Abstracts tagged "Imaging"

Abstract Number: 1169 • 2014 ACR/ARHP Annual Meeting
Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome
Maria B Lauvsnes¹, Mona K Beyer², Jan T Kvaløy^3,4, Ole J Greve⁵, Simone Appenzeller⁶, Erna Harboe⁷, Anne B Tjensvoll⁸, Lasse G Gøransson⁷ and Roald Omdal⁹, ¹Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ³Research Department, Stavanger University Hospital, Stavanger, Norway, ⁴Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway, ⁵Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil, ⁷Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ⁹Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Antibodies against the NR2 subtype of the NMDA-receptor (anti-NR2 antibodies) are detected in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS).…
Abstract Number: 2339 • 2014 ACR/ARHP Annual Meeting
Detecting Inflammation in Vivo Using Activatable Fluorescence Contrast Agents in Inflammatory Arthritis
Monica Guma¹, Beatrix Bartok², Viet Anh Nguyen Huu³, Mathieu L. Viger³, Jacques Lux³, Shivanjali Joshi-Barr³, Adah Almutairi³ and Gary S. Firestein⁴, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²Division of Rheumatology, allergy and immunology, University of California, San Diego, La Jolla, CA, ³UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences., University of California, San Diego, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Current medical imaging technology detects structural rather than functional manifestations of disease. Imaging agents designed to enhance signal based on molecular mechanisms might permit…
Abstract Number: 1173 • 2014 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging of Inflammatory Severity and Cartilage Damage of Finger Joints in Rheumatoid Arthritis
Dr. Philipp Sewerin¹, Dr. Christoph Schleich², Anja Mueller-Lutz³, Prof. Dr. Benedikt Ostendorf¹, Christian Rubbert⁴, Dr. Christian Buchbender⁵, Prof. Dr. Matthias Schneider⁶, Prof. Dr. Gerald Antoch⁷ and Dr. Falk Miese⁵, ¹Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ²Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Duesseldorf, Germany, ³Dep. for diagnostic and interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁴Univ. Duesseldorf, Düsseldorf, Germany, ⁵Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁶Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ⁷Department Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany
Background/Purpose To assess the association of inflammation severity and cartilage damage measured by delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) of metacarpophalangeal (MCP)…
Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting
Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study
T Damm¹, C Libanati², J Peña¹, G Campbell¹, R Barkmann¹, DA Hanley³, S Goemaere⁴, MA Bolognese⁵, C Recknor⁶, C Mautalen⁷, YC Yang² and CC Glüer¹, ¹Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ²Amgen Inc., Thousand Oaks, CA, ³University of Calgary, Calgary, AB, Canada, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Bethesda Health Research Center, Bethesda, MD, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Centro de Osteopatias Medicas, Buenos Aires, Argentina
Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
Abstract Number: 1041 • 2014 ACR/ARHP Annual Meeting
Imaging the Role of Chemoattractants in Inflammatory Arthritis
Yoshishige Miyabe¹, Thomas T. Murooka¹, Chie Miyabe¹, Nancy Kim², Thorsten R. Mempel¹ and Andrew D. Luster¹, ¹Massachusetts General Hospital, Charlestown, MA, ²Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil recruitment into the diseased joint. Our previous studies and the work of others have demonstrated…
Abstract Number: 2219 • 2014 ACR/ARHP Annual Meeting
Contribution of Tripartite Motif Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis
Jenna Alloush¹, Nicholas A. Young², Kevin McElhanon¹, Wael N. Jarjour³ and Noah Weisleder¹, ¹Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that result in autoimmunity toward muscles and lead to tissue destruction, but the pathogenesis…
Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Nicholas A. Young¹, Lai-Chu Wu¹, Michael Bruss², Wael N. Jarjour³ and Dana P. Ascherman⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology, Miami VAMC, Miami, FL
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
Abstract Number: 2150 • 2014 ACR/ARHP Annual Meeting
The Craniocervical Junction in Ankylosing Spondylitis: A Computed Tomography Based Study
Gleb Slobodin¹, Arsen Shpigelman², Hanna Dawood³, Doron Rimar⁴, Simona Croitoru³, Nina Boulman⁴, Michael Rozenbaum⁴, Lisa Kaly¹, Itzhak Rosner¹ and Majed Odeh³, ¹Rheumatology, Bnai Zion Medical Center, Haifa, Israel, ²Orthopedic Surgery, Bnai Zion Medical Center, Haifa, Israel, ³Bnai Zion Medical Center, Haifa, Israel, ⁴Rheumatology, Bnai Zion Medical Center / Technion Faculty of Medicine, Haifa, Israel
Background/Purpose Available studies of craniocervical junction (CCJ) involvement in ankylosing spondylitis (AS) are based on conventional radiography, which has limited ability in the definition of…
Abstract Number: 908 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Detected Tenosynovitis Independently Associates with Flare in Patients with Rheumatoid Arthritis in Clinical Remission
Emanuela Bellis¹, Greta Carrara², Carlo Alberto Scirè², Alessandra Bortoluzzi³, Alberto Batticciotto⁴, Antonella Adinolfi⁵, Giovanni Cagnotto⁶, Marta Caprioli⁷, Marco Canzoni⁸, Francesco Cavatorta⁹, Fulvia Ceccarelli¹⁰, Orazio De Lucia¹¹, Valentina Di Sabatino¹², Antonella Draghessi¹³, Georgios Filippou¹², Ilaria Farina³, Maria Cristina Focherini¹⁴, Paola Frallonardo¹⁵, Alessandra Gabba¹⁶, Angelica Gattamelata¹⁰, Marwin Gutierrez¹³, Luca Idolazzi¹⁷, Filippo Luccioli¹⁸, Pierluigi Macchioni¹⁹, Marco Massarotti²⁰, Claudio Mastaglio²¹, Luana Menza²¹, Giulia Mirabelli¹⁸, Maurizio Muratore²², Simone Parisi²³, Valentina Picerno¹², Matteo Piga²⁴, Roberta Ramonda²⁵, Bernd Raffeiner²⁶, Daniela Rossi²⁷, Paola Rossini²⁸, Garifallia Sakellariou^29,30, Crescenzio Scioscia³¹, Carlo Venditti³², Annamaria Iagnocco¹⁰ and Marco Matucci-Cerinic³³, ¹Rheumatology, Ospedale Mauriziano, Turin, Italy, ²Italian Society for Rheumatology, Milan, Italy, ³A.O.U. S.Anna di Cona, Ferrara, Italy, ⁴L.Sacco University Hospital, Milan, Italy, ⁵Policlinico le Scotte, Siena, Italy, ⁶IRCCS Policlinico San Matteo, Pavia, Italy, ⁷Istituto di Cura Città di Pavia, Pavia, Italy, ⁸A.O. Sant'Andrea, Rome, Italy, ⁹A.O.U.P. Santa Chiara, Trento, Italy, ¹⁰Sapienza University of Rome, Rome, Italy, ¹¹Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, ¹²University of Siena, Siena, Italy, ¹³Università Politecnica delle Marche, Jesi, Italy, ¹⁴Ospedale Infermi, Rimini, Italy, ¹⁵Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ¹⁶A.O.U. di Cagliari, Cagliari, Italy, ¹⁷Ospedale Civile Maggiore, Verona, Italy, ¹⁸University of Perugia, Perugia, Italy, ¹⁹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²⁰Istituto Clinico Humanitas, Rozzano, Italy, ²¹Moriggia-Pelascini, Gravedona, Italy, ²²Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy, ²³A.O. Città della Salute e della Scienza di Torino, Turin, Italy, ²⁴Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²⁵Rheumatology Unit, Department of Medicine, University of Padua, Padova, Italy, ²⁶Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²⁷University of Turin, Turin, Italy, ²⁸P.O. “Destra Secchia”, Pieve di Coriano, Italy, ²⁹Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ³⁰Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ³¹University of Bari, Bari, Italy, ³²A.O. Rummo, Benevento, Italy, ³³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose Clinical remission is now an achievable goal in patients with rheumatoid arthritis (RA). Much has been done in order to better understand and define…
Abstract Number: 2133 • 2014 ACR/ARHP Annual Meeting
Efficacy of Tocilizumab Therapy in Patients with Rheumatoid Arthritis Based on FDG-PET/CT
