Abstracts tagged "hypertension"

Abstract Number: 1500 • 2014 ACR/ARHP Annual Meeting
Preclinical and Clinical Characterization of MK-8457, a Selective Spleen Tyrosine Kinase and Zeta-Chain-Associated Protein Kinase 70 Inhibitor, in Normotensive and Hypertensive Cardiovascular Models
Hani Houshyar¹, Alan Bass², Judith Boice³, Michael Ellis⁴, Patrick Fanelli⁵, Tomoko Freshwater⁶, Jane Guo⁷, Kimberly Hoagland⁵, Janet Kerr⁵, Alan Northrup⁴, Mathew Maddess⁸, Richard Miller⁹, Marcella Ruddy¹⁰, Stella Vincent¹¹, Jayanthi Wolf⁵, Haoling Weng³, Gloria Zingaro⁵ and Gene Marcantonio³, ¹33 Avenue Louis Pasteur, Merck & Co., Boston, MA, ²Safety Assessment, Merck & Co., Boston, MA, ³Merck & Co., Whitehouse Station, NJ, ⁴Medicinal Chemistry, Merck & Co., Boston, MA, ⁵Merck & Co., West Point, PA, ⁶PPDM Early Stage, Merck & Co., Rahway, NJ, ⁷Immunology, Merck & Co., Boston, MA, ⁸Discovery Process Chemistry, Merck & Co., Boston, MA, ⁹Biochemistry & Biophysics, Merck & Co., Boston, MA, ¹⁰Merck & Co., Boston, MA, ¹¹PPDM Preclinical ADME, Merck & Co., Boston, MA
Background/Purpose: Spleen Tyrosine Kinase (SYK) and Zeta-chain-associated protein kinase 70 (ZAP70) are non-receptor protein kinases that bind phosophorylated receptor tyrosine-based activation motifs, critical in immune…
Abstract Number: 1434 • 2014 ACR/ARHP Annual Meeting
The Longitudinal Association Between Inflammation and Blood Pressure in Rheumatoid Arthritis
Chih-Chin Liu¹, Daniel H. Solomon², Rishi Desai³, Seoyoung C. Kim⁴ and Katherine Liao⁵, ¹Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, ⁴Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose Inflammation is hypothesized to have direct effects on arterial endothelial and vasomotor function, functions which regulate blood pressure (BP). While inflammation has been implicated…
Abstract Number: 2593 • 2013 ACR/ARHP Annual Meeting
The Prognosis Of Scleroderma Renal Crisis In RNA-Polymerase III Antibody (ARA) Positive Compared To ARA Negative Patients
Bernadette Lynch¹, Henry Penn², Jennifer Harvey³, Aine Burns⁴ and Christopher P. Denton⁵, ¹Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, ²Northwick Park Hospital, Harrow, United Kingdom, ³Clinical Immunology, Royal Free Hospital, London, United Kingdom, ⁴Department of Nephrology, The Royal Free Hospital, London, United Kingdom, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC) usually presenting with accelerated hypertension and acute kidney injury (AKI) is one of the most severe complications of Systemic Sclerosis…
Abstract Number: 2103 • 2013 ACR/ARHP Annual Meeting
Relationships Between Self-Efficacy, Outcome Expectancy, and Outcomes In Older Adults With Osteoarthritis Of The Knee and Hypertension: Baseline Results
Elizabeth A. Schlenk¹, Deborah Crowley-Lisowski¹, Sarah Twerski¹, Alice Fallon¹, Alyssa Sartore¹, Susan Sereika¹, Joan Rogers², G. Kelley Fitzgerald³ and C. Kent Kwoh⁴, ¹School of Nursing, University of Pittsburgh, Pittsburgh, PA, ²School of Health and Rehabilitation Sciences, Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ³School of Health and Rehabilitation Sciences, Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Staying Active with Arthritis (STAR), an intervention guided by Bandura’s Self-Efficacy Theory, is being investigated in an ongoing clinical trial of an individually delivered,…
Abstract Number: 162 • 2012 ACR/ARHP Annual Meeting
Metabolic Syndrome: The Genesis of Nephrolithiasis in Gout Patients
Filipi M. Mello¹, Rafael B. Tomita², Ricardo Fuller³, Marco Antonio G. P. Filho², Thiago B. M. Barros⁴, Leandro L. do Prado², Kristopherson L. Augusto² and Claudia Goldenstein-Schainberg⁵, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Rheumatology Division - University of São Paulo, São Paulo, Brazil, ³Reumatologia, Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology, Reumatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Reumatologia, Rheumatology Division - University of São Paulo, São Paulo, Brazil
Background/Purpose: Gout patients have a high frequency of metabolic syndrome (MS), a disorder known to be associated with hyperinsulinemia. The latter condition augments proximal tubular…
Abstract Number: 1667 • 2012 ACR/ARHP Annual Meeting
Impact of Rheumatoid Arthritis On Recognition of Hypertension in a Medically Homed Population
Christie M. Bartels¹, Heather Johnson², Katya Voelker³, Patrick Mc Bride⁴ and Maureen Smith⁵, ¹Rheumatology/Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Cardiology/Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Univ of Wisconsin School of Medicine and Public Health, Madison, AA, ⁴Cardiology/Medicine, Univ of Wisconsin School of Medicine and Public Health, Madison, WI, ⁵Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
Impact of Rheumatoid Arthritis on Recognition of Hypertension in a Medically Homed PopulationBackground/Purpose: Numerous studies report increased cardiovascular disease (CVD) events and others describe increased…
Abstract Number: 2263 • 2012 ACR/ARHP Annual Meeting
The Association Between Prior Pregnancy Morbidity and Cardiovascular Events in Women with Systemic Lupus Erythematosus
Megan E. B. Clowse¹, Eliza F. Chakarvarty², Jill P. Buyon³ and Gerald McGwin Jr.⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Adverse pregnancy outcomes have been associated with increased cardiovascular disease in healthy women. We hypothesized that women with SLE and a history of adverse…