ACR Meeting Abstracts

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Abstracts tagged "Imaging"

  • Abstract Number: 1648 • ACR Convergence 2023

    EULAR Recommendations for the Use of Imaging in Large Vessel Vasculitis in Clinical Practice: 2023 Update

    Christian Dejaco1, Sofia Ramiro2, Milena Bond3, Philipp Bosch4, Cristina Ponte5, Sarah Mackie6, Thorsten Bley7, Daniel Blockmans8, Sara Brolin9, Ertugrul Cagri Bolek10, Rebecca Cassie11, Maria C Cid12, Juan Molina-Collada13, Bhaskar Dasgupta14, Berit Dalsgaard Nielsen15, Eugenio De Miguel16, Haner Direskeneli17, Christina Duftner18, Alojzija Hocevar19, Anna Molto20, Valentin Sebastian Schäfer21, Luca Seitz22, Riemer H.J.A. Slart23 and Wolfgang Schmidt24, 1Azienda Sanitaria Alto Adige, Brunico, Italy, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Azienda sanitaria dell'Alto Adige, Merano, Italy, 4Medical University of Graz, Graz, Austria, 5Department of Rheumatology, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 7Institute of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 8Department of General Internal Medicine, University Hospitals Leuven, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium, 9Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden, 101-Hacettepe University Vasculitis Research Centre, Ankara, Turkey/ 2-Vasculitis Translational Research Program, NIAMS, NIH, US, Ankara, Turkey, 11n/a, Leicester, United Kingdom, 12Hospital Clinic Barcelona, Barcelona, Spain, 13Hospital General Universitario Gregorio Marañón, Madrid, Spain, 14Mid & South Essex University Hospitals NHS Foundation Trust; Southend University Hospital, Westcliff-on-sea, United Kingdom, 15Department of Internal Medicine, Horsens, Denmark, 16Hospital Universitario La Paz, Madrid, Spain, 17Division of Rheumatology, Medical School, Marmara University, Istanbul, Turkey, 18Medical University Innsbruck, Innsbruck, Austria, 19Department of Rheumatology, Universitiy Medical Centre Ljubljana, Ljubljana, Slovenia, 20HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 21Clinic of Internal Medicine III, Department of Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany, 22Rheumatology and Immunology, Inselspital University Hospital Bern, Bern, Switzerland, 23University of Twente, Enschede, Netherlands, 24Rheumatology, Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany

    Background/Purpose: Imaging recommendations for primary large vessel vasculitis (LVV) were developed in 2018. Several new studies have emerged since then, and an update of the…
  • Abstract Number: 1893 • ACR Convergence 2023

    Abnormalities Detected with [18F]-FDG-PET/CT Imaging in VEXAS Syndrome

    Albrecht Betrains1, Vincent Jachiet2, Yannick Dieudonne3, Jérémie Dion4, Estibaliz Lazaro5, Claire De Moreuil6, Samuel Ardois7, Sylvie Grosleron8, Jean-benoit Arlet9, Cécile-Audrey Durel10, Laure Delaval11, Sylvain Audia12, Cécile Golden13, Barbara Nicolas13, Vincent Langlois14, Antoinette Perlat7, Frédéric Vandergheynst15, Thomas Moulinet16, Maxime Samson17, Daniel Blockmans1, Olivier Kosmider18, Sophie Georgin-Lavialle19, Arsène Mekinian20 and Benjamin Terrier21, 1Department of General Internal Medicine, University Hospitals Leuven, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium, 2Service de médecine interne et Inflammation-Immunopathology-Biotherapy Department (DMU i3), Sorbonne Université, AP-HP, Hôpital Saint Antoine, Paris, France, 3Department of Clinical Immunology and Internal Medicine, National Reference Centre for Systemic Autoimmune Diseases (CNR RESO), Strasbourg University Hospital, Strasbourg, France, 4Internal Medicine Department, Toulouse University Hospital, Toulouse, France, 5Bordeaux Hospital University, Pessac, France, 6CHU de Brest, Brest, France, 7CHU Rennes, Rennes, France, 8CH Agen-Nérac, Agen, France, 9Hôpital Georges-Pompidou APHP, Paris, France, 10CHU Lyon, Lyon, France, 11Hôpital Bichat APHP, Paris, France, 12Department of Internal Medicine and Clinical Immunology, Dijon-Bourgogne University Hospital, Dijon, France, 13CHU Dijon, Dijon, France, 14Service de Médecine Interne, Hôpital Jacques Monod, Le Havre, France, 15Université Libre de Bruxelles, Bruxelles, Belgium, 16Department of Internal Medicine, Centre hospitalier universitaire de Nancy, Nancy, France, 17Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 18Hôpital Cochin APHP, Paris, France, 19AP-HP, Tenon hospital, Paris, France, 20Department of Internal Medicine, Hôpital Saint-Antoine, AP-HP, Paris, France, 21Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France

