ACR Meeting Abstracts

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Abstracts tagged "immunology"

  • Abstract Number: 2348 • ACR Convergence 2024

    Bimekizumab Efficacy and Safety Through 4 Years in Moderate to Severe Plaque Psoriasis: Long-Term Results from a Phase 3 Study and Open-Label Extension

    Diamant Thaçi1, Luis Puig2, Joseph F. Merola3, Denis Jullien4, Antonio Costanzo5, Maggie Wang6, Delphine Deherder7, José M. López Pinto8 and Mark Lebwohl9, 1Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Schleswig-Holstein, Germany, 2Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain, 3UT Southwestern Medical Center, Dallas, TX, 4Department of Dermatology, Hôpital Edouard Herriot, Hospices Civils de Lyon, University of Lyon, Lyon, France, 5Department of Dermatology, Humanitas Clinical and Research Centre, IRCCS, Rozzano, Milan, Italy, 6UCB Pharma, Morrisville, NC, 7UCB Pharma, Braine-l'Alleud, Belgium, 8UCB Pharma, Madrid, Spain, 9Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Clinical improvements through Week 152, with no unexpected safety findings, were previously reported with bimekizumab (BKZ) in the BE SURE phase 3 trial and…
  • Abstract Number: 0078 • ACR Convergence 2024

    Inhibition of the Deubiquitinase TRABID in a Pre-clinical Mouse Model of Axial Spondyloarthritis Decreases Disease Severity

    Archita Srinath1, Daniele Mauro2, Mariia Korshko3, Shaghayegh Foroozan4, Mansi Aparnathi5, Francesco Ciccia6 and Nigil Haroon7, 1University of Toronto, Toronto, ON, Canada, 2University of Campania, Italy, Naples, Naples, Italy, 3University Health Network, Toronto, ON, Canada, 4University Health Network/University of Toronto, Toronto, ON, Canada, 5University Health Network, Toronto, Canada, 6University of Campania, Naples, Italy, 7Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Axial Spondyloarthritis is characterized by both inflammation and new bone formation. Current therapeutic targets aim to control inflammation, however, over 40% of patients do…
  • Abstract Number: 0891 • ACR Convergence 2024

    Shared and Disease-Specific Mechanisms of Autoimmunity Using Single Cell Sequencing of Peripheral Immune Cells

    Jacquelyn Nestor1, Rachelly Normand1, Wamia Said1, Sergio Aguilar2, Nandini Samanta1, Sidney Martin1, Roya Best1, Hoang Anh Tran1, Adrien Antoinette1, Eilish Dillon3, Devin King3, April Jorge4, Maureen Leonard4, Pritha Sen3, Kerry Reynolds4, John Stone5, Michelle Rengarajan1, Tanuja Chitnis6, Kevin Wei7, Deepak Rao3, Andrew Luster8, Gary Reynolds1 and Alexandra-Chloe Villani1, 1Massachusetts General Hospital, Harvard Medical School, Broad Institute of MIT and Harvard, Boston, MA, 2National Center for Genomic Analysis, Barcelona, Spain, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Massachusetts General Hospital , Harvard Medical School, Concord, MA, 6Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 7Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 8Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: Rheumatologic diseases are characterized by distinct clinical presentations and patterns of organ involvement, yet share many genetic risk factors and treatment responses. This suggests…
  • Abstract Number: 1730 • ACR Convergence 2024

    Osteoarthritis Is a Risk Factor for Inflammatory Arthritis in Cancer Patients Treated with Immune Checkpoint Inhibitors

    Daniel Portnoy1, Matthieu J Piola2, Luke Hao2, Robert Winchester2, Adam Mor2 and Yevgeniya Gartshteyn3, 1Columbia University Irving Medical Center, New Yok, NY, 2Columbia University Irving Medical Center, New York, NY, 3Columbia University Irving School of Medicine, New York, NY

    Background/Purpose: Inflammatory arthritis is one of the most common immune-related adverse events (irAEs) resulting from immune checkpoint inhibitors (ICIs). We hypothesized that T cells present…
  • Abstract Number: 1867 • ACR Convergence 2024

    RNA Polymerase III Specific CD8+ T Cells at the Interface Between Scleroderma and Cancer

    Eleni Tiniakou1, Mekha Thomas2, Ami Shah3, Fredrick Wigley4, Livia Casciola-Rosen2, Kellie Smith2, Antony Rosen2 and Erika Darrah2, 1Johns Hopkins University, Lutherville Timonium, MD, 2Johns Hopkins University, Baltimore, MD, 3Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 4Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD

    Background/Purpose: Increasing evidence suggests an immunologic link between cancer and autoimmunity. Systemic sclerosis (SSc), offers a unique opportunity to study the evolution of naturally occurring…
  • Abstract Number: 2386 • ACR Convergence 2024

    Landscape of Immune Cells and Autoimmunity in Systemic Lupus Erythematosus Patients with Obesity

    Alexandra Reese1, Chandana Keshavamurthy2, Sneha Centala1, Samantha Ahrens1, Shivani Shah2, Douglas Reeves2, William Davis3, Robert Quinet4, Jerald Zakem1, Qingli Wu1, Kimmy Tran1, Teresa Leeth5, Daniyal Nadeem6, Sarwat Umer7, Samina Hayat5 and Xin Zhang1, 1Ochsner Health, New Orleans, LA, 2Ochsner Clinic Foundation, New Orleans, 3Ochsner Health System, New Orleans, LA, 4Ochsner Health, River Ridge, LA, 5Louisiana State University Shreveport, Shreveport, LA, 6LSU Shreveport, Shreveport, 7LSU HEALTH SHREVEPORT, SHREVEPORT, LA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by autoantibodies and disruption of multiple organs due to immunomodulatory dysfunction. Obesity is a…
  • Abstract Number: 0082 • ACR Convergence 2024

    Comparative Immunology of Entheseal Anchorage Sites Between Spine, Hip and Knee Demonstrates up to 70-fold Greater IL-23 Induction from Axial Enthesis Bone: A New Angle on the Failure of IL-23 Blockade in Ankylosing Spondylitis

    Mark Harland1, Paula David2, Chi Wong1, Jake Weddell1, Abhay Rao3, Almas Khan3, Jake Timothy3, Peter Loughenbury3, Robert Dunsmuir3, Vishal Borse3, Campbell MacEachern3, Antonius Pieter Van der Heuvel4, Warner Chen4, Tom Macleod1 and Dennis McGonagle5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK, Leeds, United Kingdom, 2Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel, Ramat Gan, Israel, 3Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, 4Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, PA, USA, Spring House, PA, 5National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals, Leeds, UK, Leeds, England, United Kingdom

    Background/Purpose: Both peripheral and axial spondyloarthropathy (SpA), psoriasis and inflammatory bowel disease are strongly linked to IL-23 pathway immunogenetics and immunology. Unexpectedly, IL-23 inhibition lacked…
  • Abstract Number: 0918 • ACR Convergence 2024

    Anti-VISTA Antibody Suppresses Neutrophil-mediated Inflammation

    Elizabeth Nowak1, Jiannan Li1, Mohamed ElTanbouly1, Lindsay Mendyka2, Louise Lines1, Rodwell Mabaera3, Christopher Burns4, Randolph Noelle1 and Sladjana Skopelja-Gardner1, 1Geisel School of Medicine at Dartmouth, Lebanon, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, 4Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose: A growing body of evidence suggests that VISTA, an immune checkpoint inhibitory receptor, plays a central role in the regulation of innate immunity in…
  • Abstract Number: 1762 • ACR Convergence 2024

    Multi-omic Analysis Defines Heterogeneous and Cell Specific Type I Interferon Signalling in Juvenile-onset SLE Patients Associated with Biomarkers of Cardiovascular Risk

    Junjie Peng, Thomas McDonnell, Elizabeth Jury, Coziana Ciurtin and George Robinson, University College London, London, United Kingdom

    Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disease characterised by chronic inflammation, multi-organ damage, and/or death. Despite their young age, jSLE patients have…
  • Abstract Number: 1888 • ACR Convergence 2024

    Anti-Spike Antibodies Protect Against COVID-19 Infection in Immune-Mediated Inflammatory Diseases: Findings from the SUCCEED Study

    Jeremiah Tan1, J. Antonio Avina-Zubieta2, Paul Fortin3, Anne-Claude Gingras4, Maggie Larche5, Dawn Bowdish5, Claudie Berger6, Ines Colmegna7, Carol Hitchon8, Diane Lacaille2, Dawn Richards9, Nadine Lalonde10, Ayesha Kirmani1, Jennifer Lee11 and Sasha Bernatsky6, 1Arthritis Research Canada, Vancouver, BC, Canada, 2Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 3Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, 4Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, 5McMaster University, Hamilton, ON, Canada, 6Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 7The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 8University of Manitoba, Winnipeg, MB, Canada, 9Canadian Arthritis Patients Alliance, Toronto, ON, Canada, 10COVID-19 Global Rheumatology Alliance, London, ON, Canada, 11The Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: People with immune-mediated inflammatory diseases (IMIDs) may be more vulnerable to severe COVID-19 outcomes. COVID-19 vaccination is a key element in mitigating this risk.…
  • Abstract Number: 2420 • ACR Convergence 2024

    Blood Transcriptome Analysis Reveals Enhanced B Cell and Complement Cascade Signatures in Patients with Major Neuropsychiatric Systemic Lupus Erythematosus

    Dionysis Nikolopoulos1, George Sentis2, Jason Kitsos2, Panagiotis Garantziotis3, Noemin Kapsala2, antigoni Pieta2, Myrto Nikoloudaki4, Theodora Manolakou5, Sofia Flouda2, Ioannis Parodis6, Anastasia Filia2, George Bertsias7, Antonis Fanouriakis2 and Dimitrios Boumpas8, 1Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 2National and Kapodistrian University of Athens, Athens, Greece, 3Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, Erlangen, Germany, 4Rheumatology and Clinical Immunology, University of Crete School of Medicine, Heraklion, Greece, Heraklion, Greece, 5Karolinska Institutet, Stockholm, Sweden, 6Karolinska Institutet, Karolinska University Hospital; Örebro University, Solna, Sweden, 7Laboratory of Rheumatology, Autoimmunity and Inflammation. University Hospital, Rheumatology, Clinical Immunology, Heraklion, Greece, 84th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, Athens, Greece

    Background/Purpose: The molecular basis of neuropsychiatric systemic lupus erythematosus (NPSLE) remains elusive because of clinical heterogenicity, the complexity of pathophysiologic mechanisms involved and limited access…
  • Abstract Number: 0176 • ACR Convergence 2024

    Race-Based Differences in Immune Responses Following an Episode of Acute Low Back Pain Among Those Who Develop Chronic LBP and Those Who Do Not

    Colleen Burke1, Michael Brown2, Rebecca Fillipo3, Stephanie Danyluk2, Kelley Seebeck2 and Adam Goode2, 1Duke University School of Medicine, Chapel Hill, NC, 2Duke University, Durham, NC, 3Duke University School of Medicine, Durham, NC

    Background/Purpose: Acute low back pain (LBP) affects over 25% of adults annually in the United States, and as many as one-third of these individuals will…
  • Abstract Number: 0921 • ACR Convergence 2024

    Deep Immunologic Profiling of Trisomy 8-associated Autoinflammatory Disease (TRIAD)

    Kalpana Manthiram1, Lihong Shi1, Yue Zhang2, Bayu Sisay3, Shouguo Gao4, Zhijie Wu4, Qin Xu1, Mary Bowes2, Laura Failla2, Neelam Redekar2, Abdel Elkahloun3, Pamela Schwartzberg1 and Daniel Kastner3, 1National Institute of Allergy and Infectious Disease, Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3National Human Genome Research Institute, Bethesda, MD, 4National Heart, Lung, and Blood Institute, Bethesda, MD

    Background/Purpose: Trisomy 8 mosaicism is associated with an inflammatory disease characterized by recurrent fever and oral, genital, and gastrointestinal ulcers, resembling Behçet’s disease. Little is…
  • Abstract Number: 1775 • ACR Convergence 2024

    Childhood-onset Sjögren Disease Has an Altered Peripheral Blood Immune Landscape Compared to Adult-onset Disease Characterized by Activated CD4+ T-cells Which Could Drive B-cell Dysregulation

    Junjie Peng, Lucia Martin-Gutierrez, George Robinson, Elizabeth Jury and Coziana Ciurtin, University College London, London, United Kingdom

    Background/Purpose: Childhood-onset Sjögren Disease (cSjD) is a rare, poorly understood autoimmune rheumatic disease with onset before 18 years. Differences in clinical presentation compared to adults/lack…
  • Abstract Number: 1897 • ACR Convergence 2024

    People Living with Autoimmune Disease Are at Higher Risk of Suffering from Post-Acute Sequelae of SARS-CoV-2 but Immunization Is Protective

    Shahdi Malakooti1, Marc Abboud2, Jennifer Murphy3, Nora Singer4 and Grace McComsey5, 1MetroHealth at Case Western Reserve University, Cleveland, 2Saint Joseph Medical School, Beirut, Lebanon, 3University Hospitals, Cleveland, OH, 4MetroHealth System at Case Western Reserve University School of Medicine, Cleveland, OH, 5University Hospitals at Case Western Reserve University, Cleveland

    Background/Purpose: Post-Acute Sequelae of SARS-CoV-2 (PASC) include new or worsening of existing symptoms 3 months or more after SARS-CoV-2 infection. We have shown that vaccination…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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