ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0048 • ACR Convergence 2024

    Role of the Chemokine CCL22 in Rheumatoid Arthritis Development

    Marcelo Afonso1, Masa Filipovic1, Alexandra Argyriou2, Alexandra Circiumaru3, Mikael Ringh1, Konstantin Carlberg1, Vijay Joshua1, Szu-Jing Chen1, Marianne Engström1, Heidi Wähämaa1, Tomas Ekström1, Marc H Wadsworth II4, Ravi Kumar1, Aaron Winkler5, Vivianne Malmström1, Anca Catrina1, Karine Chemin1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Solna, Sweden, 3Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden, 4Pfizer, Cambridge, 5Pfizer Inc., Cambridge, MA

    Background/Purpose: Understanding alterations of the immune homeostasis in individuals at risk of rheumatoid arthritis (RA) can be a key to achieve earlier diagnosis and prevention.…
  • Abstract Number: 0275 • ACR Convergence 2024

    Targeting IRAK4 in Monosodium Urate Crystals Induced Inflammation

    Sadiq Umar1 and Sriram Ravindran2, 1University of Illinois at Chicago, Chicago, IL, 2University of Illinois, Chicago

    Background/Purpose: Gout, the leading cause of inflammatory arthritis, is becoming increasingly prevalent worldwide, affecting both developed and developing countries. This condition results from the deposition…
  • Abstract Number: 0624 • ACR Convergence 2024

    Coexisting Tubulointerstitial Inflammation and Damage Is a Risk Factor for Chronic Kidney Disease in Patients with Lupus Nephritis

    Dong-Jin Park1, Hyemin Jeong2, Sung-Eun Choi3, Ji-Hyoun Kang2 and Shin-Seok Lee4, 1Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Chonnam National University Hospital, Gwangju, South Korea, 3Chonnam National University Medical School & Hospital, Gwangju, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and Hospital, Gwangju, KR, Gwangju, Republic of Korea

    Background/Purpose: Conflicting studies have reported varying associations between tubulointerstitial inflammation (TII), tubulointerstitial damage (TID), and the long-term outcomes of lupus nephritis (LN), due to analyzing…
  • Abstract Number: 0891 • ACR Convergence 2024

    Shared and Disease-Specific Mechanisms of Autoimmunity Using Single Cell Sequencing of Peripheral Immune Cells

    Jacquelyn Nestor1, Rachelly Normand1, Wamia Said1, Sergio Aguilar2, Nandini Samanta1, Sidney Martin1, Roya Best1, Hoang Anh Tran1, Adrien Antoinette1, Eilish Dillon3, Devin King3, April Jorge4, Maureen Leonard4, Pritha Sen3, Kerry Reynolds4, John Stone5, Michelle Rengarajan1, Tanuja Chitnis6, Kevin Wei7, Deepak Rao3, Andrew Luster8, Gary Reynolds1 and Alexandra-Chloe Villani1, 1Massachusetts General Hospital, Harvard Medical School, Broad Institute of MIT and Harvard, Boston, MA, 2National Center for Genomic Analysis, Barcelona, Spain, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Massachusetts General Hospital , Harvard Medical School, Concord, MA, 6Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 7Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 8Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: Rheumatologic diseases are characterized by distinct clinical presentations and patterns of organ involvement, yet share many genetic risk factors and treatment responses. This suggests…
  • Abstract Number: 1089 • ACR Convergence 2024

    Endothelial Activation in Gout

    Michael Toprover1, Binita Shah2, Kamelia Drenkova2, Michael Pillinger3 and Michael Garshick4, 1New York University Langone Health, New York, NY, 2NYU Langone Health, New York, NY, 3New York University Grossman School of Medicine, New York,, NY, 4NYU Langone Health, Tenafly, NJ

    Background/Purpose: Gout is the most common inflammatory arthritis and is associated with increased cardiovascular (CV) disease and cardiovascular mortality. Our prior studies have suggested that…
  • Abstract Number: 1660 • ACR Convergence 2024

    Systemic Inflammation and Transcriptional Reprogramming Contribute to Progression to Active Rheumatoid Arthritis in ACPA+ Individuals

