ACR Meeting Abstracts

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Abstracts tagged "Granulomatosis with Polyangiitis (GPA)"

  • Abstract Number: 1084 • ACR Convergence 2022

    Rituximab versus Cyclophosphamide for Induction Therapy in Granulomatosis with Polyangiitis: A Target Trial Emulation Study

    Xavier Puéchal1, Michele Iudici2, Elodie Perrodeau3, bernard bonnotte4, Francois Lifermann5, Thomas Le Gallou6, Alexandre Karras7, Claire Blanchard-Delaunay8, Thomas Quéméneur9, Achille Aouba10, Olivier Aumaître11, Vincent Cottin12, Mohamed Hamidou13, Marc Ruivard11, Pascal Cohen1, Luc Mouthon1, Loïc Guillevin1, Philippe Ravaud3, Raphaël Porcher3 and Benjamin Terrier1, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 2Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland, 3Université Paris Cité, Hôtel-Dieu, Paris, France, 4Centre Hospitalo-Universitaire de Dijon, Dijon, France, 5Dax Hospital, Dax, France, 6Rennes Sud University Hospital, Rennes, France, 7HEGP, Paris, France, 8Niort Hospital, Niort, France, 9Valenciennes Hospital, Valenciennes, France, 10Department of Internal Medicine, UR4650 PSIR, Normandie Univ, UNICAEN, CHU de Caen Normandie, Caen, France, 11Clermont Ferrand University Hospital, Clermont-Ferrand, France, 12Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University of Lyon, INRAE, Lyon, France, 13Nantes University Hospital, Nantes, France

    Background/Purpose: Randomized controlled trials showed rituximab (RTX)'s non-inferiority to cyclophosphamide (CYC) for induction therapy of ANCA-associated vasculitis and neither treatment was favoured in granulomatosis with…
  • Abstract Number: 1948 • ACR Convergence 2022

    Clinical Characteristics and Outcomes of Pediatric ANCA-Associated Vasculitis Patients: Single-Center Inception Cohort

    Hyun Ho Lee1, Lauren Blazek2 and Eveline Wu3, 1The University of North Carolina Chapel Hill, Chapel Hill, NC, 2UNC Kidney Center, The University of North Carolina Chapel Hill, Chapel Hill, NC, 3University of North Carolina, Chapel Hill, NC

    Background/Purpose: ANCA associated vasculitis (AAV) is a chronic autoimmune disorder characterized by ANCA production and small vessel inflammation and necrosis. ANCA autoantigen targets include myeloperoxidase…
  • Abstract Number: 0439 • ACR Convergence 2022

    Clinical Characteristics of Patients with ANCA-Associated Vasculitis with and Without Alpha-1 Antitrypsin Deficiency Alleles

    Lynn Fussner1, David Cuthbertson2, Peter Grayson3, David Jayne4, Carol McAlear5, Michael Walsh6, Katherine Siminovitch7, Ulrich Specks8 and Peter Merkel9, 1The Ohio State University, Columbus, OH, 2University of South Florida, Tampa, FL, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4University of Cambridge, Cambridge, United Kingdom, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 6McMaster University, Hamilton, ON, Canada, 7University of Toronto, Toronto, ON, Canada, 8Mayo Clinic, Rochester, MN, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: There are multiple reasons to suspect that alpha-1 antitrypsin (A1AT) genotype impacts disease characteristics in ANCA-associated vasculitis (AAV). A1AT serves as the predominant endogenous…
  • Abstract Number: 0416 • ACR Convergence 2021

    Pharmacological Response of Rituximab Based on Dose Intensity in Maintenance Therapy of ANCA-Associated Vasculitis

    Jason Springer1 and Ryan Funk2, 1Vanderbilt University Medical Center, Franklin, TN, 2University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Rituximab (RTX) has demonstrated efficacy in maintenance therapy in ANCA-associated vasculitis. However, different dosing protocols have been used in clinical trials and there is…
  • Abstract Number: 0421 • ACR Convergence 2021

    Negative vs. Positive Antineutrophil Cytoplasmic Antibody Granulomatosis with Polyangiitis, a Case-control Study

    Marta Casal Moura, Samuel D. Falde, Ulrich Specks and Misbah Baqir, Mayo Clinic, Rochester, MN

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA) negative granulomatosis with polyangiitis (GPA) is a challenging diagnosis. There is paucity of literature regarding the clinical course of ANCA-negative…
  • Abstract Number: 0431 • ACR Convergence 2021

    Clinical Characteristics and Outcomes of ANCA-Associated and Non Immune-Mediated Hypertrophic Pachymeningitis: A Comparative Study

    Eduardo Martin-Nares, Lilian Guadalupe Cano Cruz and Andrea Hinojosa-Azaola, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Hypertrophic pachymeningitis (HP) is an infrequent manifestation in autoimmune and non-autoimmune conditions. The differences in clinical characteristics and outcomes of ANCA-associated and non-immune-mediated HP…
  • Abstract Number: 0436 • ACR Convergence 2021

    Ocular and Orbital Manifestations of Granulomatosis with Polyangiitis: A Systematic Review of Published Cases

    Madeleine Yeakle1, Allen Tsiyer1, Daniel Bishev1, Kayvon Moin1, Victoria Garofalo1, Allison Parrill1, Alexander Hatsis2, Tyler Wickas2 and Prachi Anand3, 1American University of the Caribbean School of Medicine, Cupecoy, Netherlands Antilles, 2Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY, 3Department of Rheumatology, Nassau University Medical Center, East Meadow, NY

    Background/Purpose: Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s Granulomatosis, is a systemic autoimmune condition caused by granulomatous inflammation of small and medium arteries, arterioles…
  • Abstract Number: 0525 • ACR Convergence 2021

