ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 2005 • 2018 ACR/ARHP Annual Meeting

    Identification of a Human Cartilage Microbial DNA Signature and Characterization of Distinct Microbiome Profiles Associated with Osteoarthritis

    Chris Dunn1,2, Cassandra Velasco1,3, Alexander Rivas4, Madison Andrews3,5, Paul Jacob6 and Matlock A. Jeffries2,7, 1Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4University of Arkansas for Medical Sciences, Little Rock, AR, 5Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 6Oklahoma Sport Science and Orthopedics, Oklahoma City, OK, 7Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Osteoarthritis (OA) is both the most common form of arthritis and a leading cause of chronic disability. Bacterial products, including lipopolysaccharide (LPS), have been…
  • Abstract Number: 796 • 2018 ACR/ARHP Annual Meeting

    Demographic and Clinical Features of Systemic Sclerosis Patients with Anti-U1RNP Antibodies: A European Scleroderma Trials and Research (EUSTAR) Analysis

    Wanlong Wu1,2, Petra Hoederath1, Eric Hachulla3, Paolo Airò4, Gabriele Valentini5, Marco Matucci Cerinic6, Franco Cozzi7, Gabriela Riemekasten8, Yannick Allanore9, Patricia Carreira10, Suzana Jordan11 and Oliver Distler1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 3Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, 4Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, 5Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, 6Division of Rheumatology, Division of Rheumatology, University of Florence, Florence, Italy, 7Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, 8Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, 9Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, 10Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, 11Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Anti-U1RNP antibodies can be detected in patients with systemic sclerosis (SSc). However, their prevalence and clinical correlation with organ-specific complications have not been well…
  • Abstract Number: 2006 • 2018 ACR/ARHP Annual Meeting

    Murine Ear Wound Cartilage Superhealer Trait Is Associated with Gut Microbiota Changes and Is Transferable to Non-Healer Mice By Gut Microbiome Transplant

    Chris Dunn1,2, Cassandra Velasco1,3, Madison Andrews3,4, Alexander Rivas5 and Matlock A. Jeffries2,6, 1Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5University of Arkansas for Medical Sciences, Little Rock, AR, 6Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. Previous studies…
  • Abstract Number: 884 • 2018 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Disease Activity Predicting Incident Clinically-Apparent Interstitial Lung Disease: A Prospective Cohort Study

    Jeffrey A. Sparks1, Tracy Doyle2, Jie Huang1, Beatrice Pan2, Elaine Fletcher2, Ritu Gill3, Hiroto Hatabu2, Mizuki Nishino4, David Murphy2, Taysir Mahmoud2, Christine K Iannaccone5, Michelle Frits2, Bing Lu6, Ivan O. Rosas7, Paul Dellaripa2, Michael E Weinblatt5, Elizabeth Karlson6 and Nancy A. Shadick2, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Beth-Israel Deaconess Medical Center, Boston, MA, 4Dana-Farber Cancer Institute, Boston, MA, 5Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 6Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 7BWH - Pulmonary, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Determining modifiable risk factors for interstitial lung disease (ILD) is crucial given its substantial morbidity/mortality. Treatment to target of remission/low disease activity improves articular…
  • Abstract Number: 2067 • 2018 ACR/ARHP Annual Meeting

    Dysbiosis-Dependent Inflammasomes Activation Drives Innate Immune Responses in Ankylosing Spondylitis Patients

    Francesco Ciccia1, Giuliana Guggino1, Aroldo Rizzo2, Stefania Raimondo3, Simon Milling4 and Riccardo Alessandro3, 1Rheumatology Unit, University of Palermo, Palermo, Italy, 2Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy, 3University of Palermo, Palermo, Italy, 4University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: A growing body of evidences indicate that the aberrant activation of innate immune systems, occurring in genetically predisposed patients, drives inflammatory processes in Ankylosing…
  • Abstract Number: 905 • 2018 ACR/ARHP Annual Meeting