    Mark Gillespie1, Ziyuan He1, Adam Savage1, Pravina Venkatesan1, Marla Glass1, Lauren Okada2, Nhung Tran2, Yudong He2, Samir Rachid Zaim1, Padmapriyadarshini Ravisankar2, Christy Bennett1, Julian Reading2, Jessica Garber2, Palak Genge2, Veronica Hernandez2, Alexander Heubeck2, Erin Kawelo2, Upaasana Krishnan2, Kevin Lee2, Regina Mettey2, Blessing Musgrove2, Vaishnavi Parthasarathy2, Cole Phalen2, Charles Roll2, Tyanna Stuckey2, Morgan Weiss1, Claire Gustafson2, Qiuyu Gong2, Emma Kuan2, Tao Peng2, Lucas Graybuck2, Kristen Demoruelle3, Kristine Kuhn4, David Boyle5, Fan Zhang4, Thomas Bumol6, Ananda Goldrath2, Xiaojun Li1, V. Michael Holers7, Peter Skene1, Gary Firestein8, Kevin Deane9 and Troy Torgerson10, 1Allen Institute for Immunology, Seattle, WA, 2Allen Institute for Immunology, Seattle, 3University of Colorado Anschutz Medical Campus, Golden, CO, 4University of Colorado, Aurora, CO, 5UCSD, La Jolla, CA, 6Allen Institute for Immunology, San Diego, CA, 7University of Colorado, Denver, CO, 8University of California, San Diego, San Diego, CA, 9University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 10Allen Institute for Immunology, Enumclaw, WA

    Background/Purpose: Elevated levels of RA-associated autoantibodies (ACPA, RF) prior to the clinical onset of inflammatory arthritis (IA) define a state of risk for future development…
  • Abstract Number: 1975 • ACR Convergence 2024

    Accurate Detection of Arthritis Using Hand-held Thermal Imaging and Machine Learning

    shaye Kivity1, Nadav Sheffer2, Keren Netzer3, Lior Luria3, Yael Pri-Paz Basson4, Oshrat Tayer-Shifman5, Rotem Sivan-Hoffman6, Rami ghanayem6 and Oshrit Hoffer7, 1Meir medical center, CFAR SABA, Israel, 2School of Medical Engineering, Afeka Tel Aviv Academic College of Engineering, Tel-Aviv, Israel, 3Rheumatology Unit, Meir Medical Center, Kfar Saba, Israel, 4meir hospital, zur moshe, Israel, 5Meir Medical Center, Ra'anana, Israel, 6Radiology Department, Meir Medical Center, Kfar Saba, Israel, 7School of Electrical Engineering, Afeka, Tel Aviv Academic Collage of Engineering, Kfar saba, Israel

    Background/Purpose: Rapid and accurate detection of arthritis is crucial for initiating timely treatment and preventing long-term joint damage. Imaging techniques such as Ultra sound and…
  • Abstract Number: 2177 • ACR Convergence 2024

    CD59 Complement Membrane Regulator Deficiency: 12 Years of Clinical and Molecular Follow-up of 29 Patients

    Dror Mevorach, Netanel Karbian, Marian Zeibak and Adi Tabib, Hadassah-University Hospital, Jerusalem, Israel

    Background/Purpose: We have described in 2013, homozygous CD59-deficient children that manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), with hemolytic anemia and recurrent strokes.…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0049 • ACR Convergence 2024

    Inflammatory Priming by Anti-MAA Antibodies in Rheumatoid Arthritis

    Marcelo Afonso1, Jitong Sun1, Koji Sakuraba1, Alexandra Circiumaru2, Denis Lagutkin1, Masa Filipovic1, Anca Catrina1, Caroline Grönwall1, Aase Hensvold1 and Bence Réthi1, 1Karolinska Institutet, Stockholm, Sweden, 2Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm region, Stockholm, Sweden

    Background/Purpose: We have previously shown that autoantibodies targeting malondialdehyde-acetaldehyde protein adducts (anti-MAA) in rheumatoid arthritis (RA) patients boosted osteoclast differentiation and induced bone erosion in mice…
  • Abstract Number: 0300 • ACR Convergence 2024

    Evaluation of Long-term Primary Patency of Iliocaval Stenting in Patients with Retroperitoneal Fibrosis/chronic Periaortitis

    Raymond Lay1, Sara Achenbach2, Cynthia Crowson1, Umar Ghaffar1, Michelle Burke1, Haraldur Bjarnason1, Newton Neidert1, Kenneth Warrington1 and Matthew Koster1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, Rochester, MN

    Background/Purpose: Idiopathic retroperitoneal fibrosis (RPF) / chronic periaortitis (CP) is an uncommon condition characterized by a fibroinflammatory periarterial soft tissue thickening around the infra-renal abdominal…
  • Abstract Number: 0686 • ACR Convergence 2024

