ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 546 • 2016 ACR/ARHP Annual Meeting

    Boolean-Based Remission in Rheumatoid Arthritis Using Physician Versus Patient Global Assessment: Differences in Ultrasonographic Disease Activities, Sustainabilities, and Relapse Rates

    Gulsen Ozen1, Ali Ugur Unal2, Haner Direskeneli3 and Nevsun Inanc1, 1Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 3Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Patient global assessment (PtGA), despite not being exclusively related to disease activity, is included in Boolean-based remission (BR) criteria for RA. This study evaluated…
  • Abstract Number: 2131 • 2016 ACR/ARHP Annual Meeting

    Transient Receptor Potential Ankyrin 1 (TRPA1) Is Functionally Expressed in Primary Human Osteoarthritic Chondrocytes and Mediates Cartilage Destruction and Joint Pain in the Mia-Model of Osteoarthritis

    Elina Nummenmaa1, Lauri J Moilanen1, Mari Hämäläinen1, Erja-Leena Paukkeri1, Riina Nieminen1, Teemu Moilanen2, Katriina Vuolteenaho1 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose:  Transient receptor potential ankyrin 1 (TRPA1) is a membrane associated cation channel, which is widely expressed in neuronal cells and known to be involved…
  • Abstract Number: 2727 • 2016 ACR/ARHP Annual Meeting

    Evaluating Psoriatic Arthritis and Psoriasis Skin Lesions: Ultrasound As a Complementary Measure

    Yogan Kisten1, Per T Larsson2, Erik af Klint2, Hamed Rezaei2,3, Noémi Györi1, Liv Eidsmo4, Mona Ståhle4 and Ronald F. van Vollenhoven1,5, 1Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 2Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 3Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 4Dermatology and Venereology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, 5Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands

    Background/Purpose: The diagnosis and assessment of psoriatic arthritis (PsA) and psoriasis (PsO) lesions are mostly done by visual inspection, and when in doubt, supplemented by…
  • Abstract Number: 675 • 2016 ACR/ARHP Annual Meeting

    Association Between Structural Lesions in the Sacroiliac Joints and Spinal Inflammatory Lesions in Patients with Non-Radiographic Axial Spondyloarthritis

    Maxime Dougados1, Robert G Lambert2, Stephanie Wichuk3, Jean-Claude Becker4, Jack F Bukowski5, Heather Jones6, Lisa Marshall6, Annette Szumski7 and Walter Maksymowych3, 1Rheumatology, Paris Descartes University, Paris, France, 2Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 3Medicine, University of Alberta, Edmonton, AB, Canada, 4Becker Clinical Research Consulting, New York, NY, 5Clinical Affairs, Pfizer, Collegeville, PA, 6Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, 7inVentiv Health, Princeton, NJ

    Background/Purpose: The relevance of structural lesions in non-radiographic axial SpA (nr-axSpA) is unclear, particularly without signs of MRI inflammation. In a post hoc analysis we…
  • Abstract Number: 2135 • 2016 ACR/ARHP Annual Meeting

    Knee Osteoarthritis Pain Is Differentially Associated with Tissue Degradation and Joint Inflammation

    Anne C. Bay-Jensen1, Steven B. Abramson2, Jonathan Samuels3, Inger Byrjalsen4, Svetlana Krasnokutsky Samuels5, Tina Manon-Jensen6, Morten Asser Karsdal1 and Mukundan Attur7, 1Rheumatology, Nordic Bioscience, Herlev, Denmark, 2Rheumatology Research, NYU School of Medicine and NYU Hospital for Joint Diseases, New York, NY, 3Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, 4Nordic Bioscience, Clinical Development, Herlev, Denmark, 5Svetlana Krasnokutsky, NYU Hospital for Joint Diseases, New York, NY, 6Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 7Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY

    Background/Purpose:  Osteoarthritis (OA) is a disease characterized by pain and tissue destruction, in some cases concomitant with inflammation. The link between pain and tissue destruction…
  • Abstract Number: 3044 • 2016 ACR/ARHP Annual Meeting

    Endothelin 1 Induces a Myofibroblastic Phenotype in Vascular Smooth Muscle Cells. A Mechanism Potentially Contributing to Vascular Remodeling and Intimal Hyperplasia in Giant Cell Arteritis

