ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0749 • ACR Convergence 2020

    Locating Cellular Subsets in Rheumatoid Arthritis Synovium Using CO-Detection by IndEXing (CODEX)

    Isabella Wulur1, David Boyle2, Lin Zhang1, Andrea Martin1, Robert Benschop3 and Gary Firestein4, 1Eli Lilly, Indianapolis, IN, 2UC San Diego, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN, 4University of California, San Diego, La Jolla, CA

    Background/Purpose: To better understand site-of-disease mechanisms in arthritis, the phenotypes and organization of synovial cells and infiltrates are critical. Conventional histology-based approaches are limited in…
  • Abstract Number: 1037 • ACR Convergence 2020

    Relationship Between Air Quality and Sarcoidosis Inflammatory Activity

    Aaron Case1, Dustin Fraidenburg2, Israel Rubinstein2 and Christian Ascoli2, 1University of Illinois at Chicago, Chicago, IL, 2Division of Pulmonary,Critical Care, Sleep and Allergy; Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA, Chicago, IL

    Background/Purpose: African Americans [AA] and minorities in the lower socioeconomic strata of Chicago are disproportionately affected by pulmonary sarcoidosis, and regularly exposed to poorer air…
  • Abstract Number: 1374 • ACR Convergence 2020

    Secukinumab in the Treatment of Dactylitis in Patients with Psoriatic Arthritis: Post Hoc Analysis Results from a Randomized Phase 3 Trial

    Bruce Kirkham1, Peter Nash2, Sandra Navarra3, Erhard Quebe-Fehling4, Corine Gaillez4, Carlos Sastre4 and Philip Mease5, 1Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, 2School of Medicine Griffith University, Brisbane, Queensland, Australia, 3University of Santo Tomas, Manila, Philippines, 4Novartis Pharma AG, Basel, Switzerland, 5Seattle Rheumatology Associates, P.L.L.C., Seattle, WA

    Background/Purpose: Dactylitis is a key and frequent clinical manifestation of psoriatic arthritis (PsA)1 associated with significant disease burden and impaired function.2–3 Randomized controlled trials designed…
  • Abstract Number: 1697 • ACR Convergence 2020

    Immune Related Adverse Events from Checkpoint Inhibitor Therapy: Survey of Hospitalists’ Awareness and Experiences

    Cassandra Calabrese1, Alexa Meara2 and Varalakshmi Janamanchi1, 1Cleveland Clinic, Cleveland, OH, 2Ohio State University Wexner School of Medicine, Columbus, OH

    Background/Purpose: The introduction of immunologic checkpoint inhibitor therapy (ICI) has caused a paradigm shift in the world of cancer treatment. Their use, however, is attended…
  • Abstract Number: 0073 • ACR Convergence 2020

    A Cross-Species Map of Neutrophil Inflammatory Responses

    Felix Radtke1, Frank Huang2, Peter Nigrovic3 and Ricardo Grieshaber-Bouyer4, 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Baden-Wurttemberg, Germany, 2Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Darmstadt, Baden-Wurttemberg, Germany, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 4Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Heidelberg, Germany

    Background/Purpose: Neutrophils are important mediators of immune defense as well as key protagonists in immune-mediated disease. How these cells adapt differently to sterile and septic…
  • Abstract Number: 0528 • ACR Convergence 2020

    The Complex Relationship Between C4b Binding Protein, Warfarin and Antiphospholipid Antibodies

    Giorgia Grosso1, Kerstin Sandholm2, Aleksandra Antovic1, Iva Gunnarsson1, Agneta Zickert1, Anna Vikerfors3, Lennart Truedsson4, Maria Bruzelius1, Bo Nilsson5, Kristina Nilsson Ekdahl5 and Elisabet Svenungsson1, 1Karolinska University Hospital, Stockholm, Sweden, 2Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden, 3Swedish Medical Products Agency, Uppsala, Sweden, 4Lunds University, Lund, Sweden, 5Uppsala University, Uppsala, Sweden

    Background/Purpose: C4b Binding Protein (C4BP) is the main inhibitor of the classical complement pathway. Both β2glycoprotein-I (β2GPI), the main antigen in the antiphospholipid syndrome (APS),…
  • Abstract Number: 0772 • ACR Convergence 2020

    Modification of THP-1 Cells with Malondialdehyde-Acetaldehyde Increases Cellular Calcium Load Rendering Cells Susceptible to Citrullination of Self-Proteins

    Nozima Aripova1, Michael Duryee1, Xiarepati Tieliwaerdi1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The post translational modification of self-proteins with malondialdehyde-acetaldehyde (MAA) has been shown to alter protein function and antibodies to MAA are increased in both…
  • Abstract Number: 1041 • ACR Convergence 2020

    Pharmaco-epidemiology of Non-infectious Ocular Inflammatory Disease in a Tertiary Academic Center

    Sanjeev Patil1, Justine Cheng2, Lorraine Provencher3 and Scott Vogelgesang4, 1University of Vermont Medical Center, Essex Junction, VT, 2University of Iowa Hospitals and Clinics, Iowa City, IA, 3Cincinnati Eye Institute, Cincinnati, OH, 4University of Iowa Hospitals and Clinics, Iowa City, IA

    Background/Purpose: Non-Infectious Ocular inflammatory disease (OID) is a group of immune-mediated diseases involving the ocular surface, uveal tract, retina, optic nerve, and peri-orbital tissue. Patients…
  • Abstract Number: 1400 • ACR Convergence 2020

    cAMP Response Element Modulator (CREM)α Promotes PD-1- effector CD4+ T Cells in Psoriasis and Psoriatic Arthritis

