ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0494 • ACR Convergence 2024

    Usefulness of the Neutrophil-to-Lymphocyte Ratio, the Platelet-to-Lymphocyte Ratio and the Systemic Immune Inflammatory Index in Assessing Disease Activity in Rheumatoid Arthritis Patients

    Yelitza Cecilia Velarde Mejia1, Ventura Mejia2, guillermo velarde2 and Graciela Alarcon3, 1Hncase, Arequipa, Peru, 2UNIVERSIDAD NACIONAL DE SAN AGUSTIN, arequipa, Peru, 3The University of Alabama at Birmingham, Oakland, CA

    Background/Purpose: Rheumatoid arthritis (RA) causes systemic inflammation that leads to specific changes in the patients’ blood cells; this offers the opportunity to measure inflammatory activity…
  • Abstract Number: 0833 • ACR Convergence 2024

    Novel Loss of Function Variants in the Death Domain of Tumor Necrosis Factor Superfamily Receptor 1A (TNFRSF1A) in Children with Systemic Juvenile Idiopathic Arthritis (sJIA)

    Anthony Cruz1, Hiroto Nakano2, Sophia Chou3, Marissa Krantz4, Tianmin Fu5, Davide Randazzo6, Zuoming deng7, Hao Wu8 and Michael Ombrello9, and INCHARGE Consortium, 1National Institutes of Health, Bethesda, MD, 2NIAMS, NIH, Bethesda, MD, 3National Institutes of Health, Rockville, MD, 4University of Rochester, Rochester, NY, 5Ohio State University College of Medicine, Columbus, OH, 6NIAMS/NIH, Bethesda, MD, 7National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 8Harvard Medical School, Boston, MA, 9National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), North Bethesda, MD

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory condition characterized by recurring fevers, arthritis and hyperinflammation, but its exact etiology is unknown.  Tumor necrosis…
  • Abstract Number: 0944 • ACR Convergence 2024

    Targeting Defective Macrophages to Restore Resolution of Inflammation in Rheumatoid Arthritis -Perspectives for an Autologous Secretome Therapy

    Melanie Couturier1, Francis Bonnefoy2, emilie Gaiffe3, Charline Vauchy4, Suzanne Behlke2, ERIC TOUSSIROT5 and Sylvain Perruche2, 11MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 2MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 3INSERM CIC -1431 CHU Besançon, France, Besançon, France, 4INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, 5university hospital of BESANCON, besancon, France

    Background/Purpose: Impaired macrophage efferocytosis, a key hallmark of failed inflammation resolution, is reported in many immune-mediated inflammatory diseases, including in Rheumatoid Arthritis (RA). Hence the…
  • Abstract Number: 1512 • ACR Convergence 2024

    Association Between the Systemic Immune Inflammatory Index (Sll) and All-cause Mortality in Critically Ill Patients with Rheumatoid Arthritis

    Yunfeng Dai and Zhihan Chen, Fujian Medical University, Fuzhou City, Fujian, China (People's Republic)

    Background/Purpose: The systemic immune-inflammation index (SII) has been linked to inflammatory and immune responses, with research indicating its impact on rheumatoid arthritis (RA). However, its…
  • Abstract Number: 1799 • ACR Convergence 2024

    In VitroEvidence for the Restoration of Glucocorticoid Sensitivity by Toll-Like Receptor 7 and 8 Inhibition in Systemic Lupus Erythematosus

    Jia Xin Chow1, Rochelle Sherlock2, Taylah Bennett2, Eric Morand3 and Sarah Jones2, 1Monash University, Melbourne, Victoria, Australia, 2Monash University, Melbourne, Australia, 3School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia

    Background/Purpose: The strategy of inhibiting toll-like receptors (TLR) 7 and 8 is being evaluated in clinical trials in systemic lupus erythematosus (SLE) to assess its…
  • Abstract Number: 2010 • ACR Convergence 2024

    The Influence of Treat-to-target Urate Lowering Therapy and Anti-inflammatory Prophylaxis on Circulating Measures of Inflammation in Gout

    Austin Wheeler1, Tanner Ourada2, Michael Duryee1, Bryant England1, Richard Reynolds3, James O'Dell1, Jeff Newcomb1, Michael Pillinger4, Robert Terkeltaub5, Ryan Ferguson6, Mary Brophy6, Tony Merriman7 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska-Medical Center: College of Medicine, Omaha, NE, 3University of Alabama at Birmingham, Birmingham, AL, 4New York University Grossman School of Medicine, New York,, NY, 5Retired, San Diego, CA, 6Veterans Affairs, Boston, MA, 7University of Alabama at Birmingham, Homewood, AL

    Background/Purpose: Gout is the most common inflammatory arthritis worldwide and is associated with substantial cardiometabolic morbidity and mortality. In the STOP Gout trial (O’Dell JR…
  • Abstract Number: 2536 • ACR Convergence 2024

    Trans-Disease Microbial Biomarkers of Protection and Pathogenesis in Autoimmune Conditions: Results from the AMP AIM Consortium

    Kevin Bu1, Rebecca Blank2, Adam Cantor1, Alba Boix-Amoros3, Jose Scher4 and Jose Clemente1, and Accelerating Medicines Partnership and Immune-Mediated Diseases Network (AMP AIM), 1Icahn School of Medicine at Mount Sinai, New York, NY, 2NYU, New York, NY, 3Icahn School of Medicine, New York, NY, 4New York University School of Medicine, New York, NY

    Background/Purpose: Autoimmune and immune-mediated diseases (AIMDs) affect over 20 million Americans. Although AIMDs have distinct symptomatology, there is significant overlap in their treatment, suggesting overlap…
  • Abstract Number: 0147 • ACR Convergence 2024

