ACR Meeting Abstracts

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Abstracts tagged "inflammatory arthritis"

  • Abstract Number: 3190 • 2015 ACR/ARHP Annual Meeting

    Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis

    Aranzazu Mediero1, Tuere Wilder2 and Bruce Cronstein3, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, 3Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of the joints and some extra-articular tissues. Netrin-1 is a laminin-like…
  • Abstract Number: 3188 • 2015 ACR/ARHP Annual Meeting

    Inhibition of Lymphatic Muscle Contraction By Lymphatic Endothelial iNOS Impairs Lymph Drainage from Arthritic Joints in TNF-Tg Mice and Is Prevented By Herbal Drugs

    Qianqian Liang1, Yan Chen1, Jinlong Li1, Wensheng Wang2, Li Zhang1, Hao Xu1, Ronald Wood2, Brendan Boyce2, Edward Schwarz3, Yongjun Wang1 and Lianping Xing4, 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 2University of Rochester, Rochester, NY, 3Orthopedeatrics, University of Rochester, Rochester, NY, 4University of Rochester Medical Center, Rochester, NY

    Background/Purpose: We reported previously that inflammation in TNF-Tg mice, a model of rheumatoid arthritis (RA), inhibits lymphatic vessel maturation, resulting in decreased lymphatic smooth muscle…
  • Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting

    Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction

    Nancy E. Lane1, Wei Yao2 and Maripat Corr3, 1Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, 2University California, Davis Medical Center, Internal Medicine, Sacramento, CA, 3Medicine, University of California, San Diego, La Jolla, CA

    Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…
  • Abstract Number: 2318 • 2015 ACR/ARHP Annual Meeting

    Inflammatory Arthritis Patient Perspectives on Strategies to Support Medication Adherence: A Qualitative Study Using a Novel Group Exercise

    Sharan K. Rai1, Pavandeep Mehat2, Anne Townsend3, Carlo Marra4, Harpreet Chhina5, Rhonda Shuckett6 and Mary A. De Vera2, 1Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, 2Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, 3Medical School, University of Exeter, Exeter, United Kingdom, 4School of Pharmacy, Memorial University, St. John's, NF, Canada, 5Orthopedic Surgery, BC Children's Hospital, Vancouver, BC, Canada, 6Rheumatology, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Disappointing and inconsistent findings of adherence intervention research in inflammatory arthritis (IA) highlight the need for further work in designing interventions that promote and…
  • Abstract Number: 2263 • 2015 ACR/ARHP Annual Meeting

    Construct and Convergent Validity of Four Global Measures of at-Work Productivity Loss in Patients with Rheumatic Diseases

    Sarah Leggett1, Diane Lacaille2, Carina Mihai3, Mihai Bojinca4, Brendan van As5, Suzanne M. Verstappen6 and EULAR-PRO worker productivity group, 1Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre,The University of Manchester, Manchester, United Kingdom, 2Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, 3Internal Medicine and Rheumatology, Ion Cantacuzino Hospital, Bucharest, Romania, 4Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology, Cantacuzino Hospital, Bucharest, Romania, 5Arthritis Research Canada, Richmond, BC, Canada, 6Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Several global measures are available to assess at-work productivity loss in rheumatic diseases. Paucity in research exploring the construct validity of such measures contributes…
  • Abstract Number: 2019 • 2015 ACR/ARHP Annual Meeting

    Serum Biomarkers of Inflammatory Arthritis in First Degree Relatives of Patients with Rheumatoid Arthritis and Their Association with Lifestyle Risk Factors

    Jamie C Sergeant and RA-MAP Consortium, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (anti-CCP) and C-reactive protein (CRP) are known serum biomarkers of inflammatory arthritis (IA) and have potential predictive…
  • Abstract Number: 1006 • 2014 ACR/ARHP Annual Meeting

    Interleukin-4 As Promising, Anti-Inflammatory Transgene for Gene Therapeutic Application in Joint Diseases

    Annemarie Lang1, Johannes Neuhaus2, Moritz Pfeiffenberger3, Erik Schroeder4, Frank Buttgereit5, Michael F. G. Schmidt3 and Timo Gaber6, 1Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, 2Department of Veterinary Medicine, Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, 3Department of Veterinary Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany, 4Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 5Charité University Hospital, Berlin, Germany, 6Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany

    Background/Purpose Interleukin- 4 (IL-4), a Th2-cell released immunomodulatory factor, has potent chondroprotective and anti-inflammatory properties able to inhibit the synthesis of IL-1β and TNFα, and…
  • Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting

    A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis

    W. Alexander Stinson1, Phillip L. Campbell1, Jeffrey Ruth2, Gautam Edhayan2, Ray A. Ohara2, Nicholas Lepore3, Alisa E. Koch4, David A. Fox2 and M. Asif Amin2, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 4Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI

