ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0486 • ACR Convergence 2023

    Identifying Serum Metabolomic Markers Associated with Psoriasis Skin Disease Activity

    Hani Choksi1, Sheng Han Li2, Nikita Looby2, Max Kotlyar3, Vathany Kulasingam4, Igor Jurisica5 and Vinod Chandran6, 1Schroeder Arthritis Institute, Krembil Research Institute, Krembil Research Institute, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 4Department of Laboratory Medicine and Pathobiology, University of Toronto and Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, 6Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriasis is a chronic, immune-mediated inflammatory skin disease that affects over 2.5% of the global population. Approximately 25% of psoriasis patients also have a…
  • Abstract Number: 0881 • ACR Convergence 2023

    Deficiency of the Pattern-recognition Receptor CD14 Protects Against LPS-induced Inhibition of Osteoclastogenesis in Vitro

    Lance Murphy1, Kevin Burt2, Baofeng Hu3, Vu Nguyen2, Robert Mauck2 and Carla Scanzello2, 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Wynnewood, PA

    Background/Purpose: Osteoarthritis is associated with bone changes such as subchondral sclerosis, bone marrow lesions, and osteophyte formation (Donel S, 2019). Prior work has demonstrated that…
  • Abstract Number: 1132 • ACR Convergence 2023

    Preclinical Profiles of FZ007-119, a Highly Potent and Selective Tyk2 Inhibitor, for the Treatment of Immune Mediated Inflammatory Diseases

    Wenhe Zhong, Jielian Lu, Dong Chen, Shiqun Zhang and Daiguo Deng, Guangzhou Fermion Technology Co., LTD, Guangzhou, China

    Background/Purpose: Tyrosine Kinase 2 (TYK2) is a signaling protein within the Janus kinase (JAK) family. It plays a crucial role in transmitting signals from pro-inflammatory…
  • Abstract Number: 1663 • ACR Convergence 2023

    Clinically Severe Systemic Sclerosis Skin Harbors Inflammatory Fibroblasts Associated with Lymphocytes and Plasmacytoid Dendritic Cells

    Kimberly Lakin1, Robert Spiera2, Yaxia Zhang1, David Oliver1, Aliza Bloostein1, Hiranmayi Ravichandran3, Niroshana Anandasabapathy3, Franck Barrat1, Jessica Gordon1 and Dana Orange4, 1Hospital for Special Surgery, New York, NY, 2Hosptial for Special Surgery, New York, NY, 3Weill Cornell Medical College, New York, NY, 4The Rockefeller University, New York, NY

    Background/Purpose: We have previously shown that skin fibroblast activation is related to clinical severity and resolves with improvement in diffuse systemic sclerosis (dcSSc). The immune…
  • Abstract Number: 1761 • ACR Convergence 2023

    JAK/STAT Inhibition Modifies the Innate Lymphoid Cells 1 Immune Response in Patients with Rheumatoid Arthritis

    Lidia La Barbera1, Marianna Lo Pizzo1, Chiara Rizzo1, Leila Mohammadnezhad1, federica Camarda1, Francesco Ciccia2 and Giuliana Guggino1, 1University of Palermo, Palermo, Italy, 2University of Campania - Luigi Vanvitelli, Naples, Italy

    Background/Purpose: Recent evidence suggests that innate lymphoid cells (ILCs) might be involved in rheumatoid arthritis (RA) pathogenesis and individuals at risk of RA exhibited an…
  • Abstract Number: 2047 • ACR Convergence 2023

    Safety of Baricitinib for COVID-19 Related Hyperinflammation in Pediatric Patients: A Large Tertiary Care Center Experience

    Meredith Rae1, Jessica Nguyen2, Marietta DeGuzman3, Catherine Foster1, Flor Munoz1 and Eyal Muscal4, 1Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine, Manvel, TX, 3Baylor College of Medicine / Texas Children's Hospital, Houston, TX, 4Division of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX

    Background/Purpose: A small proportion of children with acute COVID-19 experienced life-threatening hyperinflammation. It has been proposed that an innate immune recognition of viral RNA triggers…
  • Abstract Number: 2549 • ACR Convergence 2023

    Effect of Ixekizumab Treatment on MRI Structural Lesions in the Sacroiliac Joints of Patients with Radiographic Axial Spondyloarthritis; A Post-hoc Analysis of a Placebo and Active Controlled RCT

    Walter P. Maksymowych1, Robert Lambert2, Eswar Krishnan3, Baojin Zhu3, Rebecca Bolce3 and Mikkel Østergaard4, 1University of Alberta, Edmonton, AB, Canada, 2Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 3Eli Lilly and Company, Indianapolis, IN, 4Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: The effect of Ixekizumab (IXE) on structural lesions in the sacroiliac joints (SIJ) of patients (pts) with radiographic Axial Spondylarthritis (r-axSpA) assessed by magnetic…
  • Abstract Number: 0075 • ACR Convergence 2023