    Background/Purpose: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is anautoinflammatory syndrome caused by somatic mosaicism in the UBA1 gene. [18F]-FDG-PET/CT is often performed during…
  • Abstract Number: 2411 • ACR Convergence 2023

    C-X-C Motif Chemokine Receptor 4-targeted Molecular Imaging in Giant Cell Arteritis – a Head-to-head Comparison with FDG PET

    Matthias Froehlich1, Sebastian E. Serfling2, Michael Gernert3, Konstanze V. Guggenberger4, Takahiro Higuchi2, Samuel Samnick2, Marc Schmalzing5, Andreas K. Buck2, Thorsten Bley4 and Rudolf A. Werner2, 1Rheumatology/Clinical Immunology, Department of Internal Medicine II, University of Würzburg, Würzburg, Germany, 2Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany, 3Medical Department II, Rheumatology, University Hospital Würzburg, Würzburg, Germany, 4Institute of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 5University Hospital, Rheumatology/Clinical Immunology, Department of Internal Medicine II, Würzburg, Germany

    Background/Purpose: 2-[18F]fluoro-2-deoxy-D-glucose(FDG) is the reference PET radiotracer for detecting inflammation in giant cell arteritis (GCA). C-X-C motif chemokine receptor 4 (CXCR4)-directed PET, however, allows for…
  • Abstract Number: 0812 • ACR Convergence 2023

    Length of Synovial Fluid Monosodium Urate Crystals According to Sonographic Articular Deposits: Advancing in the Crystallization Process

    Elena Sansano1, Mª Carmen López-González2, Cristina Rodríguez-Alvear3, Irene Calabuig-Sais3, Agustín Martínez-Sanchís3, Eliseo Pascual3 and Mariano Andrés3, 1Miguel Hernandez University, Alicante, Spain, 2General University Hospital Dr. Balmis, Alacante, Spain, 3Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain

    Background/Purpose: We described bands of fibers having deposited orderly arrayed monosodium urate (MSU) crystals suggesting the need for protein templates to start crystallization [PMID 9709185].…
  • Abstract Number: 1194 • ACR Convergence 2023

    Extent of Subregional Involvement of Subchondral Bone Marrow Lesions in Incident Knee OA Is Associated with Weight-Bearing Knee Pain

    Kent Kwoh1, Frank Roemer2, Erin Ashbeck3 and Ali Guermazi4, 1University of Arizona, Tucson, AZ, 2Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, 3University of Arizona Arthritis Center, Tucson, AZ, 4Boston University, Boston, MA

    Background/Purpose: Subchondral bone marrow lesions (BMLs) have been associated with incident and progressive pain and reported to fluctuate along with concurrent fluctuations in symptoms. While…
  • Abstract Number: 1650 • ACR Convergence 2023

    Optic Nerve Sheath Measurement as a Disease Activity Biomarker in Giant Cell Arteritis

    Carolyn Ross1, Stephanie Ducharme-Benard2, Samer Hussein3, Rosalie-Selene Meunier3, Christian Pagnoux4 and Jean-Paul Makhzoum1, 1Vasculitis Clinic, Canadian Network for Research on Vasculitides, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 2Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 3Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 4Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Recently, optic nerve sheath (ONS) enhancement using contrast-enhanced magnetic resonance imaging of the brain and orbits was observed in most patients with biopsy-proven GCA.…
  • Abstract Number: 1894 • ACR Convergence 2023

    3-Dimensional Regional Variation in Inter-rater Reliability of Bone Marrow Lesion Scoring in the Knee

    Stephanie Wichuk1, Walter P. Maksymowych1, Joel Paschke2, Abhilash Hareendranathan3 and Jacob Jaremko1, 1University of Alberta, Edmonton, AB, Canada, 2CARE Arthritis, Edmonton, AB, Canada, 3Radiology and Diagnostic Imaging, Edmonton, AB, Canada

    Background/Purpose: Bone marrow lesions (BML) are an important scoring feature on magnetic resonance imaging (MRI) of knee osteoarthritis (OA), and their presence in certain anatomical…
  • Abstract Number: 2424 • ACR Convergence 2023

    Exploring the Limit of Image Resolution for Human Expert Classification of Vascular Ultrasound Images in Giant Cell Arteritis and Healthy Subjects: The GCA-US-AI Project

