ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 1077 • 2018 ACR/ARHP Annual Meeting

    Identification of Biomarkers Involved in the Resolution Phase of Inflammation: Specialized Pro-Resolving Mediator Receptors Expression in Rheumatoid Arthritis

    Simone Perniola1, Liliana Dinoia1, Nunzia Lacarpia1, Dorotea Natuzzi1, Rita Bizzoca1 and Florenzo Iannone2, 1Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, 2D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy

    Background/Purpose: Inflammation is part of the complex biological response of body tissues to harmful stimuli, involving immune cells, blood vessels, and molecular mediators. At the…
  • Abstract Number: 2264 • 2018 ACR/ARHP Annual Meeting

    Methotrexate in the Treatment of Granulomatous Mastitis: A Retrospective Review of 19 Cases

    Anna Postolova1 and Mark C. Genovese2, 1Department of Medicine, Stanford University Medical Center, Palo Alto, CA, 2Department of Medicine, Stanford University, Palo Alto, CA

    Background/Purpose: Granulomatous Mastitis is a rare, inflammatory disease of the breast. Presenting symptoms in the breast can be unilateral or bilateral pain, masses, skin induration,…
  • Abstract Number: 1170 • 2018 ACR/ARHP Annual Meeting

    Sex-Specific Associations between Systemic Inflammatory Cytokines and Osteoarthritis Knee Pain

    Anthony V. Perruccio1, J. Denise Power1, Mayilee Canizares1, Elizabeth M. Badley1,2, Mohit Kapoor1, Rajiv Gandhi1 and Y. Raja Rampersaud1, 1Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Significant challenges remain in mitigating OA pain and despite growing evidence of sex differences, including in pain and in response to NSAIDs, sex has…
  • Abstract Number: 2508 • 2018 ACR/ARHP Annual Meeting

    A First-in-Man Bioelectronic Therapy for Biologic-Refractory Rheumatoid Arthritis

    David Chernoff1, Yaakov Levine1, Charles Peterfy2 and Mark C. Genovese3, 1SetPoint Medical, Inc., Valencia, CA, 2Spire Sciences LLC, Boca Raton, FL, 3Department of Medicine, Stanford University, Palo Alto, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Bioelectronic therapy (BET), such as electrical neurostimulation of…
  • Abstract Number: 51 • 2018 ACR/ARHP Annual Meeting

    Genetic Ablation of Inducible Nitric Oxide Synthase in TNF Transgenic Mice with Inflammatory-Erosive Arthritis Prevents Lymph Node Expansion and Decreases Synovial Infiltrates

    Richard Bell1, Emily Wu2, Lianping Xing3, Christopher T. Ritchlin4 and Edward Schwarz5, 1Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 2Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY, 4Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 5Orthopedeatrics, University of Rochester, Rochester, NY

    Background/Purpose: Recent studies in the TNF-Tg mouse model of rheumatoid arthritis (RA) demonstrated a critical role of lymphatic vessel (LV) function in joint homeostasis and…
  • Abstract Number: 1200 • 2018 ACR/ARHP Annual Meeting

    Unilateral Ultrasound Scoring Methods for Synovitis in Rheumatoid Arthritis: An Agreement Study Exploring the Most Inflammatory Active Side

    Lene Terslev1, Robin Christensen2, Anna-Birgitte Aga3, Joseph Sexton3, Espen A. Haavardsholm3 and Hilde B. Hammer4, 1Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 2Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, 3Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Several unilateral scoring systems have been proposed to increase the feasibility of ultrasound (US) for joint evaluation in rheumatoid arthritis (RA) patients. Both the…
  • Abstract Number: 2652 • 2018 ACR/ARHP Annual Meeting

    Engaging the Cholinergic Anti-Inflammatory Pathway By Stimulating the Vagus Nerve Reduces Pain and Fatigue in Patients with SLE

    Cynthia Aranow1, Martin Lesser2, Meggan Mackay1, Erik Anderson3, Theodoros P. Zanos2, Timir Datta-Chaudhuri2, Chad Bouton2, Kevin J. Tracey4 and Betty Diamond1, 1The Feinstein Institute for Medical Research, Manhasset, NY, 2Feinstein Institute for Medical Research, Manhasset, NY, 3Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 4Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:   Musculoskeletal (MS) pain is a common symptom of patients with Systemic Lupus Erythematosus (SLE) affecting up to 95% of patients and contributing to…
  • Abstract Number: 155 • 2018 ACR/ARHP Annual Meeting

    Polyfunctional Synovial T-Cell Responses and Synovial Invasiveness Repressed By Blockade of Phosphodiesterase 4

    Sarah M. Wade1, Mary Canavan1, Trudy McGarry1, Siobhan C. Wade1, Ronan Mullan2, Douglas J. Veale3 and Ursula Fearon1, 1Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, 2Department of Rheumatology,, Tallaght Hospital, Dublin, Ireland, 3Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland

    Background/Purpose: Genetic and functional studies strongly support the role of T-cells in PsA pathophysiology. Effective targeting of T-cells requires a detailed understanding of their phenotypic…
  • Abstract Number: 1475 • 2018 ACR/ARHP Annual Meeting