    Serum Interleukin-6 Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Alvise Berti1, Roscoe Warner2, Kent Johnson3, Divi Cornec4, Darrell Schroeder5, Brian Kabat5, Carol Langford6, Gary S. Hoffman7, Cees G.M. Kallenberg8, Philip Seo9, Robert F. Spiera10, Eugene William St. Clair11, Fernando Fervenza12, John H. Stone13, Paul A. Monach14, Ulrich Specks15 and Peter A. Merkel16, 1Pulmonary and Critical Care, Mayo Clinic College of Medicine, Rochester, MN, 2University of Michigan Medical School, Ann Arbor,, MI, 3University of Michigan Medical School, Ann Arbor, MI, 4Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France, 5Mayo Clinic, Rochester, MN, 6Rheumatic and Immunologic Diseases, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 7Rheumatology, Cleveland Clinic, Cleveland, OH, 8Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 9Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 10Hospital for Special Surgery, New York, NY, 11Medicine, Duke University Medical Center, Durham, NC, 12Nephrology, Mayo Clinic, Rochester, MN, 13Rheumatology (Medicine), Massachusetts General Hospital, Harvard Medical School, Boston, MA, 14Section of Rheumatology, Boston University School of Medicine, Boston, MA, 15Mayo Clinic College of Medicine, Rochester, MN, 16Division of Rheumatology and the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The deregulated overproduction of interleukin (IL)-6 has been implicated in several inflammatory and antibody-mediated autoimmune diseases. We aimed to investigate serum IL-6 levels (sIL-6)…
  • Abstract Number: 2073 • 2018 ACR/ARHP Annual Meeting

    Role of miRNA-21-5p As a Potential Biomarker for the Inflammation Pathway in Psoriatic Disease and Response to Methotrexate Treatment

    Rohan Machhar1, Justine Y. Ye2, Vinod Chandran2 and Dafna D Gladman3, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis occurring in patients with psoriasis. miRNAs are small non coding RNAs whose main function, at a post…
  • Abstract Number: 990 • 2018 ACR/ARHP Annual Meeting

    Guanylate Binding Protein 5 (GBP5) Inhibits Rheumatoid Arthritis Synovial Fibroblast Mediated Inflammation and Tissue Destruction

    Mahamudul Haque1, Anil K. Singh1 and Salahuddin Ahmed1,2, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA

    Background/Purpose: Guanylate binding protein 5 (GBP5), an interferon gamma (IFN-γ) inducible protein, helps to defend against invading pathogens. However, its role and properties beyond anti-viral…
  • Abstract Number: 2075 • 2018 ACR/ARHP Annual Meeting

    Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients

    Michael Gashick1, Todd Wechter2, Tessa Barrett1, Sarah Azarchi2, Stuart Katz3, Andrea L. Neimann4, James Krueger5, Sanja Jelic6, Edward Fisher1, Jose U. Scher7 and Jeffrey S. Berger8, 1Medicine/Cardiology, New York University School of Medicine, New York City, NY, 2Dermatology, New York University School of Medicine, New York City, NY, 3Medicine/Cardiology, New York University School of Medicine, New York, NY, 4Department of Dermatology, New York University School of Medicine, New York, NY, 5The Rockefeller University, New York, NY, 6Medicine/Pulmonary, Columbia University Medical Center, New York City, NY, 7New York University School of Medicine, New York, NY, 8Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Psoriatic arthritis (PsA) and Psoriasis (PsO) are chronic inflammatory diseases associated with vascular inflammation and increased CVD risk. Few studies have examined vascular inflammatory…
  • Abstract Number: 991 • 2018 ACR/ARHP Annual Meeting

    Critical Role of Interleukin-1α (IL-1α) in IL-1β-Induced Inflammatory Responses: Cooperation with NF-κBp65 in Transcriptional Regulation

    Anil K. Singh1, Sabrina Fechtner1, Mukesh Chourasia2, Jerry Sicalo1 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India

    Background/Purpose: Interleukin-1β (IL-1β) and IL-1α are cytokines of IL-1 family that orchestrate acute and chronic inflammatory diseases. However, their distinct role or the extent of…
  • Abstract Number: 2077 • 2018 ACR/ARHP Annual Meeting

