ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 1706 • 2015 ACR/ARHP Annual Meeting

    Prevalence and Factors Associated with Non-Traumatic Vertebral Fractures in Psoriatic Arthritis

    Shelly Chandran1, Sindhu R. Johnson2, Angela Cheung3, David Salonen4 and Dafna Gladman5, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Dept of Rheumatology, Toronto Western and Mt. Sinai Hospitals, University of Toronto, Toronto, ON, Canada, 3Department of Medicine, University of Toronto, Toronto, ON, Canada, 4Department of Medical Imaging, University Health Network, Toronto, ON, Canada, 5Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: The prevalence of osteoporotic vertebral fractures (VF) in psoriatic arthritis (PsA) is not known. We aim to determine the prevalence and factors associated with…
  • Abstract Number: 984 • 2015 ACR/ARHP Annual Meeting

    Tofacitinib Inhibits Inflammation and New Bone Formation in Murine Spondyloarthritis but Does Not Adversely Inhibit Normal Human MSC Function

    Rik Lories1, Katelijne De Wilde2, Kerri Heritage1, Richard Cuthbert3, Elena Jones3, Karlijn Debusschere4, Dennis McGonagle3 and Dirk Elewaut5, 1Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, 2Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology,, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, 5Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Inflammation and new bone formation at entheseal sites are hallmarks of spondyloarthritis (SpA).  As TNF inhibition has only limited impact on new bone formation,…
  • Abstract Number: 1788 • 2015 ACR/ARHP Annual Meeting

    Lipoprotein Subfractions and Cardiovascular Disease in Systemic Lupus Erythematosus

    Simantini Sakhardande1, Monica Purmalek1, Maureen Sampson2, Yenealem Temesgen-Oyelakim3, Alice Fike4, Taufiq Salahuddin5, Balaji Natarajan5, Zerai Manna6, Elizabeth Joyal6, Marcus Chen5, Sarfaraz Hasni6, Nehal N. Mehta5,7, Alan Remaley5 and Mariana J. Kaplan1, 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2CC/NIH, Bethesda, MD, 3Office of the Clinical Director,National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5NHLBI, National Institutes of Health, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7National Heart Lung Blood Institute, Cardiovascular and Pulmonary Division, NHLBI, National Institutes of Health, Bethesda, MD

    Background/Purpose: Risk of atherosclerotic cardiovascular disease (CVD) is significantly enhanced in systemic lupus erythematosus (SLE) compared to age and gender matched controls. While this risk…
  • Abstract Number: 1006 • 2015 ACR/ARHP Annual Meeting

    Incident Frequent Knee Pain Is Associated with Changes in Semi-Quantitative Imaging Biomarkers of Inflammation

    C.Kent Kwoh1, Michael J. Hannon2, Tomoko Fujii3, Frank W Roemer4, Ali Guermazi5, David Hunter6, Felix Eckstein7 and Robert M. Boudreau8, 1Department of Medicine, The University of Arizona Arthritis Center and Division of Rheumatology, Tucson, AZ, 2Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA, 4Department of Radiology, Boston University School of Medicine, Boston, MA, 5Boston University School of Medicine, Boston, MA, 6Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 7Paracelsus Med Univ, Chondrometrics GmbH, Salzburg, Austria, 8Epidemiology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: The cause of knee pain in osteoarthritis (OA) is multi-factorial, and there is increasing evidence of the role of inflammation in OA. The goal…
  • Abstract Number: 1966 • 2015 ACR/ARHP Annual Meeting

    Active PMR and GCA Is Associated with Changes in Monocyte Subset Composition

    Qi Wang1, Kornelis S.M. van der Geest2, Wayel H. Abdulahad1, Johanna Westra3, Annemieke M.H. Boots1 and Elisabeth Brouwer1, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Hanzeplein 1, Hpc: Aa21, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 3Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two closely related syndromes affecting older people. Proinflammatory cytokine IL-6 is found increased in both…
  • Abstract Number: 12 • 2015 ACR/ARHP Annual Meeting

    Delta-like 1 Enhances the Production of Pro-Inflammatory Mediators By Fibroblast-like Synoviocytes

    Chiyoko Sekine, Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan

    Background/Purpose: Notch signaling is known to regulate cell fate decision and differentiation during embryonic and post-natal development. I have been reported that a Notch ligand…
  • Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting

    Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome

    Saba Nayar1, Joana Campos1, Christopher Buckley1, Rodger Allen2, W.A. Fahy2, Andrew Payne2 and Francesca Barone1, 1University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, 2UCB Pharma, Slough, United Kingdom

    Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
  • Abstract Number: 2209 • 2015 ACR/ARHP Annual Meeting

    Stimulation of the Adenosine A2A Receptor (A2AR) Regulates the Expression of Netrin-1 (Ntn1) and Its Receptors (Unc5b, DCC) and Inhibits Wear Particle-Induced Inflammatory Osteolysis in a Model of Joint Prosthesis Loosening