    Ester Planas-Rigol1, Nekane Terrades-Garcia2, Marc Corbera-Bellalta2, Ester Lozano2, Marco Antonio Alba2, Georgina Espígol-Frigolé3, Sergio Prieto-González2, Marta Segarra2, Jose Hernández-Rodríguez2, Sara Preciado4, Rodolfo Lavilla4 and Maria C. Cid2, 1Vasculitis research unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 2Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 3Vasculitis Research Unit, Systemic Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 4Laboratory of Organic Chemistry, Faculty of Pharmacy. Barcelona Science Park, Barcelona, Spain

    Background/Purpose: Giant cell arteritis (GCA) is a vascular inflammatory disease involving large and medium sized arteries, particularly the cranial vessels. Inflammation-induced vascular remodeling leads to…
  • Abstract Number: 746 • 2016 ACR/ARHP Annual Meeting

    Discrepancy in Rituximab-Induced B-Cell Depletion in Peripheral Blood and the Kidney and Relationship with Clinical Response in Patients with Lupus Nephritis

    Ruth J. Pepper1, Venkat Reddy2, Scott Henderson3 and Maria J. Leandro4, 1UCL Centre for Nephrology, Royal Free Hospital, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 3UCL Centre for Nephrology, University College London, London, United Kingdom, 4Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Patients with lupus nephritis (LN) achieve variable clinical response following Rituximab (RTX) based B-cell depletion therapy, with rituximab treatment aiming to decrease the use…
  • Abstract Number: 2138 • 2016 ACR/ARHP Annual Meeting

    Transcriptional Analysis of Synovial Tissue Reveals Sustained Inflammatory Chemokine Expression Despite Minimal Histopathologic Change in the Destabilization of Medial Meniscus Model of Murine Knee Osteoarthritis

    Nisha Sambamurthy1,2, Vu Nguyen1,2, Jason G. Lieberthal3, George R. Dodge4,5 and Carla R. Scanzello1,2,5, 1Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, 3Internal Medicine, Mount Auburn Hospital, Cambridge, MA, 4Research, CMC Veterans Affairs Medical Center, Philadelphia, PA, 5Department of Orthopedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

    Background/Purpose: The destabilization of medial meniscus (DMM) model of instability-induced OA replicates disease-related tissue pathology (including cartilage erosion, osteophytosis) and pain-related joint dysfunction, making it…
  • Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting

    Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome

    Sean Eddy1, Viji Nair1, Hemang Parikh2, Maja Lindenmeyer3, Laura Mariani1, Felix H. Eichinger1, Huateng Huang1, Wenjun Ju2, Casey Greene4, Peter C. Grayson5, Clemens Cohen3, Jeffrey Krischer2, Peter A. Merkel6 and Matthias Kretzler1, 1Division of Nephrology, University of Michigan, Ann Arbor, MI, 2University of South Florida, Tampa, FL, 3University of Munich, Munich, Germany, 4Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
  • Abstract Number: 889 • 2016 ACR/ARHP Annual Meeting

    The Utility of Patient-Reported Outcomes in Predicting Disease Activity in Patients with Takayasu’s Arteritis

    Antoine G. Sreih1, Tanaz A. Kermani2, Gunnar Tomasson3, Joshua F. Baker4, David Cuthbertson5, Renee Borchin6, Simon Carette7, Lindsy J. Forbess8, Gary S. Hoffman9, Nader A. Khalidi10, Curry L. Koening11, Carol A. McAlear12, Paul A. Monach13, Larry W. Moreland14, Christian Pagnoux15, Philip Seo16, Robert F. Spiera17, Kenneth J. Warrington18, Steven R. Ytterberg2, Carol A. Langford19 and Peter A. Merkel20, 1Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Dept of Public Health Sciences, University of Iceland, Reykjavik, IS, 4Rheumatology, University of Pennsylvania, Philadelphia, PA, 5Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 6University of South Florida, Tampa, FL, 7Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 8Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Rheumatology, Cleveland Clinic, Cleveland, OH, 10Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 11Rheumatology, University of Utah, Salt Lake City, UT, 12University of Pennsylvania, Philadelphia, PA, 13Rheumatology, Boston University School of Medicine, Boston, MA, 14Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 15Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, 16Medicine, Johns Hopkins University, Baltimore, MD, 17Hospital for Special Surgery, Cornell, New York, NY, 18Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN, 19Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 20Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA

    Background/Purpose: Takayasu’s arteritis (TAK) is a relapsing large vessel vasculitis. There are currently no reliable predictors of disease relapse. This study explored whether changes in…
  • Abstract Number: 2155 • 2016 ACR/ARHP Annual Meeting

    Crosstalk Between IL-6 and TNF-Alpha Signaling Pathway in Rheumatoid Arthritis Synovial Fibroblasts

    Alvaro Valin1, Yolanda Ruano2, Manuel J. Del Rey3, Carmen M. García-Herrero3, Eduardo Martín-Guerrero1, Beatriz Bravo4, Juan D. Cañete5, José L. Rodríguez-Peralto2 and Jose L. Pablos3,6, 1Grupo de Enfermedades Inflamatorias y Autoimmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 2Pathology Department, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 3Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 4Servicio de Traumatología y Cirugía Ortopédica, Hospital 12 de Octubre, Madrid, Spain, 5Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 6Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain

    Background/Purpose:  Although elevated IL-6 and its soluble receptor (sIL6R) have been found in the serum and synovium of arthritic patients, the molecular mechanisms by which…
  • Abstract Number: 892 • 2016 ACR/ARHP Annual Meeting

    FDG-PET CT Evaluation By Visual Grading Is Not Sufficiently Discriminative to Assess Disease Activity in Takayasu’s Arteritis Patients with ‘Persistent’ Disease

    Ali Ugur Unal1, Fuat Dede2, Tanju Yusuf Erdil2, Tunc Ones2, Fatma Alibaz-Oner3 and Haner Direskeneli4, 1Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 2Department of Nuclear Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey, 3Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 4Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey

    Background/Purpose: Takayasu arteritis (TAK) is a large-vessel vasculitis in which assessment of disease activity is challenging. Recent studies support that 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed…
  • Abstract Number: 2164 • 2016 ACR/ARHP Annual Meeting

    Depression and the Risk of Psoriatic Arthritis Among Patients with Psoriasis: A Population-Based Cohort Study

    Ryan Lewinson1,2, Isabelle Vallerand1,3, Mark Lowerison3, Laurie Parsons4, Alexandra Frolkis1,3, Gilaad Kaplan3,4, Andrew Bulloch3,5,6, Scott Patten3,5 and Cheryl Barnabe3,4, 1Leaders in Medicine Program, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Biomedical Engineering Program, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, 3Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 4Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 6Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

    Depression and the Risk of Psoriatic Arthritis among Patients with Psoriasis: A Population-based Cohort Study Background/Purpose: The factors that contribute to the development of psoriatic…
  • Abstract Number: 903 • 2016 ACR/ARHP Annual Meeting

    Temporal Arteritis: Is There Any Correlation Between Ultrasonographic Arterial Wall Involvement and the Inflammatory Cellular Infiltrate at Histological Examination?

    Giuseppe Germanò1, Pierluigi Macchioni2, Alberto Cavazza3, Niccolò Possemato2, Mariagrazia Catanoso4, Luca Cimino5 and Carlo Salvarani6, 1Unit of Rheumatology, Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia, Italy, 2Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 4Rheumatology Service, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 5Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 6Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy

    Background/Purpose: Ultrasonographic alterations such as the halo sign and the compression test are now accepted as surrogate markers of artery inflammation. No data have yet…
  • Abstract Number: 2174 • 2016 ACR/ARHP Annual Meeting

    Effect of Anti-Rheumatic Treatment on Selenium Levels in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

    Gia Deyab1, Ingrid Hokstad2, Milada Cvancarova Småstuen3, Stefan Agewall4, Jon Elling Whist5 and Ivana Hollan5,6,7,8, 1Department of Medical Biochemistry, Innlandet Hospital Trust, Lillehammer, Norway, 2Lillehammer Hospitat for Rheumatic Diseases, Lillehammer, Norway, 3Institution of health care - Health science PhD program, Oslo and Akershus University College, Oslo, Norway, 4University of Oslo, Oslo, Norway, 5Innlandet Hospital Trust, Lillehammer, Norway, 6Brigham and Women’s Hospital, Boston, MA, 7Harvard Medical School, Boston, MA, 8Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway

    Background/Purpose: The cause of the increased cardiovascular risk in inflammatory rheumatic diseases (IRDs) is still unclear. Intriguingly, selenium-deficiency, which might be caused by poor diet or…
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