    Pathological Osteogenesis and Inflammation in Experimental Spondyloarthritis Are Associated with Aberrant Type H Blood Vessels and Development of High Endothelial Venules Accompanied By Ectopic Lymphoid Structures in Bone Marrow

    Merlijn Kaaij1, Jan Piet van Hamburg2, George Kollias3, Dominique Baeten1, Leonie van Duivenvoorde1 and Sander W. Tas2, 1Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Background/Purpose: Spondyloarthritis (SpA) is characterized by pathological osteogenesis, inflammation and extensive angiogenesis in inflamed tissues. TNF plays a central role in SpA pathology and transgenic…
  • Abstract Number: 1003 • 2018 ACR/ARHP Annual Meeting

    Neutrophil Response to Ultraviolet Light in Normal and Lupus Conditions

    Sladjana Skopelja-Gardner1, Xizhang Sun2, Joyce Tai3, Lucrezia Colonna3, Lena Tanaka4 and Keith B. Elkon5, 1Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 2Rheumatology, University of Washington, Seattle, WA, 3Division of Rheumatology, University of Washington, Seattle, WA, 4Medicine/Rheumatology, University of Washington, Seattle, WA, 5University of Washington, Seattle, WA

    Background/Purpose: Two-thirds of systemic lupus erythematosus (SLE) patients are sensitive to sunlight and artificial light. Ultraviolet (UV) B light induces sterile inflammation in the skin…
  • Abstract Number: 2101 • 2018 ACR/ARHP Annual Meeting

    UV-Induced Skin Inflammation Is Exacerbated in Lupus-Prone Ro60 Knockout Female Mice with Interferon Priming

    Masaoki Kawasumi1, Daiki Rokunohe1, Xizhang Sun2, Lena Tanaka2, Sladjana Skopelja-Gardner3, Edward Chiou2, Anne Davidson4, Sandra L. Wolin5 and Keith B. Elkon2, 1Medicine/Dermatology, University of Washington, Seattle, WA, 2Medicine/Rheumatology, University of Washington, Seattle, WA, 3University of Washington, Seattle, WA, 4Feinstein Institute for Medical Research, Manhasset, NY, 5National Cancer Institute, Frederick, MD

    Background/Purpose: Photosensitivity is a major symptom of lupus, and excessive sunlight can cause skin rashes and flares of disease activity in systemic lupus erythematosus (SLE).…
  • Abstract Number: 1012 • 2018 ACR/ARHP Annual Meeting

    Inhibition of Inflammation and Oxidative Stress in Systemic Sclerosis (SSc) Macrophages

    Rajan Bhandari1, Michael Ball2, Saemi Han2, Kathleen Aren3, Mary A. Carns3, Monique Hinchcliff4, Michael L. Whitfield5, Karen Liby6 and Patricia A. Pioli7, 1Geisel School of Medicine at Dartmouth, lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Rheumatology, Northwestern University, Chicago, IL, 5Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH, 6Michigan State University, East Lansing, MI, 7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disease of unknown etiology that is characterized by vasculopathy, fibrosis, and inflammation. Our work and that of…
  • Abstract Number: 2211 • 2018 ACR/ARHP Annual Meeting

    Technetium Tc 99m Tilmanocept: A Targeted Immunodiagnostic Radiopharmaceutical for the Assessment of Synovial Macrophage Activity in Rheumatoid Arthritis

    Arash Kardan1, Allison Kissling2, Bonnie Abbruzzese2, Ahmad Ismail2, Rachael Hershey2, Carley Hartings2, David Ralph2, Izabela Gierach2, Michael Blue2, Hannah Bailey2, Christopher Gablemann2, Katherine Repp2 and Frederick Cope2, 1Charles F. Kettering Memorial Hospital and Wright State University Boonshoft School of Medicine, Dayton, OH, 2Navidea Biopharmaceuticals, Inc., Dublin, OH

    Background/Purpose: Activated macrophages are a critical component of the inflammatory etiology of RA. It is well established that these macrophages perpetuate joint inflammation and destruction…
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