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Abstracts tagged "Granulomatosis with Polyangiitis (GPA)"

  • Abstract Number: 0453 • ACR Convergence 2022

    Validation of the 2022 – American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria in Patients with ANCA Associated Vasculitis

    Aman Sharma1, Prateek Deo1, Shankar Naidu2, Joydeep Samanta3, Sakshi Mittal3, Kusum Sharma3, Ritambhra Nada3, Varun Dhir4, sanjay jain2 and Ranjana Minz2, 1PGIMER, Chandigarh, India, Chandigarh, India, 2Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3PGIMER, Chandigarh, India, 4PGIMER, CHD, INDIA, Chandigarh, India

    Background/Purpose: The purpose of this study was to validate the recently published 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for…
  • Abstract Number: 0454 • ACR Convergence 2022

    Advantages and Disadvantages in Applying 2022 ACR/EULAR Classification Criteria to Conventionally Diagnosed Japanese GPA Patients

    Ryo Kuwata1, Yuko Shirota2, Tsuyoshi Shirai3, Hiroyuki Yamashita1, Hiroko Sato3, Tomoki Takeda2, Yumiko Oka2, Takao Kodera4, Hiroshi Kaneko1, Junichi Kameoka5, Hiroshi Fujii3 and Tomonori Ishii6, 1Division of Rheumatic diseases, National Center for Global Health and Medicine, Tokyo, Japan, 2Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, 3Department of Rheumatology, Tohoku University Hospital, Sendai, Japan, 4Department of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, 5Divison of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, 6Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan

    Background/Purpose: The Chapel Hill Consensus Conference and the European Medicines Agency algorithm were commonly used to diagnose patients with granulomatosis with polyangiitis (GPA) 1). Recently…
  • Abstract Number: 0455 • ACR Convergence 2022

    Performance of 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria in Turkish Vasculitis Patients

    Ummugulsum Gazel1, Sevinc Can Sandikci2, Ahmet Omma3, Sinem Burcu Kocaer4, Fatoş Onen5, Onay Gercik6, Servet Akar7, Kerem Abacar8, Ebru Asicioglu9, Serhan Tuglular9, Fatma Alibaz-Oner8 and Haner Direskeneli10, 1University of Ottawa, Rheumatology, Ottawa, Canada, Ottawa, ON, Canada, 2Ankara Numune Education and Research Hospital, Rheumatology, Ankara, Turkey, 3Ankara Numune Education and Research Hospital, Rheumatology, Ankara, Turkey, Istanbul, Turkey, 4Dokuz Eylul University, Faculty of Medicine, Rheumatology, Izmir, Turkey, 5Dokuz Eylul University, Faculty of Medicine, Rheumatology, İzmir, Turkey, 6Izmir Tepecik Research Hospital, Izmir, Turkey, 7Izmir Katip Celebi University School of Medicine, Izmir, Turkey, 8Marmara University, Rheumatology, Istanbul, Turkey, 9Marmara University, Faculty of Medicine, Nephrology, Istanbul, Turkey, 10Marmara University, Rheumatology, Istanbul, Istanbul, Turkey

    Background/Purpose: The American College of Rheumatology (ACR)-1990 criteria is the most used method for the classification of ANCA Associated Vasculitis (AAV). However, with ACR-1990 criteria,…
  • Abstract Number: 0416 • ACR Convergence 2021

    Pharmacological Response of Rituximab Based on Dose Intensity in Maintenance Therapy of ANCA-Associated Vasculitis

    Jason Springer1 and Ryan Funk2, 1Vanderbilt University Medical Center, Franklin, TN, 2University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Rituximab (RTX) has demonstrated efficacy in maintenance therapy in ANCA-associated vasculitis. However, different dosing protocols have been used in clinical trials and there is…
  • Abstract Number: 0421 • ACR Convergence 2021

    Negative vs. Positive Antineutrophil Cytoplasmic Antibody Granulomatosis with Polyangiitis, a Case-control Study

    Marta Casal Moura, Samuel D. Falde, Ulrich Specks and Misbah Baqir, Mayo Clinic, Rochester, MN

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA) negative granulomatosis with polyangiitis (GPA) is a challenging diagnosis. There is paucity of literature regarding the clinical course of ANCA-negative…
  • Abstract Number: 0431 • ACR Convergence 2021

    Clinical Characteristics and Outcomes of ANCA-Associated and Non Immune-Mediated Hypertrophic Pachymeningitis: A Comparative Study

    Eduardo Martin-Nares, Lilian Guadalupe Cano Cruz and Andrea Hinojosa-Azaola, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Hypertrophic pachymeningitis (HP) is an infrequent manifestation in autoimmune and non-autoimmune conditions. The differences in clinical characteristics and outcomes of ANCA-associated and non-immune-mediated HP…
  • Abstract Number: 0436 • ACR Convergence 2021

