ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 1810 • ACR Convergence 2024

    Modulation of Type I Interferon Signaling by Anifrolumab Alters the Spatial Immune Landscape in Cutaneous Lupus Erythematosus

    Ksenia Anufrieva1, Rochelle Castillo2, Ce Gao2, Jessica Liu2, Neda Shahriari2, Kimberly Hashemi2, Dustin Taylor3, Rachael Rowley2, Elizabeth Rainone2, Avery LaChance2, Rachel Gate4, ilya Korsunsky2, Ruth Ann Vleugels5 and Kevin Wei6, 1BWH, Cambridge, MA, 2Brigham and Women's Hospital, Boston, MA, 3Vanderbilt University Medical Center, Nashville, TN, 410x Genomics, Pleasanton, CA, 5Brigham and Women's Hospital, Brookline, MA, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: Reliable and effective treatments for refractory cutaneous lupus erythematosus (CLE) remained elusive until the arrival of anifrolumab, a monoclonal antibody targeting the type I…
  • Abstract Number: 2032 • ACR Convergence 2024

    A Systematic Review of Treatment Strategies in VEXAS Syndrome

    Aviraag Vijaya Prakash1, Jose Garcia2, Anurag Goel3, Vinit Gilvaz4 and Raveena Midha5, 1Saint Vincent Hospital, Department of Internal Medicine, Worcester, MA, 2Brown University, East Greenwich, RI, 3The Warren Alpert Medical School of Brown University, Providence, RI, 4The Warren Alpert Medical School of Brown University, East Providence, RI, 5Kent Hospital/Brown University, Warwick, RI

    Background/Purpose: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, first described in 2020, is an autoinflammatory condition characterized by somatic mutations in the UBA1 gene.…
  • Abstract Number: 2557 • ACR Convergence 2024

    The Relation of Colchicine to Knee/hip Replacement Among People with Gout in a Population-based Cohort Study

    Zhiqiang Wang1, Sarah Tilley2, Christine Peloquin2, Eva Petrow3, Margaret Clancy2 and Tuhina Neogi2, 1Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), 2Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 3Boston Medical Center, Boston, MA

    Background/Purpose: Colchicine, an anti-inflammatory drug commonly used in gout, has been associated with a lower incidence of total knee/hip replacement compared to placebo among participants…
  • Abstract Number: 0023 • ACR Convergence 2024

    Adenosine and Guanosine-based Oligonucleotide Attenuates Catabolic Phenotypes in Chondrocytes and Slows Progression of Surgically Induced Osteoarthritis

    Yoonhee Kim1, Jin Han2 and Seungwoo Han3, 1Kyungpook National University School of Medicine, Buk-gu, Daegu, Republic of Korea, 2Kyungpook National University, Buk-gu, Daegu, Republic of Korea, 3Kyungpook national university hospital, Daegu, South Korea

    Background/Purpose: Adenosine is a potent endogenous modulator of inflammation; however, its clinical application is limited due to its extremely short half-life in blood. In this…
  • Abstract Number: 0230 • ACR Convergence 2024

    Spine and Sacroiliac Joint Involvement in Newly Diagnosed Patients with Inflammatory Bowel Disease – Clinical and MRI Findings from a Population-Based Cohort Study

    Nora Vladimirova1, Jakob Møller2, Mohamed Attauabi2, Gorm Madsen3, Lene Terslev4, Charlotte Wiell5, Viktoria Fana6, Sanja Bay Hansen3, Hartwig Siebner3, Jakob Seidelin2, Flemming Bentsen3, Kasper Gosvig7, Johan Burisch3 and Mikkel Ostergaard8, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Righospitalet, Copenhagen, Denmark, 2Herlev and Gentofte Hospital, copenhagen, Denmark, 3Hvidovre Hospital, copenhagen, Denmark, 4Rigshospitalet-Glostrup & COPECARE, Glostrup, Denmark, 5Rigshospitalet-Glostrup, Copenhagen, Denmark, 6Rigshospitalet-Glostrup, Glostrup, Denmark, 7Department of Radiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark, 8Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark

    Background/Purpose: In patients with inflammatory bowel disease (IBD), coexistence of spondyloarthritis (SpA), the most common extraintestinal manifestation, is associated with poor outcomes and impaired quality…
  • Abstract Number: 0562 • ACR Convergence 2024