    Proteomic, Transcriptomic, and T-Cell Receptor (TCR) Profiling of Synovial Integrin-Expressing (InEx) T Cells in Axial Spondyloarthritis (axSpA)

    Zoya Qaiyum1, Michael Tang2 and Robert Inman2, 1Krembil Research Institute, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada

    Background/Purpose: The strong clinical and genetic associations between axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) underscore the pathogenic role of the gut-joint axis. The…
  • Abstract Number: 0495 • ACR Convergence 2023

    Prevalence of Undiagnosed Inflammatory Bowel Disease in Patients with Spondyloarthritis: EISER Study

    Jesus Sanz1, Zulema Plaza2, Jordi Gratacos Masmitja3, Iago Rodríguez -Lago4, Elisa Trujillo5, Ignacio Marin-Jimenez6, Eva Perez-Pampin7, Manuel Barreiro de Acosta8, Antonio Aznar Esquivel9, Marta Carrillo Palau10, Maria Luz Garcia Vivar11, Maria Carmen Muñoz12, Lourdes Ladehesa Pineda13, Eva Iglesias Flores14, carolina Merino15, Yago gonzalez-Lama16, Marta Arévalo Salaet17, Xavier calvet18, Anahy Maria Brandy-Garcia19, Marta Izquierdo Romero20, SARA MANRIQUE21, Raúl Olmedo22, Jose Francisco Garcia Llorente23, Sandra Pérez24, Inmaculada Ros25, Nuria Rull26, Jose Antonio Pinto Tasende27, Patricia Ucha Abal28, Carlos M González29, Fernando José Rodríguez Martínez30, Soledad Serrano Ladron de Guevara31, Marta Domínguez32, Francisco Javier Prado33, Enrique González-Dávila34 and Ana Gutierrez-Casbas35, 1Hospital Universitario Puerta de Hierro, Majadahonda, Spain, 2Universidad Autónoma de Madrid, Madrid, Spain, 3University Hospital Parc Taulí, Sabadell, Spain, 4Gastroenterology department Hospital Galdakao, Galdakao, Spain, 5Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 6Public Health System, Madrid, Spain, 7Rheumatology Department Complejo Hospitalario Universitario Santiago, Santiago de compostela, Spain, 8Gastroenterology department Complejo Hospitalario Universitario Santiago, Santiago de compostela, Spain, 9Rheumatology Department Hospital Universitario Canarias, Santa Cruz de Tenerife, Spain, 10Gastroenterology department Hospital Universitario Canarias, Santa Cruz de Tenerife, Spain, 11Basurto University Hospital, Bilbao, Spain, 12Gastroenterology department Basurto Hospital, Bilbao, Spain, 13Rheumatology Department Reina Sofia Universitary Hospital, Cordoba, Spain, 14Gastroenterology department Hospital Reina Sofia, Cordoba, Spain, 15Rheumatology Department Hospital Universitario Puerta de Hierro, Majadahonda (Madrid), Spain, 16Gastroenterology department Hospital Puerta de Hierro Majadahonda, Majadahonda, Spain, 17Rheumatology Department University Hospital Parc Taulí, Sabadell, Spain, 18Gastroenterology department University Hospital Parc Taulí, Sabadell, Spain, 19Hospital Germans Trias i Pujol, Badalona, Spain, 20Gastroenterology department Hospital Cabueñes, Gijon, Spain, 21Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, 22Gastroenterology department Hospital Regional Universitario Málaga, Malaga, Spain, 23Hospital de Gadakao Usansolo Osakidetza, Bilbao, Spain, 24Gastroenterology department Hospital Galdakao, Galdakao, Spain, 25Rheumatology Department HUSLL, Palma de Mallorca, Spain, 26Gastroenterology department HUSLL, Palma de Mallorca, Spain, 27Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 28Gastroenterology department Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, 29Rheumatology Department Hospital Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, 30Rheumatology Department Hospital Universitario General Santa Lucia, Murcia, Spain, 31Gastroenterology department Hospital Universitario General Santa Lucia, Murcia, Spain, 32Sociedad Española de Reumatología, Madrid, Spain, 33Research department Hospital Infantil de México Federico Gómez, Mexico City, Mexico, 34Department of Mathematics, Statistics and Operation Reseach La Laguna University, La Laguna, Spain, 35Gastroenterology department Hospital General Universitario de. Dr. Balmis de Alicante Servicio Digestivo. ISABIAL y CIBERehd, Alicante, Spain