    Sigrun Hofmann1, Franz Kapplusch2, Susanne Abraham3, Sarah Northey2, Susanne Russ1, Felix Schulze1, Anna Surace4 and Christian Hedrich5, 1Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 2Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom., Liverpool, United Kingdom, 3Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, Liverpool, United Kingdom, 5University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Psoriasis is a systemic autoimmune/inflammatory condition that primarily affects the skin, but also other organ systems. Effector CD4+ T lymphocytes have been identified as…
  • Abstract Number: 1796 • ACR Convergence 2020

    A Panel of Urinary Proteins Predicts Active Lupus Nephritis and Response to Rituximab Treatment

    Jennifer Davies1, Emil Carlsson1, Angela Midgley1, Eve Smith1, Ian Bruce2, Michael Beresford1 and Christian Hedrich3, 1Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, Liverpool, England, United Kingdom, 2Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Approximately 30% of patients with adult-onset systemic lupus erythematosus (SLE) develop lupus nephritis (LN). Presence and/or severity of LN are currently assessed by renal…
  • Abstract Number: 0075 • ACR Convergence 2020

    CD209+/CD14+ Dendritic Cells Characterization in Rheumatoid versus Psoriasis Arthritis Patients

    Viviana Marzaioli1, Achilleas Floudas2, Mary Canavan1, Siobhán Wade3, Kieran Murray4, Ronan Mullan5, Conor Hurson6, Douglas Veale7 and Ursula Fearon1, 1Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 2Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, 3Trinity College Dublin, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, 5Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 6St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which are at the interface between innate and adaptive immunity. There are different…
  • Abstract Number: 0558 • ACR Convergence 2020

    Statin Use Pattern in Patients with Inflammatory Joint Disease in a Single Site VA Medical Center

    Lenche Kostadinova1, Sofi Damjanovska2, Angela Gupta3, Ibtissam Gad4, Sameena Syed4, Alyssa Lange5, Corinne Kowal6, Carey Shive7, Christopher Burant4, Brigid Wilson4, David Canaday4, David Zidar8, Donald Anthony9 and Maya Mattar10, 1(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Highland Heights, OH, 2(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, 3(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, 4(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, ohio, 5Case Western Reserve University, Cleveland, 6Case western reserve university/Cleveland VA Medical Center, ohio, 7(2) Department of Pathology, Case Western Reserve University, ohio, 8Case Western Reserve University/Cleveland VA Medical Center, Cleveland, 9Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH, 10Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH

    Background/Purpose: Patients with inflammatory joint disease, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) carry increased risk of cardiovascular disease (CVD). Mechanisms…
  • Abstract Number: 0776 • ACR Convergence 2020

    The Influence of Adipokine Profile and Periodontal Infection in Early Stages of Rheumatoid Arthritis and First-degree Relatives

    Consuelo Romero-Sanchez1, Juliette De Avila2, Jeimmy Andrea Chaparro-Sanabria3, Philipe Chalem Choueka4, Juan Manuel Bello-Gualtero5, Alejandro Ramos-Casallas2, Lorena Chila-M2 and Wilson Bautista-Molano6, 1Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada / Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada /Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 2Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 3Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, 4Fundacion Instituto de Reumatología Fernando Chalem, Universidad El Rosario, Bogotá D.C., Colombia, 5Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada/ Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, 6University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia

    Background/Purpose: Early RA (eRA) patients have a significant incidence of periodontal inflammation and overweight/obesity. A similar degree of disease activity, functional disability and health-related quality…
  • Abstract Number: 1043 • ACR Convergence 2020

    Ocular Scleral Pathology and Immune-Mediated Inflammatory Diseases. Study of 170 Patients from a Single Universitary Center

    Lara Sanchez-Bilbao1, Inigo Gonzalez-Mazon2, José Luis Martín-Varillas3, David Martinez-Lopez4, Carmen Alvarez-Reguera1, Alba Herrero Morant1, Rosalia Demetrio-Pablo1, Vanesa Calvo-Río1, Miguel Ángel González-Gay5 and Ricardo Blanco1, 1Hospital Universitario Marques de Valdecilla, Santander, Spain, 2Hospital Universitario Marques de Valdecilla, Bezana, Spain, 3Hospital Sierrallana, Torrelavega, Spain, 4Hospital Universitario Marques de Valdecilla, Santander (SPAIN), Spain, 5Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain

    Background/Purpose: Ocular scleral pathology (OSP) includes episcleritis and scleritis. Episcleritis is generally a benign disease with a self-limited course, while scleritis is a more severe…
  • Abstract Number: 1402 • ACR Convergence 2020

    Galectin-3 Decreases the Activity of 4-1BB by Facilitating Its Decoy Surface Binding in Rheumatoid Arthritis

    Morten Aagaard Nielsen1, Kristian Juul-Madsen2, John Stegmayr3, Chao Gao4, Tue Wenzel Kragstrup1, Malene Hvid1, Thomas Vorup-Jensen1, Richard Cummings5, Hakon Leffler3 and Bent Deleuran1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark, 3Lund University, Lund, Sweden, 4Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 5Beth Israel Deaconess Medical Center Harvard Medical School, Boston

    Background/Purpose: Orchestration of immune checkpoints is central for the outcome of immune activation, especially in patients with rheumatoid arthritis (RA). We have previously shown that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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