Abstracts tagged "inflammation and rheumatoid arthritis (RA)"

Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting
Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease
Tsuyoshi Shirai¹, Eric L. Matteson², David G. Harrison³, Barbara B. Wallis⁴, Themistocles L. Assimes⁵, Jorg J. Goronzy⁶ and Cornelia M. Weyand¹, ¹Medicine, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
Abstract Number: 2872 • 2013 ACR/ARHP Annual Meeting
Long Noncoding RNA Nron Regulates The Cytoplasmic-Nuclear Shuttling and Activity Of NFAT5 In Rheumatoid Arthritis Synovial Fibroblast
Kunihiko Umekita¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay¹ and Mojca Frank Bertoncelj⁵, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) are critical regulators of gene expression and of major biological processes, such as cell migration, proliferation and invasion. The lncRNA…
Abstract Number: 2262 • 2013 ACR/ARHP Annual Meeting
Antibody To Malondialdehyde-Acetaldehyde Adducts (MAA) Is a Biomarker Of Inflammation and Is Correlated With The Disease Activity In Rheumatoid Arthritis
Kathleen Young¹, Dathe Benissan-Messan², Michael J. Duryee³, Daniel Anderson⁴, Liron Caplan^5,6, Lisa A. Davis^7,8,9, Harlan Sayles⁴, Carlos D. Hunter³, Lynell W. Klassen¹⁰, James R. O'Dell¹¹, Ted R. Mikuls⁴ and Geoffrey M Thiele¹², ¹Int Med/Sec of Rheum/Immun, University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, ⁶Department of Medicine, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, Univ. of Colorado Sch. of Medicine, Aurora, CO, ⁸Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, ⁹Denver Veterans Affairs Medical Center, Denver, CO, ¹⁰Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹¹Dept of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ¹²Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). While there are many markers used…
Abstract Number: 1411 • 2013 ACR/ARHP Annual Meeting
The Peroxisome Proliferator Activated Receptor-gamma pioglitazone Decreases Cardiovascular Risk and Disease Activity In Patients With Rheumatoid arthritis
Wendy Marder¹, Shokoufeh Khalatbari², James D. Myles³, Rita Hench⁴, Susan Lustig⁴, Srilakshmi Yalavarthi⁵, Aishwarya Parameswaran⁴, Robert Brook² and Mariana J. Kaplan⁶, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Medicine, University of Michigan at Ann Arbor, Ann Arbor, MI, ³Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Michigan Rheumatology, Ann Arbor, MI, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Rheumatoid arthritis (RA) is associated with heightened mortality due to atherosclerotic cardiovascular disease (CVD). Inflammatory pathways in RA negatively affect vascular physiology and promote…
Abstract Number: 1345 • 2013 ACR/ARHP Annual Meeting
Retinal Vascular Calibre – a Novel Biomarker Of Inflammation and Treatment Response In Rheumatoid Arthritis
John HY Moi^1,2, Lauren AB Hodgson^3,4,5, Ian P Wicks^1,6,7, Tien Yin Wong^3,4,5,8 and Sharon Van Doornum^1,3,9, ¹Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, ²Department of Medicine, The University of Melbourne, Melbourne, Australia, ³The University of Melbourne, Melbourne, Australia, ⁴Royal Victorian Eye and Ear Hospital, Melbourne, Australia, ⁵Centre for Eye Research Australia, Melbourne, Australia, ⁶Department of Medical Biology, University of Melbourne, Parkville, Australia, ⁷Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia, ⁸Singapore Eye Research Institute, Singapore, Singapore, ⁹Melbourne EpiCentre, The Royal Melbourne Hospital, Melbourne, Australia
Background/Purpose: Retinal vascular calibre measurement is a non-invasive tool for assessing systemic and vascular health. Widened retinal venular calibre (RVC) is associated with systemic inflammation,…
Abstract Number: 386 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated With Systemic Inflammation In Coronary Vessels
Inge A.M. van den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI), as compared to the…
Abstract Number: 387 • 2013 ACR/ARHP Annual Meeting
Left Ventricular Myocardial Tissue In Rheumatoid Arthritis Shows Systemic Inflammation After Fatal Myocardial Infarction
