD, 5NINDS/NIH, Bethesda, MD, 6NIAID, NIH, Silver Spring, MD, 7Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Potomac, MD

    Background/Purpose: Autoinflammatory Type I Interferonopathies (IFNopathies) include STINGopathies (e.g., SAVI and COPA syndrome), proteasomopathies (e.g., CANDLE/Proteasome associated autoinflammatory syndrome (PRAAS), and oligonucleotidopathies (e.g., AGS: Aicardi-Goutières…
  • Abstract Number: 0924 • ACR Convergence 2024

    The Cytosolic DNA Sensor AIM2 Regulates Bone Homeostasis Through Bone Progenitor Cell Differentiation

    Jia (Sijia) Chen1, Yukiko Maeda2, Catherine Manning3, Victor Le4, Jae-Hyuck Shim5, Katherine A. Fitzgerald6 and Ellen Gravallese7, 1Brigham and Women's Hospital, Boston, MA, 2Sanofi, worcester, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Digital Biology, Boston, MA, 5University of Massachusetts, Worcester, MA, 6UMass Chan Medical School, Worchester, MA, 7Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Innate sensing pathways and inflammasomes play an important role in autoimmunity and aging. AIM2 is a DNA sensor that triggers inflammasome assembly in myeloid…
  • Abstract Number: 2327 • ACR Convergence 2024

    Differential Quantitative Profile of Myeloid Derived Suppressor Cells and Monocyte Subsets Relate to Clinical Phenotype and Disease Activity in Psoriatic Arthritis Patients

    Jennifer Balderas Miranda1, Jiram Torres Ruiz2, Guillermo Guaracha Basañez3, Virginia Pascual Ramos4, Beatriz Alcalá-Carmona5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Nancy R Mejía-Domínguez5, Guillermo Juarez-Vega6 and Diana Gomez-martin7, 1Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 2INCMNSZ, Mexico, Federal District, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirón", Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Federal District, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 7INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: The innate immune system not only participates in PsA pathogenesis but may also counteract with immunomodulatory elements. Proinflammatory and repairing roles according to monocyte…
  • Abstract Number: 0932 • ACR Convergence 2024

    IRAK4 Degrader GS-6791 Inhibits TLR and IL-1R-Driven Inflammatory Signaling, and Ameliorates Disease in a Preclinical Arthritis Model

    Grace Teng1, Thomas Fung2, Annamaria Mocciaro2, Ceyda Llapashtica1, Angie Hammond3, Jesse Gurgel4, zhiyu Huang1, Maria Mouchess1, Vanessa Gorney5, Wesley Minto1, Sunish Mohanan1, Adam Schrier1, Wylie Palmer2, Alexandra Borodovsky2 and Gundula Min-oo1, 1Gilead Sciences, Foster City, CA, 2Nurix Therapeutics, San Francisco, CA, 3Gilead Sciences, Inc., Seattle, WA, 4Gilead Sciences, Seattle, CA, 5Alterome Therapeutics, San Diego, CA

    Background/Purpose: Despite advances in treatment, chronic inflammatory diseases such as rheumatoid arthritis (RA) represent areas of high unmet medical need. IRAK4 is a proximal mediator…
  • Abstract Number: 2505 • ACR Convergence 2024

    C5 Signaling Pathway Genes as Key Drivers of the Pathogenesis of IgA Vasculitis?

    Joao Carlos Batista-Liz1, Vanesa Calvo-Rio2, María Sebastián Mora-Gil3, Ligia Gabrie-Rodriguez4, Rafael Gálvez Sánchez4, Belén Sevilla-Pérez5, José Luis Callejas6, María Teresa Leonardo7, Ana Peñalba7, Javier Narvaez-García8, Luis Martín-Penagos9, Luis Caminal-Montero10, PAZ COLLADO11, Patricia Quiroga Colina12, Esther Vicente-rabaneda13, Esteban Rubio14, Manuel León Luque15, Juan María Blanco-Madrigal16, Eva Galindez-Agirregoikoa17, Santos Castañeda13, Ricardo Blanco-Alonso18, Veronica Pulito-Cueto1 and Raquel Lopez-mejias1, 1IDIVAL, Santander, Spain, 2Valdecilla Hospital, Santander, Cantabria, Spain, 3Immunopathology Group, IDIVAL, Santander, Spain, 4Immunopathology Group, IDIVAL. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, 6Systemic Autoimmune Diseases Unit, Hospital Clinico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain, 7Division of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 8Hospital Universitario de Bellvitge, Barcelona, Spain, 9Immunopathology Group, IDIVAL. Division of Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 10Internal Medicine Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain, 11Hospital Universitario Severo Ochoa, MADRID, Spain, 12Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, 13Hospital Universitario de La Princesa, Madrid, Spain, 14Division of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Sevilla, Spain, 15Division of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Sevilla, Spain, 16Division of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain., Bilbao, Spain, 17BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 18Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Immunoglobulin A Vasculitis (IgAV) is an inflammatory disease caused by the accumulation of immune complexes of IgA in the walls of small blood vessels…
  • 1
  • 2
  • 3
  • …
  • 14
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology