ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0916 • ACR Convergence 2024

    Isocitrate Dehydrogenase 2 Mutations Are Associated with Autoimmune Rheumatologic Diseases in Chronic Myelomonocytic Leukemia

    Mahmut Kaymakci1, Anuya Natu2, Clifford Csizmar2, Terra Lasho2, Christy Finke2, Abhishek Mangaonkar1, Aref Al-Kali1, Hassan Alkhateeb1, Jenna Fernandez2, Matthew Koster1, Cornelia Weyand2, Mrinal Patnaik1 and Kenneth Warrington1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester

    Background/Purpose: Somatic mutations occurring in the hematopoietic system can be associated with concomitant hematologic and inflammatory diseases. Chronic myelomonocytic leukemia (CMML) is a hematologic neoplasm…
  • Abstract Number: 1197 • ACR Convergence 2024

    Safety and Immunogenicity of an Active Anti-IL-6 Immunotherapy in a Phase 1 Clinical Trial in Knee Osteoarthritis Patients

    François Rannou1, Christelle Nguyen1, Camille Daste1, Quentin Kirren1, marie-martine Lefevre-Colau1, Odile Launay2, Lucille Desallais3, Edita Dolimier3, René Azoulai3, Jean-Pierre Salles3 and Jean-François Zagury4, 1AP-HP. Centre-Université Paris Cité, Hôpital Cochin, Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Paris, Ile-de-France, France, 2Centre d’Investigation Clinique en Vaccinologie (CIC Cochin Pasteur), Hôpital Cochin, Paris, Ile-de-France, France, 3Peptinov, Paris, Ile-de-France, France, 4Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA 7528, Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, Paris, Ile-de-France, France

    Background/Purpose: Interleukin-6 (IL-6) is a major inflammatory cytokine involved in pain and potentially in osteoarthritis (OA) disease progression. PPV-06 is an IL-6-derived peptide coupled with…
  • Abstract Number: 1706 • ACR Convergence 2024

    Multi-omic Study in Patients with SITRAME Syndrome

    Yixiang Yves-Jean Zhu1, Angèle Soria2, Thomas Moreau3, Guilaine Boursier4, Vincent Bondet5, Françoise Donnadieu6, Clara Cretet7, Aness Haddouche7, Carine Schmidt3, Diego Bletry3, Emmanuelle Amsler2, Annick Barbaud2, Farah Rahal5, Yannick Chantran8, Margaux Cescato3, François Maillet9, Anne-Sophie Korganow10, Benjamin Chaigne11, Yannick Dieudonné10, Guillaume Lefevre12, Makoto Miyara7, Vivien Beziat13, Caroline Deswarte13, Michael White6, Sophie Georgin-lavialle1, Darragh duffy5 and Mathieu Paul Rodero3, 1Sorbonne Université, Department of internal medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 2Sorbonne Université, Department of dermatology and allergology, Tenon hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 3Université Paris CIté, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Faculté des Saint-Pères, Paris, France, 4University of Montpellier, Montpellier, 5Translational Immunology Unit, Institut Pasteur, Université Paris-Cité, Paris, France, Paris, France, 6Pasteur Institut, Laboratoire d'épidémiologie et analyse des maladies infectieuses, Paris, France, 7Sobonne University, Centre d'Immunologie et des Maladies Infectieuses, Paris, France, 8Departmen of Biological Immunology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 9AP HP, Paris, France, 10University of Strasbourg, Department of Clinical Immunology and Internal Medicine, Nouvel Hôpital Civil, Strasbourg, France, 11Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France, 12CHU Lille, Institut d’Immunologie, Lille, France., Lille, France, 13IMAGINE Institut, Human Genetics of Infectious Diseases Laboratory, Paris, France

    Background/Purpose: The SITRAME syndrome (Systemic Inflammatory Trunk Recurrent Acute Macular Eruption) is a newly described inflammatory entity affecting adult patients with no family history (Soria…
  • Abstract Number: 1989 • ACR Convergence 2024

    Higher Early Cumulative Glucocorticoid Exposure Is Associated with Worse Progression-Free Survival in Patients with Immune Checkpoint Inhibitor Inflammatory Arthritis

    Minerva Nong1, Deanna Jannat-Khah2, Karmela Kim Chan2, Nilasha Ghosh3 and Anne Bass4, 1Hospital for Special Surgery, Tampa, FL, 2Hospital For Special Surgery, New York, NY, 3Hospital for Special Surgery, New York, NY, 4Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: Although immune checkpoint inhibitors (ICI) have transformed cancer treatment, they unleash a range of immune-related adverse events (irAE), including inflammatory arthritis (ICI-IA). Glucocorticoids are…
  • Abstract Number: 2293 • ACR Convergence 2024

    Altered Expression of the MicroRNA Biogenesis Machinery Components Correlates with Inflammatory Parameters in Salivary Glands of Patient with Sjögren’s Disease

