Abstracts tagged "Imaging"

Abstract Number: 1169 • 2014 ACR/ARHP Annual Meeting
Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome
Maria B Lauvsnes¹, Mona K Beyer², Jan T Kvaløy^3,4, Ole J Greve⁵, Simone Appenzeller⁶, Erna Harboe⁷, Anne B Tjensvoll⁸, Lasse G Gøransson⁷ and Roald Omdal⁹, ¹Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ³Research Department, Stavanger University Hospital, Stavanger, Norway, ⁴Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway, ⁵Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil, ⁷Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ⁹Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Antibodies against the NR2 subtype of the NMDA-receptor (anti-NR2 antibodies) are detected in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS).…
Abstract Number: 2339 • 2014 ACR/ARHP Annual Meeting
Detecting Inflammation in Vivo Using Activatable Fluorescence Contrast Agents in Inflammatory Arthritis
Monica Guma¹, Beatrix Bartok², Viet Anh Nguyen Huu³, Mathieu L. Viger³, Jacques Lux³, Shivanjali Joshi-Barr³, Adah Almutairi³ and Gary S. Firestein⁴, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²Division of Rheumatology, allergy and immunology, University of California, San Diego, La Jolla, CA, ³UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences., University of California, San Diego, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Current medical imaging technology detects structural rather than functional manifestations of disease. Imaging agents designed to enhance signal based on molecular mechanisms might permit…
Abstract Number: 1173 • 2014 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging of Inflammatory Severity and Cartilage Damage of Finger Joints in Rheumatoid Arthritis
Dr. Philipp Sewerin¹, Dr. Christoph Schleich², Anja Mueller-Lutz³, Prof. Dr. Benedikt Ostendorf¹, Christian Rubbert⁴, Dr. Christian Buchbender⁵, Prof. Dr. Matthias Schneider⁶, Prof. Dr. Gerald Antoch⁷ and Dr. Falk Miese⁵, ¹Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ²Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Duesseldorf, Germany, ³Dep. for diagnostic and interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁴Univ. Duesseldorf, Düsseldorf, Germany, ⁵Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁶Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ⁷Department Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany
Background/Purpose To assess the association of inflammation severity and cartilage damage measured by delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) of metacarpophalangeal (MCP)…
Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting
Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study
T Damm¹, C Libanati², J Peña¹, G Campbell¹, R Barkmann¹, DA Hanley³, S Goemaere⁴, MA Bolognese⁵, C Recknor⁶, C Mautalen⁷, YC Yang² and CC Glüer¹, ¹Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ²Amgen Inc., Thousand Oaks, CA, ³University of Calgary, Calgary, AB, Canada, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Bethesda Health Research Center, Bethesda, MD, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Centro de Osteopatias Medicas, Buenos Aires, Argentina
Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
Abstract Number: 1041 • 2014 ACR/ARHP Annual Meeting
Imaging the Role of Chemoattractants in Inflammatory Arthritis
Yoshishige Miyabe¹, Thomas T. Murooka¹, Chie Miyabe¹, Nancy Kim², Thorsten R. Mempel¹ and Andrew D. Luster¹, ¹Massachusetts General Hospital, Charlestown, MA, ²Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil recruitment into the diseased joint. Our previous studies and the work of others have demonstrated…
Abstract Number: 1159 • 2013 ACR/ARHP Annual Meeting
Exercise Suppresses Systemic Inflammation Via Inhibition Of NF-κB Activation In Monocytes
Alisa Blazek¹, Derrick Knapik², Lai-Chu Wu³, Nicholas A. Young³, Wael N. Jarjour⁴ and Sudha Agarwal⁵, ¹Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH, ²College of Medicine, The Ohio State University, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Inflammation is integral to joint damage and bone erosion in rheumatoid arthritis. We reported previously that physiologic levels of exercise are anti-inflammatory and suppress local…
Abstract Number: 1134 • 2013 ACR/ARHP Annual Meeting
More Evidence For Breaking The ‘law Of valgus’: Imaging Evidence For Higher Prevalence and Volume Of Bone Marrow Lesions In The Medial Patellofemoral Joint
Charles Ratzlaff¹ and Jeffrey W. Duryea², ¹Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ²Radiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…
Abstract Number: 1128 • 2013 ACR/ARHP Annual Meeting
Validation Of a Rapid, Quantitative Method Of Magnetic Resonance Imaging-Detected Osteoarthritis-Related Bone Marrow Lesions In The Patellofemoral Joint
Charles Ratzlaff¹ and Jeffrey W. Duryea², ¹Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ²Dept of Radiology, Brigham & Women, Boston, MA
