Abstract Number: 1510 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR5 Ligation Is a Novel Strategy for RA Therapy
Background/Purpose: TLR5 expression is highly elevated in RA and CIA lining and sublining macrophages and endothelial cells compared to non-arthritic controls. Additionally, expression of TLR5…Abstract Number: 32 • 2014 ACR/ARHP Annual Meeting
Regulation of Senescence and Inflammatory Mediators By N- and C-Terminal Parathyroid Hormone-Related Protein in Osteoarthritic Human Osteoblasts
Background/Purpose In osteoarthritis (OA), there is an abnormal remodeling process in subchondral bone associated with an altered osteoblast metabolism. Inflammatory mediators participate in bone remodeling…Abstract Number: 2339 • 2014 ACR/ARHP Annual Meeting
Detecting Inflammation in Vivo Using Activatable Fluorescence Contrast Agents in Inflammatory Arthritis
Background/Purpose: Current medical imaging technology detects structural rather than functional manifestations of disease. Imaging agents designed to enhance signal based on molecular mechanisms might permit…Abstract Number: 1468 • 2014 ACR/ARHP Annual Meeting
Mechanism of Effectiveness of IL-6 Blockade for Reduction of SAA Production and Amyloid a Deposition in AA Amyloidosis Patients with RA
Background/Purpose AA amyloidosis is a serious complication of chronic inflammatory and infectious diseases resulting from the deposition of amyloid A protein. Serum amyloid A (SAA),…Abstract Number: L17 • 2014 ACR/ARHP Annual Meeting
Bariatric Surgery Improves Rheumatoid Arthritis Disease Activity, Reduces Inflammatory Markers, and Decreases Medication Usage
Background/Purpose: Obesity causes a chronic inflammatory state. Increased body mass index (BMI) is associated with incident rheumatoid arthritis (RA) and may impact RA disease activity.…Abstract Number: 2239 • 2014 ACR/ARHP Annual Meeting
Efficacy of Ketoprofen Lysine Salt in Reducing Inflammation and Pain in Primary Osteoarthritis of the Hand: Preliminary Results of a Retrospective and Prospective Clinical Trial
Background/Purpose: Osteoarthritis (OA) is a common progressive joint disease and a leading cause of musculoskeletal pain and functional disability worldwide. Despite various interventional treatment approaches…Abstract Number: 1291 • 2014 ACR/ARHP Annual Meeting
Relationships Between Inflammation, Disease Severity and Synovial Fluid Calcium Crystals Detected By Scanning Electronic Microscopy in Early Osteoarthritis
Background/Purpose The presence of calcium crystals (CC) in synovial fluid (SF) of osteoarthritis (OA) is a well known and frequent feature (1). However, their role…Abstract Number: 2225 • 2014 ACR/ARHP Annual Meeting
Does Previous Corticosteroid Treatment Affect the Inflammatory Infiltrate Found in Polymyositis Muscle Biopsies?
Background/Purpose: We conducted this study because there have been no studies evaluating the effect of the use of corticosteroids (CE) on the presence of inflammatory…Abstract Number: 1204 • 2014 ACR/ARHP Annual Meeting
Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFkB Signaling and Macrophage Migration
Background/Purpose: The major obstacles to successful use of curcumin as an anti-inflammatory agent are its low solubility in water and rapid metabolism, which both translate…Abstract Number: 2168 • 2014 ACR/ARHP Annual Meeting
Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation
Background/Purpose: Many rheumatic diseases are driven by chronic, repeated activation of Toll-like receptors (TLR) causing the initiation and perpetuation of disease. However, TLR-activated innate immune…Abstract Number: 1195 • 2014 ACR/ARHP Annual Meeting
Activation of the nlrp3 Inflammasome By an Endogenous TLR2 Ligand in Rheumatoid Arthritis
Background/Purpose: The inflammasome is a large multiprotein complex which plays a key role in innate immunity by mediating the production of pro-inflammatory cytokines interleukin-1β (IL-1β)…Abstract Number: 1979 • 2014 ACR/ARHP Annual Meeting
Pseudostarvation By AMPK Activator Therapy Is Associated with Reduced Disease Activity and Downregulation of Pro-Inflammatory Responses in Rheumatoid Arthritis (RA)
Background/Purpose AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…Abstract Number: 1050 • 2014 ACR/ARHP Annual Meeting
A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation
Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
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