    Sergio Aguilera1, Patricia Carvajal2, Isabel Castro2, María-José Barrera3, Sergio González4, Claudio Molina3 and María-Julieta González2, 1Clinica Indisa, Santiago, Chile, 2Universidad de Chile, Santiago, Chile, 3Universidad San Sebastián, Santiago, Chile, 4Universidad Mayor, Santiago, Chile

    Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level (by translational blocking or mRNA degradation). The…
  • Abstract Number: 2616 • ACR Convergence 2024

    Associations of Circulating Inflammatory Cytokines with Long COVID Among Patients with Systemic Autoimmune Rheumatic Diseases

    Jeffrey Sparks1, Xiaosong Wang2, Pui Lee3, Kailey Brodeur4, Miao Lin5, Naomi Patel5, Yumeko Kawano6, Abigail Schiff7, Andrew King5, Jennifer Hanberg6, Shruthi Srivatsan5, Emily Kowalski6, Colebrook Johnson5, Kathleen Vanni6, Zachary Williams5, Grace Qian2, Caleb Bolden5, Kevin Mueller6, Katarina Bade6, Alene Saavedra6, Rathnam Venkat8 and Zachary Wallace9, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Boston Children's Hospital, Newton, MA, 4Boston Children's Hospital, Cumberland, RI, 5Massachusetts General Hospital, Boston, MA, 6Brigham and Women's Hospital, Boston, MA, 7Brigham and Women's Hospital, Cambridge, MA, 8Tufts University School of Medicine, Boston, MA, 9Massachusetts General Hospital, Newton, MA

    Background/Purpose: While the incidence of severe acute COVID-19 has decreased, post-acute sequelae of COVID-19 characterized by prolonged symptoms, or ‘long COVID,’ is common and associated…
  • Abstract Number: 0066 • ACR Convergence 2024

    Association Between Gut Microbiota, Inflammation, and Epigenetics in Rheumatoid Arthritis Patients

    jose Manuel Lisbona-Montañez1, Arkaitz Mucientes2, Patricia Ruiz-Limón3, Gracia María Martín-Nuñez4, Rocio Redondo-Rodríguez4, Laura Cano-García4, Sara Manrique-Arija5, Isabel Moreno-Indias2, Natalia Mena Vázquez6 and Antonio Fernández-Nebro7, 1University of Malaga, Malaga, Andalucia, Spain, 2IBIMA Plataforma BIONAND, Malaga, Andalucia, Spain, 3IBIMA, Instituto de Biomedicina de Málaga, Cordoba, Spain, 4IBIMA Plataforma Bionand, Malaga, Spain, 5Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 6IBIMA, Málaga, Andalucia, Spain, 7Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is not entirely known. Epigenetic modifications could be the link between genetic and environmental factors related to the…
  • Abstract Number: 0380 • ACR Convergence 2024

    Joint Acoustic Emissions as a Digital Biomarker for Knee Inflammation in Juvenile Idiopathic Arthritis: A Pilot Study Using Musculoskeletal Ultrasound as Ground Truth

    Quentin Goossens1, Christopher Nichols1, Diana Sofia Villacis-Nunez2, Lori Ponder3, Omer Inan4 and Sampath Prahalad5, 1Georgia Institute of Technology, Atlanta, GA, 2Emory University School of Medicine, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA, 4Georgia Institute of Technology, Marietta, GA, 5Emory + Children's Pediatric Institute, Atlanta, GA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic childhood arthropathy affecting 1 in 1000 children under 16, classified into seven categories by ILAR. Commonly, JIA…
  • Abstract Number: 0759 • ACR Convergence 2024

    Macrophage-Lineage Cells in Giant Cell Arteritis Express MMP12, Phagocytosis and Osteoclast-associated Molecules That May Contribute to Destruction of the Tunica Media

    Makoto Sugihara1, Nobumasa Watanabe2, Yuichiro Hara2, Yasumasa Nishito3, Mai Kounoe4, Kazunari Sekiyama4, Eisuke Takamasu5, Naofumi Chinen6, Kota Shimada5 and Hideya Kawaji2, 1Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Hokubu Medical Center, Tokyo, Japan, Higashimurayama-shi, Tokyo, Japan, 2Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 3Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 4Center for Medical Research Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 5Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, Fuchu-shi, Tokyo, Japan, 6Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Nambu Chiiki Hospital, Tokyo, Japan, Tama-shi, Tokyo, Japan

    Background/Purpose: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by inflammatory cell infiltration and destruction of the tunica media. In this study, we…
  • Abstract Number: 0921 • ACR Convergence 2024

    Deep Immunologic Profiling of Trisomy 8-associated Autoinflammatory Disease (TRIAD)

    Kalpana Manthiram1, Lihong Shi1, Yue Zhang2, Bayu Sisay3, Shouguo Gao4, Zhijie Wu4, Qin Xu1, Mary Bowes2, Laura Failla2, Neelam Redekar2, Abdel Elkahloun3, Pamela Schwartzberg1 and Daniel Kastner3, 1National Institute of Allergy and Infectious Disease, Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3National Human Genome Research Institute, Bethesda, MD, 4National Heart, Lung, and Blood Institute, Bethesda, MD

