Abstracts tagged "inflammatory arthritis"

Abstract Number: 3190 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of the joints and some extra-articular tissues. Netrin-1 is a laminin-like…
Abstract Number: 3188 • 2015 ACR/ARHP Annual Meeting
Inhibition of Lymphatic Muscle Contraction By Lymphatic Endothelial iNOS Impairs Lymph Drainage from Arthritic Joints in TNF-Tg Mice and Is Prevented By Herbal Drugs
Qianqian Liang¹, Yan Chen¹, Jinlong Li¹, Wensheng Wang², Li Zhang¹, Hao Xu¹, Ronald Wood², Brendan Boyce², Edward Schwarz³, Yongjun Wang¹ and Lianping Xing⁴, ¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ²University of Rochester, Rochester, NY, ³Orthopedeatrics, University of Rochester, Rochester, NY, ⁴University of Rochester Medical Center, Rochester, NY
Background/Purpose: We reported previously that inflammation in TNF-Tg mice, a model of rheumatoid arthritis (RA), inhibits lymphatic vessel maturation, resulting in decreased lymphatic smooth muscle…
Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting
Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction
Nancy E. Lane¹, Wei Yao² and Maripat Corr³, ¹Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, ²University California, Davis Medical Center, Internal Medicine, Sacramento, CA, ³Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…
Abstract Number: 2318 • 2015 ACR/ARHP Annual Meeting
Inflammatory Arthritis Patient Perspectives on Strategies to Support Medication Adherence: A Qualitative Study Using a Novel Group Exercise
Sharan K. Rai¹, Pavandeep Mehat², Anne Townsend³, Carlo Marra⁴, Harpreet Chhina⁵, Rhonda Shuckett⁶ and Mary A. De Vera², ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ³Medical School, University of Exeter, Exeter, United Kingdom, ⁴School of Pharmacy, Memorial University, St. John's, NF, Canada, ⁵Orthopedic Surgery, BC Children's Hospital, Vancouver, BC, Canada, ⁶Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Disappointing and inconsistent findings of adherence intervention research in inflammatory arthritis (IA) highlight the need for further work in designing interventions that promote and…
Abstract Number: 2263 • 2015 ACR/ARHP Annual Meeting
Construct and Convergent Validity of Four Global Measures of at-Work Productivity Loss in Patients with Rheumatic Diseases
Sarah Leggett¹, Diane Lacaille², Carina Mihai³, Mihai Bojinca⁴, Brendan van As⁵, Suzanne M. Verstappen⁶ and EULAR-PRO worker productivity group, ¹Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre,The University of Manchester, Manchester, United Kingdom, ²Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Internal Medicine and Rheumatology, Ion Cantacuzino Hospital, Bucharest, Romania, ⁴Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology, Cantacuzino Hospital, Bucharest, Romania, ⁵Arthritis Research Canada, Richmond, BC, Canada, ⁶Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Several global measures are available to assess at-work productivity loss in rheumatic diseases. Paucity in research exploring the construct validity of such measures contributes…
Abstract Number: 2019 • 2015 ACR/ARHP Annual Meeting
Serum Biomarkers of Inflammatory Arthritis in First Degree Relatives of Patients with Rheumatoid Arthritis and Their Association with Lifestyle Risk Factors
Jamie C Sergeant and RA-MAP Consortium, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
Background/Purpose: Rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (anti-CCP) and C-reactive protein (CRP) are known serum biomarkers of inflammatory arthritis (IA) and have potential predictive…
Abstract Number: 1006 • 2014 ACR/ARHP Annual Meeting
Interleukin-4 As Promising, Anti-Inflammatory Transgene for Gene Therapeutic Application in Joint Diseases
Annemarie Lang¹, Johannes Neuhaus², Moritz Pfeiffenberger³, Erik Schroeder⁴, Frank Buttgereit⁵, Michael F. G. Schmidt³ and Timo Gaber⁶, ¹Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ²Department of Veterinary Medicine, Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ³Department of Veterinary Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁵Charité University Hospital, Berlin, Germany, ⁶Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany
Background/Purpose Interleukin- 4 (IL-4), a Th2-cell released immunomodulatory factor, has potent chondroprotective and anti-inflammatory properties able to inhibit the synthesis of IL-1β and TNFα, and…
Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
W. Alexander Stinson¹, Phillip L. Campbell¹, Jeffrey Ruth², Gautam Edhayan², Ray A. Ohara², Nicholas Lepore³, Alisa E. Koch⁴, David A. Fox² and M. Asif Amin², ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
Abstract Number: 400 • 2014 ACR/ARHP Annual Meeting
Clinical Utility of 14-3-3η in the Evaluation of Inflammatory Arthritis
Lance Feller¹, Paul Tuttle IV² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
Abstract Number: 415 • 2014 ACR/ARHP Annual Meeting
a Dual-Center, Double Blind Randomized Study for a New Scientific Approach in Assessment of Tender Joints in Inflammatory Arthritis Using the Smart Joint Assessor Glove Device (Smart JAG Device)
Mohammad Khan¹, Larry Willis², Swapan Nath³, Cheryl Guest², Lindsey Gillispie⁴ and Mary Jane Rorick⁴, ¹Arthritis & Rheumatology Center of Oklahoma, Oklahoma City, OK, ²Research, Arthritis & Rheumatology Center of Oklahoma, PLLC, Oklahoma City, OK, ³Department of Pediatrics and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Rheumatology, McBride Orthopedic Hospital, Oklahoma City, OK
Background/Purpose Tender Joint Count (TJC) is a vital quality measure to assess the progression of Inflammatory Arthritis both from a therapeutic and a diagnostic standpoint.…
Abstract Number: 333 • 2014 ACR/ARHP Annual Meeting
Deletion of the Prolactin Receptor Aggravates the Course of Antigen-Induced Arthritis
Norma Adan, Maria G. Ledesma-Colunga, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico
Background/Purpose: Prolactin (PRL), the hormone essential for lactation, may protect against joint damage in rheumatoid arthritis. PRL frequently increases in the circulation of patients with…
Abstract Number: 183 • 2014 ACR/ARHP Annual Meeting
Musculoskeletal Ultrasound Reveals Calcific Deposition Arthropathy in Seronegative Inflammatory Arthritis Patients
Sheila L. Arvikar¹, Janice Lin² and Minna J. Kohler³, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Dermatology, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background/Purpose Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have vastly improved the diagnosis of rheumatoid arthritis (RA), but the diagnosis and management of seronegative…
Abstract Number: 124 • 2014 ACR/ARHP Annual Meeting
Ultrasound Power Doppler Findings in the Wrists and Hands Joints of Anti-CCP Antibody Positive Individuals with Non-Specific Musculoskeletal Symptoms and the Development of Inflammatory Arthritis
Jackie L. Nam, Laura Hunt, Elizabeth M.A. Hensor, Philip G. Conaghan, Richard J. Wakefield and Paul Emery, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose The use of musculoskeletal ultrasound is increasing in rheumatology practice. Recently we have shown that use of power Doppler signal (PD) on ultrasound in…
Abstract Number: 2559 • 2014 ACR/ARHP Annual Meeting
Vitamin D insufficiency and Deficiency in Two European Cohorts of Patients with Inflammatory Rheumatic Disorders
Alessandra Vacca¹, Giovanni Porru¹, Grazia Dessole¹, Alessandro Mathieu¹, Catherine Cormier², Yvonne Fulla², Andre Kahan² and Yannick Allanore³, ¹Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France, ³Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France
Background/Purpose Vitamin D plays an important role in the modulation of immune system and epidemiologic data indicate low vitamin D levels in autoimmune diseases such…
Abstract Number: 2442 • 2014 ACR/ARHP Annual Meeting
Aligning Ethics with Digital Health Technologies and Shared Decision-Making: Interview Accounts of Patients and Clinicians
Anne F. Townsend^1,2,3,4, Paul Adam⁵, Jenny Leese⁶, Linda C. Li^6,7, Michael McDonald², Sheila Kerr⁸, Gordon Whitehead⁸ and Catherine Backman^6,9, ¹Qualitative Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Maurice Young Centre for Applied Ethics, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ³Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁶Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁷Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ⁸Arthritis Patient Advisory Board, Richmond, BC, Canada, ⁹Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose Medical ethics evolves as health care develops. Digital health technologies are transforming health care delivery and patient and clinician relationships. Ethical approaches are shifting…