    Ocular and Orbital Manifestations of Granulomatosis with Polyangiitis: A Systematic Review of Published Cases

    Madeleine Yeakle1, Allen Tsiyer1, Daniel Bishev1, Kayvon Moin1, Victoria Garofalo1, Allison Parrill1, Alexander Hatsis2, Tyler Wickas2 and Prachi Anand3, 1American University of the Caribbean School of Medicine, Cupecoy, Netherlands Antilles, 2Department of Ophthalmology, Nassau University Medical Center, East Meadow, NY, 3Department of Rheumatology, Nassau University Medical Center, East Meadow, NY

    Background/Purpose: Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s Granulomatosis, is a systemic autoimmune condition caused by granulomatous inflammation of small and medium arteries, arterioles…
  • Abstract Number: 0525 • ACR Convergence 2021

    STEAP3, FZD2 and EGFLAM Are Novel Genetic Risk Loci for Granulomatosis with Polyangitis: A Genome Wide Association Study from UK Biobank

    Mehmet Hocaoglu1, Jamal Mikdashi2, Yi-Ju Chen2, James Perry2 and Charles Hong2, 1University of Maryland Medical Center, Midtown Campus, Baltimore, MD, 2University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Granulomatosis with Polyangitis (GPA) is a systemic ANCA associated small vessel vasculitis. Prior genetic studies demonstrated a strong association of HLA Class II region…
  • Abstract Number: 1438 • ACR Convergence 2020

    Rituximab Immunogenicity in ANCA-associated Vasculitis (RITUXIMAV)

    Jason Springer1 and Ryan Funk2, 1University of Kansas Medical Center, Overland Park, KS, 2UNIVERSITY OF KANSAS, Kansas City, KS

    Background/Purpose: Rituximab (RTX), an anti-CD20 chimeric monoclonal antibody, has been shown to be an effective maintenance therapy for granulomatosis with polyangitiis (GPA) and microscopic polyangiitis…
  • Abstract Number: 1524 • ACR Convergence 2020

    Interstitial Lung Disease, Kidney Inflammation and Myositis Are Induced by Transfer of PBMC Derived from Systemic Sclerosis Patients into Rag2-/-/ IL2rg-/- mice

    Xiaoyang Yue1, Frank Petersen1, Xinhua Yu1, Gabriela Riemekasten2, Peter Lamprecht3, Antje Müller3 and Junping Yin4, 1Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany, 2University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany, 3University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 41 Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL),, Borstel, Germany

    Background/Purpose: To explore the pathogenic potential of lymphocytes in systemic sclerosis (SSc) and granulomatosis with polyangiitis (GPA), a humanized mouse model was generated by transferring…
  • Abstract Number: 2048 • ACR Convergence 2020

    Comparison of Two Rituximab Regimens for Induction of Remission in Antineutrophil Cytoplasm Antibody-associated Vasculitis: Systematic Review and Meta-analysis

    Valerie Benard1, Cynthia Farhat2, Melissa Zarandi-Nowroozi2, Madeleine Durand3, Christian Pagnoux4, Pierre Charles5, Xavier Puechal6, Loïc Guillevin7 and Jean-Paul Makhzoum1, 1Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Internal Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montreal, QC, Canada, 2Department of Medecine, University of Montreal, Montreal, QC, Canada, 3Department of Internal Medicine, Centre Hospitalier de l’Universite de Montreal (CHUM) and Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CRCHUM), Montreal, QC, Canada, 4Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Department of Internal Medicine, Institut Mutualiste Montsouris, Paris, France, 6National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 7Department of Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France

    Background/Purpose: Organ or life-threatening granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), two of the antineutrophil cytoplasm antibody-associated vasculitis (AAV), are treated with cyclophosphamide or…
  • Abstract Number: 2049 • ACR Convergence 2020

    Nasal Bacteria Associated with Disease Activity and ANCA Levels in Granulomatosis with Polyangiitis

    Rennie Rhee1, Jiarui Lu1, Kyle Bittinger2, Antoine Sreih1, Jung-Jin Lee3, Lisa Mattei3, Brendan Kelly4, Peter C. Grayson5, Hongzhe Lee4, Ronald Collman4 and Peter Merkel1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Children's Hospital of Philadelphia, Philadelphia, 4University of Pennsylvania, Philadelphia, 5Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Nasal bacteria have been linked to disease activity in granulomatosis with polyangiitis (GPA) with most studies focused on Staphylococcus aureus. Our previous study identified…
  • Abstract Number: 2050 • ACR Convergence 2020