    Serum Interleukin IL-40 as a Potential Biomarker Associated with Pro-inflammatory Activity in Inflammatory Bowel Diseases and Spondyloarthritis: A Preliminary Study

    Lucia Ondrejčáková1, Adéla Navrátilová2, Monika Gregová3, Kristýna Bubová4, Tomáš Grega5, Ladislav Šenolt6, Karel Pavelka7 and Lucie Andrés Cerezo8, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 21st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine Charles University, Prague, Czech Republic, 4Institute of Rheumatology and Charles University, Prague, Czech Republic, 53Department of Internal Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Charles University, Praha, Czech Republic, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Interleukin 40 (IL-40) is a novel cytokine with a proposed role in the pathogenesis of inflammatory diseases. Inflammatory bowel diseases (IBD)-associated with spondyloarthritis (SpA)…
  • Abstract Number: 0846 • ACR Convergence 2024

    Three Novel Metabolomic Signatures of Inflammation for Female Gout Risk: A Prospective Cohort Study over 26 Years

    Sharan Rai1, Hyon K. Choi2, Chio Yokose1 and Natalie McCormick1, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Only 20% of those with hyperuricemia develop clinically evident gout, suggesting that other, likely inflammatory, factors influence NLRP3 inflammasome activation and progression to gout.…
  • Abstract Number: 0957 • ACR Convergence 2024

    Increased Collagen Deposition and Altered Immune Cell Profiles Are Present in Early and Late Stage Systemic Sclerosis with Gastrointestinal Involvement

    Laura Much1, Elena Pachera2, Andrea Laimbacher1, Henriette Didriksen3, Lars Aabakken4, Knut Ea Lundin4, Lumeng Li1, Astrid Hofman1, Pietro Bearzi5, Sophie Wagner6, Michael Scharl7, Øyvind Molberg8, Håvard Fretheim9, Oliver Distler10 and Anna-Maria Hoffmann-Vold9, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3Oslo University Hospital, Moss, Norway, 4Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland, 6University of Zurich, Schlieren, Switzerland, 7Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 8Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 9Oslo University Hospital, Oslo, Norway, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: Gastrointestinal tract (GIT) involvement is highly prevalent among patients with systemic sclerosis (SSc) and is associated with high morbidity and mortality. However, treatment options…
  • Abstract Number: 1577 • ACR Convergence 2024

    Elevated Neutrophil Extracellular Traps in Systemic Sclerosis-associated Vasculopathy and Suppression by a Synthetic Prostacyclin Analog

    Neda Kortam1, Wenying Liang1, Claire Shiple1, Suiyuan Huang1, Rosemary Gedert1, James St. Clair1, Cyrus Sarosh2, Caroline Foster1, Eliza Pei-Suen Tsou1, John Varga1, Jason Knight1, Dinesh Khanna1 and Ramadan Ali1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: Neutrophils and neutrophil extracellular traps (NETs) contribute to the vascular complications of multiple diseases, but their role in systemic sclerosis (SSc) is understudied. We…
  • Abstract Number: 1830 • ACR Convergence 2024

    Single-cell RNA Sequencing Profiling of Very Early-Stage Systemic Sclerosis Skin Reveals a Fibroblast Pro-inflammatory Gene Signature and Keratinocyte Dysregulation

    Lumeng Li1, Elena Pachera2, Rucsandra Dobrota3, Kristina Bürki1, Carina Mihai3, Muriel Elhai4, Laura Much1, Astrid Hofman1, Pietro Bearzi5, Sophie Wagner6, Sarah Lötscher7, Anna-Maria Hoffmann-Vold8 and Oliver Distler9, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3University Hospital Zurich, University of Zurich, Zurich, Switzerland, 4University Hospital zurich, Zürich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland, 6University of Zurich, Schlieren, Switzerland, 7Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Zurich, Switzerland, 8Oslo University Hospital, Oslo, Norway, 9Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: The poor prognosis of patients with systemic sclerosis (SSc) underscores the need to prevent disease onset and irreversible organ damage. This study aims to…
  • Abstract Number: 2042 • ACR Convergence 2024

    Overview of Lung Manifestations in Sarcoidosis and Various Treatment Approaches at a University Center

