Abstracts tagged "inflammatory arthritis"

Abstract Number: 726 • 2016 ACR/ARHP Annual Meeting
Comparison of Infliximab Immunogenicity in Inflammatory Arthritis Versus Inflammatory Bowel Disease Patients in Routine Clinical Practice
Marianne Guirgis¹, Melanie Favre dit Jeanfavre², Charles Benaim³, Matthieu Perreau⁴, Pierre Michetti⁵, Michel Maillard¹ and Pascal Zufferey⁶, ¹gastroenterology, Lausanne, Switzerland, ²DAL, RHU, Lausanne, Switzerland, ³DAL, MPR, Lausanne, Switzerland, ⁴Medecine /CHUV, Immunology, Lausanne, Switzerland, ⁵La Source-Beaulieu, Lausanne, Switzerland, ⁶Rhu /Dal .Chuv, Rheumatology, Lausanne, Switzerland
Background/Purpose: Infliximab is a biological agent frequently used for inflammatory arthritis (IA) such as spondyloarthritis, rheumatoid arthritis, psoriatic arthritis as well as for the inflammatory…
Abstract Number: 917 • 2016 ACR/ARHP Annual Meeting
B Cells Inhibit Osteoblast Differentiation in Inflammatory Arthritis
Wen Sun^1,2, Nida Meednu³, Alex Rosenberg¹, Javier Rangel-Moreno⁴, Victor Wang³, Teresa Owen¹, Hengwei Zhang⁵, Brendan Boyce¹, Jennifer H. Anolik¹ and Lianping Xing¹, ¹University of Rochester Medical Center, Rochester, NY, ²Nanjing Medical University, Nanjing, China, ³Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴Allergy, Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is frequently associated with bone loss due to imbalanced bone resorption and formation. B cell depletion therapy (BCDT) attenuates bone erosion…
Abstract Number: 2318 • 2015 ACR/ARHP Annual Meeting
Inflammatory Arthritis Patient Perspectives on Strategies to Support Medication Adherence: A Qualitative Study Using a Novel Group Exercise
Sharan K. Rai¹, Pavandeep Mehat², Anne Townsend³, Carlo Marra⁴, Harpreet Chhina⁵, Rhonda Shuckett⁶ and Mary A. De Vera², ¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ³Medical School, University of Exeter, Exeter, United Kingdom, ⁴School of Pharmacy, Memorial University, St. John's, NF, Canada, ⁵Orthopedic Surgery, BC Children's Hospital, Vancouver, BC, Canada, ⁶Rheumatology, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Disappointing and inconsistent findings of adherence intervention research in inflammatory arthritis (IA) highlight the need for further work in designing interventions that promote and…
Abstract Number: 2576 • 2015 ACR/ARHP Annual Meeting
Treatment of Inflammatory Arthritis with a Hybrid Compound, LLP2A-Ale, Can Prevent Joint Destruction
Nancy E. Lane¹, Wei Yao² and Maripat Corr³, ¹Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA, ²University California, Davis Medical Center, Internal Medicine, Sacramento, CA, ³Medicine, University of California, San Diego, La Jolla, CA
Background/Purpose: Nearly 2% of the US population suffers from inflammatory arthritis, and while there are effective treatments that reduce the joint destruction, over 20% of…
Abstract Number: 3188 • 2015 ACR/ARHP Annual Meeting
Inhibition of Lymphatic Muscle Contraction By Lymphatic Endothelial iNOS Impairs Lymph Drainage from Arthritic Joints in TNF-Tg Mice and Is Prevented By Herbal Drugs
Qianqian Liang¹, Yan Chen¹, Jinlong Li¹, Wensheng Wang², Li Zhang¹, Hao Xu¹, Ronald Wood², Brendan Boyce², Edward Schwarz³, Yongjun Wang¹ and Lianping Xing⁴, ¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ²University of Rochester, Rochester, NY, ³Orthopedeatrics, University of Rochester, Rochester, NY, ⁴University of Rochester Medical Center, Rochester, NY
Background/Purpose: We reported previously that inflammation in TNF-Tg mice, a model of rheumatoid arthritis (RA), inhibits lymphatic vessel maturation, resulting in decreased lymphatic smooth muscle…
Abstract Number: 3190 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of the joints and some extra-articular tissues. Netrin-1 is a laminin-like…
Abstract Number: 34 • 2015 ACR/ARHP Annual Meeting
The Impact of Cardiovascular and Lung Disorder Morbidities on Physical Activity in People with Inflammatory Arthritis Compared to the General Population in the UK
Michael Cook¹, Eftychia Bellou², Jamie C Sergeant³, John Bowes², Anne Barton⁴, Terence W. O'Neill¹ and Suzanne M.M. Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Cardiovascular and lung disorder morbidities are more common in people with inflammatory arthritis (IA) than in the general population. However, little is known about…
Abstract Number: 3250 • 2015 ACR/ARHP Annual Meeting
Systemic Inflammation and Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Laura Frey-Law², Devyani Misra¹, Michael C. Nevitt³, Lars Arendt-Nielsen⁴, Emily K. Quinn⁵ and Cora E. Lewis⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²UIowa, Iowa City, IA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴Aalborg University, Aalborg, Denmark, ⁵Data Coordinating Center, Boston University School of Public Health, Boston, MA, ⁶Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well-understood. We recently demonstrated that local…
Abstract Number: 152 • 2015 ACR/ARHP Annual Meeting
Anti-CCP Positive Patients without Clinical Synovitis Progress If Ultrasound Positive
Jackie L. Nam¹, Elizabeth M.A. Hensor¹, Laura Hunt¹, Philip G. Conaghan², Richard J. Wakefield¹ and Paul Emery³, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: To determine whether ultrasound can identify which anti-cyclic citrullinated peptide (anti-CCP) antibody positive patients with musculoskeletal (MSK) symptoms and without clinical synovitis progress to…
Abstract Number: 3265 • 2015 ACR/ARHP Annual Meeting
Sustaining Employment with Arthritis: Can Existing Workplace Policies and Accommodations Make a Difference?