    Aranzazu Mediero1, Bhama Ramkhelawon2, Miguel Perez-Aso3, Kathryn Moore2 and Bruce Cronstein4, 1Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, 2Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, 3Provital S.A., Barberà del Vallès, Spain, 4Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY

    Background/Purpose: Ntn1 is a member of the family of axonal guidance proteins that plays a role in leukocyte function and inflammation and is critical for…
  • Abstract Number: 30 • 2015 ACR/ARHP Annual Meeting

    Complications of Inflammatory Arthritis in First Nations and Non-First Nations Populations of Alberta, Canada

    Cheryl Barnabe1, Gilaad Kaplan2, J Antonio Avina-Zubieta3, Diane Lacaille4, Brenda Hemmelgarn5 and JM Esdaile6, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, 3Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, 4Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, 5Division of Nephrology, University of Calgary, Calgary, AB, Canada, 6Rheumatology, Arthritis Research Canada, Richmond, BC, Canada

    Background/Purpose: With markedly improved control of the acute effects of inflammatory arthritis, the major causes of morbidity and premature death now arise from the complications…
  • Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting

    Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype

    Robert Good1, Sarah L. Trinder2, Christopher P. Denton3, David Abraham4 and Alan M. Holmes1, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom

    Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…
  • Abstract Number: 2467 • 2015 ACR/ARHP Annual Meeting

    Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis

    Ian D. Ferguson1, Patricia Griffin2, Hiroshi Yano3, Joshua J. Michel2, Jeffrey A. Dvergsten4, Sarah L. Gaffen5, Margalit E. Rosenkranz1, Daniel A. Kietz1 and Abbe N. Vallejo1, 1Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Department of Pediatrics, Duke University Medical Center, Durham, NC, 5Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…
  • Abstract Number: 87 • 2015 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA) Risk Gene CCR6 Polymorphism: Drug-Induced “Reversal” of ER Binding and the Expression of Inflammatory Mediators -Potential Molecular Mechanism Links Between Estrogen and RA

    Ming-Fen Ho1, Richard M. Weinshilboum2, Liewei Wang2, James N. Ingle3 and Tim Bongartz4, 1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, Rochester, MN, 2Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 3Department of Medical Oncology, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 SNP rs3093024, is in tight linkage disequilibrium with rs3093023 which has been associated with RA risk. RA…
  • Abstract Number: 1176 • 2015 ACR/ARHP Annual Meeting

    Interleukin-37 Prevents New-Onset Joint Inflammation but Does Not Inhibit Existing Experimental Arthritis

    Marije I. Koenders1, Debbie M. Roeleveld1, Charles Dinarello2, Peter M. van der Kraan1 and Leo Joosten3, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, 3Internal Medicine, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Interleukin-37 (IL-37) is a recently identified cytokine with potent anti-inflammatory and immunosuppressive functions. This cytokine has been shown to be expressed in synovial tissue…
  • Abstract Number: 2613 • 2015 ACR/ARHP Annual Meeting

    Patient Reported Physical Capacity Correlates with Phenylalanine Serum Levels in Patients with Early Untreated Rheumatoid Arthritis

    Aulikki Kononoff1, Leena Arstila1,2, Hannu Kautiainen3,4, Pia Elfving1, Elina Savolainen5, Helena Niinisalo6,7 and Oili Kaipiainen-Seppanen1, 1Department of Medicine, Kuopio University Hospital, Kuopio, Finland, 2Iisalmi Hospital, Iisalmi, Finland, 3Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, 4Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland, 5Kuopio Municipal Hospital, Kuopio, Finland, 6Suonenjoki Health Center, Suonenjoki, Finland, 7Varkaus Hospital, Varkaus, Finland

    Background/Purpose: Lipolysis is increased in rheumatoid arthritis (RA), and lipid-induced insulin resistance coincides with anabolic resistance. Ability to maintain skeletal muscle mass is impaired in…
  • Abstract Number: 99 • 2015 ACR/ARHP Annual Meeting

    Personalised Genetic Medicine: HLA-DRB1 Amino Acid Positions 11, 71 and 74 Predict Inflammation Level, Disease Activity and Disability in Rheumatoid Arthritis

    Stephanie Ling1, Sebastien Viatte2, Mark Lunt3, Alper van Sijl4, Lucía Silva Fernández4,5, Soumya Raychaudhuri2,6,7, Deborah P.M. Symmons4,8, Adam Young9,10, Alex J Macgregor11 and Anne Barton12, 1Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Mancheser Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 3Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 4Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 5Rheumatology, Complexo Hospitalario Universitario de Ferrol, Ferrol, Spain, 6Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 7Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, 8Centre for Musculoskeletal Research, University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 9Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom, 10School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 11School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom, 12Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom

    Background/Purpose: Amino acid (AA) positions 11, 71 and 74 inside HLA-DRB1 confer susceptibility to rheumatoid arthritis (RA). AAs from these positions form 16 haplotypes, hierarchically…
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