    Aleeza Qamar1, Upasana Agrawal2, Karan Sachdeva3, Zara Hassan4, Alex Zamora1, Syeda Nida5, Sarwat Umer1, Samina Hayat1 and Kinza Muzaffar6, 1LSU Health-Shreveport, Shreveport, 2LSU Health, Shreveport, Shreveport, LA, 3Louisiana state university health shreveport LA, Shreveport, 4Louisiana State University Health Sciences, Shreveport, LA, 5LSU Healh-Shreveport, Shreveport, 6LSU HEALTH SHREVEPORT, SHREVEPORT, LA

    Background/Purpose: Sarcoidosis is a disease occurring in the form of non-caseating granulomas, with unclear etiology and multi-system manifestations. Pulmonary involvement in sarcoidosis is a cardinal…
  • Abstract Number: 2562 • ACR Convergence 2024

    Efficacy and Safety of Tocilizumab in the Treatment of Chronic Inflammatory Forms of CPPD: Retrospective Study of 55 Cases

    Sophie Carrabin1, Margaux Houze2, Charlotte Jauffret3, Thomas Bardin4, Hang Korng Ea4, Frédéric Lioté4, Pascal Richette5, Tristan Pascart2 and Augustin Latourte6, 1Hôpital Lariboisière APHP.Nord, Paris, Paris, France, 2Lille Catholic University, Lille, France, 3Lille Catholic University, Lille, Nord-Pas-de-Calais, France, 4Hôpital Lariboisière APHP.Nord, Paris, France, 5Lariboisière Hospital, Paris, France, 6AP-HP, Paris, France

    Background/Purpose: Calcium pyrophosphate deposition disease (CPPD) is a heterogeneous disease that can manifest as acute or chronic arthritis. Treatment options for chronic forms of the…
  • Abstract Number: 0024 • ACR Convergence 2024

    Trans-Signaling by Soluble CD14 Sensitizes Chondrocytes to Lipopolysaccharide Stimuli, Increasing Chondrocyte Inflammatory Responses

    Anna E. Rapp, Baofeng Hu and Carla Scanzello, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: The understanding of osteoarthritis (OA) has evolved significantly over the past decade. Recently attention is being drawn to the role of pattern-recognition receptor (PRR)…
  • Abstract Number: 0246 • ACR Convergence 2024

    Selectively Targeting TRBV11-2+ T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Using Bispecific T Cell-Engaging Antibodies

    Elana Shaw, Stephanie Glavaris, Brian Mog, Alexander Pearlman, Sarah DiNapoli, Jin Liu, Kyle J. Kaeo, Kenneth W. Kinzler, Chetan Bettegowda, Shibin Zhou, Bert Vogelstein, Suman Paul and Maximilian F. Konig, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but potentially deadly immune complication after infection with SARS-CoV-2. In patients with MIS-C, a striking…
  • Abstract Number: 0563 • ACR Convergence 2024

    Clinical Features of Patients with SpA, with or Without IBD: Results from the METEOR Cohort

    Manouk de hOoge1, Pedro M. Machado2, Sytske Anne Bergstra3, Maxime Dougados4, Clementina López Medina5, Victoria Navarro Compán6, Diego Benavent7, Denis Poddubnyy8, Levent kilic9, Philippe Carron10, Dirk Elewaut11, Filip Van den Bosch12 and Gaelle Varkas12, 1Dept. of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium, 2Department of Rheumatology, University College London Hospitals NHS Foundation Trust; and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust; and Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 3LUMC, Leiden, Netherlands, 4Rheumatology Department, Cochin Hospital and Clinical Epidemiology and Biostatistics, University of Paris, INSERM (U1153), Paris, France, 5Reina Sofia University Hospital, Cordoba, Spain, 6La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, 7Rheumatology Department, Hospital Universitari de Bellvitge, Barcelona, Spain, CAMBRILS, Spain, 8Charite-Universitatsmedizin Berlin, Berlin, Germany, 9Dept. of Rheumatology, Hacettepe University, Ankara, Turkey, Ankara, Turkey, 10UZ Gent, Gent, Belgium, 11Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, 12Ghent University Hospital, Ghent, Belgium

    Background/Purpose: To investigate clinical features of SpA patients with and without IBD, identifying the patient group that would benefit from initiating therapy with efficacy in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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