Abstracts tagged "Imaging"

Abstract Number: 2027 • 2015 ACR/ARHP Annual Meeting
Development of a Dual Energy Computed Tomography Scoring System for Measurement of Urate Deposition in Gout
Sara Bayat¹, Opetaia Aati², Juergen Rech¹, Alexander Cavallaro³, Michael Lell³, Elizabeth Araujo⁴, Christina Petsch⁴, Lisa K. Stamp⁵, Georg A. Schett⁶, Bernhard Manger¹ and Nicola Dalbeth², ¹Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Department of Radiology, University of Erlangen-Nuremberg, Department of Radiology, Erlangen, Germany, ⁴Medical Department 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ⁶University of Erlangen-Nuremberg, Erlangen, Germany
Development of a Dual Energy Computed Tomography Scoring System for Measurement of Urate Deposition in Gout Background/Purpose: Dual energy computed tomography (DECT) can visualize urate…
Abstract Number: 1299 • 2015 ACR/ARHP Annual Meeting
Can Bone Marrow Lesions be Scored More Reliably and Responsively in Knee Osteoarthritis Using a Web-Based Overlay System (KIMRISS) Than By Standard MRI Osteoarthritis Knee Scoring (MOAKS)? Data from the Osteoarthritis Initiative and a Prospective Trial of Adaluminab Therapy
Jacob Jaremko¹, Mark Buller², Dean Jeffery², David McDougall³, Benjamin Smith², Robert G Lambert¹ and Walter Maksymowych⁴, ¹Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ²Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Bone marrow lesions (BML) relate to pain and prognosis in knee osteoarthritis. The Knee Inflammation MRI Scoring System (KIMRISS) offers simple template-assisted binary BML…
Abstract Number: 2093 • 2015 ACR/ARHP Annual Meeting
Are General and Central Adiposity Associated with MRI-Assessed Structural Changes in the Knees of Older Adults?
Tomoko Fujii¹, Iva Miljkovic¹, Robert M. Boudreau², Ali Guermazi³, Sara R. Piva⁴, Elsa S. Strotmeyer², Laura Carbone⁵, Tamara B. Harris⁶, Elisa A. Marques⁶, M Kyla Shea⁷, Michael C. Nevitt⁸, Anne B. Newman² and C Kent Kwoh⁹, ¹University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Georgia Regents University, Augusta, GA, ⁶National Institute on Aging, Bethesda, MD, ⁷Tuffs University, Boston, MA, ⁸Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁹University of Arizona, Tucson, AZ
Background/Purpose: Obesity is one of the few modifiable risk factors of knee osteoarthritis (OA). However, it is not established whether a mechanical or metabolic mechanism…
Abstract Number: 1314 • 2015 ACR/ARHP Annual Meeting
Quantitative MRI Measurement of Tenosynovitis Demonstrates Differing Responses of Synovitis and Tenosynovitis after RA Treatment
Michael A. Bowes¹, Gwenael Guillard¹, Graham R. Vincent², Jane E. Freeston³, Edward M. Vital⁴, Paul Emery⁵ and Philip G. Conaghan⁶, ¹Imorphics, Manchester, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³LIMM Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds Gen Infirmary, Leeds, United Kingdom, ⁶University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom
Background/Purpose: Inflammation of the tendon sheaths (tenosynovitis) is a recognised component of rheumatoid arthritis (RA). A comprehensive assessment of inflammation will require the inclusion of…
Abstract Number: 2110 • 2015 ACR/ARHP Annual Meeting
Imaging and Safety Assessments Following Treatment with Febuxostat and Placebo for 2 Years in Subjects with Early Gout
Nicola Dalbeth¹, Kenneth G. Saag², William Palmer³, Hyon Choi³, Barbara Hunt⁴, Patricia MacDonald⁴, Ulrich Thienel⁴ and Lhanoo Gunawardhana⁴, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²Div Clinical Immun & Rheum, University of Alabama at Birmingham, Birmingham, AL, ³Massachusetts General Hospital/Harvard Medical School, Boston, MA, ⁴Takeda Pharmaceuticals International, Deerfield, IL
Background/Purpose: No clinical trials had previously investigated the characteristics of joint damage in early gout or the benefit of instituting urate-lowering therapy (ULT) earlier in…
Abstract Number: 1317 • 2015 ACR/ARHP Annual Meeting
Clinical Utility of Joint Space Width and X-Ray Radiogrammetry in RA: Markers for Early Radiographic Progression