    Valentin Sebastian Schäfer1, Stavros Chrysidis2, Christian Dejaco3, Sara Monti4, Matthew Koster5, Pantelis Karakostas1, Wolfgang Schmidt6, Eugenio De Miguel7, Christina Duftner8, Alojzija Hocevar9, Annamaria Iagnocco10, Marcin Milchert11, Chetan Mukhtyar12, Cristina Ponte13, Lene Terslev14, Tanaz Kermani15, Uffe Møller Døhn16, Berit Dalsgaard Nielsen17, Aaron Juche18, Luca Seitz19, Minna Kohler20, Kresten Keller21, Rositsa Karalilova22, Thomas Daikeler23, Sarah Mackie24, Karina Torralba25, Kornelis van der Geest26, Dennis Boumans27, Philipp Bosch28, Alessandro Tomelleri29, Markus Aschwanden30, Peter Brossart1, Charlotte Behning31 and Claus Juergen Bauer1, 1Clinic of Internal Medicine III, Department of Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany, 2Department of Rheumatology, Southwest Jutland Hospital Esbjerg, Esbjerg, Denmark, 3Department of Rheumatology, Medical University Graz, Graz, Austria; Department of Rheumatology, Hospital of Bruneck (ASAA-SABES), Teaching Hospital of the Paracelsius Medical University, Brunico, Italy, 4Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy, 5Mayo Clinic, Rochester, MN, 6Rheumatology, Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, 7Hospital Universitario La Paz, Madrid, Spain, 8Department of Internal Medicine, Clinical Division of Internal Medicine II, Medical University Innsbruck, Innsbruck, Austria, 9Department of Rheumatology, Universitiy Medical Centre Ljubljana, Ljubljana, Slovenia, 10University of Turin, Roma, Italy, 11Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland, 12Vasculitis service, Rheumatology department, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 13Department of Rheumatology, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 14Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 15Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 16Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 17Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Medicine, The Regional Hospital in Horsens, Horsens, Denmark, 18Department of Rheumatology, Immanuel Hospital, Berlin, Germany, 19Rheumatology and Immunology, Inselspital University Hospital Bern, Bern, Switzerland, 20Massachusetts General Hospital, Harvard Medical School, Boston, MA, 21Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 22Clinic of Rheumatology, Medical University Plovdiv, Plovdiv, Bulgaria, 23Clinic for Rheumatology, University Hospital Basel, Basel, Switzerland, 24Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 25Division of Rheumatology, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, 26Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 27Rheumatology and Clinical Immunology, Hospital Group Twente, Almelo, Netherlands, 28Medical University of Graz, Graz, Austria, 29Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Scientific Institute, Milano, Italy, 30Department of Angiology, University Hospital Basel, Basel, Switzerland, 31Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of vasculitis in adults, necessitating prompt diagnosis to prevent severe complications. However, access to expert…
  • Abstract Number: 0923 • ACR Convergence 2023

    Identification of Lupus Nephritis Kidney Immune Populations via Hi-Resolution 20-Plex Immunohistochemistry Single-Cell Spatial Analyses

    Caleb Marlin1, Alessandra Ida Celia2, Richard Furie3, Judith James1, Andrea Fava4, Joel Guthridge1, Avi Rosenberg5, Tayte Stephens1, Christian Wright1, Jeff Hodgin6, Peter Izmirly7, H Michael Belmont8, Jennifer Anolik9, Michelle Petri10, Jill Buyon11, Diane L. Kamen12, Chaim Putterman13, Accelerating Medicines Partnership in RA/SLE The1, Chen-Yu Lee4 and Xiaoping Yang4, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2John Hopkins University of Medicine, Rome, Italy, 3Northwell Health, Manhasset, NY, 4Johns Hopkins University, Baltimore, MD, 5Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, 6University of Michigan, Ann Arbor, MI, 7New York University School of Medicine, New York, NY, 8NYU School of Medicine, New York, NY, 9University of Rochester Medical Center, Rochester, NY, 10Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 11NYU Grossman School of Medicine, New York, NY, 12Medical University of South Carolina, Charleston, SC, 13Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Immunohistochemistry is the gold standard for antibody staining in microscopy. However, a lack of multiplexing limits its utility in the use of discovery. Here…
  • Abstract Number: 1195 • ACR Convergence 2023

    Relationship of Depth-Specific Subchondral Bone Mineral Density to MRI Cartilage Worsening: The Multicenter Osteoarthritis Study

