Abstracts tagged "imaging techniques"

Abstract Number: 2855 • 2015 ACR/ARHP Annual Meeting
Non-Response to Antitnf Treatment in Psoriatic Arthritis Can be Predicted By an Objective Automated Measurement of Fluorescence-Signal Intensities in Fluorescence-Optical Imaging Technique – the First Interims Analysis of the Xplore-Study
Michaela Koehm^1,2, Tanja Rossmanith³, Ulf Henkemeier⁴, Peer Aries⁵, Rieke Alten⁶, Hans-Eckhard Langer⁷, Harald Burkhardt^8,9 and Frank Behrens^1,9, ¹Clinical Research, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt/Main, Germany, ²Rheumatology, Goethe-University Frankfurt, Frankfurt/Main, Germany, ³Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany, ⁴Centre of Innovative Diagnostics and Therapeutics Rheumatology/Immunology at Goethe-University, Frankfurt, Germany, ⁵Rheumatologie im Struenseehaus, Hamburg, Germany, ⁶Internal Medicine, Rheumatology & Clinical Immunology, Schlosspark-Klinik, University Medicine Berlin, Berlin, Germany, ⁷RHIO (Rheumatology, Immunology, Osteology) Duesseldorf, Duesseldorf, Germany, ⁸Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt/Main, Germany, ⁹Rheumatology, Goethe-University Frankfurt, Frankfurt, Germany
Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disorder. AntiTNF-therapy is initiated after failure of NSAID and DMARD-treatment. Up to 30-40% of the patients are…
Abstract Number: 2980 • 2015 ACR/ARHP Annual Meeting
Assessment of Sublingual Frenulum Perfusion in Systemic Sclerosis
Tracy M. Frech¹, Daniel R. Machin², Phillip E. Gates², Robyn T. Domsic³, Lee S. Shapiro⁴, John D. Pauling⁵ and Anthony J. Donato², ¹Div of Rheumatology, University of Utah, Salt Lake City, UT, ²University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake, UT, ³Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Steffens Scleroderma Center, Albany, NY, ⁵Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom
Background/Purpose: SSc is characterized by vasculopathy that precedes fibrosis and progresses to end-stage vascular manifestations such as malnutrition due to gastro-intestinal tract (GIT) involvement. Clinical…
Abstract Number: 2981 • 2015 ACR/ARHP Annual Meeting
Measurement of Tissue Damage in Scleroderma Using Digital Mammographic Xrays: A Proof of Concept Study
John Highton¹, Terence Doyle² and Simon Stebbings³, ¹Dept of Medicine, University of Otago, Dunedin, New Zealand, ²Medicine, University of Otago, Dunedin, New Zealand, ³Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Background/Purpose: We have used digital mammographic soft tissue Xrays of the fingers from patients with Scleroderma and related conditons to show damage related to the…
Abstract Number: 3123 • 2015 ACR/ARHP Annual Meeting
Evidence of Altered Blood Brain Barrier Permeability in Systemic Lupus Erythematosus Using Magnetic Resonance Imaging
Gaurav Gulati¹, Jordan T. Jones², Mekibib Altaye³, Jamie Meyers Eaton⁴, Kasha Wiley², Mark DiFrancesco⁵ and Hermine I. Brunner⁶, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Biostatistics and Epidemiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Pediatric Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction is a common manifestation of childhood-onset Systemic Lupus Erythematosus (cSLE). Murine models suggest that loss of the blood-brain barrier (BBB) integrity allows…
Abstract Number: 3177 • 2015 ACR/ARHP Annual Meeting
Whole-Body MRI: A Valuable Diagnostic Tool for the Assessment of Disease Damage in Juvenile Dermatomyositis
Clara Malattia¹, Agnese Beltramo¹, Isabella Buffoni¹, Annalisa Madeo¹, Francesca Magnaguagno², Stefania Viola¹ and Alberto Martini^1,3, ¹Istituto G Gaslini, Pediatria II, Reumatologia, Genova, Italy, ²Istituto G Gaslini, UO Radiologia Pediatrica, Genoa, Italy, ³Pediatria, Istituto G Gaslini, Pediatria II, Reumatologia, Genova, Italy
Background/Purpose: Although the prognosis of JDM has significantly improved during the past decade, some patients still experience persistent active disease, which potentially leads to irreversible…
Abstract Number: 192 • 2015 ACR/ARHP Annual Meeting
Comparison of Bone Scan with Xiralite (FOI) in Patients with Rheumatoid Arthritis and Psoriatic Arthritis
