ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 1993 • ACR Convergence 2024

    Identification of Elevated Soluble Factors in Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis and Their Association with Severity and Persistence

    Elise Gray-Gaillard1, Clifton Bingham1, Ami Shah2 and Laura Cappelli3, 1Johns Hopkins University, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 3Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Immune checkpoint inhibitors (ICI) are a type of cancer immunotherapy being implemented as the standard of care for an increasing number of malignancies. Due…
  • Abstract Number: 2362 • ACR Convergence 2024

    Achievement of Remission Defined by Absence of Objective Signs of Inflammation versus ASDAS ID in Patients with Active Axial Spondyloarthritis Treated with Bimekizumab: 52-Week Results from Two Phase 3 Studies

    Lianne S Gensler1, Helena Marzo-Ortega2, Vanessa Taieb3, Diana Voiniciuc4, Alexander Marten5, George Stojan6, Mindy Kim6 and Martin Rudwaleit7, 1Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3UCB Pharma, Colombes, France, 4UCB Pharma, Slough, United Kingdom, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Atlanta, GA, 7University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany

    Background/Purpose: Bimekizumab (BKZ) is a monoclonal antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A. BKZ has demonstrated sustained efficacy and safety to Week…
  • Abstract Number: 2643 • ACR Convergence 2024

    Integrated Bulk and Single Cell RNA Sequencing Defines Key Pathways Regulating Myofibroblast Differentiation Across ANA Subgroups in Diffuse Systemic Sclerosis

    Kristina Clark1, Corrado Campochiaro2, Emma Derrett-Smith3, Voon Ong4, Christopher Buckley5 and Christopher Denton6, 1University of Oxford, Oxford, United Kingdom, 2IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 3University College London Division of Medicine, Birmingham, United Kingdom, 4University College London, London, England, United Kingdom, 5Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 6University College London, Northwood, United Kingdom

    Background/Purpose: Myofibroblasts are key cells in the pathogenesis of systemic sclerosis (SSc).  TGFβ is a key growth factor driving myofibroblast formation in SSc.  The main…
  • Abstract Number: 0069 • ACR Convergence 2024

    Activation of Cardiovascular Inflammation and Wnt Signaling in Spondyloarthritis: Insights from the HLA-B27 Transgenic Rat Model

    Su-Ah Yoon, Chorong Kim, Hansun Song, Mie Jin Lim and Seong-Ryul Kwon, College of Medicine, Inha University, Incheon, Republic of Korea

    Background/Purpose: Despite the well-documented link between cardiovascular (CV) disease and spondyloarthritis (SpA), no animal studies have empirically validated this connection or integrated SpA, vascular inflammation,…
  • Abstract Number: 0396 • ACR Convergence 2024

    Inflammatory Markers of Autoimmune Uveitis in the Eye, Tears and Blood

    Maryrose Hahn1, Madison Mangin2, Kellen Winden3, Pui Lee4, Mindy Lo2, Bharti Nihalani-Gangwani2, Yasmin Massoudi5, Tate Valerio5, Amanda Colombo5, Jessica Scott6, Stephen Anesi6, C. Stephen Foster6, Peter Nigrovic7, sheila Angeles-Han8, Peter Chang6 and Margaret Chang2, 1Boston Children's Hospital, Georgetown, MA, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, Boston, MA, 4Boston Children's Hospital, Newton, MA, 5Massachusetts Eye Research and Surgery Institution, Waltham, MA, 6Massachusetts Eye Research and Surgery Institution, Waltham, 7Boston Children's Hospital, Brookline, MA, 8Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose: Autoimmune uveitis is an inflammatory disorder of the eye that is associated with significant morbidity, including vision-threatening complications and chronic reliance on immunosuppressive therapies.…
  • Abstract Number: 0783 • ACR Convergence 2024

    Spatial Reconstruction of Interstitial Lung Disease

    Miles Tran1, Ce Gao1, Mukta G Palshikar1, Jessica Liu1, Mari Kamiya1, Gregory McDermott2, Elena Joerns3, Daimon Simmons1, Rachel Gate4, Deepak Rao5, Jeffrey Sparks6, Edy Kim7, Kevin Wei8 and ilya Korsunsky1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Brookline, MA, 3Mayo Clinic, Rochester, MN, 410x Genomics, Pleasanton, CA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 7Brigham and Women's Hospital, Cambridge, MA, 8Brigham and Women's Hospital at Harvard Medical School, Boston, MA

    Background/Purpose: Interstitial lung disease encompasses a heterogenous group of conditions broadly characterized by inflammation and progressive fibrosis of the lung[1]. There remains an ongoing search…
  • Abstract Number: 0928 • ACR Convergence 2024

    In Vitro Study of Fibroblast-Like Synoviocytes and Macrophages-Like Synoviocytes Isolated from Rheumatoid Arthritis, Psoriatic Arthritis Patients and Healthy Subjects

    monia Maccaferri1, Francesco Zambianchi2, Carlo Salvarani3 and Elisa Pignatti3, 1Azienda Ospedaliero Universitaria di Modena, Modena, Italy, 2Department of Maternal, Child and Adult Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy, 3Department of Surgery, Medicine Dentistry and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

    Background/Purpose: Interactions between fibroblast-like synoviocytes (FLSs) and macrophage-like synoviocytes (MLSs) are pivotal in the pathogenesis of RA and PsA. FLSs both activate and are activated…
  • Abstract Number: 1385 • ACR Convergence 2024

    A Novel Oral 3D-Printed Delayed- and Extended-Release Tofacitinib (T19) for the Treatment of Rheumatoid Arthritis and Related Inflammatory Diseases

