Abstracts tagged "inflammatory arthritis"

Abstract Number: 3251 • 2016 ACR/ARHP Annual Meeting
Sleep and Physical Activity: A Nationwide Survey Among People with Rheumatic Disease in Ireland
Sean McKenna¹, Alan Donnelly², Sandy Fraser³ and Norelee Kennedy¹, ¹Department of Clinical Therapies, University of Limerick, Ireland, Limerick, Ireland, ²Department of Physical Education and Sports Sciences, University of Limerick, Ireland, Limerick, Ireland, ³Department of Rheumatology, University Hospitals Limerick, Ireland, Limerick, Ireland
Background/Purpose: Sleep is an important aspect in maintaining the body’s circadian rhythm and plays an important role in maintaining health. Disrupted or lower levels…
Abstract Number: 19 • 2016 ACR/ARHP Annual Meeting
Tumour Necrosis Factor Inhibition Is Associated with Weight Gain in Patients with Inflammatory Arthritis
Peter Wong¹, Alison Bowling², Cheryl Tulk³, Di Freeman³ and Hanish Bagga³, ¹Mid-North Coast Arthritis Clinic and University of New South Wales Rural Clinical School, Coffs Harbour, Australia, ²School of Health and Human Sciences, Southern Cross University, Coffs Harbour, Australia, ³Mid-North Coast Arthritis Clinic, Coffs Harbour, Australia
Background/Purpose: Targeted blockade of tumour necrosis factor (TNF) has been a major therapeutic advance in the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and…
Abstract Number: 479 • 2015 ACR/ARHP Annual Meeting
How to Recruit Anti-CCP Positive Patients from Primary Care
Jackie L. Nam¹, Laura Hunt¹, Elizabeth M.A. Hensor¹ and Paul Emery^1,2, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom
Background/Purpose: Around 1% of the population test positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies. This biomarker predicts progression to rheumatoid arthritis (RA) but over a…
Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting
DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Carmelo Carmona-Rivera³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Marta J. Gonzalez-Hernandez⁶, Julie M. Jorns⁷, Srilakshmi Yalavarthi⁸, Smriti Mohan⁹, Dave Pai¹⁰, Kristine Angevine¹¹, Barbara Adams¹², Jason S. Knight⁸, Alisa E. Koch^13,14,15, David Fox¹⁴, Dave Engelke¹⁶, Mariana J. Kaplan¹⁷ and David Markovitz⁴, ¹Infectious Diseases, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Albion College, Ann Arbor, MI, ⁶Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁷Pathology, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁰Scripps Research Institute, San Diego, CT, ¹¹Appistry, Inc, St. Louis, MO, ¹²Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, ¹³VA Medical Service, Ann Arbor, MI, ¹⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ¹⁵Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, ¹⁶Biochemistry, University Michigan, Ann Arbor, MI, ¹⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…
Abstract Number: 1176 • 2015 ACR/ARHP Annual Meeting
Interleukin-37 Prevents New-Onset Joint Inflammation but Does Not Inhibit Existing Experimental Arthritis
Marije I. Koenders¹, Debbie M. Roeleveld¹, Charles Dinarello², Peter M. van der Kraan¹ and Leo Joosten³, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ³Internal Medicine, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-37 (IL-37) is a recently identified cytokine with potent anti-inflammatory and immunosuppressive functions. This cytokine has been shown to be expressed in synovial tissue…
Abstract Number: 1192 • 2015 ACR/ARHP Annual Meeting
The F-Word: Why Is Talking about Fatigue so Hard?