Background/Purpose : We recently developed an efficient semi-automated measure of tibial and femoral BML volume and validated it against the Whole-Organ Magnetic Resonance Imaging Score…
Abstract Number: 1112 • 2013 ACR/ARHP Annual Meeting
Examining Phenotypes Of Patients With Psoriasis In The Prepare Study For Similarities Between Diagnosed Psoriatic Arthritis and Those With Signs Of Subclinical Psoriatic Arthritis Detected By Imaging
Philip Mease¹, Javier Coindreau², Lotus Mallbris², Annette Szumski³ and Heather Jones², ¹Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, ²Pfizer Inc., Collegeville, PA, ³Specialty Care, Pfizer Inc., Collegeville, PA
Background/Purpose: Progression of psoriatic arthritis (PsA) has traditionally been evaluated using clinical assessments. However, a strong relationship between clinical and radiological outcomes has been shown,…
Abstract Number: 1086 • 2013 ACR/ARHP Annual Meeting
The Straight Neck in Fibromyalgia
Robert S. Katz¹ and Anthony Farkasch², ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: In patients with fibromyalgia a straight neck is based on calculating the Cobb angle, a standard radiographic measurement, of lateral view radiographs of the…
Abstract Number: 2889 • 2013 ACR/ARHP Annual Meeting
Bone Marrow Edema and Structural Lesions In The Sacroiliac Joint In a Large Cohort Of Patients With Axial Spondyloarthritis, Chronic Low Back Pain and Healthy Controls
L. van Hoeven^1,2, J.J. Luime², P.D.M. de Buck³, J.M.W. Hazes² and A.E.a.M. Weel⁴, ¹Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Rheumatology, MC Haaglanden, Den Haag, Netherlands, ⁴Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands
Background/Purpose: MRI of the sacroiliac joint (SIJ) is included in the ASAS classification criteria for axial spondyloarthritis (axSpA) to identify patients at an earlier stage of…
Abstract Number: 863 • 2013 ACR/ARHP Annual Meeting
Romosozumab Administration Is Associated With Significant Improvements In Lumbar Spine and Hip Volumetric Bone Mineral Density and Content Compared With Teriparatide
H K Genant¹, S Boonen², M A Bolognese³, C Mautalen⁴, J P Brown⁵, C Recknor⁶, S Goemaere⁷, K Engelke⁸, Y-C Yang⁹, M Austin⁹, A Grauer⁹ and C Libanati⁹, ¹UCSF & Synarc Inc., San Francisco, CA, ²Leuven University Division of Geriatric Medicine, Leuven, Belgium, ³The Bethesda Health Research Center, Bethesda, MD, ⁴Centro de Osteopatias Medicas, Buenos Aires, Argentina, ⁵CHU de Québec Research Centre and Laval University, Québec, QC, Canada, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Ghent University Hospital, Ghent, Belgium, ⁸Synarc Germany, Hamburg, Germany, ⁹Amgen Inc., Thousand Oaks, CA
Background/Purpose: Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. Romosozumab, a monoclonal antibody to sclerostin stimulates bone formation and decreases bone resorption. In a phase…
Abstract Number: 2820 • 2013 ACR/ARHP Annual Meeting
Disease-Regulated Local Interleukin-10 Gene Therapy Diminishes Synovitis and Articular Cartilage Damage In Experimental Arthritis
Eline A. Vermeij¹, Mathijs G.A. Broeren¹, Miranda B. Bennink¹, Onno J. Arntz², Inger Gjertsson³, Wim B. van den Berg¹ and Fons A.J. van de Loo¹, ¹Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease and in most patients the disease follows an intermittent course with periods of exacerbation and…
Abstract Number: 615 • 2013 ACR/ARHP Annual Meeting
Relationship Between 25-Hydroxyvitamin D [25(OH)D] and Risk For Cardiovascular Events In Systemic Lupus Erythematosus Over 11 Years In An Inception Cohort
Apinya Lertratanakul¹, Peggy Wu², Alan Dyer¹, Dafna D. Gladman³, Murray B. Urowitz³, Paul R. Fortin⁴, Dominique Ibanez³, Rosalind Ramsey-Goldman⁵ and for the Systemic Lupus International Collaborating Clinics (SLICC)⁶, ¹Northwestern University, Chicago, IL, ²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine, Centre de Recherche du Chu de Québec et Université Laval, Quebec City, QC, Canada, ⁵Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Toronto Western Hospital, Division of Rheumatology, University of Toronto, Toronto Western Hospital (Coordinating Center), Toronto, ON, Canada
Background/Purpose: 25(OH)D deficiency has been associated with increased cardiovascular disease (CVD) in the general population. We investigated the relationship between 25(OH)D and CVD events in…
Abstract Number: 2801 • 2013 ACR/ARHP Annual Meeting
Comparative Longitudinal Analysis Of Periarticular Bone Structure In Patients Treated With Methotrexate In Combination Of Either TNF Blockers Or Tocilizumab
Sebastian Kraus¹, Matthias Englbrecht¹, Juergen Rech², Roland Kocijan¹, Georg A. Schett¹ and Stephanie Finzel¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Inhibition of tumor necrosis factor alpha (TNFi) and interleukin-6 receptor (IL6Ri, tocilzumab) are among the most potent therapeutic strategies in patients with rheumatoid arthritis…

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