ACR Meeting Abstracts

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Abstracts tagged "immunology"

  • Abstract Number: L11 • ACR Convergence 2024

    Rheumatology Diagnostics Utilizing Artificial Intelligence (ANA Reader©) for ANA Pattern Identification and Titer Quantification

    May Choi1, Farbod Moghaddam1, Mohammad Sajadi1, Ann E. Clarke1, Sasha Bernatsky2, Karen Costenbader3, Irene Chen4, Murray Urowitz5, John Hanly6, Caroline Gordon7, Sang-Cheol Bae8, Juanita Romero-Diaz9, Jorge Sanchez-Guerrero10, Daniel Wallace11, David Isenberg12, Anisur Rahman13, Joan Merrill14, Paul Fortin15, Dafna Gladman16, Ian Bruce17, Michelle Petri18, Ellen Ginzler19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Susan Manzi22, Andreas Jönsen23, Graciela Alarcón24, Ronald Van Vollenhoven25, Cynthia Aranow26, Meggan Mackay26, Guillermo Ruiz-Irastorza27, S. Sam Lim28, Murat Inanç29, Kenneth Kalunian30, Soren Jacobsen31, Christine Peschken32, Diane Kamen33, Anca Askanase34, Marvin Fritzler35 and Mina Aminghafari1, 1University of Calgary, Calgary, AB, Canada, 2Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 4UC Berkeley and UCSF, Berkeley, CA, 5Self employed, Toronto, ON, Canada, 6Dalhousie University, Halifax, NS, Canada, 7University of Birmingham, Birmingham, United Kingdom, 8Hanyang University Medical Center, Seoul, South Korea, 9The National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, 10Krembil Research Institute, Toronto, ON, Canada, 11Cedars Sinai Medical Center, Studio City, CA, 12Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, University College London, London, United Kingdom, 13University College London, London, United Kingdom, 14Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Centre ARThrite - CHU de Québec - UniversitéLaval, Quebec, QC, Canada, 16University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 17Queen's University Belfast, Belfast, United Kingdom, 18Johns Hopkins University School of Medicine, Baltimore, MD, 19SUNY Downstate Health Sciences University, New York, NY, 20UNC physician network, Chapel Hill, NC, 21Northwestern University, Chicago, IL, 22Allegheny Health Network, Pittsburgh, PA, 23Lund University, Lund, Sweden, 24The University of Alabama at Birmingham, Oakland, CA, 25Amsterdam UMC, Amsterdam, Netherlands, 26Feinstein Institutes for Medical Research, New York, NY, 27Biobizkaia Health Research Institute, Bilbao, Spain, 28Emory University, Atlanta, GA, 29Istanbul University, Istanbul, Turkey, 30UC San Diego, La Jolla, CA, 31Rigshospitalet, Copenhagen, Denmark, 32University of Manitoba, Winnipeg, MB, Canada, 33Medical University of South Carolina, Johns Island, SC, 34Columbia University Medical Center, New York, NY, 35Mitogen Diagnostics Corp, Calgary, AB, Canada

    Background/Purpose: Antinuclear antibody (ANA) immunofluorescence (IFA) patterns and titers are a key part of rheumatology diagnostics, however, there is considerable intra- and inter-laboratory variability with…
  • Abstract Number: 0032 • ACR Convergence 2024

    Increased Expression of Malondialdehyde-Acetaldehyde and Citrullinated Proteins in Myocardial Tissues During the Early Evolution of Collagen-Induced Arthritis

    Wenxian Zhou1, Michael Duryee2, Nozima Aripova2, Jill Poole2, Carlos Hunter2, Amy Nelson2, Tate Johnson2, Daniel Anderson3, Geoffrey Thiele2 and Ted Mikuls2, 1University of Nebraska Medical Center, Bellevue, NE, 2University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: The risk of heart failure (HF) is increased in patients with rheumatoid arthritis (RA), although mechanisms of myocardial dysfunction underlying HF development in RA…
  • Abstract Number: 0811 • ACR Convergence 2024

    High-Throughput Proteomic Profiling of Longitudinal Serum Samples to Predict Treatment Response in Lupus Nephritis

    Benjamin Jones1, Rufei Lu2, Andrea Fava3, Peter Izmirly4, Jennifer Anolik5, Chaim Putterman6, David Wofsy7, Matthias Kretzler8, Celine Berthier9, E. Steven Woodle10, Michael Weisman11, Mariko Ishimori12, The Accelerating medicines Partnership: RA/SLE Network13, Betty Diamond14, Jill Buyon15, Michelle Petri16, Judith James13 and Joel Guthridge13, 1Oklahoma State University, Oklahoma City, OK, 2University of California San Francisco, San Bruno, CA, 3Johns Hopkins University, Baltimore, MD, 4New York University Grossman School of Medicine, New York, NY, 5University of Rochester Medical Center, Rochester, NY, 6Albert Einstein College of Medicine, Safed, Israel, 7University of California San Francisco, SF, CA, 8University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, 9University of Michigan, Ann Arbor, MI, 10University of Cincinnati College of Medicine, Cincinnati, OH, USA, Cinncinnati, OH, 11Stanford University, Los Angeles, CA, 12Cedars-Sinai Health System, Los Angeles, CA, 13Oklahoma Medical Research Foundation, Oklahoma City, OK, 14The Feinstein Institutes for Medical Research, Manhasset, NY, 15NYU Grossman School of Medicine, New York, NY, 16Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Lupus nephritis (LN) can lead to severe morbidity and early mortality in SLE patients. While therapeutic options for LN have improved, they are not…
  • Abstract Number: 1620 • ACR Convergence 2024

    Unveiling of a New Molecular Imaging Biomarker? Vascular Adhesion Protein-1 and [68Ga]Ga-DOTA-Siglec-9 PET/CT in Detecting Giant Cell Arteritis Relapse

    Simon Petzinna1, Jim Küppers2, Benedikt Schemmer2, Anna Kernder3, Claus Juergen Bauer1, Pantelis Karakostas1, Denada Bruci3, Adina Morar3, Anja Winklbauer2, Markus Essler2 and Valentin S. Schäfer2, 1Clinic of Internal Medicine III, Department of Rheumatology, University Hospital of Bonn, Bonn, Germany, Bonn, Germany, 2University Hospital Bonn, Bonn, Germany, 3University Hospital Düsseldorf, Düsseldorf, Nordrhein-Westfalen, Germany

    Background/Purpose: Vascular adhesion protein-1 (VAP-1) is a transmembrane adhesion molecule with oxidative deamination functionality, which is expressed in vascular smooth muscle cells and endothelial cells.…
  • Abstract Number: 1847 • ACR Convergence 2024

    Expression Levels of the ATP-Gated Ion Channel P2RX7 Do Not Predict T Cell Sensitivity to Extracellular ATP and NAD

    William Valente1, Ka Hyun Rhee2, Kelsey Wanhainen2 and Stephen Jameson2, 1University of Minnesota, Burnsville, MN, 2University of Minnesota, Minneapolis, MN

    Background/Purpose: Extracellular NAD+ and ATP are two of the many damage-associated molecular pattern molecules (DAMPs) released at sites of tissue damage which modify activities of…
  • Abstract Number: 2193 • ACR Convergence 2024

    Prospective Evaluation of Reactogenicity and Safety Following COVID-19 Vaccination in Children with a History of MIS-C

    Mariana Sanchez Villa1, Jessica Nguyen2, Danielle Guffey3, Leila Sahni4, Miriah Gillispie-Taylor5, Marietta De Guzman2, S. Kristen Sexson Tejtel2, Sridevi Devaraj4, Flor Munoz4 and Tiphanie Vogel2, 1Baylor college of Medicine, Huffman, TX, 2Baylor College of Medicine, Houston, TX, 3Baylor College of Medicine, Houston, 4Baylor COM, Houston, TX, 5Baylor College of Medicine/Texas Children's Hospital, Houston, TX

    Background/Purpose: A rare subset of children who contract SARS-CoV-2 later develop the hyperinflammatory condition known as multisystem inflammatory syndrome in children (MIS-C). There has been…
  • Abstract Number: 2676 • ACR Convergence 2024

    Timeframe for Initiating Methotrexate and Vaccine Response Against Pneumococcus in Rheumatoid Arthritis: The VACIMRA Study

