Abstracts tagged "Inflammation"

Abstract Number: 2016 • 2017 ACR/ARHP Annual Meeting
Favourable Changes in Power Doppler Scores in the Feet over 1-Year in an Early Rheumatoid Arthritis Cohort: The Role of Rheumatoid Factor and Anti–Citrullinated Protein Antibody
Karen A. Beattie¹, Hanyan Zou², George Ioannidis³ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose : MTP joints are seldom examined in routine clinical visits. As such, it is important to understand how the standard treatment of patients with…
Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting
Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans
Madhur Motwani¹, Fran Bennett¹, Mark Tepper², Barbara White², Paul Norris³, Raymond MacAllister¹, Charles Serhan³ and Derek Gilroy¹, ¹University College London, London, United Kingdom, ²Corbus Pharmaceuticals, Norwood, MA, ³Harvard Medical School, Cambridge, MA
Background/Purpose: Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis. A normal innate…
Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting
Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Richard Bell¹, Emily Wu^1,2, Homaira Rahimi³ and Edward Schwarz^1,4,5, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, ⁴University of Rochester, Rochester, NY, ⁵Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
Abstract Number: 2063 • 2017 ACR/ARHP Annual Meeting
Relation of Serum Urate and Gout Duration to Tophi, Urate Deposition, and Inflammation
Ana Beatriz Vargas-Santos¹, S. Reza Jafarzadeh², Geraldo Castelar-Pinheiro¹, Nicola Dalbeth³, William J. Taylor⁴, Jaap Fransen⁵, Tim L. Jansen⁶, H. Ralph Schumacher⁷ and Tuhina Neogi², ¹Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³University of Auckland, Auckland, New Zealand, ⁴Department of Medicine, University of Otago, Wellington, New Zealand, ⁵Department of Rheumatolgy, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁷Medicine, Rheumatology, U Penn & VA Med Ctr, Philadelphia, PA
Background/Purpose: Gout duration and serum urate (SU) levels are thought to influence development of tophi and chronic inflammatory gouty arthropathy, but the extent to which…
Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting
Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium
Takeshi Ueha¹, Yoshitada Sakai¹, Kohjin Suzuki², Koji Fukuda³, Toshihisa Maeda³, Hanako Nishimoto³, Shinya Hayashi⁴, Yasushi Miura⁴, Ryosuke Kuroda³ and Akira Hashiramoto², ¹Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…
Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting
p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis
Adelheid Korb-Pap¹, Anja Römer-Hillmann¹, Marianne Heitzmann¹, Masaru Kato², Kerstin Klein², Caroline Ospelt², Steffen Gay³, Susanne Buergis⁴, Thomas Pap¹, Thomas Weide⁵, André Gessner⁴ and Hermann Pavenstädt⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, ⁴Department of Immunology, University Erlangen, Erlangen, Germany, ⁵Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…
Abstract Number: 2330 • 2017 ACR/ARHP Annual Meeting
Evidence for Alternatively Activated (M2) Macrophage Activation in Patients with Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Amita Aggarwal¹, Priyanka Gaur² and Akhilesh Yadav³, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Among juvenile idiopathic arthritis (JIA), enthesitis related arthritis (ERA) category includes most children with juvenile onset spondyloarthropathy (SpA). Synovial fluid from patients with SpA…
Abstract Number: 33 • 2017 Pediatric Rheumatology Symposium
An extracellular ionic milieu renders human granulocytic S100A12 into a pro-inflammatory TLR4-binding alarmin
Christoph Kessel¹, Sabrina Fuehner¹, Bastian Zimmermann², Dirk Holzinger¹, Helmut Wittkowski¹, Claas Hinze¹ and Dirk Foell¹, ¹Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ²Biaffin GmbH & Co KG, Kassel, Germany
Background/Purpose: Granulocytic S100A12 is a member of the calgranulin-subgroup within the S100 family of calcium-binding proteins. Similar to other S100 proteins S100A12 can bind divalent…
Abstract Number: 131 • 2017 Pediatric Rheumatology Symposium
Balancing JAK/STAT-signaling with tofacitinib may foster anti-inflammatory functions of human monocytes
Friederike Cordes¹, Eva Lenker², Toni Weinhage², Georg Varga² and Dirk Foell³, ¹Gastroenterology, Internal Medicine, University of Muenster, Muenster, Germany, ²Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ³Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany
Background/Purpose: Monocytes are bridging natural and acquired immunity. Information about JAK signaling in monocytes is scarce especially in an inflammatory milieu. JAK-inhibition is a promising…