Joerg Polter, Susanne Drynda and Jörn Kekow, Clinic for Rheumatology, Vogelsang-Gommern, Germany
Background/Purpose: In recent years Xiralite, an ICG-enhanced fluorescence optical imaging (FOI) technology, has gained growing importance as a non-radioactive imaging technique for the detection of…
Abstract Number: 1340 • 2015 ACR/ARHP Annual Meeting
Value of 18F-FDG PET for Therapeutic Assessment in Patients with Polymyalgia Rheumatica Treated in First Line By Tocilizumab
Xavier Palard¹, Solene Querellou², Maelenn Gouillou³, Alain Saraux^4,5, Thierry Marhadour⁶, Florent Garrigues⁷, Ronan Abgral⁸, Pierre-Yves Salaun⁸ and Valerie Devauchelle^9,10, ¹Department of nuclear medicine, University hospital of Brest, Brest, France, ²Department of nuclear medicine, Université Européenne de Bretagne; Université de Brest; EA3878 (GETBO) IFR148, Brest, French Polynesia, ³Clinical Investigation Centre (CIC) 1412, CHU Cavale Blanche- Institut National de la Santé et de la Recherche Médicale (INSERM), Brest, France, ⁴Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, ⁵Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ⁶CHU La Cavale Blanche, Brest, France, ⁷Radiology department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ⁸Department of nuclear medicine, Université Européenne de Bretagne; Université de Brest; EA3878 (GETBO) IFR148, Brest, France, ⁹Service de Rhumatologie, CHU Brest, Brest, France, ¹⁰Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France
Background/Purpose: To evaluate the interest of 18F-FDG positron emission tomography-computed tomography (PET-CT) for therapeutic assessment in polymyalgia rheumatica (PMR) patients undergoing tocilizumab (TCZ) therapy at first…
Abstract Number: 2364 • 2014 ACR/ARHP Annual Meeting
PET-CT Imaging of Joints: A Quantitative Tool for Developing Novel Anti-Inflammatory Drugs
Siba Raychaudhuri¹, Anupam Mitra², Smriti K. Raychaudhuri³ and Abhijit Chaudhari⁴, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Radiology, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Mouse collagen induced arthritis (CIA) is the most commonly used preclinical model to screen new drug candidates for inflammatory arthritis. The conventional read out…
Abstract Number: 2136 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography
Stephanie Finzel¹, Cheryl Barnabe², Kathryn Stok³, A. Scharmga⁴, Andrew J. Burghardt⁵, Ellen-Margrethe Hauge⁶, Hubert Marotte⁷, Stephanie Boutroy⁸, Klaus Engelke⁹, Dominique Toepfer¹⁰, Sebastian Kraus¹¹, Roland Kocijan¹², Xiaojuan Li¹³ and J. de Jong⁴, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Hpi F 26, Worfgang-Paul Str. 1, ETH Zurich Institute for Biomechanics, Zurich, Switzerland, ⁴Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁶Reumatologisk Afdeling, Aarhus Universitetshospital, Aarhus C, Denmark, ⁷Rheumatology, University Hospital of Saint Etienne, Saint Etienne, France, ⁸INSERM U1033 and University of Lyon, Hôpital Edouard Herriot, Lyon, France, ⁹Henkestr. 91, Institute of Medcial Physics Synarc, Hamburg, Germany, ¹⁰Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, ¹¹Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹²Medical Department II, St. Vincent Hospital, Vienna, Austria, ¹³Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data.…
Abstract Number: 2147 • 2014 ACR/ARHP Annual Meeting
Automatically Extracted Quantitative Biomarkers for Assessing Connective Tissue Disease Using Nailfold Capillaroscopy
Michael Berks¹, Graham Dinsdale², Andrea Murray², Tonia Moore³, Chris Taylor¹ and Ariane Herrick², ¹Centre for Imaging Sciences, University of Manchester, Institute of Population Health, Manchester, United Kingdom, ²Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ³Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom
Background/Purpose Videomicroscopy can capture high-magnification images of nailfold capillaries, allowing non-invasive assessment of microvasculature change indicative of connective tissue disease. Whilst images may be qualitatively…
Abstract Number: 2126 • 2014 ACR/ARHP Annual Meeting
The Utility of Digital Activity Fluorescence Optical Imaging in Quantifying Hand and Wrist Inflammation in Rheumatic Diseases