Ruth Hart¹, Katie Hackett², Julia Newton³, Wan-Fai Ng^3,4 and Ben Thompson^4,5, ¹Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Newcastle University, Newcastle upon Tyne, United Kingdom, ⁴Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ⁵Newcastle University, Newcastle-upon-Tyne, United Kingdom
Background/Purpose: Fatigue is a common symptom for people with inflammatory arthritis and associated auto-immune conditions. Its impact is wide-ranging and significantly reduces health-related quality of…
Abstract Number: 1354 • 2015 ACR/ARHP Annual Meeting
Whipple’s Disease: The Diagnostic Utility of Synovial Fluid Tropheryma Whipplei Polymerase Chain Reaction
Zoran Kvrgic¹, Kelly Cawcutt², Robin Patel³, Abinash Virk², Clement J. Michet Jr.⁴, Eric L. Matteson⁵ and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Infectious Diseases, Mayo Clinic, Rochester, MN, ³Medicine, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Inflammatory arthritis is a common, non-specific symptom of Whipple’s disease. Recovery of the organism by conventional culture is often unsuccessful. Synovial fluid polymerase chain…
Abstract Number: 1480 • 2015 ACR/ARHP Annual Meeting
Adiposity in Children with Juvenile Psoriatic Arthritis (JPsA)
Aaida Samad¹, Matthew L. Stoll², Idit Lavi³, Kriti Gupta¹, Joyce Hsu⁴, Vibeke Strand^5,6, Elizabeth D. Mellins⁷, Devy Zisman⁸ and for the CARRA Registry Investigators, ¹Dept of Pediatrics CSSR, Stanford University Med Ctr, Stanford, CA, ²University of Alabama at Birmingham, Birmingham, AL, ³Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel, ⁴Pediatric Rheumatology, Stanford University, Palo Alto, CA, ⁵Stanford University, Palo Alto, CA, ⁶Biopharmaceutical Consultant, Portola Valley, CA, ⁷Dept of Pediatrics CCSR, Stanford University Med Ctr, Stanford, CA, ⁸Rheumatology Unit, Carmel Medical CenterThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel, Haifa, Israel
Background/Purpose: To assess the adiposity/BMI of children diagnosed with JPsA in a North American registry, examining differences between overweight and non-overweight patients with regard to…
Abstract Number: 2019 • 2015 ACR/ARHP Annual Meeting
Serum Biomarkers of Inflammatory Arthritis in First Degree Relatives of Patients with Rheumatoid Arthritis and Their Association with Lifestyle Risk Factors
Jamie C Sergeant and RA-MAP Consortium, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
Background/Purpose: Rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (anti-CCP) and C-reactive protein (CRP) are known serum biomarkers of inflammatory arthritis (IA) and have potential predictive…
Abstract Number: 2263 • 2015 ACR/ARHP Annual Meeting
Construct and Convergent Validity of Four Global Measures of at-Work Productivity Loss in Patients with Rheumatic Diseases
Sarah Leggett¹, Diane Lacaille², Carina Mihai³, Mihai Bojinca⁴, Brendan van As⁵, Suzanne M. Verstappen⁶ and EULAR-PRO worker productivity group, ¹Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre,The University of Manchester, Manchester, United Kingdom, ²Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Internal Medicine and Rheumatology, Ion Cantacuzino Hospital, Bucharest, Romania, ⁴Carol Davila University of Medicine and Pharmacy, Internal Medicine and Rheumatology, Cantacuzino Hospital, Bucharest, Romania, ⁵Arthritis Research Canada, Richmond, BC, Canada, ⁶Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Several global measures are available to assess at-work productivity loss in rheumatic diseases. Paucity in research exploring the construct validity of such measures contributes…
Abstract Number: 2318 • 2015 ACR/ARHP Annual Meeting
Inflammatory Arthritis Patient Perspectives on Strategies to Support Medication Adherence: A Qualitative Study Using a Novel Group Exercise
Sharan K. Rai¹, Pavandeep Mehat², Anne Townsend³, Carlo Marra⁴, Harpreet Chhina⁵, Rhonda Shuckett⁶ and Mary A. De Vera², ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ³Medical School, University of Exeter, Exeter, United Kingdom, ⁴School of Pharmacy, Memorial University, St. John's, NF, Canada, ⁵Orthopedic Surgery, BC Children's Hospital, Vancouver, BC, Canada, ⁶Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Disappointing and inconsistent findings of adherence intervention research in inflammatory arthritis (IA) highlight the need for further work in designing interventions that promote and…
Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting
Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction
Nancy E. Lane¹, Wei Yao² and Maripat Corr³, ¹Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, ²University California, Davis Medical Center, Internal Medicine, Sacramento, CA, ³Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…
Abstract Number: 3188 • 2015 ACR/ARHP Annual Meeting
Inhibition of Lymphatic Muscle Contraction By Lymphatic Endothelial iNOS Impairs Lymph Drainage from Arthritic Joints in TNF-Tg Mice and Is Prevented By Herbal Drugs
Qianqian Liang¹, Yan Chen¹, Jinlong Li¹, Wensheng Wang², Li Zhang¹, Hao Xu¹, Ronald Wood², Brendan Boyce², Edward Schwarz³, Yongjun Wang¹ and Lianping Xing⁴, ¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ²University of Rochester, Rochester, NY, ³Orthopedeatrics, University of Rochester, Rochester, NY, ⁴University of Rochester Medical Center, Rochester, NY
Background/Purpose: We reported previously that inflammation in TNF-Tg mice, a model of rheumatoid arthritis (RA), inhibits lymphatic vessel maturation, resulting in decreased lymphatic smooth muscle…
Abstract Number: 3190 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of the joints and some extra-articular tissues. Netrin-1 is a laminin-like…
Abstract Number: 34 • 2015 ACR/ARHP Annual Meeting
The Impact of Cardiovascular and Lung Disorder Morbidities on Physical Activity in People with Inflammatory Arthritis Compared to the General Population in the UK
Michael Cook¹, Eftychia Bellou², Jamie C Sergeant³, John Bowes², Anne Barton⁴, Terence W. O'Neill¹ and Suzanne M.M. Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Cardiovascular and lung disorder morbidities are more common in people with inflammatory arthritis (IA) than in the general population. However, little is known about…

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