Abstract Number: 32 • ACR/ARP Annual Meeting 2019
Aberration of Histone Lysine Methylation in Adult-Onset Still’s Disease Are Novel Biomarker Candidates Associated with the Disease Activity
Background/Purpose: Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disorder characterized by spiking fever, transient rash, arthritis and leukocytosis. Macrophage and neutrophil activation is a…Abstract Number: 35 • ACR/ARP Annual Meeting 2019
Mass Cytometry Identifies Enhanced Histone H3 Citrullination and TNFα Production by CD14 Monocytes in Subjects At-Risk for Future Development of Rheumatoid Arthritis
Background/Purpose: Our group previously demonstrated that sputum neutrophils from subjects At-Risk for future rheumatoid arthritis (RA) spontaneously form neutrophil extracellular traps with elevated histone H3…Abstract Number: 113 • ACR/ARHP Annual Meeting 2018
Epigenetic Changes in Dermal Fibroblasts By Inhibition of DOT1L Affect Cell Proliferation and Cell Cycle, but Have No Direct Effects on Collagen Deposition in in Vitro and In Vivo models of Fibrosis
Background/Purpose: Fibrosis is a key feature of systemic sclerosis, a devastating disease that is not well understood. The role of epigenetic factors in the pathophysiology…Abstract Number: 293 • ACR/ARHP Annual Meeting 2017
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…Abstract Number: 1575 • ACR/ARHP Annual Meeting 2017
JMJD3 Epigenetically Regulate Ankylosing Spondylitis Inflammation through Th17 Differentiation
JMJD3 epigenetically regulate ankylosing spondylitis inflammation through Th17 differentiation Background/Purpose: Inflammation is the initial stage of ankylosing spondylitis (AS), looking for possible inflammatory regulator will…Abstract Number: 2709 • ACR/ARHP Annual Meeting 2017
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…Abstract Number: 82 • ACR/ARHP Annual Meeting 2017
CKD-506, a Novel Inhibitor of Histone Deacetylase 6 (HDAC6) Has a Therapeutic Potential in Rheumatoid Arthritis and Inflammatory Bowel Disease
Background/Purpose: Autoimmune disease such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) is a chronic inflammatory disorder, significantly limiting quality of life. Even though…Abstract Number: 147 • Pediatric Rheumatology Symposium 2017
Epigenetic and Transcriptomic Profiling of Primary Juvenile Idiopathic Arthritis Patient Cells: Better Understanding of Disease Pathogenesis
Background/Purpose: For many autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA), the molecular mechanisms remain elusive. JIA can be used as a model to study autoimmune…Abstract Number: 182 • ACR/ARHP Annual Meeting 2016
Histone Methylation in γδ T Cells As a Biomarker of Behcet’s Disease Activity
Background/Purpose: Behcet’s disease (BD) is a chronic recurrent, multisystem inflammatory disorder. The phenotypic characteristics include oral aphtha, genital ulcers, uveitis and skin lesions. No specific…Abstract Number: 2870 • ACR/ARHP Annual Meeting 2016
Overexpression of EZH2 at the microRNA-142 Regulatory Region Contributes to Down-Regulation of microRNA-142-3p/5p in Systemic Lupus Erythematosus
Background/Purpose: Recently, our group has demonstrated that decreased microRNA-142-3p/5p (miR-142-3p/5p) which contributes to T cell overactivation and B cell hyperstimulation plays an essential role in…Abstract Number: 205 • ACR/ARHP Annual Meeting 2015
Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis
Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…Abstract Number: 3080 • ACR/ARHP Annual Meeting 2015
Histone H2AX Phosphorylation As a Measure of DNA Double Strand Breaks and a Marker of Environmental Stress and Disease Activity in Lupus
Background/Purpose: Studies suggested that defective or inefficient DNA double strand break (DSB) repair results in failure to preserve genomic integrity leading to apoptotic cell death,…Abstract Number: 3154 • ACR/ARHP Annual Meeting 2015
The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies
Background/Purpose: We previously showed that anti-citrullinated peptide/protein antibodies (ACPA) targeting citrullinated antigens contained in neutrophils extracellular traps (NETs) can be manufactured within ectopic germinal center-like…Abstract Number: 1005 • ACR/ARHP Annual Meeting 2014
Histone Lysine Demethylase KDM6A Mediates Joint Destruction in Osteoarthritic Knees By Epigenetic Disturbance of SOX9 Promoter and Histone H3K27
Background/Purpose: Intensive articular cartilage deterioration and synovial fibrosis in joints are prominently pathogenic features of osteoarthritic (OA) knees. Epigenetic reactions in joint microenvironments are linked…Abstract Number: 870 • ACR/ARHP Annual Meeting 2014
IRF1 Influences on Histone H4 Acetylation in Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus (SLE) is the classical systemic autoimmune disease. Epigenetic processes, such as posttranslational histone modifications, can regulate gene expression without altering the…
ACR Meeting Abstracts