Abstracts tagged "inflammatory arthritis"

Abstract Number: 33 • 2012 ACR/ARHP Annual Meeting
Novel Targets for Blocking Osteoclast-Mediated Resorption in Inflammatory Disorders
Kevin P. McHugh¹, Tania N. Crotti¹, Jun Li², Jon Hill³, Gerald H. Nabozny², Steven R. Goldring⁴ and P. Edward Purdue⁵, ¹Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, ²Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY
Background/Purpose: Osteoclasts are specialized myeloid lineage cells that mediate both pathologic and physiologic bone remodeling Fully differentiated and functional osteoclasts are found exclusively associated with…
Abstract Number: 14 • 2012 ACR/ARHP Annual Meeting
EPAC1 Activation Is Required for NFkB Nuclear Translocation and Osteoclast Differentiation
Aranzazu Mediero¹ and Bruce N. Cronstein², ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Previous work demonstrated that one mechanism by which bisphosphonates inhibit osteoclast differentiation and function is via inhibition of Rap1A isoprenylation and, as a result,…
Abstract Number: 2649 • 2012 ACR/ARHP Annual Meeting
Trends in US Arthroplasty Rates 1991-2005: Patients with Inflammatory Arthritis Continue to Require Joint Replacement
Christina Mertelsmann-Voss¹, Ting Jung Pan², Stephen L. Lyman³, Mark P. Figgie⁴ and Lisa A. Mandl⁵, ¹Pediatric Rheumatology, Hospital for Special Surgery, Cornell University, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Research, Hospital Special Surgery, New York, NY, ⁴Orthopedics, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Overall rates of total joint replacement surgeries (TJR) have increased dramatically over the past decades. By contrast, TJR rates among patients with rheumatoid arthritis…
Abstract Number: 2447 • 2012 ACR/ARHP Annual Meeting
Accuracy of Sensewear Mini^TM and Actigraph GT3X^TM Accelerometers for Differentiating Sedentary and Light Physical Activities in a Controlled Laboratory Setting
April Y. F. Leung¹, Lynne M. Feehan², Cynthia Macdonald¹, Jenny Leese³, Erin Carruthers⁴ and Linda C. Li⁵, ¹Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ²Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: People living with inflammatory arthritis are likely to be less physically active due to pain and fatigue. To understand the relationship between physical inactivity…
Abstract Number: 2452 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Associated PTPN22 Modulates Toll-Like Receptor-Mediated, Type 1 Interferon-Dependent Innate Immunoregulation
Yaya Wang¹, Stephanie Stanford², Wenbo Zhou³, Jennifer L. Auger⁴, Genhong Cheng⁵, Amanda Campbell⁶, Fernanda M. Shoyama¹, Henry H. Balfour Jr.⁷, Andrew C. Chan⁸, Bryce A. Binstadt⁴, Nunzio Bottini⁶ and Erik J. Peterson³, ¹Department of Medicine, University of Minnesota, Minneapolis, MN, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³University of Minnesota, Minneapolis, MN, ⁴Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ⁵University of California, Los Angeles, Los Angeles, CA, ⁶La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁷University of Minnesota, Minneapolis, ⁸Immunology, Genentech Inc, South San Francisco, CA
Background/Purpose: A coding polymorphism (C1858T) in PTPN22 is strongly associated with risk of Rheumatoid Arthritis (RA) and other autoimmune diseases. PTPN22 encodes Lymphoid Phosphatase (Lyp);…
Abstract Number: 2091 • 2012 ACR/ARHP Annual Meeting
The Effect of Pretreatment with Capsaicin On Measurement of Arthritis Pain by Dynamic Weight Bearing and Evoked Pain Responses in an Acute Murine Arthritis Model
Hollis E. Krug¹, Christopher W. Dorman², Sandra Frizelle² and Maren L. Mahowald³, ¹Medicine, VA Health Care System, Minneapolis, MN, ²Research, Minneapolis VA Health Care System, Minneapolis, MN, ³Medicine, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN

Background/Purpose: Murine models are important to study arthritis pain and new analgesics, however measuring pain in mice is challenging. The Dynamic Weight Bearing (DWB) device…
Abstract Number: 2055 • 2012 ACR/ARHP Annual Meeting
TEAM-Managed Care of Biological Patients At A Canadian Centre
Melissa Deamude¹, Dawn Heap², Melanie Kanellos², Debbie Kislinsky³, Kathy Kislinsky¹, Cynthia Mech⁴, Helena Ross¹, Peggy Saldanha³, Lauri Vanstone⁵, Kathleen Brown⁶ and William G. Bensen⁷, ¹Dr. William G. Bensen, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, ²Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, ³Dr. William Bensen Rheumatology Clinic, Hamilton, ON, Canada, ⁴Dr. William G. Bensen, Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, ⁵Dr. William Bensen Rheumatology Biologic Clinic, Rheumatology Health Team, Hamilton, ON, Canada, ⁶Dr. William Bensen Rheumatology Clinic, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, ⁷Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada
Background/Purpose: Managing complex arthritic patients with biologics is exacting and time consuming. As a result in January 2008 we established a separate biologic clinic with…
Abstract Number: 1660 • 2012 ACR/ARHP Annual Meeting
Development of a Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA)
Toshio Yoshizawa, Yuko Ariza, Yoshiko Ueda, Shingo Hotta, Masami Narita and Kazuhito Kawabata, Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, and tyrosine kinases have key roles in the signaling pathways that regulate…
Abstract Number: 1663 • 2012 ACR/ARHP Annual Meeting
G Protein Signaling Modulator 3 Is a Key Regulator of Monocyte-Driven Inflammatory Arthritis
Matthew J. Billard¹, Patrick M. Giguére², Brian Buckley², Marcus W. McGinnis¹, Roman Timoshchenko¹, Peng Liu¹, David P. Siderovski² and Teresa K. Tarrant³, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Monocytes are critical to rheumatoid arthritis (RA) disease pathogenesis and are recruited to the inflamed synovium by inflammation-driven chemokines. G protein signaling modulator 3…
Abstract Number: 1621 • 2012 ACR/ARHP Annual Meeting
In Vivo Synovial Oxygen Levels Are Inversely Related to Metabolic Turnover and Disease Activity in Rheumatoid and Psoriatic Arthritis Biologic Responders
Leonard C. Harty¹, John Ryan², Chin Teck Ng³, Monika Biniecka⁴, Aisling Kennedy⁴, Eric J. Heffernan⁵, Ursula Fearon³ and Douglas J. Veale⁶, ¹Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Ziltron, Unit 4, Castletroy Business Park, Plassey, Limerick, Ireland, ³Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁴Dublin Academic Medical Centre, St. Vincent's University Hospital, Translation Rheumatology Research Group, Dublin, Ireland, ⁵Radiology, St. Vincent's University Hospital, Dublin, Ireland, ⁶Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: Hypoxia, leukocyte infiltration and dysfunctional vascularity play a key role in the pathogenesis of inflammatory arthritis (IA). We examine the relationship of metabolic turnover…
Abstract Number: 1051 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging in Inflammatory Bowel Disease Patients with Arthralgia
W. Stomp¹, L.K.P.M. Brakenhoff², F.a. van Gaalen³, D. van der Heijde⁴, H.H. Fidder⁵, D.W. Hommes⁶, M. Reijnierse¹ and J.L Bloem¹, ¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Joint manifestations frequently occur in chronic inflammatory bowel diseases (IBD). Arthralgia, non-inflammatory joint pain without objective evidence of swelling or effusion, is present in…
Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting
Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages
Nam Hoon Kim, Research Institute of Immunobiology, Catholic university of Korea, Seoul of Korea, Seoul, South Korea
Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…
Abstract Number: 767 • 2012 ACR/ARHP Annual Meeting
Patients with Early Inflammatory Arthritis Who Fulfil the 2010 American College Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis Have Increased Mortality Compared to Those Who Do Not: Results From the Norfolk Arthritis Register
Jh Humphreys¹, Suzanne Verstappen², Mark Lunt³, Jackie Chipping⁴, Kimme Hyrich⁵, Tarnya Marshall⁶ and Deborah Symmons⁷, ¹Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit,, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁴Norfolk Arthritis Register, School of Medicine Health Policy and Practice Faculty of Health UEA, Norwich, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁶Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁷Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom
Background/Purpose: Mortality is increased in rheumatoid arthritis (RA) in comparison with the general population. The majority of studies have used the 1987 ACR criteria to…
Abstract Number: 332 • 2012 ACR/ARHP Annual Meeting
Blockade of CTGF Restores Aberrant Ostoclastgenesis in Collagen Induced Arthritis (CIA) Mice Through Inhibition of Th-17 Differentiation
Kazuhisa Nozawa¹, Maki Fujishiro², Ayako Yamaguchi¹, Mikiko Kawasaki², Shouzou Ichinose², Mitsuaki Yanagida², Kazuhisa Iwabuchi², Keigo Ikeda³, Shinji Morimoto⁴, Megumi Morioka⁵, Yoshinari Takasaki⁶ and Iwao Sekigawa³, ¹Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ³Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, ⁴Juntendo University Urayasu Hospital, Tokyo, Japan, ⁵Nihon Nosan Corporation, Nihon Nosan Corporation, Kanagawa, Japan, ⁶Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Our previous study demonstrated changes in the profiles of serum protein biomarkers in infliximab-treated rheumatoid arthritis (RA) patients using a novel approach to proteomic…
Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting
Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software
Diane Thome, Donald Souza, Aruna Behera, Jie Zheng, Jennifer Swantek and Gerald H. Nabozny, Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…

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