Abstracts tagged "Inflammation"

Abstract Number: 99 • 2015 ACR/ARHP Annual Meeting
Personalised Genetic Medicine: HLA-DRB1 Amino Acid Positions 11, 71 and 74 Predict Inflammation Level, Disease Activity and Disability in Rheumatoid Arthritis
Stephanie Ling¹, Sebastien Viatte², Mark Lunt³, Alper van Sijl⁴, Lucía Silva Fernández^4,5, Soumya Raychaudhuri^2,6,7, Deborah P.M. Symmons^4,8, Adam Young^9,10, Alex J Macgregor¹¹ and Anne Barton¹², ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Mancheser Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ³Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁵Rheumatology, Complexo Hospitalario Universitario de Ferrol, Ferrol, Spain, ⁶Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ⁸Centre for Musculoskeletal Research, University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ⁹Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom, ¹⁰School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, ¹¹School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom, ¹²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom
Background/Purpose: Amino acid (AA) positions 11, 71 and 74 inside HLA-DRB1 confer susceptibility to rheumatoid arthritis (RA). AAs from these positions form 16 haplotypes, hierarchically…
Abstract Number: 1361 • 2015 ACR/ARHP Annual Meeting
Synovial Macrophages Promote TGF-β Signaling but Protect Against Influx of S100A8/S100A9-Producing Cells after Intra-Articular Injections of Oxidized Low-Density Lipoproteins
Wouter de Munter¹, Martijn H. van den Bosch¹, Arjen Blom¹, Birgitte Walgreen², Monique Helsen¹, Leo Joosten³, Johannes Roth⁴, Thomas Vogl⁵, Fons van de Loo¹, Marije Koenders¹, Wim van den Berg¹, Peter van der Kraan¹ and Peter van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Internal Medicine, Radboud university medical center, Nijmegen, Netherlands, ⁴Institute of Immunology, University of Münster, Münster, Germany, ⁵University of Muenster, Muenster, Germany
Background/Purpose: In previous studies we found that synovial macrophages regulate joint pathology during experimental osteoarthritis (OA). Recently, we found that high systemic levels of LDL…
Abstract Number: 2773 • 2015 ACR/ARHP Annual Meeting
Novel Mechanisms of Action for Methotrexate and Doxycycline: Prevention of Protein Adduct Formation and Free Radical Scavenging
Daniel Anderson¹, Michael J. Duryee², Matthew Zimmerman³, Jun Tian³, Cleofes Sarmiento³, Lynell W. Klassen⁴, James R. O'Dell¹, Geoffrey M. Thiele⁵ and Ted R. Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Cell Biology and Physiology, University of Nebraska Medical Center, Omaha, NE, ⁴Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Oxidative stress and free radical formation play an important pathogenic role in rheumatoid arthritis (RA) and a number of other inflammatory diseases. Oxidative stress…
Abstract Number: 119 • 2015 ACR/ARHP Annual Meeting
Triage in Chronic Rheumatic Diseases: Quantitative Physician Estimates for Inflammation (Reversible), Damage (Irreversible), and Distress in Patients with Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia Seen in Usual Care
Isabel Castrejón¹, Kathryn A. Gibson², Ruchi Jain¹, Annie Huang¹, Joel A. Block³ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Liverpool, Australia, ³Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of a patient’s global status (DOCGL) often is most often the most efficient of all 7 rheumatoid arthritis (RA) core data…
Abstract Number: 1366 • 2015 ACR/ARHP Annual Meeting
Natural Antibodies, Not B Cells, Contribute to Acute Cell Death-Induced Inflammation
Hiroshi Kataoka, Rheumatology and Clinical Immunology, Sapporo City General Hospital, Sapporo, Japan
Background/Purpose: Alarmins, such as uric acid, released from dying cells activate inflammasomes and mediate dead cell-induced inflammation (Ref.). Since it is remains unknown whether or…
Abstract Number: 2892 • 2015 ACR/ARHP Annual Meeting
Statin Treatment in Patients with Ankylosing Spondylitis
Grunde Wibetoe¹, Eirik Ikdahl¹, Tore K. Kvien², Silvia Rollefstad¹ and Anne Grete Semb³, ¹Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Patients with ankylosing spondylitis (AS) have increased risk of cardiovascular disease (CVD). In the general population, CVD risk reduction can be achieved by lipid…
Abstract Number: 135 • 2015 ACR/ARHP Annual Meeting
Limitations of Treat-to-Target in Rheumatoid Arthritis: Joint Damage Appears As Severe As Inflammation in Contemporary Care at One Site
Theodore Pincus¹, Alex D. Luta², Isabel Castrejón¹, Annie Huang¹, Ruchi Jain¹, Sarah L. Everakes³ and Joel A. Block⁴, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Georgetown University, Washington, DC, ³Internal Medicine, Rush University Medical Center, Chicago, IL, ⁴Rush University Medical Center, Chicago, IL
Background/Purpose: Treatment of rheumatoid arthritis is directed to “treat-to-target,” with intensification of therapy in patients with moderate/high disease activity according to a quantitative index toward…
Abstract Number: 1369 • 2015 ACR/ARHP Annual Meeting
Enhanced Myelopoiesis Downstream of Toll-like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Monocytes are myeloid cells important for the initiation of inflammation and have been implicated in the pathogenesis of autoimmunity. Monocytes interact with their environment…
Abstract Number: 3093 • 2015 ACR/ARHP Annual Meeting
Development and Validation of Diagnostic Criteria for Cryopyrin Associated Periodic Syndromes