Yogan Kisten¹, Noémi Györi¹, Hamed Rezaei^2,3, Adrian Levitsky⁴, Anna Karlsson¹, Erik af Klint³ and Ronald van Vollenhoven^3,5, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ²Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The rheumatology clinic of the Karolinska University Hospital, Stockholm, Sweden, ⁴The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ⁵Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden
Background/Purpose The objective detection and quantification of disease activity in its earliest pathophysiological stage is critical for achieving optimal therapy results. Fluorescence optical imaging (FOI)…
Abstract Number: 1699 • 2014 ACR/ARHP Annual Meeting
Endothelial and Platelet Microparticles As Potential Novel Biomarkers of Peripheral Microvascular Dysfunction in Systemic Sclerosis and Primary Raynaud’s Phenomenon
John D. Pauling^1,2, Daniel Moreno-Martinez³, Fiona Wilkinson⁴, Ben Parker^5,6, Jacqueline A. Shipley¹, Darren Hart¹, Neil J McHugh^1,2 and Yvonne Alexander³, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁴School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Institute of Inflammation and Repair School of Translation Medicine The University of Manchester, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). MPs form during cell activation…
Abstract Number: 909 • 2014 ACR/ARHP Annual Meeting
A Diagnostic Protocol for Giant Cell Arteritis (GCA) Using Ultrasound Assessment
Jennifer Piper¹, Ana Sofia Serafim¹, Cristina Ponte¹, Surjeet Singh², Bhaskar Dasgupta³, Wolfgang A. Schmidt⁴, Eugene McNally⁵, Andreas P. Diamantopoulos⁶, Andrew Hutchings⁷ and Raashid Luqmani⁸, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²University of Oxford, Sciences, Oxford, England, ³Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁴Rheumatology, Immanuel Krankenhaus, Berlin, Germany, ⁵Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom, ⁶Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁷Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁸Oxford NIHR Musculoskeletal Biomedical Research Unit, Oxford, United Kingdom
Background/Purpose Ultrasound (US) has not yet superseded temporal artery biopsy as a diagnostic test. This may reflect poor consistency of the scanning technique, due to…
Abstract Number: 1970 • 2013 ACR/ARHP Annual Meeting
The Utility Of Fluorescence Optical Imaging For Detecting Clinically Silent Synovitis Of The Hands and Wrists
Yogan Kisten¹, Noémi Györi², Hamed Rezaei³, Anna Karlsson¹, Carolina Romanus², Ronald van Vollenhoven⁴ and Erik af Klint⁵, ¹Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute,Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden, ²Unit for Clinical Therapy Research Inflammaroty Diseases (ClinTRID) Department of Medicine, the Karolinska Insitute, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁴Unit for Clinical Research Therapy. Inflammatory Diseases (ClinTrid), Karolinska Institute, Stockholm, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The rheumatology clinic of the Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: The detection of subclinical synovial inflammation (“silent synovitis”) would be of critical importance for the detection of rheumatoid arthritis (RA) in its earliest pathophysiological…
Abstract Number: 1975 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk Stratification In Rheumatic Diseases : Carotid Ultrasound Is More Sensitive Than Coronary Artery Calcification Score To Detect Subclinical atherosclerosis In Patients With Rheumatoid Arthritis
Francisco Ortiz-Sanjuán¹, Alfonso Corrales², José Antonio Parra³, Carlos González-Juanatey⁴, Montserrat Santos⁵, Javier Rueda⁶, Ricardo Blanco⁷, Vanesa Calvo-Río⁸, Javier Loricera⁸, Javier Llorca⁹ and Miguel A González-Gay¹⁰, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Hospital Marques de Valdecilla, Santander, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a disease associated to accelerated atherogenesis leading to increased incidence of cardiovascular (CV) mortality. Adequate stratification of the CV risk…

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