Monique A.M. Gignac^1,2, Elizabeth M. Badley³, Dorcas Beaton⁴, Vicki Kristman⁵, Cameron Mustard⁶, Peter Smith⁶ and Selahadin Ibrahim⁶, ¹Instititue for Work and Health, Toronto, ON, Canada, ²Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada, ⁴St. Michael's Hospital, Toronto, ON, Canada, ⁵Lakehead University, Toronto, ON, Canada, ⁶Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: Despite improved treatment, many individuals with inflammatory arthritis (IA) and osteoarthritis (OA) report difficulties working, reduced productivity and elevated absenteeism. Lacking is research on…
Abstract Number: 189 • 2015 ACR/ARHP Annual Meeting
Indocyanine Green (ICG) -Enhanced Fluorescence Optical Imaging (FOI) in Patients with Active Rheumatoid Arthritis; A Comparative Study with Ultrasound and Association with Biomarkers
Shin-ya Kawashiri^1,2, Ayako Nishino³, Masataka Umeda³, Shoichi Fukui¹, Yoshikazu Nakashima³, Naoki Iwamoto¹, Kunihiro Ichinose¹, Hideki Nakamura¹, Tomoki Origuchi⁴, Kiyoshi Aoyagi² and Atsushi Kawakami³, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁴Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Methods: Twenty-five active RA patients (mean disease durations 7.5 years and DAS28-ESR 5.90) who fulfilled 2010 RA classification criteria were consecutively enrolled in this study.…
Abstract Number: 3266 • 2015 ACR/ARHP Annual Meeting
Keeping Baby Boomers in the Labour Force Longer: What Does It Mean for Workers with Arthritis?
Monique A.M. Gignac¹, Elizabeth M. Badley², Dorcas Beaton³, Vicki Kristman⁴, Cameron Mustard⁵, Peter Smith⁵ and Selahadin Ibrahim⁵, ¹Instititue for Work and Health, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto, ON, Canada, ³St. Michael's Hospital, Toronto, ON, Canada, ⁴Lakehead University, Toronto, ON, Canada, ⁵Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: There is concern that an aging workforce results in lost skills and high burden on pension programs. This has resulted in the dissolution of…
Abstract Number: 201 • 2015 ACR/ARHP Annual Meeting
Innate Lymphoid Cells Are Present at Normal Human Enthesis Providing a Potential Mechanism for Spondyloarthropathy Pathogenesis
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Peter Millner², Robert Dunsmuir², Yasser El-Sherbiny¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom
Background/Purpose: The pathogenesis of murine spondyloarthropathy (SpA) has been intimately linked to the presence of IL-23 responsive, innate like lymphocytes at peripheral and spinal enthesis.…
Abstract Number: 479 • 2015 ACR/ARHP Annual Meeting
How to Recruit Anti-CCP Positive Patients from Primary Care
Jackie L. Nam¹, Laura Hunt¹, Elizabeth M.A. Hensor¹ and Paul Emery^1,2, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom
Background/Purpose: Around 1% of the population test positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies. This biomarker predicts progression to rheumatoid arthritis (RA) but over a…
Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting
DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Carmelo Carmona-Rivera³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Marta J. Gonzalez-Hernandez⁶, Julie M. Jorns⁷, Srilakshmi Yalavarthi⁸, Smriti Mohan⁹, Dave Pai¹⁰, Kristine Angevine¹¹, Barbara Adams¹², Jason S. Knight⁸, Alisa E. Koch^13,14,15, David Fox¹⁴, Dave Engelke¹⁶, Mariana J. Kaplan¹⁷ and David Markovitz⁴, ¹Infectious Diseases, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Albion College, Ann Arbor, MI, ⁶Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁷Pathology, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁰Scripps Research Institute, San Diego, CT, ¹¹Appistry, Inc, St. Louis, MO, ¹²Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, ¹³VA Medical Service, Ann Arbor, MI, ¹⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ¹⁵Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, ¹⁶Biochemistry, University Michigan, Ann Arbor, MI, ¹⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…

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