Abstracts tagged "Inflammation"

Abstract Number: 51 • 2018 ACR/ARHP Annual Meeting
Genetic Ablation of Inducible Nitric Oxide Synthase in TNF Transgenic Mice with Inflammatory-Erosive Arthritis Prevents Lymph Node Expansion and Decreases Synovial Infiltrates
Richard Bell¹, Emily Wu², Lianping Xing³, Christopher T. Ritchlin⁴ and Edward Schwarz⁵, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³University of Rochester Medical Center, Rochester, NY, ⁴Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY
Background/Purpose: Recent studies in the TNF-Tg mouse model of rheumatoid arthritis (RA) demonstrated a critical role of lymphatic vessel (LV) function in joint homeostasis and…
Abstract Number: 1200 • 2018 ACR/ARHP Annual Meeting
Unilateral Ultrasound Scoring Methods for Synovitis in Rheumatoid Arthritis: An Agreement Study Exploring the Most Inflammatory Active Side
Lene Terslev¹, Robin Christensen², Anna-Birgitte Aga³, Joseph Sexton³, Espen A. Haavardsholm³ and Hilde B. Hammer⁴, ¹Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ²Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ³Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Several unilateral scoring systems have been proposed to increase the feasibility of ultrasound (US) for joint evaluation in rheumatoid arthritis (RA) patients. Both the…
Abstract Number: 2652 • 2018 ACR/ARHP Annual Meeting
Engaging the Cholinergic Anti-Inflammatory Pathway By Stimulating the Vagus Nerve Reduces Pain and Fatigue in Patients with SLE
Cynthia Aranow¹, Martin Lesser², Meggan Mackay¹, Erik Anderson³, Theodoros P. Zanos², Timir Datta-Chaudhuri², Chad Bouton², Kevin J. Tracey⁴ and Betty Diamond¹, ¹The Feinstein Institute for Medical Research, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY, ³Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, ⁴Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Musculoskeletal (MS) pain is a common symptom of patients with Systemic Lupus Erythematosus (SLE) affecting up to 95% of patients and contributing to…
Abstract Number: 155 • 2018 ACR/ARHP Annual Meeting
Polyfunctional Synovial T-Cell Responses and Synovial Invasiveness Repressed By Blockade of Phosphodiesterase 4
Sarah M. Wade¹, Mary Canavan¹, Trudy McGarry¹, Siobhan C. Wade¹, Ronan Mullan², Douglas J. Veale³ and Ursula Fearon¹, ¹Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ²Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, ³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Genetic and functional studies strongly support the role of T-cells in PsA pathophysiology. Effective targeting of T-cells requires a detailed understanding of their phenotypic…
Abstract Number: 1475 • 2018 ACR/ARHP Annual Meeting
Eicosanoid Mediators of Systemic Inflammation and Arthritis in the Elderly
Roxana Coras^1,2, Rekha Narasimhan¹, Arthur Kavanaugh³, Lourdes Mateo⁴, Oswald Quehenberger⁵, Melania Martinez-Morillo⁶ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³University of California, San Diego, School of Medicine, La Jolla, CA, ⁴Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵Pharmacology, Medicine, University of California San Diego, La Jolla, CA, ⁶Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain
Background/Purpose: Elderly-onset RA, EORA, which is defined as rheumatoid arthritis (RA) starting at >60 years of age, has received less attention than young-onset RA. Polymyalgia rheumatica (PMR) is…
Abstract Number: 207 • 2018 ACR/ARHP Annual Meeting
Divergent Patterns of Cardiovascular Risk in Biomarkers of Lipids and Subclinical Myocardial Injury during Increased Inflammation in Rheumatoid Arthritis
Katherine P. Liao¹, Jie Huang², Gabrielle Cremone³, Ethan Lam³, Nicole Yang¹, Martin Playford⁴, Christine K Iannaccone¹, Jonathan Coblyn⁵, Elena Massarotti¹, Michael E Weinblatt⁵, Nancy A. Shadick¹, Nehal Mehta⁴ and Jorge Plutzky¹, ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴NHLBI, Bethesda, MD, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Inflammation is an independent risk factor for cardiovascular (CV) risk in rheumatoid arthritis (RA). Paradoxically, potentially cardioprotective decreases in inflammation is associated with increased…
Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting
Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice
Qi Quan Huang¹, Renee E. Doyle², Alexander Misharin³, Shang-Yang Chen⁴, Deborah R. Winter⁵ and Richard M. Pope², ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, ⁵Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
Abstract Number: 306 • 2018 ACR/ARHP Annual Meeting
The Role of Inflammation in the Evolution of MRI Erosions in the Feet of Patients with Early RA
Hanyan Zou¹, Karen A. Beattie², Saara Totterman³, George Ioannidis¹ and Maggie Larche^2,4, ¹McMaster University, Hamilton, ON, Canada, ²Medicine, McMaster University, Hamilton, ON, Canada, ³Qmetrics Technologies, Pittsford, NY, ⁴St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Patients with aggressive RA develop early structural damage. As persistent inflammation is associated with bone erosions, assessing inflammatory activity may be key in treatment…
