ACR Meeting Abstracts

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Abstracts tagged "inflammatory arthritis"

  • Abstract Number: 2447 • 2012 ACR/ARHP Annual Meeting

    Accuracy of Sensewear MiniTM and Actigraph GT3XTM Accelerometers for Differentiating Sedentary and Light Physical Activities in a Controlled Laboratory Setting

    April Y. F. Leung1, Lynne M. Feehan2, Cynthia Macdonald1, Jenny Leese3, Erin Carruthers4 and Linda C. Li5, 1Physical Therapy, University of British Columbia, Vancouver, BC, Canada, 2Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada, 3Arthritis Research Centre of Canada, Vancouver, BC, Canada, 4Arthritis Research Centre of Canada, Richmond, BC, Canada, 5Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: People living with inflammatory arthritis are likely to be less physically active due to pain and fatigue.  To understand the relationship between physical inactivity…
  • Abstract Number: 2452 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis-Associated PTPN22 Modulates Toll-Like Receptor-Mediated, Type 1 Interferon-Dependent Innate Immunoregulation

    Yaya Wang1, Stephanie Stanford2, Wenbo Zhou3, Jennifer L. Auger4, Genhong Cheng5, Amanda Campbell6, Fernanda M. Shoyama1, Henry H. Balfour Jr.7, Andrew C. Chan8, Bryce A. Binstadt4, Nunzio Bottini6 and Erik J. Peterson3, 1Department of Medicine, University of Minnesota, Minneapolis, MN, 2Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 3University of Minnesota, Minneapolis, MN, 4Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, 5University of California, Los Angeles, Los Angeles, CA, 6La Jolla Institute for Allergy and Immunology, La Jolla, CA, 7University of Minnesota, Minneapolis, 8Immunology, Genentech Inc, South San Francisco, CA

    Background/Purpose: A coding polymorphism (C1858T) in PTPN22 is strongly associated with risk of Rheumatoid Arthritis (RA) and other autoimmune diseases. PTPN22 encodes Lymphoid Phosphatase (Lyp);…
  • Abstract Number: 2091 • 2012 ACR/ARHP Annual Meeting

    The Effect of Pretreatment with Capsaicin On Measurement of Arthritis Pain by Dynamic Weight Bearing and Evoked Pain Responses in an Acute Murine Arthritis Model

    Hollis E. Krug1, Christopher W. Dorman2, Sandra Frizelle2 and Maren L. Mahowald3, 1Medicine, VA Health Care System, Minneapolis, MN, 2Research, Minneapolis VA Health Care System, Minneapolis, MN, 3Medicine, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN

    Background/Purpose:  Murine models are important to study arthritis pain and new analgesics, however measuring pain in mice is challenging. The Dynamic Weight Bearing (DWB) device…
  • Abstract Number: 2055 • 2012 ACR/ARHP Annual Meeting

    TEAM-Managed Care of Biological Patients At A Canadian Centre

    Melissa Deamude1, Dawn Heap2, Melanie Kanellos2, Debbie Kislinsky3, Kathy Kislinsky1, Cynthia Mech4, Helena Ross1, Peggy Saldanha3, Lauri Vanstone5, Kathleen Brown6 and William G. Bensen7, 1Dr. William G. Bensen, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, 2Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, 3Dr. William Bensen Rheumatology Clinic, Hamilton, ON, Canada, 4Dr. William G. Bensen, Rheumatology Health Team, Dr. Bensen's Rheumatology Clinic, Hamilton, ON, Canada, 5Dr. William Bensen Rheumatology Biologic Clinic, Rheumatology Health Team, Hamilton, ON, Canada, 6Dr. William Bensen Rheumatology Clinic, Rheumatology Health Team, St. Joseph's Hospital Hamilton, Hamilton, ON, Canada, 7Department of Medicine, Division of Rheumatology, St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada

    Background/Purpose: Managing complex arthritic patients with biologics is exacting and time consuming.  As a result in January 2008 we established a separate biologic clinic with…
  • Abstract Number: 1660 • 2012 ACR/ARHP Annual Meeting

    Development of a Bruton’s Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA)

    Toshio Yoshizawa, Yuko Ariza, Yoshiko Ueda, Shingo Hotta, Masami Narita and Kazuhito Kawabata, Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, and tyrosine kinases have key roles in the signaling pathways that regulate…
  • Abstract Number: 1663 • 2012 ACR/ARHP Annual Meeting

    G Protein Signaling Modulator 3 Is a Key Regulator of Monocyte-Driven Inflammatory Arthritis

    Matthew J. Billard1, Patrick M. Giguére2, Brian Buckley2, Marcus W. McGinnis1, Roman Timoshchenko1, Peng Liu1, David P. Siderovski2 and Teresa K. Tarrant3, 1Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Monocytes are critical to rheumatoid arthritis (RA) disease pathogenesis and are recruited to the inflamed synovium by inflammation-driven chemokines.  G protein signaling modulator 3…
  • Abstract Number: 1621 • 2012 ACR/ARHP Annual Meeting

    In Vivo Synovial Oxygen Levels Are Inversely Related to Metabolic Turnover and Disease Activity in Rheumatoid and Psoriatic Arthritis Biologic Responders

    Leonard C. Harty1, John Ryan2, Chin Teck Ng3, Monika Biniecka4, Aisling Kennedy4, Eric J. Heffernan5, Ursula Fearon3 and Douglas J. Veale6, 1Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Ziltron, Unit 4, Castletroy Business Park, Plassey, Limerick, Ireland, 3Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 4Dublin Academic Medical Centre, St. Vincent's University Hospital, Translation Rheumatology Research Group, Dublin, Ireland, 5Radiology, St. Vincent's University Hospital, Dublin, Ireland, 6Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland

    Background/Purpose: Hypoxia, leukocyte infiltration and dysfunctional vascularity play a key role in the pathogenesis of inflammatory arthritis (IA). We examine the relationship of metabolic turnover…
  • Abstract Number: 1051 • 2012 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging in Inflammatory Bowel Disease Patients with Arthralgia

    W. Stomp1, L.K.P.M. Brakenhoff2, F.a. van Gaalen3, D. van der Heijde4, H.H. Fidder5, D.W. Hommes6, M. Reijnierse1 and J.L Bloem1, 1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands, 6Center for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Joint manifestations frequently occur in chronic inflammatory bowel diseases (IBD). Arthralgia, non-inflammatory joint pain without objective evidence of swelling or effusion, is present in…
  • Abstract Number: 876 • 2012 ACR/ARHP Annual Meeting

    Xanthine Oxidase-Derived ROS Direct Context-Dependent Action of NFAT5 Toward Inflammatory Response in Macrophages

    Nam Hoon Kim, Research Institute of Immunobiology, Catholic university of Korea, Seoul of Korea, Seoul, South Korea

    Background/Purpose: NFAT5, a well known osmo-protective factor, can be activated by isotonic stimuli, such as Toll-like receptor (TLR) triggering. Here, we identified a novel signal…
  • Abstract Number: 767 • 2012 ACR/ARHP Annual Meeting

    Patients with Early Inflammatory Arthritis Who Fulfil the 2010 American College Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis Have Increased Mortality Compared to Those Who Do Not: Results From the Norfolk Arthritis Register

    Jh Humphreys1, Suzanne Verstappen2, Mark Lunt3, Jackie Chipping4, Kimme Hyrich5, Tarnya Marshall6 and Deborah Symmons7, 1Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, 2Arthritis Research UK Epidemiology Unit,, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, 3Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 4Norfolk Arthritis Register, School of Medicine Health Policy and Practice Faculty of Health UEA, Norwich, United Kingdom, 5Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, 6Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, 7Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom

    Background/Purpose: Mortality is increased in rheumatoid arthritis (RA) in comparison with the general population.  The majority of studies have used the 1987 ACR criteria to…
  • Abstract Number: 332 • 2012 ACR/ARHP Annual Meeting

    Blockade of CTGF Restores Aberrant Ostoclastgenesis in Collagen Induced Arthritis (CIA) Mice Through Inhibition of Th-17 Differentiation

    Kazuhisa Nozawa1, Maki Fujishiro2, Ayako Yamaguchi1, Mikiko Kawasaki2, Shouzou Ichinose2, Mitsuaki Yanagida2, Kazuhisa Iwabuchi2, Keigo Ikeda3, Shinji Morimoto4, Megumi Morioka5, Yoshinari Takasaki6 and Iwao Sekigawa3, 1Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, 3Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, 4Juntendo University Urayasu Hospital, Tokyo, Japan, 5Nihon Nosan Corporation, Nihon Nosan Corporation, Kanagawa, Japan, 6Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Our previous study demonstrated changes in the profiles of serum protein biomarkers in infliximab-treated rheumatoid arthritis (RA) patients using a novel approach to proteomic…
  • Abstract Number: 32 • 2012 ACR/ARHP Annual Meeting

    Development of a Quantitative Model of Endotoxin-Induced Calvarial Bone Erosion Utilizing Micro-Computed Tomography and Pax-It Imaging Analysis Software

    Diane Thome, Donald Souza, Aruna Behera, Jie Zheng, Jennifer Swantek and Gerald H. Nabozny, Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT

    Background/Purpose: To facilitate an understanding of the biological factors involved in inflammation- mediated bone loss, in vitro systems and murine models of bone loss, such…
  • Abstract Number: 33 • 2012 ACR/ARHP Annual Meeting

    Novel Targets for Blocking Osteoclast-Mediated Resorption in Inflammatory Disorders

    Kevin P. McHugh1, Tania N. Crotti1, Jun Li2, Jon Hill3, Gerald H. Nabozny2, Steven R. Goldring4 and P. Edward Purdue5, 1Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, 2Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 3Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, 4Hospital for Special Surgery, New York, NY, 5Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY

    Background/Purpose: Osteoclasts are specialized myeloid lineage cells that mediate both pathologic and physiologic bone remodeling   Fully differentiated and functional osteoclasts are found exclusively associated with…
  • Abstract Number: 14 • 2012 ACR/ARHP Annual Meeting

    EPAC1 Activation Is Required for NFkB Nuclear Translocation and Osteoclast Differentiation

    Aranzazu Mediero1 and Bruce N. Cronstein2, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: Previous work demonstrated that one mechanism by which bisphosphonates inhibit osteoclast differentiation and function is via inhibition of Rap1A isoprenylation and, as a result,…
  • Abstract Number: 2649 • 2012 ACR/ARHP Annual Meeting

    Trends in US Arthroplasty Rates 1991-2005: Patients with Inflammatory Arthritis Continue to Require Joint Replacement

    Christina Mertelsmann-Voss1, Ting Jung Pan2, Stephen L. Lyman3, Mark P. Figgie4 and Lisa A. Mandl5, 1Pediatric Rheumatology, Hospital for Special Surgery, Cornell University, New York, NY, 2Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, 3Research, Hospital Special Surgery, New York, NY, 4Orthopedics, Hospital for Special Surgery, New York, NY, 5Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose: Overall rates of total joint replacement surgeries (TJR) have increased dramatically over the past decades. By contrast, TJR rates among patients with rheumatoid arthritis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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