    Yue Zhou, Meng Ji, luo wang, Feihuang Deng, Senping Cheng, Xiaoling Li and Yulian Zhang, Triastek, Inc., Nanjing, China (People's Republic)

    Background/Purpose: Patients with inflammatory diseases, such as rheumatoid arthritis (RA), frequently continue to suffer from morning symptoms despite treatment with conventional therapies 1,2.  Routine morning…
  • Abstract Number: 1788 • ACR Convergence 2024

    Memory B Cell Activation and Dysregulation in Systemic Lupus Erythematosus

    Shady Younis1, Salvinaz Moutusy2, Shaghayegh Jahanbani2, Xiaohao Wu2, Marlayna Harris2, Mahesh Pandit3, Laura van Dam4, orr Sharpe5, Paul Utz1 and William Robinson6, 1Stanford University, Stanford, CA, 2Stanford University School of Medicine, Stanford, 3Stanford University School of Medicine, Stanofrd, 4Stanford, Palo Alto, CA, 5Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 6Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: B cell dysregulation and production of autoantibodies against autoantigens are hallmarks of Systemic lupus erythematosus (SLE). In healthy adults (HC), B cells with autoreactive…
  • Abstract Number: 1998 • ACR Convergence 2024

    Association Between Small Interfering RNA Therapy and Autoimmune Diseases: U.S. Prospective Cohort Study

    Liang Sien Chen, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City, Taoyuan, Taiwan (Republic of China)

    Background/Purpose: Monoclonal antibody (mAb) therapy and small interfering RNA (siRNA) therapy represent two cutting-edge approaches in treating various diseases, such as hyperlipidemia. Our study aims…
  • Abstract Number: 2386 • ACR Convergence 2024

    Landscape of Immune Cells and Autoimmunity in Systemic Lupus Erythematosus Patients with Obesity

    Alexandra Reese1, Chandana Keshavamurthy2, Sneha Centala1, Samantha Ahrens1, Shivani Shah2, Douglas Reeves2, William Davis3, Robert Quinet4, Jerald Zakem1, Qingli Wu1, Kimmy Tran1, Teresa Leeth5, Daniyal Nadeem6, Sarwat Umer7, Samina Hayat5 and Xin Zhang1, 1Ochsner Health, New Orleans, LA, 2Ochsner Clinic Foundation, New Orleans, 3Ochsner Health System, New Orleans, LA, 4Ochsner Health, River Ridge, LA, 5Louisiana State University Shreveport, Shreveport, LA, 6LSU Shreveport, Shreveport, 7LSU HEALTH SHREVEPORT, SHREVEPORT, LA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by autoantibodies and disruption of multiple organs due to immunomodulatory dysfunction. Obesity is a…
  • Abstract Number: 2655 • ACR Convergence 2024

    Diagnostic Challenges of Dermatomyositis: A Retrospective Study of Its Dermatologic Mimics and Misdiagnoses

    Aaron Bao1, Eleni Tiniakou2, Lisa Christopher-Stine3, Christopher Mecoli3, Jemima Albayda1, Julie Paik3, William Kelly4 and Jun Kang5, 1Johns Hopkins School of Medicine, Baltimore, MD, 2Johns Hopkins University, Lutherville Timonium, MD, 3Johns Hopkins University, Baltimore, MD, 4Johns Hopkins University, Hillsboro, NH, 5Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Dermatomyositis (DM) is often misdiagnosed due to its diverse clinical presentation. This study aimed to identify common dermatologic mimics of DM, characterize misdiagnosis rates…
  • Abstract Number: 0070 • ACR Convergence 2024

    Shared and Unique Fecal and Plasma Metabolic Signatures and Increased Inflammatory Markers in Ankylosing Spondylitis, Psoriatic Arthritis and Acute Anterior Uveitis

    Sneha Couvillion1, Javier Flores1, Sean Davin2, Kimberly Ogle2, Emma Fale-Olsen2, John Davis2, Gina Many1, Carley Shaut2, Tammy Martin2, Eric Suhler2, Atul Deodhar3, James Rosenbaum4, Ernesto Nakayasu1 and Tejpal Gill2, 1PNNL, Richland, WA, 2OHSU, Portland, OR, 3Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 4Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Spondyloarthritis (SpA) is a group of immune-mediated inflammatory disorders such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), along with acute anterior uveitis (AAU)…
  • Abstract Number: 0461 • ACR Convergence 2024

    Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis

    ivan Ferraz-Amaro1, Maria Garcia-Gonzalez2, Fuensanta Gomez-Bernal3, Juan Carlos Quevedo-Abeledo4 and Miguel Angel Gonzalez-Gay5, 1Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 2Hospital Universitario de Canarias, SC Tenerife, Canarias, Spain, 3Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 4Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 5University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain

    Background/Purpose: The complement (C) system has been implicated in the etiopathogenesis of rheumatoid arthritis (RA). We aimed to examine the correlation between an in-depth evaluation…
  • Abstract Number: 0801 • ACR Convergence 2024

    Neutrophil Activation as a Novel Marker of Lung Disease in Rheumatoid Arthritis

    Jia Shi1, Yang Wu1, Ting Wang2, Chen Yu3, qian wang4, Xinping Tian5, Mengtao Li4, Kristen Demoruelle6, Joshua Solomon7 and Christian Lood2, 1University of Washington, Seattle, 2University of Washington, Seattle, WA, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Cheng Qu, China (People's Republic), 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7National Jewish Health, Denver, CO

    Background/Purpose: Neutrophil activation is seen in rheumatoid arthritis (RA), but its involvement in RA interstitial lung disease (RA-ILD) is not clear. Levels of N-formyl methionine…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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