Abstracts tagged "Imaging"

Abstract Number: 1576 • 2014 ACR/ARHP Annual Meeting
Reversal of Damage in Psoriatic Arthritis
Amir Haddad¹, Ker-Ai Lee², Arane Thavaneswaran¹, Vinod Chandran¹, Richard J. Cook² and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose Psoriatic arthritis could lead to severe damage and disability. However, cases of improvement in joint damage over time have been reported in the literature.…
Abstract Number: 1405 • 2014 ACR/ARHP Annual Meeting
Five-Year Changes in Myocardial Structure and Function in Patients with Rheumatoid Arthritis
John M. Davis III¹, Grace Lin², Jae Oh³, Cynthia S. Crowson⁴, Terry M. Therneau⁵, Eric L. Matteson¹ and Sherine E. Gabriel⁶, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Cardiology, Mayo Clinic, Rochester, MN, ³Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research, Mayo Clinic, Rochester, MN, ⁵Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁶Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Patients with rheumatoid arthritis (RA) suffer an increased risk of heart failure not explained by traditional cardiovascular risk factors. Previously, we have shown…
Abstract Number: 1204 • 2014 ACR/ARHP Annual Meeting
Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFkB Signaling and Macrophage Migration
Nicholas A. Young¹, Michael Bruss², Mark Gardner³, William Willis³, Xiaokui Mo³, Giancarlo Valiente³, Yu Cao⁴, Zhongfa Liu⁴, Lai-Chu Wu¹ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The major obstacles to successful use of curcumin as an anti-inflammatory agent are its low solubility in water and rapid metabolism, which both translate…
Abstract Number: 2995 • 2014 ACR/ARHP Annual Meeting
Surrogate Measures of Extent of Interstitial Lung Disease As Measured By Quantitative Radiographic Analysis in Patients with Systemic Sclerosis
Elizabeth Volkmann¹, Donald Tashkin², Chi-hong Tseng¹, Kim Hyun³, Jonathan Goldin³, Philip J. Clements⁴, Daniel E. Furst¹, Dinesh Khanna⁵, Eric Kleerup¹, Michael Roth¹ and Robert Elashoff⁶, ¹Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Medicine, University of California at Los Angeles, Los Angeles, CA, ³Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁵University of Michigan Health System, Ann Arbor, MI, ⁶Biomathematics, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Extent of systemic sclerosis (SSc)-related interstitial lung disease (ILD) predicts disease course, mortality and treatment response. While quantitative analyses of total extent of ILD…
Abstract Number: 1190 • 2014 ACR/ARHP Annual Meeting
Osteoarthritis-like Changes Are Present in the Tibia and Femur 1 Year Following ACL Reconstruction
Valentina Pedoia¹, Drew A. Lansdown², Musa Zaid³, Charles McCulloch⁴, C. Benjamin Ma² and Xiaojuan Li⁵, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ²Department of Orthopedic Surgery, UCSF, San Francisco, CA, ³Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁴Department of Epidemiology and Biostatistics, San Francisco, CA, ⁵Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose Statistical Shape Modeling (SSM) is a promising tool that has the ability to characterize complex shapes in a brief feature vector. The application of…
Abstract Number: 2930 • 2014 ACR/ARHP Annual Meeting
Precisely Quantified Fibrosis in Labial Salivary Glands Predicts Sjögren’s Syndrome Classification in a Multiple Regression Model
Kerry M. Leehan^1,2, Michael Brown¹, Courtney Montgomery¹, Astrid Rasmussen¹, David M. Lewis³, Lida Radfar⁴, Donald U. Stone⁵, Stephen Young³, R. Hal Scofield^1,6, Kathy L. Sivils^1,2 and A. Darise Farris^2,7, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Department of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic, progressive autoimmune exocrinopathy that presents diagnostic challenges. Focal lymphocytic infiltrates in labial salivary gland (SG) biopsies, serum…
Abstract Number: 1184 • 2014 ACR/ARHP Annual Meeting
Subclinical Inflammation in Psoriatic Patients with No History of Psoriatic Arthritis: An Assessment By Magnetic Resonance Imaging
David Simon¹, Francesca Faustini¹, Matthias Englbrecht¹, Arnd Kleyer¹, Roland Kocijan², Judith Haschka³, Sebastian Kraus³, Axel J. Hueber¹, Michael Sticherling⁴, Georg Schett¹ and Jürgen Rech³, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Six to 39% of patients with cutaneous psoriasis (PSO) can develop psoriatic arthritis (PsA). The transition from skin disease to joint involvement is only…
Abstract Number: 2772 • 2014 ACR/ARHP Annual Meeting
The Use of Imaging in the Diagnosis of Polymyalgia Rheumatica: Systematic Literature Review and Meta-Analysis
Sarah Mackie¹, Gouri Koduri², Catherine L. Hill^3,4, Andrew Hutchings⁵, Richard J. Wakefield⁶, Bhaskar Dasgupta⁷ and Jeremy Wyatt⁸, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²Rheumatology, York Teaching Hospital NHS Foundation Trust, York, United Kingdom, ³Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia, ⁴Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁵Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁸Leeds Insitute of Health Sciences, University of Leeds, Leeds, United Kingdom