Inge A.M. van Den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI) and a diminished survival…
Abstract Number: 358 • 2013 ACR/ARHP Annual Meeting
Inflammatory Burden Predicts Carotid Plaque Progression and Subsequent Cardiovascular Events In Rheumatoid Arthritis: The 2-Year Prospective Cohort Study
Churl Hyun Im¹, Sang Hoon Kwon², Jeong Soo Eun¹, Na Ri Kim¹, Eon Jeong Nam¹ and Young Mo Kang³, ¹Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ²Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ³Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea
Background/Purpose: Rheumatoid arthritis (RA) patients have increased prevalence of carotid atherosclerosis, especially plaque formation, which has been associated with inflammatory burden in a previous study.…
Abstract Number: 2097 • 2012 ACR/ARHP Annual Meeting
Adiponectin Is Associated with Pro-Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives (FDRs) of Patients with Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kevin D. Deane², Lezlie A. Derber³, Gary O. Zerbe⁴, Dana M. Dabelea¹, Jeremy Sokolove⁵, William H. Robinson⁶, V. Michael Holers⁷ and Jill M. Norris⁸, ¹Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: While adiponectin is generally considered an anti-inflammatory adipokine, it has also been shown to participate in active RA in inflammatory, matrix-destructive and fibrotic processes…
Abstract Number: 1658 • 2012 ACR/ARHP Annual Meeting
Signal Transducer and Activator of Transcription 3 Induced Synovial Invasion and Migration Is Mediated in Part Through the Notch/Hypoxia-Inducible Factor 1α Pathways
Wei Gao¹, Douglas J. Veale² and Ursula Fearon³, ¹Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ³Dublin Academic Medical Centre, Translation Rheumatology Research Group, Dublin, Ireland
Background/Purpose: To examine the role of Signal Transducer and Activator of Transcription 3 (STAT3) in mediating synovial cell-cell interactions, migration/invasion and key downstream signaling pathways…
Abstract Number: 1065 • 2012 ACR/ARHP Annual Meeting
Hypoxia-Inducible Factor-1α: Trigger of Toll-Like Receptor Signalling-Engaged Inflammation in Rheumatoid Arthritis
Fanlei Hu¹, Rong Mu¹, Jiaxin Zhu¹, Wenwei Shao², Lianjie Shi¹, Philip L. Cohen³, Xiaoyan Qiu² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China, ³Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Hyperplasia of synovial fibroblasts, infiltration with lymphocytes, and tissue hypoxia are the major characteristics of rheumatoid arthritis (RA). Data has confirmed the central role…
Abstract Number: 338 • 2012 ACR/ARHP Annual Meeting
The Potent Phosphoinositide-3-Kinase-(δ,γ) Inhibitor IPI-145 Is Active in Preclinical Models of Arthritis and Well Tolerated in Healthy Adult Subjects
James R. Porter¹, Janid Ali², Jonathan P. DiNitto², Joi Dunbar², Kerrie Faia², Jennifer Hoyt², Brianne Leary², Alice R. Lim², Christian Martin², Charlotte McKee², Patrick O'Hearn², Melissa Pink², Jennifer Proctor², John Soglia², Bonnie Tillotson², Kerry White², David G. Winkler² and Vito J. Palombella², ¹Product Development, Infinity Pharmaceuticals, Inc., Cambridge, MA, ²Infinity Pharmaceuticals, Inc., Cambridge, MA
Background/Purpose: Phosphoinositide-3-kinases (PI3K) play pivotal roles in cell signaling and regulate a variety of cellular functions. PI3K-δ and PI3K-γ isoforms are necessary for adaptive and…
Abstract Number: 2663 • 2012 ACR/ARHP Annual Meeting
A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results From a Candidate Gene Study
Cecilia P. Chung¹, Joseph F. Solus², Annette M. Oeser³, Chun Li⁴, Paolo Raggi⁵, Jeffrey R. Smith³ and C. Michael Stein³, ¹Medicine, Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt Medical Center, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Emory University, Atlanta, GA
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. However, this association is not fully explained by traditional cardiovascular risk factors or markers of inflammation. Little is…

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