Abstracts tagged "inflammation and rheumatoid arthritis (RA)"

Abstract Number: 151 • 2018 ACR/ARHP Annual Meeting
Molecular Mechanisms of Pathogenic T Cell Resilience in Human Arthritis
Pavanish Kumar¹, Jing Yao Leong¹, Bhairav Paleja¹, Suzan Saidin¹, jorg van Loosdregt¹, Thaschawee Arkachaisri², Alessandro Consolaro³, Marco Gattorno⁴, Alberto Martini⁵, Gary W Williams⁶, Ken D Pischel⁶, Martin Lotz⁷ and Salvatore Albani⁸, ¹Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, ²KK Women's and Children's Hospital, Singapore, Singapore, ³Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genova, Italy, ⁴Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genoa, Italy, ⁵Pediatric Rheumatology International Trial Organization (PRINTO) Coordinating Centre, Genoa, Italy, ⁶Scripps Clinic, La Jolla,, California, CA, ⁷Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA, ⁸Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore
Background/Purpose: T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and is associated with…
Abstract Number: 1021 • 2018 ACR/ARHP Annual Meeting
Impact of TLR7 Ligation in RA Pathology
Sadiq Umar^1,2, Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2 and Shiva Shahrara¹, ¹Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Jesse Brown VA Medical Center, Chicago, IL
Background/Purpose: Expression of Toll-like receptor 7 (TLR-7) is highly elevated in rheumatoid arthritis (RA) and osteoarthritis (OA) compared to normal (NL) synovial tissue lining and…
Abstract Number: 2052 • 2018 ACR/ARHP Annual Meeting
Immune Therapy of Rheumatoid Arthritis Patients with a Microbiome-Derived, Self/Non-Self Peptide Induces Clinically Relevant Immune Tolerance Pivoting on Immune Checkpoint-Expressing, Therapy-Induced Tregs
Salvatore Albani¹, Jing Yao Leong² and Theodorus van den Broek³, ¹Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore, ²Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, ³University Medical Center of Utrecht, Utrecht, Netherlands
Background/Purpose: We have previously reported in patients with RA abnormal inflammatory T cell responses to an E. coli peptide (dnaJP1) which shares homology with the…
Abstract Number: 12L • 2017 ACR/ARHP Annual Meeting
Evaluation of Intravenous Injection of Tc 99m Tilmanocept in Static Planar Gamma Emission Imaging and Fused SPECT/CT Imaging for Rheumatoid Arthritis
Arash Kardan¹, Bonnie Abbruzzese², James Sanders², Allison Kissling², David Ralph², Joanna Shuping², Michael Blue², Carley Hartings², Rachael Hershey², Ahmad Ismail², Izabela Gierach², Hannah Bailey², Amelia Spaulding², Matthew Haynam², George Zubal³ and Frederick Cope², ¹Charles F. Kettering Memorial Hospital and Wright State University Boonshoft School of Medicine, Dayton, ND, ²Navidea Biopharmaceuticals, Inc., Dublin, OH, ³Z-Concepts, LLC, East Haven, CT

