ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 24 • 2017 ACR/ARHP Annual Meeting

    Trafficking of Innate B Cells to the Lungs As a Novel Mechanism in a Model of Pulmonary Lupus and Vasculitis

    Priti Prasad1, Michael Fishbein2, Rohan Sharma3, Ramesh Halder4, Isela Valera1 and Ram R. Singh5, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los ángeles, CA, 3Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los angeles, CA, 4Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los ángeles, CA, 5Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Lung is involved in up to 50% patients with SLE. Among manifestations of pulmonary lupus, pneumonitis, vasculitis and diffuse pulmonary hemorrhage (DPH) carry a…
  • Abstract Number: 976 • 2017 ACR/ARHP Annual Meeting

    Cannabinoid Receptor 2 Agonist (JWH-015) Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts

    Sabrina Fechtner and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by activated synovial fibroblasts in which pro-inflammatory cytokine interleukin-1β (IL-1β) mediates inflammation. The endocannabinoid system…
  • Abstract Number: 1790 • 2017 ACR/ARHP Annual Meeting

    Sphingosine -1 Phosphate Receptor-1-Mediated Endothelial Cell Barrier Function Protects Against Immune Complex-Induced Vascular Injury: A Potential Novel Therapeutic Target for SLE

    Nathalie Burg1, Steven Swendeman2, Stefan Worgall3, Timothy Hla2 and Jane E. Salmon1, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Boston Children's Hospital, Boston, MA, 3Pediatrics/ Pulmonary, Weill Cornell Medical Center, New York, NY

    Background/Purpose: Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid, is important for vascular homeostasis via signaling through S1P receptors. HDL-bound apolipoprotein M (ApoM) is a physiological S1P…
  • Abstract Number: 73 • 2017 ACR/ARHP Annual Meeting

    Regulation of Th17 Cell Responses By IL-25

    Sophie Archer, Ash Maroof, Meryn Griffiths and Stevan Shaw, UCB Pharma, Slough, United Kingdom

    Background/Purpose: IL-17A is a Th17 proinflammatory cytokine that contributes to the pathophysiology of several immune-mediated inflammatory diseases including PsA; while previously underestimated, there is increasing…
  • Abstract Number: 1071 • 2017 ACR/ARHP Annual Meeting

    Increased Susceptibility of SLE-Prone Mice to Pulmonary Haemophilus Influenzae Infection Was Attributed to Dysfunctions of Innate Immune Responses

    Wenchao Li and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

    Background/Purpose: Aside from the disease itself, infections represent the major cause of morbidity and mortality in systemic lupus erythematosus (SLE) patients. Although the daily usage…
  • Abstract Number: 1863 • 2017 ACR/ARHP Annual Meeting

    Inflammatory Dietary Pattern and Risk of Developing Rheumatoid Arthritis in Women

    Bing Lu1, Jeffrey A. Sparks1, Susan Malspeis1, Medha Barbhaiya1, Sara K. Tedeschi2, Karen H. Costenbader3 and Elizabeth Karlson3, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: The preclinical period of rheumatoid arthritis (RA) is characterized by elevated inflammatory biomarkers but it is unclear whether inflammatory diet may contribute to RA…
  • Abstract Number: 82 • 2017 ACR/ARHP Annual Meeting

    CKD-506, a Novel Inhibitor of Histone Deacetylase 6 (HDAC6) Has a Therapeutic Potential in Rheumatoid Arthritis and Inflammatory Bowel Disease

    Jieun Shin1, Nina Ha1, Daekwon Bae1, Dong-Hyeon Suh1, Yu Jin Jang2, Sehui Shon3, Ji-yeon Baek1, Jae Hyun Jun1, Yong Jae Lee1, Changsik Lee1, Sei-Hwan Kim1, Hosung Yu1, Young Il Choi1, Keun Ho Ryu1, Soung-Min Lee4, Yeong Wook Song2, Su K Seo4 and Seong Kon Kim1, 1Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 3Department of Molecular Medicine and Biopharmaceutical Sciences, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), 4Department of Microbiology and Immunology, Inje University College of Medicine, Busan, Korea, Republic of (South)

    Background/Purpose: Autoimmune disease such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) is a chronic inflammatory disorder, significantly limiting quality of life. Even though…
  • Abstract Number: 1101 • 2017 ACR/ARHP Annual Meeting

    Systematic Physician Assessment Beyond Inflammation in Routine Rheumatology Care Using Visual Analog Scale Scores for Inflammation, Damage, and Distress to Document Patient Status and Support Clinical Decisions: Analysis of Inter-Rater Reliability

    Shakeel M. Jamal1, Theodore Pincus2, Isabel Castrejón2, Jacquelin R. Chua1, Aman Kugasia1, Juan Schmukler1, Stacy Weinberg1 and Joel A. Block3, 1Division of Rheumatology, Rush University Medical Center, Chicago, IL, 2Rheumatology, Rush University Medical Center, Chicago, IL, 3Rush University Medical Center, Chicago, IL