    Jacques MOREL1, Emmanuelle Dernis2, christian roux3, Christophe Richez4, OLIVIER BROCQ5, Bruno Fautrel6, Carine SALLIOT7, Olivier Vittecoq8, Xavier Mariette9, Frédéric LIOTE10, Slim Lassoued11, Cécile Gaujoux-Viala12, Arnaud Constantin13, MArtin Soubrier14, Valerie Devauchelle15, Vincent Goeb16, Jacques-Eric Gottenberg17, Hubert Marotte18, Annouc Rémy Moulard1, Corinne Merle de Boever1, Héléna Huguet1, Odile Launay19, Florence Galtier1 and Marie Christine Picot1, and F-CRIN networks iREIVAC and CRI-IMMIDIATE, 1CHU and University of Montpellier, Montpellier, France, 2CH LE MANS, LE MANS, Pays de la Loire, France, 3rheumatology department, university Cote d'Azur, nice, France, 4Université de Bordeaux, Bordeaux, France, 5Service de Rhumatologie, centre hospitalier Princesse-Grâce, Monaco, Monaco, 6INSERM, UMRS 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, and Sorbonne University – Assistance Publique-Hôpitaux de Paris, Département de Rhumatologie, Hôpital Pitié-Salpêtrière, Paris, Ile-de-France, France, 7CHU and University of Orléans, Orléans, France, 8CHU and University of Rouen, Rouen, France, 9Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France, 10CHU and University of Paris Nord, Paris, France, 11CH of Cahors, Cahors, France, 12CHU Nîmes, Nïmes, Languedoc-Roussillon, France, 13Hôpitaux de Toulouse, Toulouse, France, 14Gabriel-Montpied Hospital, Clermont-ferrand, France, 15UBO, Brest, France, 16CHu and University of Amiens, Ameins, France, 17Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 18Université Jean Monnet, CHU Saint-Etienne, Mines Saint-Etienne, INSERM SAINBIOSE 1059, Saint-Etienne, France, 19Centre d’Investigation Clinique en Vaccinologie (CIC Cochin Pasteur), Hôpital Cochin, Paris, Ile-de-France, France

    Background/Purpose: Pneumococcal vaccination is recommended for patients with chronic inflammatory rheumatism treated with immunosuppressants. Methotrexate (MTX) is the first-line treatment used in rheumatoid arthritis (RA),…
  • Abstract Number: 0038 • ACR Convergence 2024

    The Role of Dual Specificity Phosphatase 22 (DUSP22) in Rheumatoid Arthritis: Mechanism and Genetic Investigations

    Wei-Ting Hung1, Yi-Ming Chen2, Wen-Nan Huang3, Tsai-Hung Yen4, Tse-Hua Tan5 and Huai-Chia Chuang6, 1Taichung Veteran General Hospital, Taichung City, Taiwan (Republic of China), 2Taichung Veterans General Hospital, Taiwan, Taichung, Taiwan (Republic of China), 3Taichung Veterans General Hospital, Taichung, Taiwan, Taichung, Taiwan (Republic of China), 4Taichung Veterans General Hospital, Xitun District, Taichung City, Taiwan (Republic of China), 5National Health Research Institutes, Mao-Li, Taiwan (Republic of China), 6National Health Research Institutes, Zhunan, Taiwan (Republic of China)

    Background/Purpose: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation and joint damage. This study investigates the role of Dual Specificity Phosphatase…
  • Abstract Number: 0815 • ACR Convergence 2024

    Interferon-stimulated Gene Expression in Non-lesional Skin Is Similarly Elevated in Incomplete SLE and SLE

    Svenja Henning1, Lam Tsoi2, Benjamin Klein2, Celine Berthier2, Joseph Kirma2, Rachael Wasikowski3, Gilles Diercks4, Barbara Horvath1, Hendrika Bootsma5, Johann Gudjonsson2, Johanna Westra4, Karina de Leeuw6 and J. Michelle Kahlenberg2, 1University of Groningen, Groningen, Netherlands, 2University of Michigan, Ann Arbor, MI, 3Michigan, Dept. of Dermatology, Ann Arbor, MI, 4University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 5Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 6University Medical Center Groningen, Groningen, Groningen, Netherlands

    Background/Purpose: Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria are referred to as incomplete SLE (ILE). These patients are…
  • Abstract Number: 1636 • ACR Convergence 2024