Jasmin B. Kuemmerle-Deschner¹, Seza Ozen², Pascal N. Tyrrell³, Isabelle Koné-Paut⁴, Raphaela Goldbach-Mansky⁵, Helen Lachmann⁶, Norbert Blank⁷, Hal M. Hoffman⁸, Elisabeth Weissbarth-Riedel⁹, Boris Huegle¹⁰, Tilmann Kallinich¹¹, Marco Gattorno¹², Ahmet Gul¹³, Nienke M. ter Haar¹⁴, Marlen Oswald¹⁵, Fatma Dedeoglu¹⁶ and Susanne M. Benseler¹⁷, ¹Universitätsklinikum Tübingen, Klinik fuer Kinder- und Jugendmedizin, Tübingen, Germany, ²Pediatric Nephrology and Rheumatology, Hacettepe University, Ankara, Turkey, Ankara, Turkey, ³Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁴Pediatrics Rheumatology, CHU Bicêtre, Le Kremlin Bicêtre, France, ⁵Bldg10 rooom 6D47-B, NIH | NIAMS, Bethesda, MD, ⁶UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom, ⁷Med 5-Rheumatology, University of Heidelberg, Heidelberg, Germany, ⁸University of California at San Diego, San Diego, CA, ⁹Rheumatology, Pediatrics, Universitaetskinderklinik Hamburg, Hamburg, Germany, ¹⁰Pediatric Rheumatology, German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, ¹¹Charite, University Medicine Berlin, Berlin, Germany, ¹²Pediatry, G. Gaslini Institute, Genova, Italy, ¹³Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹⁴Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁵University Hospital Tuebingen, Tuebingen, Germany, ¹⁶Division of Immunology, Boston Children's Hospital, Boston, MA, ¹⁷Rheumatology, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada
Background/Purpose: Cryopyrin Associated Periodic Syndromes (CAPS) are a rare, clinically heterogeneous group of devastating inflammatory illnesses. NLRP3gene gain-of function mutations result in unceasingly raised IL1…
Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Rebecca Baum¹, Kerstin Nundel¹, Sudesh Pawaria^1,2, Shruti Sharma¹, Patricia Busto¹, Tara Robidoux¹, Katherine A. Fitzgerald¹, Ellen M. Gravallese³ and Ann Marshak-Rothstein¹, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…
Abstract Number: 1372 • 2015 ACR/ARHP Annual Meeting
Characterization of Synovial Mast Cells in Knee Osteoarthritis: Association with Clinical Parameters
Badelog J.E. de Lange-Brokaar¹, Margreet Kloppenburg¹, Stefan Andersen¹, Annemarie Dorjee¹, Erlangga Yusuf¹, Linda van Toorn¹, Herman Kroon², Anne-Marie Zuurmond³, Vedrana Stojanovic-Susulic⁴, Johan Bloem², Rob Nelissen⁵, René E. M. Toes⁶ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³TNO, Leiden, Netherlands, ⁴Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA, ⁵Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Synovial inflammation is a common feature of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. Comparative studies indicated that synovitis, measured by histology or imaging,…
Abstract Number: 3097 • 2015 ACR/ARHP Annual Meeting
Innovative Approach for the Identification of an Appropriate Dose Regimen of a Targeted Treatment, NI-0501, an Anti-Interferon Gamma (IFNg) Antibody, in Patients with Hemophagocytic Lymphohistiocytosis (HLH)
Cristina De Min¹, Philippe Jacqmin², Christian Laveille³, Robert Nelson¹, Florence Guilhot¹, Maureen Deehan¹, Marie Kosco-Vilbois¹, Walter Ferlin¹ and Genevieve Lapeyre¹, ¹NovImmune S.A., Geneva, Switzerland, ²SGS Exprimo, Mechelen, Belgium, ³SGS Exprimo NV, Mechelen, Belgium
Background/Purpose: Based on the growing evidence that IFNg plays a pivotal role in HLH, NI-0501, an anti-IFNg monoclonal antibody, is being developed as the first…
Abstract Number: 223 • 2015 ACR/ARHP Annual Meeting
Increased Platelet Reactivity in Gout: A Potential Mechanism for Adverse Cardiovascular Events
Richard Conway¹, Claire-Louise Murphy², Anne Madigan², Patricia Kavanagh², Liz Geraghty², Laura Helbert², Kelly Stephens³, John J. Carey⁴, Eimear Dunne⁵, Dermot Kenny⁵ and Geraldine M. McCarthy⁶, ¹Rheumatology, Mater Misericordiae University Hospital, Dublin 2, Ireland, ²Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ³Mater Misericordiae University Hospital, Clinical Research Center, Dublin, Ireland, ⁴Rheumatology, Galway University Hospitals, Galway, Ireland, ⁵Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland, ⁶University College Dublin, Dublin, Ireland
Background/Purpose: Patients with inflammatory arthritis, including gout, have an increased risk of cardiovascular events and mortality. Increased platelet reactivity is a risk marker for cardiovascular…
Abstract Number: 1504 • 2015 ACR/ARHP Annual Meeting
Increased Risk of Thromboembolism Among Patients with VTE Association with Rheumatoid Arthritis
Howard Amital^1,2 and Arnon-Dov Cohen³, ¹Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, ²Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel, ³Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel
Increased risk of thromboembolism among patients with VTE association with Rheumatoid Arthritis Background/Purpose: Rheumatoid arthritis (RA), is among most common autoimmune conditions manifested by progressive and…
Abstract Number: 3116 • 2015 ACR/ARHP Annual Meeting
High Level of Inflammation Predicts the Development of Diabetes Mellitus in Patients with Psoriatic Arthritis
Lihi Eder¹, Vinod Chandran¹, Richard J. Cook² and Dafna D. Gladman¹, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: To estimate trends in the prevalence of diabetes mellitus (DM) in patients with psoriatic arthritis (PsA) in comparison to the general population in Ontario,…

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