Background/Purpose: Activated macrophages play a critical role in RA by perpetuating inflammation via TNFα release and participating in the destruction of bone and cartilage. Notably,…
Abstract Number: 2025 • 2017 ACR/ARHP Annual Meeting
Potential Clinical Utility of Manu-Scan, the Novel Optical Molecular Imaging, in Patients with Hand Rheumatoid Arthritis
Dong Jin Go¹, Sang Jin Lee^1,2, Sang Hyun Joo³, Eun Hye Park⁴, Gi Jeong Cheon⁵, Sung Hwan Hong⁶ and Yeong Wook Song^1,4, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Kyungpook National University Hospital, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Jungang Medical Foundation, Jeju, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁵Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁶Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Recently, optical molecular imaging is expected to serve as the new technique for early diagnosis and treatment monitoring of rheumatoid arthritis (RA). "Manu-Scan" is…
Abstract Number: 2357 • 2017 ACR/ARHP Annual Meeting
Retinal Vessel Morphological Associations with Systemic Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Panagiota Anyfanti¹, Areti Triantafyllou¹, Eugenia Gkaliagkousi¹, Xenophon Zabulis², Stella Douma¹ and Spyros Aslanidis³, ¹3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece, ²Institute of Computer Science, Foundation for Research and Technology-Hellas (FORTH), Heraklion, Greece, Heraklion, Greece, ³Rheumatology Department-2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece
Background/Purpose: Rheumatoid arthritis (RA) is associated with a chronic inflammatory state, accelerated atherosclerosis and excess cardiovascular risk. Quantification of morphological changes in the retinal microvasculature…
Abstract Number: 2369 • 2017 ACR/ARHP Annual Meeting
Relationship of Bone Mineral Density and Inflammatory Burden with Carotid Plaque Formation in Rheumatoid Arthritis: A 5-Year Prospective Study
Na Ri Kim, Jong Wan Kang, Jung Su Eun, Ji Hun Kim, Jin Young Kang, Gi Bum Bae, Sang Jin Lee, Eon Jeong Nam and Young Mo Kang, Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease. The incidence of the cardiovascular (CV) disease is significantly increased in patients with RA…
Abstract Number: 2399 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Have Lower Glomerular Filtration Rate Compared to Healthy Population: Role of Inflammation
Suad Hannawi¹ and Issa Al Salmi², ¹Rheumatology, Asst.Prof, Dubai, United Arab Emirates, ²Prof, Muscat, Oman
Background/Purpose: Rheumatoid Arthritis-(RA) is associated with subclinical kidney impairment which contributes to increase mortality and morbidity. The role of inflammation on kidney function in inflammatory…
Abstract Number: 2400 • 2017 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis: Vitamin-D Deficiency Is an Outcome and a Cause of Subclinical Renal Impairment
Suad Hannawi¹ and Issa Al Salmi², ¹Rheumatology, Asst.Prof, Dubai, United Arab Emirates, ²Prof, Muscat, Oman
Background/Purpose: Vitamin D deficiency is highly prevalent in patients with rheumatoid arthritis (RA), and it is linked to RA disease severity. Two steps of hydroxylation…
Abstract Number: 2401 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis with Kidney Dysfunction Contributes to Higher Risk of Cardiovascular Disease Development
Suad Hannawi¹ and Issa Al Salmi², ¹Rheumatology, Asst.Prof, Dubai, United Arab Emirates, ²Prof, Muscat, Oman
Background/Purpose: Reduced kidney function render patients with RA rheumatoid arthritis (RA), have an increased risk of cardtiovascular disease (CVD), particulary ischemic heart disease (IHD). This…
Abstract Number: 2794 • 2017 ACR/ARHP Annual Meeting
Apolipoprotein B Binds to Enolase-1 and Aggravates Inflammation in Rheumatoid Arthritis
Joo Youn Lee¹, Min Jueng Kang¹, Ji Yong Choi², Ji Soo Park³, Jin Kyun Park^1,2, Eun Young Lee⁴, Eun Bong Lee⁵, Thomas Pap⁶, Eugene Yi¹ and Yeong Wook Song^1,2, ¹Department of Molecular medicine and biopharmaceutical science, Seoul National University, seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, Korea, Republic of (South), ³Department of Molecular medicine and biopharmaceutical science, Seoul National University, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University, seoul, Korea, Republic of (South), ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and joint destruction. Monocytes and synovial macrophages are key players in…
Abstract Number: 2912 • 2017 ACR/ARHP Annual Meeting
The Neural Correlates of Inflammation in RA: A Multi-Modal MRI Study
Andrew Schrepf¹, Chelsea Cummiford¹, Eric Ichesco¹, Tony Larkin¹, Steven E. Harte¹, Richard E. Harris¹, Alison Murray², Gordon Waiter³, Daniel J. Clauw⁴ and Neil Basu⁵, ¹Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ²Aberdeen Brain Imaging Center, University of Aberdeen, Aberdeen, United Kingdom, ³Aberdeen Brain Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, ⁴Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁵Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
Background/Purpose: Inflammation is the hallmark of disease activity in rheumatoid arthritis (RA). RA is characterized by fatigue and cognitive/affective disturbances, and these symptoms often worsen…
Abstract Number: 287 • 2017 ACR/ARHP Annual Meeting
Anti-TNF Agents Induce Alternative Macrophages
Yannick Degboé¹, Benjamin Rauwel², Michel Baron², Jean Frédéric Boyer², Alain Cantagrel², Arnaud Constantin³ and Jean-Luc Davignon², ¹Centre de Physiopathologie Toulouse Purpan, INSERM UMR 1043, Toulouse, France, ²CPTP, INSERM UMR 1043, Toulouse, France, ³Department of Rheumatology, Purpan Hospital, Toulouse III University, Toulouse, France, Toulouse, France
Background/Purpose: Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display various states of activation or « polarization », characterized by distinct functions…
Abstract Number: 482 • 2017 ACR/ARHP Annual Meeting
The Link between ACPA and Erosion Development: Is ACPA Sufficient? an Association Study in Clinically Suspect Arthralgia
Robin M ten Brinck¹, REM Toes² and Annette H.M. van der Helm-van Mil¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) associate with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and…
Abstract Number: 1386 • 2017 ACR/ARHP Annual Meeting
Tenosynovitis in the Forefoot at Disease Presentation Is Specific for RA: Results from a Cross-Sectional MRI Study in Early Arthritis
Yousra J. Dakkak¹, Debbie M. Boeters², Annette H.M. van der Helm-van Mil² and M. Reijnierse³, ¹Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The foot is a preferential location for rheumatoid arthritis (RA)-manifestation, but physical examination of the metatarsophalangeal (MTP) joints is difficult. Magnetic Resonance Imaging (MRI)…

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