Michael Platten¹, Yogan Kisten², Johan Kälvesten³, Kristina Forslind⁴ and Ronald F. van Vollenhoven⁵, ¹Medicine, Karolinska Institutet, Huddinge, Sweden, ²ClinTRID, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ³Sectra AB, Stockholm, Sweden, ⁴Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden
Background/Purpose: Early prediction of radiographic progression is beneficial in rheumatoid arthritis (RA) patient management. The van der Heijde modified Sharp score (SHS) is currently the…
Abstract Number: 2404 • 2015 ACR/ARHP Annual Meeting
Implications of a Positive Patellar Bulge Sign of Knee Joint Effusion in Patients with Osteoarthritis: Association with MRI Signs of Inflammation and with Increased Rate of 5-Year Total Knee Arthroplasty. Data from the Osteoarthritis Initiative
Benjamin Smith¹, David McDougall², Robert G Lambert³, Walter Maksymowych⁴ and Jacob Jaremko³, ¹Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Most of our understanding of the clinical significance of a knee joint effusion is derived from trauma in young patients, with surprisingly little assessment…
Abstract Number: 2219 • 2014 ACR/ARHP Annual Meeting
Contribution of Tripartite Motif Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis
Jenna Alloush¹, Nicholas A. Young², Kevin McElhanon¹, Wael N. Jarjour³ and Noah Weisleder¹, ¹Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that result in autoimmunity toward muscles and lead to tissue destruction, but the pathogenesis…
Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Nicholas A. Young¹, Lai-Chu Wu¹, Michael Bruss², Wael N. Jarjour³ and Dana P. Ascherman⁴, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology, Miami VAMC, Miami, FL
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …
Abstract Number: 2150 • 2014 ACR/ARHP Annual Meeting
The Craniocervical Junction in Ankylosing Spondylitis: A Computed Tomography Based Study
Gleb Slobodin¹, Arsen Shpigelman², Hanna Dawood³, Doron Rimar⁴, Simona Croitoru³, Nina Boulman⁴, Michael Rozenbaum⁴, Lisa Kaly¹, Itzhak Rosner¹ and Majed Odeh³, ¹Rheumatology, Bnai Zion Medical Center, Haifa, Israel, ²Orthopedic Surgery, Bnai Zion Medical Center, Haifa, Israel, ³Bnai Zion Medical Center, Haifa, Israel, ⁴Rheumatology, Bnai Zion Medical Center / Technion Faculty of Medicine, Haifa, Israel
Background/Purpose Available studies of craniocervical junction (CCJ) involvement in ankylosing spondylitis (AS) are based on conventional radiography, which has limited ability in the definition of…
Abstract Number: 908 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Detected Tenosynovitis Independently Associates with Flare in Patients with Rheumatoid Arthritis in Clinical Remission
Emanuela Bellis¹, Greta Carrara², Carlo Alberto Scirè², Alessandra Bortoluzzi³, Alberto Batticciotto⁴, Antonella Adinolfi⁵, Giovanni Cagnotto⁶, Marta Caprioli⁷, Marco Canzoni⁸, Francesco Cavatorta⁹, Fulvia Ceccarelli¹⁰, Orazio De Lucia¹¹, Valentina Di Sabatino¹², Antonella Draghessi¹³, Georgios Filippou¹², Ilaria Farina³, Maria Cristina Focherini¹⁴, Paola Frallonardo¹⁵, Alessandra Gabba¹⁶, Angelica Gattamelata¹⁰, Marwin Gutierrez¹³, Luca Idolazzi¹⁷, Filippo Luccioli¹⁸, Pierluigi Macchioni¹⁹, Marco Massarotti²⁰, Claudio Mastaglio²¹, Luana Menza²¹, Giulia Mirabelli¹⁸, Maurizio Muratore²², Simone Parisi²³, Valentina Picerno¹², Matteo Piga²⁴, Roberta Ramonda²⁵, Bernd Raffeiner²⁶, Daniela Rossi²⁷, Paola Rossini²⁸, Garifallia Sakellariou^29,30, Crescenzio Scioscia³¹, Carlo Venditti³², Annamaria Iagnocco¹⁰ and Marco Matucci-Cerinic³³, ¹Rheumatology, Ospedale Mauriziano, Turin, Italy, ²Italian Society for Rheumatology, Milan, Italy, ³A.O.U. S.Anna di Cona, Ferrara, Italy, ⁴L.Sacco University Hospital, Milan, Italy, ⁵Policlinico le Scotte, Siena, Italy, ⁶IRCCS Policlinico San Matteo, Pavia, Italy, ⁷Istituto di Cura Città di Pavia, Pavia, Italy, ⁸A.O. Sant'Andrea, Rome, Italy, ⁹A.O.U.P. Santa Chiara, Trento, Italy, ¹⁰Sapienza University of Rome, Rome, Italy, ¹¹Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, ¹²University of Siena, Siena, Italy, ¹³Università Politecnica delle Marche, Jesi, Italy, ¹⁴Ospedale