Background/Purpose ACR/EULAR provisional classification criteria for polymyalgia rheumatica (PMR) incorporate musculoskeletal ultrasound of shoulder and hip (bursitis and synovitis given equal weight). Our objective was…
Abstract Number: 1169 • 2014 ACR/ARHP Annual Meeting
Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome
Maria B Lauvsnes¹, Mona K Beyer², Jan T Kvaløy^3,4, Ole J Greve⁵, Simone Appenzeller⁶, Erna Harboe⁷, Anne B Tjensvoll⁸, Lasse G Gøransson⁷ and Roald Omdal⁹, ¹Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ³Research Department, Stavanger University Hospital, Stavanger, Norway, ⁴Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway, ⁵Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil, ⁷Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ⁹Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Antibodies against the NR2 subtype of the NMDA-receptor (anti-NR2 antibodies) are detected in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS).…
Abstract Number: 2339 • 2014 ACR/ARHP Annual Meeting
Detecting Inflammation in Vivo Using Activatable Fluorescence Contrast Agents in Inflammatory Arthritis
Monica Guma¹, Beatrix Bartok², Viet Anh Nguyen Huu³, Mathieu L. Viger³, Jacques Lux³, Shivanjali Joshi-Barr³, Adah Almutairi³ and Gary S. Firestein⁴, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²Division of Rheumatology, allergy and immunology, University of California, San Diego, La Jolla, CA, ³UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences., University of California, San Diego, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Current medical imaging technology detects structural rather than functional manifestations of disease. Imaging agents designed to enhance signal based on molecular mechanisms might permit…
Abstract Number: 1173 • 2014 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging of Inflammatory Severity and Cartilage Damage of Finger Joints in Rheumatoid Arthritis
Dr. Philipp Sewerin¹, Dr. Christoph Schleich², Anja Mueller-Lutz³, Prof. Dr. Benedikt Ostendorf¹, Christian Rubbert⁴, Dr. Christian Buchbender⁵, Prof. Dr. Matthias Schneider⁶, Prof. Dr. Gerald Antoch⁷ and Dr. Falk Miese⁵, ¹Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ²Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Duesseldorf, Germany, ³Dep. for diagnostic and interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁴Univ. Duesseldorf, Düsseldorf, Germany, ⁵Department of Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany, ⁶Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ⁷Department Diagnostic and Interventional Radiology, Univ. Duesseldorf, Düsseldorf, Germany
Background/Purpose To assess the association of inflammation severity and cartilage damage measured by delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC) of metacarpophalangeal (MCP)…
Abstract Number: 2255 • 2014 ACR/ARHP Annual Meeting
Vertebral Cortical Bone Mass and Structure Significantly Improved with Romosozumab Compared with Teriparatide: HR-QCT Analyses of Postmenopausal Women with Low BMD from a Phase 2 Study
T Damm¹, C Libanati², J Peña¹, G Campbell¹, R Barkmann¹, DA Hanley³, S Goemaere⁴, MA Bolognese⁵, C Recknor⁶, C Mautalen⁷, YC Yang² and CC Glüer¹, ¹Christian-Albrechts-Universität zu Kiel, Kiel, Germany, ²Amgen Inc., Thousand Oaks, CA, ³University of Calgary, Calgary, AB, Canada, ⁴Ghent University Hospital, Ghent, Belgium, ⁵Bethesda Health Research Center, Bethesda, MD, ⁶United Osteoporosis Centers, Gainesville, GA, ⁷Centro de Osteopatias Medicas, Buenos Aires, Argentina
Background/Purpose : Understanding the effect of therapies in the vertebral compartments is relevant to bone biology and clinical practice. We developed an improved technique using…
Abstract Number: 1041 • 2014 ACR/ARHP Annual Meeting
Imaging the Role of Chemoattractants in Inflammatory Arthritis
Yoshishige Miyabe¹, Thomas T. Murooka¹, Chie Miyabe¹, Nancy Kim², Thorsten R. Mempel¹ and Andrew D. Luster¹, ¹Massachusetts General Hospital, Charlestown, MA, ²Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil recruitment into the diseased joint. Our previous studies and the work of others have demonstrated…
Abstract Number: 2219 • 2014 ACR/ARHP Annual Meeting
Contribution of Tripartite Motif Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis
Jenna Alloush¹, Nicholas A. Young², Kevin McElhanon¹, Wael N. Jarjour³ and Noah Weisleder¹, ¹Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that result in autoimmunity toward muscles and lead to tissue destruction, but the pathogenesis…
Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Nicholas A. Young¹, Lai-Chu Wu¹, Michael Bruss², Wael N. Jarjour³ and Dana P. Ascherman⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology, Miami VAMC, Miami, FL
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …

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