    Background/Purpose: Trisomy 8 mosaicism is associated with an inflammatory disease characterized by recurrent fever and oral, genital, and gastrointestinal ulcers, resembling Behçet’s disease. Little is…
  • Abstract Number: 1198 • ACR Convergence 2024

    Impact of Metabolic Syndrome on Knee Osteoarthritis Severity and Progression: A PROCOAC Cohort Study

    Natividad Oreiro1, Ana Raga2, Vanesa Balboa-Barreiro3, Ignacio Rego-Perez4, Belen Acasuso5, Laura Galindo Domínguez6 and francisco J Blanco7, 1CHUAC, La Coruna, Galicia, Spain, 2Grupo de Investigación en Reumatología (GIR). INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC). SERGAS, A Coruña, Spain, 3Unidad de Epidemiología Clínica y Bioeostadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC)., A Coruña, Spain, 4Instituto de Investigacion Biomedica de A Coruña-SERGAS, A Coruña, Spain, 5Unidad de Investigacion Clinica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas., Investigation, A Coruña, Spain, A Coruña, Spain, 6Instituto de Investigacion Biomedica de A Coruña (INIBIC), A Coruña, Spain, 7INIBIC-University of A Coruña, A Coruña, Spain

    Background/Purpose: The contribution of metabolic factors to the development of osteoarthritis (OA) has not been fully elucidated. The aim of this study is to analyze…
  • Abstract Number: 1712 • ACR Convergence 2024

    Transcriptome Analysis Characterizes the Role of Monocytes in Ankylosing Spondylitis with TNF-blocker Treatment

    Yulong Tang1, Jiangnan Xie2, Dachun Zhuo1, Qi ZHU3, Jiucun Wang1 and Jing Liu2, 1Fudan University, Shanghai, China (People's Republic), 2Fudan University, Shanghai, Shanghai, China (People's Republic), 3Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China (People's Republic)

    Background/Purpose: Ankylosing spondylitis (AS) is an autoimmune and auto-inflammatory disease characterized by chronic inflammation of the spine, sacroiliac joint, and occasionally peripheral joints. TNF-α inhibitor…
  • Abstract Number: 1991 • ACR Convergence 2024

    Initial Corticosteroid Dosing and Effects on Disease Activity, Survival, and Tumor Progression in Immune Checkpoint Inhibitor-induced Inflammatory Arthritis

    Muhammad Bukhari1, Ami Shah2, Clifton Bingham3, Michelle Jones4 and Laura Cappelli1, 1Johns Hopkins School of Medicine, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 3Johns Hopkins University, Baltimore, MD, 4Johns Hopkins School of Medicine, Pittsburgh, PA

    Background/Purpose: Immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) occurs in 3-7% of patients receiving ICI therapy for cancer. ICI-IA is routinely treated with corticosteroids, however, there…
  • Abstract Number: 2314 • ACR Convergence 2024

    Serum Calprotectin (S100A8/9) and Complement Factor C3 as Potential Inflammatory Markers in Obese and “CRP Negative” Early PsA Patients: Data from a Multicenter METAPSA Cohort

    Alla Ishchenko1, Margot Van Mechelen2, Sofia Pazmino3, Lies Storms4, Patrick Verschueren5, Rik Lories6 and Kurt de Vlam7, 1UZ Gasthuisberg, Leuven, Belgium, 2Antwerp University Hospital, Belgium, Antwerp, Belgium, 3KU Leuven University, Leuven, Belgium, Leuven, Belgium, 4KU Leuven, Leuven, Belgium, 5Department of Rheumatology, University Hospital Leuven and KU Leuven, Leuven, Belgium, 6Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 7Department of Rheumatology, UZ Leuven, and Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium

    Background/Purpose: Systemic inflammation is an integral part of psoriatic arthritis (PsA). Despite substantial inflammation in the affected tissues such as skin, entheses and joints, C-reactive…
  • Abstract Number: 2637 • ACR Convergence 2024

    Chaperone-mediated Autophagy in Synovitis Distinguishes Psoriatic Arthritis from Rheumatoid Arthritis

    Vincenzo Venerito1, Gerardo Cazzato2, Fabio Cacciapaglia3, Eleonora Ceglie4, Sergio Del Vescovo4, Teresa Caferri4, Giuseppe Lopalco4, Francesco Girolamo5 and Florenzo Iannone1, 1Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 2Pathology Unit - University of Bari "Aldo Moro", IT, Bari, Italy, 3Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 4Rheumatology Unit - University of Bari "Aldo Moro", IT, Bari, Italy, 5Human Anatomy Department - University of Bari "Aldo Moro", IT, Bari, Italy

    Background/Purpose: Recent studies have suggested that autophagy may play different roles in the pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Lysosome-associated membrane protein type 2A…
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