Abstract Number: 1369 • 2015 ACR/ARHP Annual Meeting
Enhanced Myelopoiesis Downstream of Toll-like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response
Background/Purpose: Monocytes are myeloid cells important for the initiation of inflammation and have been implicated in the pathogenesis of autoimmunity. Monocytes interact with their environment…Abstract Number: 3093 • 2015 ACR/ARHP Annual Meeting
Development and Validation of Diagnostic Criteria for Cryopyrin Associated Periodic Syndromes
Background/Purpose: Cryopyrin Associated Periodic Syndromes (CAPS) are a rare, clinically heterogeneous group of devastating inflammatory illnesses. NLRP3gene gain-of function mutations result in unceasingly raised IL1…Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…Abstract Number: 1372 • 2015 ACR/ARHP Annual Meeting
Characterization of Synovial Mast Cells in Knee Osteoarthritis: Association with Clinical Parameters
Background/Purpose: Synovial inflammation is a common feature of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. Comparative studies indicated that synovitis, measured by histology or imaging,…Abstract Number: 3097 • 2015 ACR/ARHP Annual Meeting
Innovative Approach for the Identification of an Appropriate Dose Regimen of a Targeted Treatment, NI-0501, an Anti-Interferon Gamma (IFNg) Antibody, in Patients with Hemophagocytic Lymphohistiocytosis (HLH)
Background/Purpose: Based on the growing evidence that IFNg plays a pivotal role in HLH, NI-0501, an anti-IFNg monoclonal antibody, is being developed as the first…Abstract Number: 223 • 2015 ACR/ARHP Annual Meeting
Increased Platelet Reactivity in Gout: A Potential Mechanism for Adverse Cardiovascular Events
Background/Purpose: Patients with inflammatory arthritis, including gout, have an increased risk of cardiovascular events and mortality. Increased platelet reactivity is a risk marker for cardiovascular…Abstract Number: 1504 • 2015 ACR/ARHP Annual Meeting
Increased Risk of Thromboembolism Among Patients with VTE Association with Rheumatoid Arthritis
Increased risk of thromboembolism among patients with VTE association with Rheumatoid Arthritis Background/Purpose: Rheumatoid arthritis (RA), is among most common autoimmune conditions manifested by progressive and…Abstract Number: 3116 • 2015 ACR/ARHP Annual Meeting
High Level of Inflammation Predicts the Development of Diabetes Mellitus in Patients with Psoriatic Arthritis
Background/Purpose: To estimate trends in the prevalence of diabetes mellitus (DM) in patients with psoriatic arthritis (PsA) in comparison to the general population in Ontario,…Abstract Number: 316 • 2015 ACR/ARHP Annual Meeting
Effect of Vitamin D on Effusion-Synovitis in Knee Osteoarthritis: a Randomized Controlled Trial
Background/Purpose: To examine the effect of vitamin D supplementation on synovial inflammation in patients with knee osteoarthritis (OA) and low vitamin D levels over 24…Abstract Number: 1523 • 2015 ACR/ARHP Annual Meeting
Ischemia Modified Albumin Levels in Rheumatoid Arthritis
Background/Purpose: Cardiovascular diseases, among which atherosclerotic heart disease, are known to be one of the most important mortality and morbidity causes in patients with Rheumatoid…Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting
Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes
Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…Abstract Number: 931 • 2015 ACR/ARHP Annual Meeting
mTOR Complex 1 Signaling Is Required for the Steady-State in Vivo Development of Inflammatory Monocytes
Background/Purpose: Monocytes and macrophages are essential to innate immunity but also propagate the inflammatory response in autoimmune arthritis and lupus nephritis. Spontaneous development of inflammatory…Abstract Number: 1527 • 2015 ACR/ARHP Annual Meeting
Serum Inflammation Identifies Increased Risk of Frailty in Rheumatoid Arthritis
Background/Purpose: Frailty has been defined as “an excess vulnerability to stressors, with reduced ability to maintain or regain homeostasis after a destabilizing event” 1. Frailty…Abstract Number: 940 • 2015 ACR/ARHP Annual Meeting
NOD2-Associated Autoinflammatory Disease: Therapy and Outcomes
Background/Purpose: NOD2-associated autoinflammatory disease, now redesignated as Yao Syndrome(YS) is a newly described and increasingly recognized entity. It is characterized by periodic fever, dermatitis, polyarthritis, sicca-like…Abstract Number: 1624 • 2015 ACR/ARHP Annual Meeting
Epigenetic Profiling of CD14+ and CD16+ Monocyte Subtypes in Rheumatoid Arthritis. Alterations Related to Cardiovascular Disease and Endothelial Dysfunction
Background/Purpose: Monocytes play a key role in the pathogenesis of the cardiovascular disease (CVD). Three monocyte subsets have been described based on their CD14 and…
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