    Autoantibodies Targeting Complement Receptors C3aR and C5aR1 Are Decreased in ANCA-associated Vasculitis and Correlate with a Higher Relapse Rate

    Sebastian Klapa1, Antje Müller2, Andreas Koch3, Anja Kerstein-Staehle4, Wataru Kaehler3, Harald Heidecke5, Susanne Schinke6, Markus Huber-Lang7, Martin Nitschke8, Silke Pitann9, Christian Karsten10, Gabriela Riemekasten11 and Peter Lamprecht2, 1University of Lübeck and Institute of Experimental Medicine, Christian-Albrechts-University of Kiel c/o German Naval Medical Institute, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 2University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, 3Institute of Experimental Immunology, Christian-Albrechts-University Kiel, c/o German Naval Medical Institute, Kronshagen, Germany, 4University of Lübeck, Dept Rheumatology and Clinical Immunology, Luebeck, Germany, 5CellTrend GmbH, Luckenwalde, Germany, 6University of Lübeck, Department of Rheumatology and Clinical Immunology, Luebeck, Germany, 7Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, Ulm, Germany, 8Department of Internal Medicine I, Transplant Center, University of Lübeck, Luebeck, Germany, 9University of Lübeck, Department of Rheumatology and Clinical Immunology,, Luebeck, Germany, 10Institute of Systemic Inflammation Research, University of Lübeck, Luebeck, Germany, 11University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany

    Background/Purpose: Activation of the alternative and common terminal complement pathways has been shown in ANCA-associated vasculitis (AAV). Circulating titers of the anaphylatoxin C5a are increased…
  • Abstract Number: 2051 • ACR Convergence 2020

    Localized versus Systemic Granulomatosis with Polyangiitis: Data from the French Vasculitis Study Group Database

    Michele Iudici1, Christian Pagnoux2, Delphine Courvoisier3, Pascal Cohen4, Mohamed Hamidou5, Achille Aouba6, François Lifermann7, Marc Ruivard8, Olivier Aumaitre9, Bernard Bonnotte10, Julien Campagne11, Olivier Decaux12, Eric Hachulla13, Alexandre Karras14, Chahéra Khouatra15, Noémie Jourde-Chiche16, Jean-François Viallard17, Pascal Godmer18, Claire Blanchard-Delaunay19, Alain Le Quellec20, Thomas Quéméneur21, Claire de Moreuil22, Alexis Regent4, Benjamin Terrier4, Luc Mouthon4, Loïc Guillevin4 and Xavier Puechal4, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University and Geneva University Hospitals, Geneva, Switzerland, 2Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 3Division of rheumatology, Geneva University Hospitals, Geneva, Switzerland, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris-Descartes University, Paris, France, 5Department of Internal Medicine, Hôtel-Dieu, CHU Nantes, Nantes, France, 6Department of Internal Medicine, CHU Côte de Nacre, Caen, France, 7Department of Internal Medicine, CH Côte d’Argent, Dax, France, 8Department of Internal Medicine, CHU Estaing, Clermont Ferrand, France, 9Department of Internal Medicine, CHU Gabriel Montpied, Clermont Ferrand, France, 10CHU Dijon, Dijon, France, 11Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 12CHU Rennes, Rennes, France, 13Department of Internal Medicine, CHRU, Lille Cedex, France, 14Department of Nephrology, Hôpital Européen Georges Pompidou, Paris, France, 15Department of Respiratory Medicine, CHU Louis Pradel, Lyon, France, 16Department of Nephrology, CHU de la Conception, Marseille, France, 17Department of Internal Medicine, CHU Haut-Lévêque, Bordeaux, France, 18Department of Internal Medicine, CH Bretagne Atlantique, Vannes, France, 19Department of Internal Medicine, CH, Niort, France, 20Department of Internal Medicine, CHU Saint Eloi, Montpellier, France, 21Department of Internal Medicine, CH, Valenciennes, France, 22Department of Internal Medicine, CHU Cavale Blanche, Brest, France

    Background/Purpose: The clinical picture at onset and evolution of localized forms of granulomatosis with polyangiitis (L-GPA) have already been investigated but, to our knowledge, have…
  • Abstract Number: 0060 • ACR Convergence 2020

    ANCA-associated Vasculitis in Caucasian and Hispanics of the Inland Empire of Southern California

    Sandy Lee1, Patil Injean1, Paulina Tran2, Deepa Panikkath1 and Christina Downey1, 1Loma Linda University Medical Center, Redlands, CA, 2UC Riverside School of Medicine, Riverside, CA

    Background/Purpose: ANCA-associated vasculitis (AAV) is often studied in the Caucasian population with few studies looking at the disease in other races. Disease presentation and treatment…
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