Background/Purpose:

Rheumatoid Arthritis-(RA) is associated with subclinical kidney impairment which contributes to increase mortality and morbidity. The role of inflammation on kidney function in inflammatory arthritis is not well studied. The purpose of this stufy is to investigate associations between estimated-glomerular-filtration-rates(eGFR), traditional cardiovascular risk factors, and markers of inflammation in RA compared to healthy controls.

Methods:

Participants were recruited from a specialized rheumatology clinic at Ministry of Health and Prevention of UAE, from January 2013 to January 2016. Healthy subjects recruited from the community through brochure advertisement. The Modification-of-Diet-in-Renal- Disease-Study-MDRD-formula was used to calculate the eGFR. ttest and compare laboratory values and kidney function parameters between two groups. Linear regression analysis used to look for the correlation between the eGFR and each of the traditional cardiovascular risk factors and inflammatory markers.

Results:

98 RA-patients and 82-controls were recruited. None of the participants has history of diabetes, atherosclerosis or kidney impairment. The mean age for total participants was 49 ±13 years (Min16 –Max 82). The mean eGFR of inflammatory arthritis patients was 118 ± 30 ml/min (range 60 – 227) and 128 ±37 ml/min (range 62 – 286) for the controls. Patients and control had no significant difference in Systolic-SBP and diastolic-blood-pressure-DBP.

Inflammatory arthritis patients had lower GFR, albumin (P<0.001), and total protein (p=0.03) levels, and had higher ESR (P<0.001), CRP (P<0.001), and uric acid level (p=0.01),

Negative linear relationships were found as follow: Among RA patients and controls; there was a negative linear relationship between GFR and each of: age of participants; (p<0.001, CI: -1.24, -0.40 for patients and p=0.01, CI: -1.82, -0.26 for controls, & SBP; (p= 0.04, CI: -0.61, -.00 for patients and p=0.022, CI: -0.61, -0.05 for controls.

Among RA patients: GFR had a negative linear relationship with age of participants, age at RA onset (p=0.002, CI: -1.18, -0.29), dbp (p=-2.14, CI: -1.24, -0.05), ESR (p=0.04, CI: -0.24,-0.01), CRP (p=0.02, CI: -0.47, -0.04), uric acid (p<0.001, CI -0.18, -0.05), and total protein (p= 0.01, CI: -0.91, -0.16). There was a positive linear relationship between eGFR and albumin level (p=0.03, p= 0.14, 2.35),

Conclusion:

non-traditional CVD risk factors such as inflammatory markers are associated with sub-clinical kidney injury in patients with RA. Inflammation is involved in the early stages of impaired kidney function in RA patients. Hence, anti-inflammatory therapies may be effective in slowing down the deterioration of kidney function in the arthritis diseases.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/rheumatoid-arthritis-have-lower-glomerular-filtration-rate-compared-to-healthy-population-role-of-inflammation/