    Clinical Characteristics and Biomarkers Associated with Detectable High-Sensitivity Cardiac Troponin in Patients with Rheumatoid Arthritis

    Ilana Usiskin1, Mary Jeffway1, Feng Liu1, Nancy Shadick1, Michael Weinblatt2, Brittany Weber3 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, 3Brigham and Women's Hospital, DEDHAM, MA

    Background/Purpose: General population-based cardiovascular (CV) risk estimators are known to underestimate CV risk in RA. High-sensitivity cardiac troponin T (hs-cTnT), typically measured during a work-up…
  • Abstract Number: 0515 • ACR Convergence 2024

    Scavenging Isolevuglandins with 2-HOBA Decreases In Vitro Neutrophil Extracellular Traps in Cells from Patients with Rheumatoid Arthritis

    Olivia Posey, Anastasiia Phothisane, Phicharmon Kulapatana and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Neutrophils contribute to the innate immune response of killing pathogens through the formation of neutrophil extracellular traps (NETs), which is also called NETosis. NETosis…
  • Abstract Number: 0834 • ACR Convergence 2024

    Evolution of Lung Inflammation in a Mouse Model of Chronic/Recurrent Macrophage Activation Syndrome

    Richard Chhaing, Natsumi Inoue, Jana Latayan and grant schulert, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Systemic juvenile idiopathic arthritis-associated lung disease (SJIA-LD) is a life-threatening complication and associated in >80% of cases with macrophage activation syndrome (MAS); however, the…
  • Abstract Number: 0951 • ACR Convergence 2024

    A Feedback Loop Involving mtDNA, Platelets and Neutrophil Extracellular Traps Amplifies Inflammation in Systemic Sclerosis

    Stavros Giaglis1, Diego Kyburz2 and Ulrich Walker3, 1Experimental Rheumatology Laboratory, University of Basel, Basel, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3Basel University Hospital, Basel, Switzerland

    Background/Purpose: Mitochondria are essential eucaryotic cell organelles with several bacterial features, such as a double-stranded circular genome with hypomethylated CpG areas (1). A fundamental role of…
  • Abstract Number: 1567 • ACR Convergence 2024

    Systemic Sclerosis Is Associated with Sub-Clinical Abnormalities in Myocardial Energetics, Perfusion and Increased Fibrosis

    Chin Yit Soo1, Nicholas Jex2, Stefano Di Donato3, Lucy Elizabeth Thornton4, Vishal Kakkar5, Riccardo Bixio6, Raluca Tomoaia1, Thomas Anderton2, May Lwin2, Christel Kamani2, Amrit Chowdhary2, Henry Procter1, Sharmaine Thirunavukarasu1, Sindhoora Kotha2, Marilena Giannoudi2, Eylem Levelt2, Sven Plein1, Francesco Delgado6 and Lesley-Anne Bissell7, 1Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom., Leeds, England, United Kingdom, 2Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom., Leeds, United Kingdom, 31. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, United Kingdom, 41. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, 5University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom., Leeds, United Kingdom, 7Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Primary cardiac involvement in systemic sclerosis (SSc) is heterogenous, poorly defined and associated with significant cardiac morbidity and mortality. The underlying mechanism is not…
  • Abstract Number: 1810 • ACR Convergence 2024

    Modulation of Type I Interferon Signaling by Anifrolumab Alters the Spatial Immune Landscape in Cutaneous Lupus Erythematosus

    Ksenia Anufrieva1, Rochelle Castillo2, Ce Gao2, Jessica Liu2, Neda Shahriari2, Kimberly Hashemi2, Dustin Taylor3, Rachael Rowley2, Elizabeth Rainone2, Avery LaChance2, Rachel Gate4, ilya Korsunsky2, Ruth Ann Vleugels5 and Kevin Wei6, 1BWH, Cambridge, MA, 2Brigham and Women's Hospital, Boston, MA, 3Vanderbilt University Medical Center, Nashville, TN, 410x Genomics, Pleasanton, CA, 5Brigham and Women's Hospital, Brookline, MA, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: Reliable and effective treatments for refractory cutaneous lupus erythematosus (CLE) remained elusive until the arrival of anifrolumab, a monoclonal antibody targeting the type I…
  • Abstract Number: 2032 • ACR Convergence 2024

    A Systematic Review of Treatment Strategies in VEXAS Syndrome

    Aviraag Vijaya Prakash1, Jose Garcia2, Anurag Goel3, Vinit Gilvaz4 and Raveena Midha5, 1Saint Vincent Hospital, Department of Internal Medicine, Worcester, MA, 2Brown University, East Greenwich, RI, 3The Warren Alpert Medical School of Brown University, Providence, RI, 4The Warren Alpert Medical School of Brown University, East Providence, RI, 5Kent Hospital/Brown University, Warwick, RI

    Background/Purpose: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, first described in 2020, is an autoinflammatory condition characterized by somatic mutations in the UBA1 gene.…
  • Abstract Number: 2557 • ACR Convergence 2024

    The Relation of Colchicine to Knee/hip Replacement Among People with Gout in a Population-based Cohort Study

    Zhiqiang Wang1, Sarah Tilley2, Christine Peloquin2, Eva Petrow3, Margaret Clancy2 and Tuhina Neogi2, 1Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), 2Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 3Boston Medical Center, Boston, MA

    Background/Purpose: Colchicine, an anti-inflammatory drug commonly used in gout, has been associated with a lower incidence of total knee/hip replacement compared to placebo among participants…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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