Infermi, Rimini, Italy, ¹⁵Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ¹⁶A.O.U. di Cagliari, Cagliari, Italy, ¹⁷Ospedale Civile Maggiore, Verona, Italy, ¹⁸University of Perugia, Perugia, Italy, ¹⁹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²⁰Istituto Clinico Humanitas, Rozzano, Italy, ²¹Moriggia-Pelascini, Gravedona, Italy, ²²Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy, ²³A.O. Città della Salute e della Scienza di Torino, Turin, Italy, ²⁴Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²⁵Rheumatology Unit, Department of Medicine, University of Padua, Padova, Italy, ²⁶Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²⁷University of Turin, Turin, Italy, ²⁸P.O. “Destra Secchia”, Pieve di Coriano, Italy, ²⁹Division of Rheumatology, University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ³⁰Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico S.Matteo Foundation/University of Pavia, Pavia, Italy, ³¹University of Bari, Bari, Italy, ³²A.O. Rummo, Benevento, Italy, ³³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Background/Purpose Clinical remission is now an achievable goal in patients with rheumatoid arthritis (RA). Much has been done in order to better understand and define…
Abstract Number: 2133 • 2014 ACR/ARHP Annual Meeting
Efficacy of Tocilizumab Therapy in Patients with Rheumatoid Arthritis Based on FDG-PET/CT
Koichi Okamura¹, Yukio Yonemoto¹, Chisa Okura² and Kenji Takagishi¹, ¹Orthopaedic Surgery, Gunma University, Maebashi, Japan, ²Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan
Background/Purpose: A humanized anti-interleukin-6 receptor (anti-IL-6R) antibody, tocilizumab (TCZ), is one of the biologics and the C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR)…
Abstract Number: 828 • 2014 ACR/ARHP Annual Meeting
Extent of Urate Deposition in Asymptomatic Hyperuricemia and Symptomatic Gout: A Dual Energy Computed Tomography Study
Nicola Dalbeth¹, Meaghan House¹, Opetaia Aati¹, Paul Tan², Christopher Franklin², Anne Horne¹, Gregory Gamble¹, Lisa K. Stamp³, Anthony Doyle² and Fiona M. McQueen⁴, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Recent studies have reported that ultrasound features of urate crystal deposition are present in some asymptomatic individuals with hyperuricemia, suggesting that subclinical urate deposition…
Abstract Number: 2136 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography
Stephanie Finzel¹, Cheryl Barnabe², Kathryn Stok³, A. Scharmga⁴, Andrew J. Burghardt⁵, Ellen-Margrethe Hauge⁶, Hubert Marotte⁷, Stephanie Boutroy⁸, Klaus Engelke⁹, Dominique Toepfer¹⁰, Sebastian Kraus¹¹, Roland Kocijan¹², Xiaojuan Li¹³ and J. de Jong⁴, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Hpi F 26, Worfgang-Paul Str. 1, ETH Zurich Institute for Biomechanics, Zurich, Switzerland, ⁴Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁶Reumatologisk Afdeling, Aarhus Universitetshospital, Aarhus C, Denmark, ⁷Rheumatology, University Hospital of Saint Etienne, Saint Etienne, France, ⁸INSERM U1033 and University of Lyon, Hôpital Edouard Herriot, Lyon, France, ⁹Henkestr. 91, Institute of Medcial Physics Synarc, Hamburg, Germany, ¹⁰Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, ¹¹Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹²Medical Department II, St. Vincent Hospital, Vienna, Austria, ¹³Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data.…
Abstract Number: 797 • 2014 ACR/ARHP Annual Meeting
PET/CT for the Diagnosis of Giant Cell Arteritis: A Prospective Study
Alison Clifford¹, Elana Murphy¹, Steven Burrell², Matthew Bligh³, Godfrey Heathcote³, Mathieu Castonguay³, Kara Thompson⁴ and John G. Hanly⁵, ¹Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ²Diagnostic imaging, Dalhousie University and Capital Health, Halifax, NS, Canada, ³Dalhousie University and Capital Health, Halifax, NS, Canada, ⁴Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, ⁵Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: Temporal artery (TA) biopsies are negative in up to 50% of patients with giant cell arteritis (GCA). In such cases, increased uptake in large…

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