Abstracts tagged "Inflammation"

Abstract Number: 2330 • 2017 ACR/ARHP Annual Meeting
Evidence for Alternatively Activated (M2) Macrophage Activation in Patients with Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Amita Aggarwal¹, Priyanka Gaur² and Akhilesh Yadav³, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Among juvenile idiopathic arthritis (JIA), enthesitis related arthritis (ERA) category includes most children with juvenile onset spondyloarthropathy (SpA). Synovial fluid from patients with SpA…
Abstract Number: 387 • 2017 ACR/ARHP Annual Meeting
F4/80hi Synovial Macrophages in the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang^1,2, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter⁴ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Synovial tissue macrophages (STMs) are critical in the pathogenesis of rheumatoid arthritis (RA). During homeostasis, the majority of murine synovial tissue resident macrophages (TRMs)…
Abstract Number: 1396 • 2017 ACR/ARHP Annual Meeting
Can 3 0-10 Physician Visual Analog Scales (VAS) to Assess Levels of Inflammation, Damage and Distress Offer Comprehensive Quantitative Data That May be As Informative As Detailed, Formal Swollen and Tender Joint Counts?
MJ Bergman¹ and Theodore Pincus², ¹Drexel University College of Medicine, Philadelphia, PA, ²Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Management of patients with rheumatoid arthritis (RA) remains primarily according to a patient history and physical examination, unlike in many other chronic diseases, in…
Abstract Number: 2427 • 2017 ACR/ARHP Annual Meeting
Exosomes Derived from T Lymphocytes Enhance Expression of CXCL10 Induced By IFN-γin Rheumatoid Arthritis Synovial Fibroblasts Via Pattern Recognition Receptor, RIG-I
Kunihiko Umekita, Shunichi Miyauchi, Koshou Iwao, Mao Rikitake, Yuuki Rikitake, Chihiro Kawada, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Takeshi Kawaguchi, Hajime Nomura, Ichiro Takajo and Akihiko Okayama, Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan
Background/Purpose: Exosomes have been recognized to have a function in cell-to-cell communication by transporting various factors including proteins and nucleic acids. These factors impact cell…
Abstract Number: 391 • 2017 ACR/ARHP Annual Meeting
Defective Glucose and Lipid Metabolism in Rheumatoid Arthritis Is Determined By Chronic Inflammation in Metabolic Tissues
Nuria Barbarroja¹, Ivan Arias de la Rosa², Sergio Rodriguez-Cuenca³, Yolanda Jiménez-Gómez¹, Patricia Ruiz-Limon², Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Irene Cecchi², Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez¹, Rocio Guzman-Ruiz⁴, Maria del Mar Malagon⁵, Eduardo Collantes-Estévez¹, Antonio Vidal-Puig³, Alejandro Escudero-Contreras² and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁵Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain
Background/Purpose: Rheumatoid arthritis (RA) patients are at higher risk for insulin resistance (IR). The association between RA and IR, and its role on the different…
Abstract Number: 1410 • 2017 ACR/ARHP Annual Meeting
Tyrosine Kinase Receptor Axl Is Down Regulated in Highly Inflamed Rheumatoid Synovium and Negatively Correlates with Markers of Disease Activity
Alessandra Nerviani¹, Sara Pagani¹, Daniele Mauro¹, Frances Humby¹, Stephen Kelly¹, Felice Rivellese¹, Gloria Lliso Ribera¹, Myles J. Lewis², Michele Bombardieri³ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ³Willian Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Emerging evidence highlighted the role of Tyro3, Axl and Mer Tyrosine Kinase receptors (TAMs) and their ligands Gas6 and ProteinS in the pathogenesis of…