Abstract Number: 1952 • 2018 ACR/ARHP Annual Meeting
Experimental Tendinopathy Treatment with SM04755, a Topical Small Molecule Inhibitor of the Wnt Pathway
Vishal Deshmukh, Timothy Seo and Yusuf Yazici, Samumed, LLC, San Diego, CA
Background/Purpose: Tendinopathy is an inflammatory and degenerative disorder caused by injuries and overuse. The Wnt pathway is upregulated in chronic tendinopathy and involved in inflammation,…
Abstract Number: 562 • 2018 ACR/ARHP Annual Meeting
Low Inflammation on Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis That Achieved Sustained Clinical Remission on Adalimumab
Paul Emery¹, Gerd R. Burmester², Esperanza Naredo³, Ivan Lagunes Galindo⁴, Ying Zhang⁵, Xin Wang⁵, Maja Hojnik⁶ and Philip G. Conaghan⁷, ¹University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ²Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, ³Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ⁴AbbVie Inc., North Chicago, IL, ⁵AbbVie, North Chicago, IL, ⁶AbbVie, Ljubljana, Slovenia, ⁷University of Leeds, Leeds, United Kingdom
Background/Purpose: ACR and EULAR recommend bDMARD tapering in patients (pts) with rheumatoid arthritis (RA) who achieved stable clinical remission. Yet, there are limited systematically collected…
Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting
Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide
Elena F. Burguera^1,2, Angela Vela-Anero³, Carlos Vaamonde-Garcia³, Tamara Hermida-Gómez^1,2, Purificacion Filgueira-Fernandez^1,2, Lucía Gato-Calvo², Rosa Meijide-Failde⁴ and Francisco J Blanco⁵, ¹CIBER-BBN, Madrid, Spain, ²Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, ³Department of Physiotherapy, Medicine and Biological sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁴Department of Physiotherapy, Medicine and Biological Sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, ⁵Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…
Abstract Number: 757 • 2018 ACR/ARHP Annual Meeting
Urinary Galectin-3 Binding Protein As a Novel Biomarker of Renal Disease Activity in Lupus Nephritis
Huihua Ding¹, Cheng Ling², Roberto Bassi³, Shinji L Okitsu⁴, Julie A. DeMartino⁴ and Nan Shen¹, ¹Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ²Department of Rheumatology, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁴TIP Immunology, EMD Serono Research and Development Institute, Inc., Billerica, MA
Background/Purpose: Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus (SLE). This study investigates urinary galecting-3 binding protein…
Abstract Number: 2005 • 2018 ACR/ARHP Annual Meeting
Identification of a Human Cartilage Microbial DNA Signature and Characterization of Distinct Microbiome Profiles Associated with Osteoarthritis
Chris Dunn^1,2, Cassandra Velasco^1,3, Alexander Rivas⁴, Madison Andrews^3,5, Paul Jacob⁶ and Matlock A. Jeffries^2,7, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴University of Arkansas for Medical Sciences, Little Rock, AR, ⁵Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Oklahoma Sport Science and Orthopedics, Oklahoma City, OK, ⁷Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is both the most common form of arthritis and a leading cause of chronic disability. Bacterial products, including lipopolysaccharide (LPS), have been…
Abstract Number: 796 • 2018 ACR/ARHP Annual Meeting
Demographic and Clinical Features of Systemic Sclerosis Patients with Anti-U1RNP Antibodies: A European Scleroderma Trials and Research (EUSTAR) Analysis
Wanlong Wu^1,2, Petra Hoederath¹, Eric Hachulla³, Paolo Airò⁴, Gabriele Valentini⁵, Marco Matucci Cerinic⁶, Franco Cozzi⁷, Gabriela Riemekasten⁸, Yannick Allanore⁹, Patricia Carreira¹⁰, Suzana Jordan¹¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, ⁴Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁶Division of Rheumatology, Division of Rheumatology, University of Florence, Florence, Italy, ⁷Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁸Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ⁹Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ¹⁰Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Anti-U1RNP antibodies can be detected in patients with systemic sclerosis (SSc). However, their prevalence and clinical correlation with organ-specific complications have not been well…
Abstract Number: 2006 • 2018 ACR/ARHP Annual Meeting
Murine Ear Wound Cartilage Superhealer Trait Is Associated with Gut Microbiota Changes and Is Transferable to Non-Healer Mice By Gut Microbiome Transplant
Chris Dunn^1,2, Cassandra Velasco^1,3, Madison Andrews^3,4, Alexander Rivas⁵ and Matlock A. Jeffries^2,6, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵University of Arkansas for Medical Sciences, Little Rock, AR, ⁶Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. Previous studies…

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