    STEAP3, FZD2 and EGFLAM Are Novel Genetic Risk Loci for Granulomatosis with Polyangitis: A Genome Wide Association Study from UK Biobank

    Mehmet Hocaoglu1, Jamal Mikdashi2, Yi-Ju Chen2, James Perry2 and Charles Hong2, 1University of Maryland Medical Center, Midtown Campus, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Granulomatosis with Polyangitis (GPA) is a systemic ANCA associated small vessel vasculitis. Prior genetic studies demonstrated a strong association of HLA Class II region…
  • Abstract Number: 1420 • ACR Convergence 2020

    Characterization of ANCA-Associated Vasculitis Among African American Patients

    Sehris Khawaja1, Saloni Godbole1, Maryann Kimoto2, Virginia Steen3 and Kaitlin Quinn4, 1Georgetown University, Washington, DC, 2UCLA, Los Angeles, CA, 3Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 4National Institutes of Health, Washington, DC

    Background/Purpose: ANCA-associated vasculitis (AAV) comprises a group of disorders characterized by inflammation of small and medium-sized arteries.  Prevalence and phenotype of these diseases appear to…
  • Abstract Number: 1421 • ACR Convergence 2020

    Clinical Features, Disease Activity and Prognosis of ANCA-Associated Vasculitis in US African Americans

    Luis Palomino1, Angelo Gaffo2, Sebastian Sattui3 and Dongmei Sun2, 1University of Alabama at Birmingham Hospital, Birmingham, AL 2University of Alabama at Birmingham, Birmingham, AL, 3Hospital for Special Surgery, New York, NY

    Background/Purpose: ANCA-associated vasculitis (AAV), including Granulomatosis with Polyangiitis (GPA), Eosinophilic Granulomatosis with Polyangiitis (EGPA) and Microscopic Polyangiitis (MPA), affect mostly Caucasians of European descent. Clinical…
  • Abstract Number: 1425 • ACR Convergence 2020

    Reduced Risk of Cardiovascular Diseases Events with Renal Transplantation in Granulomatosis with Polyangiitis in the United States: Data from the US Renal Data System

    Zachary Wallace1, April Jorge2, Xiaoqing Fu3, Yuqing Zhang4 and Hyon Choi5, 1Massachusetts General Hospital, Newton, MA, 2Massachusetts General Hospital, Boston, MA, 3Massachusetts General Hospital, Boston, 4Massachusetts General Hospital, Quincy, MA, 5Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA

    Background/Purpose: Granulomatosis with polyangiitis (GPA) is a common cause of glomerulonephritis and leads to end-stage renal disease (ESRD) in approximately 25% of patients. Both GPA…
  • Abstract Number: 1430 • ACR Convergence 2020

    The Role of Lung Biopsy in Pediatric ANCA-associated Vasculitis

    Edouard Sayad1, Tiphanie Vogel1, David Moreno McNeill1, Nahir Cortes-Santiago1, David Spielberg1, Kalyani Patel1 and Manuel Silva Carmona1, 1Baylor College of Medicine/Texas Children's Hospital, Houston, TX

    Background/Purpose: Anca-associated vasculitis (AAV) is characterized by vascular inflammation in multiple organs. The diagnosis can be made clinically using a number of different criteria. The…
  • Abstract Number: 1438 • ACR Convergence 2020

    Rituximab Immunogenicity in ANCA-associated Vasculitis (RITUXIMAV)

    Jason Springer1 and Ryan Funk2, 1University of Kansas Medical Center, Overland Park, KS, 2UNIVERSITY OF KANSAS, Kansas City, KS

    Background/Purpose: Rituximab (RTX), an anti-CD20 chimeric monoclonal antibody, has been shown to be an effective maintenance therapy for granulomatosis with polyangitiis (GPA) and microscopic polyangiitis…
  • Abstract Number: 1524 • ACR Convergence 2020

    Interstitial Lung Disease, Kidney Inflammation and Myositis Are Induced by Transfer of PBMC Derived from Systemic Sclerosis Patients into Rag2-/-/ IL2rg-/- mice

    Xiaoyang Yue1, Frank Petersen1, Xinhua Yu1, Gabriela Riemekasten2, Peter Lamprecht3, Antje Müller3 and Junping Yin4, 1Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany, 2University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany, 3University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 41 Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL),, Borstel, Germany

    Background/Purpose: To explore the pathogenic potential of lymphocytes in systemic sclerosis (SSc) and granulomatosis with polyangiitis (GPA), a humanized mouse model was generated by transferring…
  • Abstract Number: 2048 • ACR Convergence 2020

    Comparison of Two Rituximab Regimens for Induction of Remission in Antineutrophil Cytoplasm Antibody-associated Vasculitis: Systematic Review and Meta-analysis

    Valerie Benard1, Cynthia Farhat2, Melissa Zarandi-Nowroozi2, Madeleine Durand3, Christian Pagnoux4, Pierre Charles5, Xavier Puechal6, Loïc Guillevin7 and Jean-Paul Makhzoum1, 1Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Internal Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montreal, QC, Canada, 2Department of Medecine, University of Montreal, Montreal, QC, Canada, 3Department of Internal Medicine, Centre Hospitalier de l’Universite de Montreal (CHUM) and Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CRCHUM), Montreal, QC, Canada, 4Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Department of Internal Medicine, Institut Mutualiste Montsouris, Paris, France, 6National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 7Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France

    Background/Purpose: Organ or life-threatening granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), two of the antineutrophil cytoplasm antibody-associated vasculitis (AAV), are treated with cyclophosphamide or…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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