    Jean Liew1, JD Johnston2, Gabriela Rabasa1, Beth Lewis3, John Lynch4, James Torner5 and Tuhina Neogi6, 1Boston University, Boston, MA, 2University of Saskatchewan, Saskatoon, SK, Canada, 3University of Alabama at Birimingham, Birmingham, AL, 4University of California San Francisco, San Francisco, CA, 5University of Iowa, Iowa City, IA, 6Boston University School of Medicine, Boston, MA

    Background/Purpose: While OA has been considered a disease of cartilage, early subchondral bone changes may precede cartilage abnormalities. Although higher systemic BMD has a known…
  • Abstract Number: 1690 • ACR Convergence 2023

    Apremilast Reduces Inflammation as Measured by MRI of the Hand in Patients with Psoriatic Arthritis: Primary Results from the Phase 4 MOSAIC Study

    Mikkel Østergaard1, Walter P. Maksymowych2, Mikael Boesen3, Robert Lambert4, Guillermo Valenzuela5, Michael Bubb6, Olga Kubassova7, Jyotsna Reddy8, Stephen Colgan9, Yuri Klyachkin10, Cynthia Deignan11, Lihua Tang8, Maria Paris8 and Philip J. Mease12, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark, 2University of Alberta, Edmonton, AB, Canada, 3Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Naerum, Denmark, 4Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 5Integral Rheumatology & Immunology Specialists, Plantation, FL, 6University of Florida, Gainesville, FL, 7Image Analysis Group, Philadelphia, PA, 8Amgen, Inc., Thousand Oaks, CA, 9Amgen, Inc., Halton Hills, ON, Canada, 10Amgen, Inc., Lexington, KY, 11Amgen, Inc., Agoura Hills, CA, 12Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA

    Background/Purpose: PsA is characterized by inflammatory arthritis, enthesitis, dactylitis, and spondylitis. Apremilast (APR) is an oral immunomodulating phosphodiesterase-4 inhibitor approved for the treatment of PsA.…
  • Abstract Number: 1926 • ACR Convergence 2023

    Use of 18F-FDG PET in Assessing Response to Treatment in Adults with Pulmonary Sarcoidosis: A Systematic Literature Review

    Koushan Kouranloo1, Mathangi Krishnakumar2 and Mrinalini Dey3, 1Rheumatology & Internal Medicine Trainee- Surrey, UK. Education fellow University of Liverpool, Liverpool, United Kingdom, 2Wrexham Maelor Hospital, Wrexham, United Kingdom, 3Queen Elizabeth Hospital, London, United Kingdom; University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Sarcoidosis is a chronic, multisystem, granulomatous disease commonly affecting the lungs. Immunosuppressants, particularly corticosteroids, are the mainstay of treatment. Symptoms, severity and response to…
  • Abstract Number: 2436 • ACR Convergence 2023

    Characterizing Spatial Organization of Immune Infiltrates in Rheumatoid Arthritis Synovia Using Spatial Transcriptomic Analysis

    Roopa Madhu1, Kartik Bhamidipati1, Anna Helena Jonsson1, Fan Zhang2, Lucy MacDonald3, Youngmi Kim4, Yi Cui4, STARS BWH1, Accelerating Medicines Partnership Program RA SLE Network5, Mariola Kurowska-Stolarska3, Stefano Alvernini6, Ellen Gravallese7, Michael Brenner7, Soumya Raychaudhuri1, Kevin Wei7 and ilya Korsunsky1, 1Brigham and Women's Hospital, Boston, MA, 2University of Colorado, Aurora, CO, 3Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, United Kingdom, 4Nanostring, Seattle, WA, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy, 7Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune infiltration of the synovial tissue lining joints. RA is clinically heterogenous, with patients having…
  • Abstract Number: 029 • 2023 Pediatric Rheumatology Symposium

    Cardiac Magnetic Resonance Imaging in Children with Systemic Lupus Erythematosus and Scleroderma Spectrum Disorders: A Single Center Experience

    Meredith Rae, Tam Doan and Eyal Muscal, Baylor College of Medicine, Houston, TX

    Background/Purpose: Cardiac disease is a major cause of morbidity and mortality in children with SLE and SSc. Various studies have demonstrated an association between duration…
  • Abstract Number: 0478 • ACR Convergence 2022

    Sonographic Prevalence of Subclinical GCA in Newly Diagnosed PMR

    Colm Kirby1, Rachael Flood1, Ronan Mullan1, Grainne Murphy2 and David Kane1, 1Tallaght University Hospital, Dublin, Ireland, 2Cork University Hospital, Cork, Ireland

    Background/Purpose: It has been reported that 20-50% of patients with PMR have subclinical GCA. The natural history of US-defined subclinical GCA in PMR is not…
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