    Age-associated B Cells Contribute to Inflammation of Takayasu’s Arteritis in an Antibody-secreting Cell Differentiation Independent Manner

    Chenglong Fang1, Xiaochuan Sun2, Shangyi Jin2, Lihong du2, Jing Li2, Xiaofeng Zeng3, Yuexin Chen4, Mengtao Li5 and Xinping Tian3, 1Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (People's Republic), 2Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 4Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China, 5Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China

    Background/Purpose: Although Takayasu’s arteritis (TAK) is not a prototypical autoantibody-mediated autoimmune disease, several lines of evidence suggested the pathogenic potential of B cells. However, limited…
  • Abstract Number: 1855 • ACR Convergence 2024

    ­Identification of Autoreactive Cytotoxic T Cells in ANCA-Associated Vasculitis

    Laura van Dam1, Shady Younis2, Jae-Seung Moon3, Mengrui Zhang4, Shima Parfasar4, Audra Horomanski3, orr Sharpe3, Jolijn van Leeuwen5, Tobias Lanz4, Cees van Kooten6, Onno Teng7 and William Robinson8, 1Stanford, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 4Department of Immunology and Rheumatology, Stanford University, Stanford, 5Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Nephrology, Leiden University Medical Center, Leiden, 7Leiden University Medical Center, Leiderdorp, Netherlands, 8Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by a pauci-immune necrotizing vasculitis leading to inflammation and damage…
  • Abstract Number: 2201 • ACR Convergence 2024

    Immunodeficiency-Related Monogenic Autoinflammatory Diseases; Expanding Spectrum of Immunodysregulation Disorders

    Alhanouf Alsaleem1, Lujain Akbar2 and Sulaiman Al-Mayouf3, 1KFSH&RC, Riyadh, Saudi Arabia, 2RIYADH, RIYADH, Saudi Arabia, 3KFSHRRC, Riyadh, Saudi Arabia

    Background/Purpose: Human inborn errors of immunity are caused by monogenic germline mutations characterized by Immunodeficiency like features with increase susceptibility to infection as well as…
  • Abstract Number: 2678 • ACR Convergence 2024

    History of Cutaneous Lupus Promotes Blood and Skin Interferon Signatures in SLE Patients

    Svenja Henning1, Lam Tsoi2, Craig Dobry2, Celine Berthier2, Benjamin Klein2, Amy Hurst2, Rachael Wasikowski3, Johann Gudjonsson2 and J. Michelle Kahlenberg2, 1University of Groningen, Groningen, Netherlands, 2University of Michigan, Ann Arbor, MI, 3Michigan, Dept. of Dermatology, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus (CLE) can present in isolation or as one of the most common manifestations of systemic lupus erythematosus (SLE). Interferon (IFN) stimulated genes…
  • Abstract Number: 0053 • ACR Convergence 2024

    Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis

    Márcia Pereira1, Katja Stuhlträger2, Natalie Scherff3, Anika Rajput Khokhar4, Sylvio Redanz1, Hebah Ebid5, Bérénice Hansen5, Cédric C. Lacny5, Ulrike Löschberger2, Stefan Bletz6, Jochen G. Schneider7, Paul Wilmes7, Christian S. Kessler4, Andreas Michalsen4, Alexander Mellmann3 and Martin Kriegel1, 1Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 2Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, 3Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, 4Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, 54University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, 6Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, 7University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg

    Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
  • Abstract Number: 0837 • ACR Convergence 2024

    Bispecific Autoantigen-T Cell Engagers (BaiTE) to Selectively Target Autoreactive B Cells in Antiphospholipid Syndrome

    Yuanxuan Xia1, Jin Liu1, Alexander Pearlman1, Brian Mog1, Elana Shaw1, Kyle J. Kaeo1, Colin Gliech1, Brock Moritz1, Tolulope Awosika1, Sarah DiNapoli1, Stephanie Glavaris1, Jiaxin Ge1, Tushar Nichakawade1, Nikita Marcou1, Suman Paul1, Drew Pardoll1, Chetan Bettegowda1, Daniel Goldman2, Michelle Petri2, Antony Rosen1, Kenneth W. Kinzler1, Shibin Zhou1, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Available drugs to treat autoimmune diseases are indiscriminate, suppressing self-reactive and protective immune responses alike. This lack of therapeutic precision results in infection and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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