    Background/Purpose: A physician global estimate of patient status (DOCGL) on a 0-10 visual analog scales (VAS) is as effective as any rheumatoid arthritis (RA) Core…
  • Abstract Number: 1928 • 2017 ACR/ARHP Annual Meeting

    Fibroblast-like Synovial Cell Production of ED-a Fibronectin Contributes to Inflammation in Osteoarthritis

    Tue Wenzel Kragstrup1,2,3, Dong Hyun Sohn4, Christin Lepus3, Kazuhiro Onuma5, Qian Wang3, William H. Robinson3 and Jeremy Sokolove3, 1Randers Regional Hospital, Randers, Denmark, 2Department of Biomedicine, Aarhus University, Aarhus, Denmark, 3VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 4Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Korea, Republic of (South), 5VA Palo Alto Healthcare System and Stanford University, Stanford, CA

    Background/Purpose: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Wear and tear leads to tissue degradation followed by…
  • Abstract Number: 86 • 2017 ACR/ARHP Annual Meeting

    Regulation of Interleukin-1β Signaling By Inhibition of O-Glc-Nacase in Rheumatoid Arthritis Synovial Fibroblasts

    Mahamudul Haque1, Anil Singh2, Kelly Kopczynski1 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Washington State University, College of Pharmacy, Spokane, WA

    Background/Purpose: O-GlcNAcylation is an important post-translational modification of nuclear and cytosolic proteins involved in the cytokine signaling networks. Studies show both pro- and anti-inflammatory roles…
  • Abstract Number: 1203 • 2017 ACR/ARHP Annual Meeting

    Differences in Serum Protein Biomarkers between Combined Glucosamine and Chondroitin Versus Celecoxib Treatment in a Randomized, Double-Blind Trial in Osteoarthritis Patients

    Sandi L Navarro1, Marta Herrero2, Helena Martinez2, Jon Ladd1, Yuzheng Zhang1, Edward Lo1, David Shelley1, Timothy W Randolph1, Yvonne Schwarz1, Johanna W Lampe1 and Paul D Lampe1, 1Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 2Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain

    Background/Purpose: Non-steroidal anti-inflammatory drugs, e.g., celecoxib, are commonly used for inflammatory conditions, including osteoarthritis (OA), but are associated with adverse effects. Combined glucosamine hydrochloride plus…
  • Abstract Number: 1949 • 2017 ACR/ARHP Annual Meeting

    Anti-Inflammatory Effects of Standardized Platelet-Rich Plasma Releasates in Knee and Hip OA Chondrocytes

    Lucia Gato-Calvo1, Ángela Vela-Anero2, Elena F. Burguera1 and Francisco J Blanco3, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade de A Coruña (UDC), A Coruña, Spain, 2Cell Therapy and Regenerative Medicine Group, Department of Medicine, University of A Coruña, A Coruña, Spain, 3Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Spain

    Background/Purpose : There is a need to standardize platelet-rich plasma (PRP)-derived products and their dosage to evaluate efficacy for each intended indication. Our purpose here…
  • Abstract Number: 165 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Risk Polymorphisms in CCR6, SNP and Estrogen-Dependent Response to Immune Mediator Gene Expression, and NF-κb Transcriptional Activity: Crosstalk between the Immune and Endocrine Systems

    Ming-Fen Ho1, Tim Bongartz2, James N. Ingle3, Liewei Wang1 and Richard M. Weinshilboum1, 1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 2Emergency Medicine, Vanderbilt University, Nashville, TN, 3Department of Medical Oncology, Mayo Clinic, Rochester, MN

    Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 rs3093024 SNP is associated with increased risk of RA in a sex-specific pattern in Asian populations. Specifically,…
  • Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting

    Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial

    E.A.M. Mahler1, M.J.M Minten1, M.M. Leseman-Hoogenboom2, P.M.P. Poortmans2, S.S. Boks3, J.W.J. Bijlsma4, F.H.J. van den Hoogen1,5, A.A. Den Broeder1,5 and C.H.M. van den Ende1,5, 1Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, 3Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, 5Rheumatology, Radboud university medical centre, Nijmegen, Netherlands

    Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
  • Abstract Number: 2016 • 2017 ACR/ARHP Annual Meeting

    Favourable Changes in Power Doppler Scores in the Feet over 1-Year in an Early Rheumatoid Arthritis Cohort: The Role of Rheumatoid Factor and Anti–Citrullinated Protein Antibody

    Karen A. Beattie1, Hanyan Zou2, George Ioannidis3 and Maggie Larche1, 1Medicine, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

    Background/Purpose : MTP joints are seldom examined in routine clinical visits. As such, it is important to understand how the standard treatment of patients with…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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