Abstract Number: 146 • 2017 Pediatric Rheumatology Symposium
Age-Related Differences in Neuronal High Mobility Group Box-1 and Resolvin D1 Receptors in Collagen-Induced Arthritis
Tracy Wilson-Gerwing and Alan Rosenberg, Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: More thorough understanding of age-related molecular interactions that drive inflammation and inflammatory pain is required to help guide evidenced-based, age appropriate treatment strategies that…
Abstract Number: 289 • 2016 ACR/ARHP Annual Meeting
Metabolic and Inflammatory Links to Development of Rotator Cuff Tear in Hand Osteoarthritis
Young Sun Suh¹, Hyun-Ok Kim¹, Yun-Hong Cheon², Ki-Soo Park³, Rock-Bum Kim³, Hye Song Lim⁴, Hae Sook Noh⁴, Jae-Bum Na⁵, Hyung Bin Park⁶ and Sang-Il Lee⁷, ¹Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ³Department of Preventive Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁴Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁵Department of Radiology, Gyeongsang National University School of Medicine, Jinju, Korea, The Republic of, ⁶Department of Orthopedic Surgery, Gyeongsang National University School of Medicine, jinju, Korea, The Republic of, ⁷Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: Rotator cuff tear (RCT) and hand osteroarthritis (HOA) are commonly accompanied because they share a similar pathogenesis. However, there was no previous study investigating…
Abstract Number: 1745 • 2016 ACR/ARHP Annual Meeting
Disturbance of Renal Circadian Rhythm in Lupus Nephritis
Rakesh Mishra¹, Ramalingam Bethunaickan², Weijia Zhang³ and Anne Davidson⁴, ¹Feinstein Institute, Manhasset, NY, ²Autoimmune and musculosketal diseases, Feinstein Institute for Medical Research, Manhasset, NY, ³Nephrology, Mount Sinai School of Medicine, New York, NY, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Circadian rhythm is a universal phenomenon that allows organisms to anticipate and respond to changes in their environment by regulating sleep and feeding patterns,…
Abstract Number: 2599 • 2016 ACR/ARHP Annual Meeting
TCZ Improves the Pro-Atherothrombotic Profile of Rheumatoid Arthritis Patients Modulating Endothelial Dysfunction, Netosis and Inflammation
Patricia Ruiz-Limon¹, Rafaela Ortega-Castro², IVÁN ARIAS DE LA ROSA², Carlos Perez-Sanchez², Yolanda Jiménez-Gómez², Maria Carmen Abalos-Aguilera¹, Pilar Font-Ugalde², Eduardo Collantes-Estévez², Alejandro Escudero-Contreras², Chary Lopez-Pedrera² and Nuria Barbarroja², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Inhibition of the interleukin IL-6 receptor pathway by tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). TCZ reduces atherosclerosis markers and improves endothelial function.…
Abstract Number: 294 • 2016 ACR/ARHP Annual Meeting
Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients with Medial Knee Osteoarthritis
Charles Oshinsky¹, Mukundan Attur², Sisi Ma³, Hua Zhou³, Fangfei Zheng¹, Meng Chen⁴, Jyoti Patel², Jonathan Samuels⁵, Virginia Pike⁶, Ravinder Regatte⁷, Jenny Bencardino⁸, Leon Rybak⁹, Steven B. Abramson¹⁰, Michael H. Pillinger¹¹ and Svetlana Krasnokutsky Samuels¹², ¹Medicine/Rheumatology, NYU School of Medicine, NEW YORK, NY, ²Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ³Bioinformatics, New York University, New York, NY, ⁴NYU School of Medicine, NEW YORK, NY, ⁵Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, New York, NY, ⁶Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁷NYU Department of Radiology, NEW YORK, NY, ⁸Radiology, NYU Langone Medical Center, New York, NY, ⁹Department of Radiology, NYU Langone Medical Center, New York, NY, ¹⁰Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ¹¹NYU School of Medicine, New York, NY, ¹²NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Osteoarthritis (OA) etiopathogenesis includes an inflammatory component. Published reports indicate that synovial fluid urate levels, even in patients without gout, associate with OA prevalence/severity.…
Abstract Number: 1756 • 2016 ACR/ARHP Annual Meeting
Novel Role of Rho Kinase in Neutrophil Netosis during UVB Induced-Skin Inflammation
Ming-Lin Liu^1,2, Meena Sharma^2,3 and Victoria P. Werth^4,5, ¹Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, ²Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, ⁴Dermatology, University of Pennsylvania, Philadelphia, PA, ⁵Philadelphia V.A. Medical Center, Philidelphia, PA
Background/Purpose: Skin inflammation appears in cutaneous or systemic lupus erythematosus. Ultraviolet B (UVB) is an important environmental trigger of skin inflammation in lupus. Mechanisms linking…

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