    Eicosanoid Mediators of Systemic Inflammation and Arthritis in the Elderly

    Roxana Coras1,2, Rekha Narasimhan1, Arthur Kavanaugh3, Lourdes Mateo4, Oswald Quehenberger5, Melania Martinez-Morillo6 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3University of California, San Diego, School of Medicine, La Jolla, CA, 4Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 5Pharmacology, Medicine, University of California San Diego, La Jolla, CA, 6Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain

    Background/Purpose: Elderly-onset RA, EORA, which is defined as rheumatoid arthritis (RA) starting at >60 years of age, has received less attention than young-onset RA. Polymyalgia rheumatica (PMR) is…
  • Abstract Number: 207 • 2018 ACR/ARHP Annual Meeting

    Divergent Patterns of Cardiovascular Risk in Biomarkers of Lipids and Subclinical Myocardial Injury during Increased Inflammation in Rheumatoid Arthritis

    Katherine P. Liao1, Jie Huang2, Gabrielle Cremone3, Ethan Lam3, Nicole Yang1, Martin Playford4, Christine K Iannaccone1, Jonathan Coblyn5, Elena Massarotti1, Michael E Weinblatt5, Nancy A. Shadick1, Nehal Mehta4 and Jorge Plutzky1, 1Brigham and Women's Hospital, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Rheumatology, Brigham and Women's Hospital, Boston, MA, 4NHLBI, Bethesda, MD, 5Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Inflammation is an independent risk factor for cardiovascular (CV) risk in rheumatoid arthritis (RA). Paradoxically, potentially cardioprotective decreases in inflammation is associated with increased…
  • Abstract Number: 1823 • 2018 ACR/ARHP Annual Meeting

    Loss of Synovial Tissue Resident Macrophages Permits Monocyte to Macrophage Differentiation and Inflammation in Hupo Mice

    Qi Quan Huang1, Renee E. Doyle2, Alexander Misharin3, Shang-Yang Chen4, Deborah R. Winter5 and Richard M. Pope2, 1Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/pulmonary, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, chicago, IL, 5Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: We established a mouse model (HUPO) by deletion of Flip in CD11c+ cells that spontaneously develops erosive inflammatory arthritis resembling rheumatoid arthritis (RA). Since…
  • Abstract Number: 306 • 2018 ACR/ARHP Annual Meeting

    The Role of Inflammation in the Evolution of MRI Erosions in the Feet of Patients with Early RA

    Hanyan Zou1, Karen A. Beattie2, Saara Totterman3, George Ioannidis1 and Maggie Larche2,4, 1McMaster University, Hamilton, ON, Canada, 2Medicine, McMaster University, Hamilton, ON, Canada, 3Qmetrics Technologies, Pittsford, NY, 4St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

    Background/Purpose: Patients with aggressive RA develop early structural damage. As persistent inflammation is associated with bone erosions, assessing inflammatory activity may be key in treatment…
  • Abstract Number: 1952 • 2018 ACR/ARHP Annual Meeting

    Experimental Tendinopathy Treatment with SM04755, a Topical Small Molecule Inhibitor of the Wnt Pathway

    Vishal Deshmukh, Timothy Seo and Yusuf Yazici, Samumed, LLC, San Diego, CA

    Background/Purpose: Tendinopathy is an inflammatory and degenerative disorder caused by injuries and overuse. The Wnt pathway is upregulated in chronic tendinopathy and involved in inflammation,…
  • Abstract Number: 562 • 2018 ACR/ARHP Annual Meeting

    Low Inflammation on Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis That Achieved Sustained Clinical Remission on Adalimumab

    Paul Emery1, Gerd R. Burmester2, Esperanza Naredo3, Ivan Lagunes Galindo4, Ying Zhang5, Xin Wang5, Maja Hojnik6 and Philip G. Conaghan7, 1University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 2Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, 3Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 4AbbVie Inc., North Chicago, IL, 5AbbVie, North Chicago, IL, 6AbbVie, Ljubljana, Slovenia, 7University of Leeds, Leeds, United Kingdom

    Background/Purpose: ACR and EULAR recommend bDMARD tapering in patients (pts) with rheumatoid arthritis (RA) who achieved stable clinical remission. Yet, there are limited systematically collected…
  • Abstract Number: 1994 • 2018 ACR/ARHP Annual Meeting

    Osteoarthritis Severity Is Reduced By Intra-Articular Administration of Hydrogen Sulfide

    Elena F. Burguera1,2, Angela Vela-Anero3, Carlos Vaamonde-Garcia3, Tamara Hermida-Gómez1,2, Purificacion Filgueira-Fernandez1,2, Lucía Gato-Calvo2, Rosa Meijide-Failde4 and Francisco J Blanco5, 1CIBER-BBN, Madrid, Spain, 2Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Agrupación Estratégica CICA-INIBIC, Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, 3Department of Physiotherapy, Medicine and Biological sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, 4Department of Physiotherapy, Medicine and Biological Sciences, Tissue Engineering and Regenerative Medicine group (University of A Coruña), A Coruña, Spain, 5Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

    Background/Purpose: Hydrogen sulphide (H2S) is recognized as a therapeutic target in osteoarthritis (OA). Exogenous supplementation with synthetic salts in in vitro models of OA has…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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