Koichi Okamura¹, Yukio Yonemoto¹, Chisa Okura² and Kenji Takagishi¹, ¹Orthopaedic Surgery, Gunma University, Maebashi, Japan, ²Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan
Background/Purpose: A humanized anti-interleukin-6 receptor (anti-IL-6R) antibody, tocilizumab (TCZ), is one of the biologics and the C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR)…
Abstract Number: 828 • 2014 ACR/ARHP Annual Meeting
Extent of Urate Deposition in Asymptomatic Hyperuricemia and Symptomatic Gout: A Dual Energy Computed Tomography Study
Nicola Dalbeth¹, Meaghan House¹, Opetaia Aati¹, Paul Tan², Christopher Franklin², Anne Horne¹, Gregory Gamble¹, Lisa K. Stamp³, Anthony Doyle² and Fiona M. McQueen⁴, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Recent studies have reported that ultrasound features of urate crystal deposition are present in some asymptomatic individuals with hyperuricemia, suggesting that subclinical urate deposition…
Abstract Number: 2136 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography
Stephanie Finzel¹, Cheryl Barnabe², Kathryn Stok³, A. Scharmga⁴, Andrew J. Burghardt⁵, Ellen-Margrethe Hauge⁶, Hubert Marotte⁷, Stephanie Boutroy⁸, Klaus Engelke⁹, Dominique Toepfer¹⁰, Sebastian Kraus¹¹, Roland Kocijan¹², Xiaojuan Li¹³ and J. de Jong⁴, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Hpi F 26, Worfgang-Paul Str. 1, ETH Zurich Institute for Biomechanics, Zurich, Switzerland, ⁴Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁶Reumatologisk Afdeling, Aarhus Universitetshospital, Aarhus C, Denmark, ⁷Rheumatology, University Hospital of Saint Etienne, Saint Etienne, France, ⁸INSERM U1033 and University of Lyon, Hôpital Edouard Herriot, Lyon, France, ⁹Henkestr. 91, Institute of Medcial Physics Synarc, Hamburg, Germany, ¹⁰Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, ¹¹Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹²Medical Department II, St. Vincent Hospital, Vienna, Austria, ¹³Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data.…
Abstract Number: 797 • 2014 ACR/ARHP Annual Meeting
PET/CT for the Diagnosis of Giant Cell Arteritis: A Prospective Study
Alison Clifford¹, Elana Murphy¹, Steven Burrell², Matthew Bligh³, Godfrey Heathcote³, Mathieu Castonguay³, Kara Thompson⁴ and John G. Hanly⁵, ¹Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ²Diagnostic imaging, Dalhousie University and Capital Health, Halifax, NS, Canada, ³Dalhousie University and Capital Health, Halifax, NS, Canada, ⁴Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, ⁵Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: Temporal artery (TA) biopsies are negative in up to 50% of patients with giant cell arteritis (GCA). In such cases, increased uptake in large…
Abstract Number: 2142 • 2014 ACR/ARHP Annual Meeting
Sensitivity and Precision of Automated Osteophyte Volumetric Measurement in Knee Osteoarthritis over Four Years
Michael Hakky¹, Charles Ratzlaff², Mohamed Jarraya³, Ali Guermazi⁴ and Jeffrey Duryea⁵, ¹Radiology, Lahey Clinic, Burlington, MA, ²Harvard Medical School / Brigham and Women's Hospital, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Dept of Radiology, Brigham & Women, Boston, MA
Background/Purpose: Osteophyte formation and evolution is a hallmark of knee OA, and their radiographic identification and progression is fundamental in clinical practice, observational research and…
Abstract Number: 547 • 2014 ACR/ARHP Annual Meeting
Comparison of Clinical and Imaging Characteristics of Axial Psoriatic Arthritis and Axial Spondyloarthritis
Neha Garg¹, Abhijeet Danve², Kiana Vakil-Gilani³ and Atul A. Deodhar⁴, ¹Arthritis & Rheumatic Diseases, Oregon Health and Sciences University, Portland, OR, ²Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ³OHSU, Portland, OR, ⁴Oregon Health and Science University, Portland, OR
Background/Purpose Few studies have compared the clinical and imaging (x-ray and MRI) characteristics between axial psoriatic arthritis (axPsA) and axial spondyloarthritis patients without psoriasis (axSpA).…

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