Abstract Number: 2702 • 2017 ACR/ARHP Annual Meeting
Tissue-Invasive T Cells in Rheumatoid Arthritis
Cornelia M. Weyand¹, Yi Shen², Yinyin Li¹, Eric L. Matteson³, Stuart Goodman⁴ and Jorg Goronzy⁵, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Orthopaedic Surgery, Stanford Medical Center Outpatient Clinic, Redwood City, CA, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: A key pathogenic event in rheumatoid arthritis (RA) is the formation of lasting lymphoid microstructures in the synovial tissue. It requires the transmigration of…
Abstract Number: 392 • 2017 ACR/ARHP Annual Meeting
Effects of Synthetic Dmards on the Insulin Resistance and Obesity Associated with Rheumatoid Arthritis: An Obese Mouse Model of Arthritis
Nuria Barbarroja¹, Ivan Arias de la Rosa², Miriam Ruiz-Ponce¹, Sergio Rodriguez-Cuenca³, Maria Carmen Abalos-Aguilera², Yolanda Jiménez-Gómez¹, Patricia Ruiz-Limon², Carlos Perez-Sanchez¹, Eduardo Collantes-Estévez¹, Antonio Vidal-Puig³, Alejandro Escudero-Contreras² and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Numerous studies have demonstrated the closely association between rheumatoid arthritis (RA) and metabolic complications such as obesity and insulin resistance (IR). Thus, there is…
Abstract Number: 1415 • 2017 ACR/ARHP Annual Meeting
TNF-Induced IRF1 Is Critical for the Inflammatory Gene Expression in Fibroblast-like Synoviocytes
Michael Bonelli¹, Karolina von Dalwigk², Birgit Niederreiter¹, Thomas Pap³, Josef S. Smolen⁴, Hans Peter Kiener¹ and Thomas Karonitsch¹, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁴Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria
Background/Purpose: Fibroblast-like synoviocytes (FLS) are increasingly recognised as major pathogenic cells in synovial inflammation of patients with Rheumatoid Arthritis (RA). In response to pro-inflammatory stimuli,…
Abstract Number: 2771 • 2017 ACR/ARHP Annual Meeting
NOMID-Associated Complications in Mice Are Prevented By CDD-450, a Small Molecule Inhibitor of the Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Pathway
Gabriel Mbalaviele¹, Chun Wang¹, Susan Hockerman², Jon Jacobsen², Jeff Hirsch², Steve Mnich², Heidi Hope², Matt Saabye², Hal Hoffman³ and Joseph Monahan², ¹Medicine, Washington University School of Medicine,, St. Louis, MO, ²Confluence Life Sciences, Inc, St. Louis, MO, ³University of California, San Diego, San Diego, CA
Background/Purpose: NLRP3-activating mutations cause cryopyrinopathies of which NOMID is the most severe phenotype. NLRP3 assembles a protein complex, responsible for the maturation of IL-1β and…
Abstract Number: 495 • 2017 ACR/ARHP Annual Meeting
Efficacy of Tofacitinib in Patients with Moderate to Severe Rheumatoid Arthritis By Baseline C-Reactive Protein Levels and Erythrocyte Sedimentation Rates
Sergio Schwartzman¹, Ronald F van Vollenhoven², Alan K Matsumoto³, Dana Orange⁴, Shweta Shah⁵, Ryan DeMasi⁵, Haiyun Fan⁵, Palle Dahl⁶, Ann Wouters⁷ and Edward C. Keystone⁸, ¹Hospital for Special Surgery, New York, NY, ²Karolinska Institute, Stockholm, Sweden, ³Arthritis & Rheumatism Associates, Wheaton, MD, ⁴Rockefeller University; Hospital for Special Surgery; and New York Genome Center, New York, NY, ⁵Pfizer Inc, Collegeville, PA, ⁶Pfizer Inc, Ballerup, Denmark, ⁷Pfizer Inc, New York, NY, ⁸University of Toronto, Toronto, ON, Canada