    Background/Purpose: EISER is a cross-sectional, multicenter, observational, SER-GETECCU cooperative study involving 13 Spanish hospitals whose main objective was to estimate the prevalence of undiagnosed Inflammatory…
  • Abstract Number: 0882 • ACR Convergence 2023

    Activation of Ovarian Cancer G-Protein Coupled Receptor (OGR1) Attenuates Chondrocytes Inflammation via ERK1/2 Signaling Pathways in an in Vitro Model of Osteoarthritis

    Omar Syed, Bhakti Patel, William Martin, Martha Diaz-Hernandez, Hicham Drissi and Mohd Nazir Khan, Emory University, Atlanta, GA

    Background/Purpose: Osteoarthritis (OA) is the most prevalent joint disease, accounting for 50% of the musculoskeletal burden. Inflammation plays a crucial role in the development of…
  • Abstract Number: 1139 • ACR Convergence 2023

    From Skin to Bone Lesions: A Pioneer Study Unraveling the Underdiagnosis of SAPHO Syndrome in the Dominican Republic

    Leeany Maletta1, Diana Jimenez2 and Rosanna de Jesus3, 1UNIBE School of Medicine, San Antonio, TX, 2UNIBE School of Medicine, Miami, FL, 3Hospital General Plaza de la Salud, Distrito Nacional, Dominican Republic

    Background/Purpose: SAPHO syndrome is a rare chronic inflammatory condition that affects the skin and osteoarticular structures. Despite being first described over 30 years ago, it…
  • Abstract Number: 1670 • ACR Convergence 2023

    Exacerbation of Immune-mediated Inflammatory Diseases in COVID19 Sequelae

    CAMILA CAETANO1, Tamiris Azamor1, Nikki M. Meyer1, Cassandra Calabrese2, Leonard Calabrese2, Nicolas Piuzzi3, M. Elaine Husni2, Suan-Sin Foo1 and Weiqiang Chen1, 1Cleveland Clinic / Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland, OH, 2Cleveland Clinic / Department of Rheumatic and Immunologic Diseases, Cleveland, OH, 3Cleveland Clinic / Department of Orthopedic Surgery, Cleveland, OH

    Background/Purpose: Patients with underlying immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), have a higher susceptibility to severe COVID19…
  • Abstract Number: 1766 • ACR Convergence 2023

    Inflammatory Priming of the Joints via Pre-activation of Macrophages by Anti-MAA Antibodies in Rheumatoid Arthritis

    Marcelo Afonso1, Jitong Sun1, Koji Sakuraba1, Anca Catrina1, Aase Hensvold2, Caroline Grönwall1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet. Center for Rheumatology, Academic Specialist Center, Stockholm, Sweden

    Background/Purpose: We have previously shown that certain malondialdehyde/acetaldehyde modified protein binding autoantibodies (anti-MAA), obtained from the inflamed joints of rheumatoid arthritis (RA) patients, induced osteoclast…
  • Abstract Number: 2119 • ACR Convergence 2023

    Serum Alarmin Concentrations and Risk of Incident Major Adverse Cardiovascular Events and Heart Failure in a Multicenter, Prospective Rheumatoid Arthritis Cohort

    Tate Johnson1, Yangyuna Yang1, Punyasha Roul1, Michael Duryee1, Carlos Hunter1, Joshua Baker2, Brian Sauer3, Grant Cannon4, Amy Joseph5, K Wysham6, Aleksander Lenert7, Geoffrey Thiele1, Jill Poole1, Ted R Mikuls8 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3Salt Lake City VA/University of Utah, Salt Lake City, UT, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Washington University / St. Louis VA, St. Louis, MO, 6VA Puget Sound/University of Washington, Seattle, WA, 7University of Iowa, Iowa City, IA, 8Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Alarmins are endogenous cytokines released following cellular damage and physiologic stress to promote homeostasis through tissue inflammation, remodeling, and fibrosis. Alarmins may facilitate maladaptive…
  • Abstract Number: 2550 • ACR Convergence 2023

    The Incidence of Uveitis in Patients with Axial Spondylarthritis Treated with Biologics or Targeted Synthetics: A Systematic Review and Network Meta-analysis

    Zijing Yang1, Maryam Adas1, Bechman Katie1, Deepak Nagra1, Ali Soykan Uguzlar1, Mark Russell1, Nicky Wilson2, Sophia Steer1, Sam Norton1 and James Galloway1, 1King's College London, London, United Kingdom, 2King's College Hospital, London, United Kingdom

    Background/Purpose: Anterior uveitis (AU) is one of the commonly observed extraspinal manifestations in Axial spondyloarthritis (AxSpA). Data on the protective effects of targeted immunomodulatory therapies…
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