    Background/Purpose:  Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
  • Abstract Number: 400 • 2014 ACR/ARHP Annual Meeting

    Clinical Utility of 14-3-3η in the Evaluation of Inflammatory Arthritis

    Lance Feller1, Paul Tuttle IV2 and Terry L. Moore3, 1Rheumatology, Saint Louis University, St. Louis, MO, 2Rheumatology, Saint Louis University, Saint Louis, MO, 3Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO

    Background/Purpose 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
  • Abstract Number: 415 • 2014 ACR/ARHP Annual Meeting

    a Dual-Center, Double Blind Randomized Study for a New Scientific Approach in Assessment of Tender Joints in Inflammatory Arthritis Using the Smart Joint Assessor Glove Device (Smart JAG Device)

    Mohammad Khan1, Larry Willis2, Swapan Nath3, Cheryl Guest2, Lindsey Gillispie4 and Mary Jane Rorick4, 1Arthritis & Rheumatology Center of Oklahoma, Oklahoma City, OK, 2Research, Arthritis & Rheumatology Center of Oklahoma, PLLC, Oklahoma City, OK, 3Department of Pediatrics and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Rheumatology, McBride Orthopedic Hospital, Oklahoma City, OK

    Background/Purpose Tender Joint Count (TJC) is a vital quality measure to assess the progression of Inflammatory Arthritis both from a therapeutic and a diagnostic standpoint.…
  • Abstract Number: 333 • 2014 ACR/ARHP Annual Meeting

    Deletion of the Prolactin Receptor Aggravates the Course of Antigen-Induced Arthritis

    Norma Adan, Maria G. Ledesma-Colunga, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico

    Background/Purpose: Prolactin (PRL), the hormone essential for lactation, may protect against joint damage in rheumatoid arthritis. PRL frequently increases in the circulation of patients with…
  • Abstract Number: 183 • 2014 ACR/ARHP Annual Meeting

    Musculoskeletal Ultrasound Reveals Calcific Deposition Arthropathy in Seronegative Inflammatory Arthritis Patients

    Sheila L. Arvikar1, Janice Lin2 and Minna J. Kohler3, 1Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, 2Dermatology, Brigham and Women's Hospital, Boston, MA, 3Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Background/Purpose Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have vastly improved the diagnosis of rheumatoid arthritis (RA), but the diagnosis and management of seronegative…
  • Abstract Number: 124 • 2014 ACR/ARHP Annual Meeting

    Ultrasound Power Doppler Findings in the Wrists and Hands Joints of Anti-CCP Antibody Positive Individuals with Non-Specific Musculoskeletal Symptoms and the Development of Inflammatory Arthritis

    Jackie L. Nam, Laura Hunt, Elizabeth M.A. Hensor, Philip G. Conaghan, Richard J. Wakefield and Paul Emery, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose The use of musculoskeletal ultrasound is increasing in rheumatology practice. Recently we have shown that use of power Doppler signal (PD) on ultrasound in…
  • Abstract Number: 2559 • 2014 ACR/ARHP Annual Meeting

    Vitamin D insufficiency  and Deficiency in Two European Cohorts of Patients with Inflammatory Rheumatic Disorders

    Alessandra Vacca1, Giovanni Porru1, Grazia Dessole1, Alessandro Mathieu1, Catherine Cormier2, Yvonne Fulla2, Andre Kahan2 and Yannick Allanore3, 1Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, 2Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France, 3Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France

    Background/Purpose Vitamin D plays an important role in the modulation of immune system and epidemiologic data indicate low vitamin D levels in autoimmune diseases such…
  • Abstract Number: 2442 • 2014 ACR/ARHP Annual Meeting

    Aligning Ethics with Digital Health Technologies and Shared Decision-Making: Interview Accounts of Patients and Clinicians

    Anne F. Townsend1,2,3,4, Paul Adam5, Jenny Leese6, Linda C. Li6,7, Michael McDonald2, Sheila Kerr8, Gordon Whitehead8 and Catherine Backman6,9, 1Qualitative Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, 2Maurice Young Centre for Applied Ethics, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, 3Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, 4University of British Columbia, Vancouver, BC, Canada, 5Mary Pack Arthritis Centre, Vancouver, BC, Canada, 6Arthritis Research Centre of Canada, Richmond, BC, Canada, 7Physical Therapy, University of British Columbia, Vancouver, BC, Canada, 8Arthritis Patient Advisory Board, Richmond, BC, Canada, 9Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose Medical ethics evolves as health care develops. Digital health technologies are transforming health care delivery and patient and clinician relationships. Ethi­cal approaches are shifting…
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