ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "hypertension"

  • Abstract Number: 1500 • 2014 ACR/ARHP Annual Meeting

    Preclinical and Clinical Characterization of MK-8457, a Selective Spleen Tyrosine Kinase and Zeta-Chain-Associated Protein Kinase 70 Inhibitor, in Normotensive and Hypertensive Cardiovascular Models

    Hani Houshyar1, Alan Bass2, Judith Boice3, Michael Ellis4, Patrick Fanelli5, Tomoko Freshwater6, Jane Guo7, Kimberly Hoagland5, Janet Kerr5, Alan Northrup4, Mathew Maddess8, Richard Miller9, Marcella Ruddy10, Stella Vincent11, Jayanthi Wolf5, Haoling Weng3, Gloria Zingaro5 and Gene Marcantonio3, 133 Avenue Louis Pasteur, Merck & Co., Boston, MA, 2Safety Assessment, Merck & Co., Boston, MA, 3Merck & Co., Whitehouse Station, NJ, 4Medicinal Chemistry, Merck & Co., Boston, MA, 5Merck & Co., West Point, PA, 6PPDM Early Stage, Merck & Co., Rahway, NJ, 7Immunology, Merck & Co., Boston, MA, 8Discovery Process Chemistry, Merck & Co., Boston, MA, 9Biochemistry & Biophysics, Merck & Co., Boston, MA, 10Merck & Co., Boston, MA, 11PPDM Preclinical ADME, Merck & Co., Boston, MA

    Background/Purpose:  Spleen Tyrosine Kinase (SYK) and Zeta-chain-associated protein kinase 70 (ZAP70) are non-receptor protein kinases that bind phosophorylated receptor tyrosine-based activation motifs, critical in immune…
  • Abstract Number: 1434 • 2014 ACR/ARHP Annual Meeting

    The Longitudinal Association Between Inflammation and Blood Pressure in Rheumatoid Arthritis

    Chih-Chin Liu1, Daniel H. Solomon2, Rishi Desai3, Seoyoung C. Kim4 and Katherine Liao5, 1Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, 4Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 5Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose Inflammation is hypothesized to have direct effects on arterial endothelial and vasomotor function, functions which regulate blood pressure (BP).  While inflammation has been implicated…
  • Abstract Number: 2593 • 2013 ACR/ARHP Annual Meeting

    The Prognosis Of Scleroderma Renal Crisis In RNA-Polymerase III Antibody (ARA) Positive Compared To ARA Negative Patients

    Bernadette Lynch1, Henry Penn2, Jennifer Harvey3, Aine Burns4 and Christopher P. Denton5, 1Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, 2Northwick Park Hospital, Harrow, United Kingdom, 3Clinical Immunology, Royal Free Hospital, London, United Kingdom, 4Department of Nephrology, The Royal Free Hospital, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC) usually presenting with accelerated hypertension and acute kidney injury (AKI) is one of the most severe complications of Systemic Sclerosis…
  • Abstract Number: 2103 • 2013 ACR/ARHP Annual Meeting

    Relationships Between Self-Efficacy, Outcome Expectancy, and Outcomes In Older Adults With Osteoarthritis Of The Knee and Hypertension: Baseline Results

    Elizabeth A. Schlenk1, Deborah Crowley-Lisowski1, Sarah Twerski1, Alice Fallon1, Alyssa Sartore1, Susan Sereika1, Joan Rogers2, G. Kelley Fitzgerald3 and C. Kent Kwoh4, 1School of Nursing, University of Pittsburgh, Pittsburgh, PA, 2School of Health and Rehabilitation Sciences, Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, 3School of Health and Rehabilitation Sciences, Physical Therapy, University of Pittsburgh, Pittsburgh, PA, 4School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Staying Active with Arthritis (STAR), an intervention guided by Bandura’s Self-Efficacy Theory, is being investigated in an ongoing clinical trial of an individually delivered,…
  • Abstract Number: 162 • 2012 ACR/ARHP Annual Meeting

    Metabolic Syndrome: The Genesis of Nephrolithiasis in Gout Patients

    Filipi M. Mello1, Rafael B. Tomita2, Ricardo Fuller3, Marco Antonio G. P. Filho2, Thiago B. M. Barros4, Leandro L. do Prado2, Kristopherson L. Augusto2 and Claudia Goldenstein-Schainberg5, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Rheumatology Division - University of São Paulo, São Paulo, Brazil, 3Reumatologia, Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 4Rheumatology, Reumatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Reumatologia, Rheumatology Division - University of São Paulo, São Paulo, Brazil

    Background/Purpose: Gout patients have a high frequency of metabolic syndrome (MS), a disorder known to be associated with hyperinsulinemia. The latter condition augments proximal tubular…
  • Abstract Number: 1667 • 2012 ACR/ARHP Annual Meeting

    Impact of Rheumatoid Arthritis On Recognition of Hypertension in a Medically Homed Population

    Christie M. Bartels1, Heather Johnson2, Katya Voelker3, Patrick Mc Bride4 and Maureen Smith5, 1Rheumatology/Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Cardiology/Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Univ of Wisconsin School of Medicine and Public Health, Madison, AA, 4Cardiology/Medicine, Univ of Wisconsin School of Medicine and Public Health, Madison, WI, 5Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI

    Impact of Rheumatoid Arthritis on Recognition of Hypertension in a Medically Homed PopulationBackground/Purpose: Numerous studies report increased cardiovascular disease (CVD) events and others describe increased…
  • Abstract Number: 2263 • 2012 ACR/ARHP Annual Meeting

    The Association Between Prior Pregnancy Morbidity and Cardiovascular Events in Women with Systemic Lupus Erythematosus

    Megan E. B. Clowse1, Eliza F. Chakarvarty2, Jill P. Buyon3 and Gerald McGwin Jr.4, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, 3Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Adverse pregnancy outcomes have been associated with increased cardiovascular disease in healthy women.  We hypothesized that women with SLE and a history of adverse…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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