    The Role of Inflammation in Systemic Sclerosis: CRP-Associated Phenotypes and Prognostic Implications

    cristiana sieiro santos1, Miriam Retuerto2, Paula Pérez García2, Jose Ordas Martínez3, Pedro Baenas2, Clara Moriano Morales2 and Elvira Díez Álvarez4, 1Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 2Complejo Asistencial Universitario de León, León, Spain, 3Complejo Asistencial Universitario de Leon, Leon, 4Complejo Asistencial Universitario de León, Leon, Spain

    Background/Purpose: Systemic sclerosis (SSc) manifests through a diverse interplay of inflammatory, fibrotic, and vascular alterations, intricately entwined in its pathogenesis, which encompasses immune system dysregulation,…
  • Abstract Number: 0894 • ACR Convergence 2024

    HOXD13 Regulation of Primary Cilia in Rheumatoid Arthritis Synovial Fibroblasts: Implications for Joint-Specific Pathogenesis

    Masoumeh Mirrahimi1, Kerstin Klein2, Alexandra Khmelevskaya3, Eva Camarillo Retamosa3, Miranda Houtmen3, Oliver Distler1 and Caroline Ospelt1, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland, 2University of Bern, Bern, Switzerland, 3Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Zurich, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) follows a characteristic pattern of joint involvement. The embryonic development of limbs and joints influences certain joints' propensity to develop arthritis.…
  • Abstract Number: 1128 • ACR Convergence 2024

    A Meta-Analysis of Statin Efficacy in Controlling Disease Activity in Psoriasis

    Barbara Abreu Lopez1, Ernesto Calderon Martinez2, Tania Siu Xiao3, Zulma Sosa Carcamo4, Alejandra Maria Aleman Reyes5, Felix Ricardo Bonilla Bonilla6, María Isabel Murillo Pineda5, Edgar Josué Sanabria Herrera7, Alberto Ayala Aguilar8, Adreina Del Valle Rojas Marron9, Valentina Contreras Duran,10, Kevin J. Lopez Romero11 and Marcela Garzon12, 1Universidad de Carabobo, Carabobo, Venezuela, 2The University of Texas Science Medical Center at Houston, Tomball, 3Thomas Jefferson University Hospital, Philadelphia, 4Universidad Evangélica de El Salvador, San Salvador, El Salvador, 5Universidad Católica de Honduras, Tegucigalpa, Honduras, 6Hospital Militar Central, San Salvador, El Salvador, 7Universidad Nacional Autónoma de Honduras, Tegucigalpa, 8Baylor College of Medicine, Houston, 9Universidad de Oriente Núcleo Anzoátegui, Barcelona, Venezuela, 10MD Anderson Cancer Center, Texas, Houston, 11Universidad de El Salvador, San Salvador, El Salvador, 12Universidad de Los Andes, Bogotá, Colombia

    Background/Purpose: Psoriasis is a chronic inflammatory skin disorder that is associated with an increased risk of cardiovascular diseases. Chronic inflammation in psoriasis can produce excessive…
  • Abstract Number: 1664 • ACR Convergence 2024

    Identification of Spatial Determinants of Treatment Response in Rheumatoid Arthritis Synovia

    ilya Korsunsky1, Roopa Madhu2, Kevin Wei3, Kartik Bhamidipati1, Miles Tran1, Sonia Presti1, Anna Helena Jonsson4, Ellen Gravallese5, Michael Brenner6, Soumya Raychaudhuri1, Jennifer Seifert7, Costantino Pitzalis8, Fan Zhang9, Larry Moreland10, V. Michael Holers10, Michael Clayman11, Myles Lewis12, Ce Gao1, Michael J Zuscik13 and Accelerating Medicines Partnership Autoimmune and Immune-Mediated Disease14, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Brookline, MA, 3Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 4University of Colorado School of Medicine, Aurora, CO, 5Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, 6Brigham and Women's Hospital, Harvard Medical School, Newton, MA, 7University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 8QMUL, Bromley Kent, United Kingdom, 9University of Colorado, Aurora, CO, 10University of Colorado, Denver, CO, 11University of Colorado School of Medicine, Burlington, MA, 12Queen Mary University of London, London, United Kingdom, 13Department of Orthopedic Surgery, University of Colorado School of Medicine, Aurora, CO, 14Multiple Institutions, Oklahoma City

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune infiltration of the synovial tissue, resulting in joint damage. In RA, synovia exhibit distinct…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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