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post-hoc analysis investigated the impact of inflammation severity at baseline (BL)…
Abstract Number: 1417 • 2017 ACR/ARHP Annual Meeting
Mitophagy Defect in Fibroblast-like Synoviocytes of Rheumatoid Arthritis Is Improved By Pyruvate Treatment
Jeong Yeon Kim^1,2, ShinEui Kang^3,4, Hyun Jung Yoo^1,5, Ji Soo Park^1,2, Sehui Shon^1,2, Eun Young Lee², Eun Bong Lee⁵ and Yeong Wook Song^1,6, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁶Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining produce pro-inflammatory cytokines resulting in increase of joint inflammation. Recent studies about the cellular metabolism in…
Abstract Number: 2900 • 2017 ACR/ARHP Annual Meeting
Osteoarthritis-Associated Calcium-Containing Crystals and Biomaterial Microparticles Both Drive M1 Macrophage Polarization in a Syk and MAP Kinase-Dependent Manner
Geraldine M. McCarthy¹, Olwyn Mahon², Sarah O'Hanlon³, Daniel Kelly⁴ and Aisling Dunne⁵, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry and Immunology,, ,Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, ⁴Trinity Center for Bioengineering, ,Trinity College Dublin, Dublin, Ireland, ⁵School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular basic calcium phosphate (BCP) crystals are associated with advanced osteoarthritis (OA) andsynovitis. OA-associated synovium exhibits increased numbers of macrophages compared with non-OA joints.…
Abstract Number: 549 • 2017 ACR/ARHP Annual Meeting
Increases in Lipid Levels Following Sirukumab Treatment Are Associated with Suppression of Inflammation in Rheumatoid Arthritis: Results from Two Phase 3 Trials
Bidisha Dasgupta¹, Matthew Loza¹, Androniki Bili¹, Shruti Daga², Kurt Brown³, Jennifer Gilbride⁴, Benjamin Hsu¹ and Iain B. McInnes⁵, ¹Janssen Research & Development, LLC, Spring House, PA, ²GlaxoSmithKline, Uxbridge, United Kingdom, ³GlaxoSmithKline, Collegeville, PA, ⁴Sum of Squares Ltd, Hertfordshire, United Kingdom, ⁵University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Understanding interactions of inflammatory cytokines and lipid metabolism in RA is of considerable interest. Blocking IL-6 receptor elevates lipid levels in RA while lowering…
Abstract Number: 1568 • 2017 ACR/ARHP Annual Meeting
Existence of IL-6 and IL-17 Mediated Inflammation Amplifier Loop in Reactive Arthritis
Ramnath Misra¹, Sandeep Kumar², Rajeev Singh³, Abhisek Singh⁴, Daisuke Kamimura⁵, Smriti Chaurasia², Yasunobu Aria⁶, Tori Austria⁷, Ratnadeep Mukherjee⁸, Balachandran Ravindran⁹, Vikas Agarwal² and Masaaki Murakami¹⁰, ¹Clinical Immunology, Sanjay Gandhi Postgraduate of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Biochemistry, King George Medical University, Lucknow, India, ⁴Division of Molecular Neroimmunology, Post Doctoral Fellow, Sapporo, Japan, ⁵Molecular Neuroimmunology, Lecturer, Sapporo 060-0815,, Japan, ⁶Division of Molecular Neuroimmunology, Assistant Professor, Sapporo 060-0815, Japan, ⁷Division of Molecular Neuroimmunology, Special appointed - Assistant Professor, Sapporo 060-0815, Japan, ⁸Institute of Life Sciences, Ph D student, Bhubaneswar, India, ⁹Institute of Life Sciences, Distinguished Scientist, Bhubaneswar, India, ¹⁰Institute of Genetic Medicine, Director, Sapporo 060-0815, Japan
Background/Purpose: F759 mice with a single amino-acid substitution in signal transducer subunit of IL-6 receptor gp130 (Y759F) develops arthritisspontaneously due to IL-17A and IL-6 mediated…

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