Abstracts tagged "gout"

Abstract Number: 3167 • 2015 ACR/ARHP Annual Meeting
Association of the Apolipoprotein A1-C3-A4 Gene Cluster with the Risk of Gout: Evidence for a Causal Role in Gout
Tony R. Merriman¹, Amanda Phipps-Green², Ruth Topless², Malcolm D. Smith³, Catherine Hill⁴, Susan Lester⁴, Maureen Rischmueller⁵, Matthijs Janssen⁶, Tim Jansen⁷, Leo A. Joosten⁸, Timothy Radstake⁹, Philip L. Riches¹⁰, Anne-Kathrin Tausche¹¹, Frederic Lioté¹², Alex So^13,14, Andre M. van Rij², Gregory T. Jones¹⁵, Sally McCormick¹⁶, Andrew Harrison², Lisa K. Stamp¹⁷, Nicola Dalbeth¹⁸ and Humaira Rasheed¹⁶, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Rheumatology, Repatriation General Hospital, Adelaide, Australia, ⁴Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia, ⁵Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ⁶Rheumatology Dept, Ziekenhuis Rijnstate, Arnhem, Netherlands, ⁷P O Box 581, Haarlem, Netherlands, ⁸Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁹Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁰Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom, ¹¹Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ¹²Rheumatology Department; Inserm UMR-S606; Paris-Diderot University, hôpital Lariboisiere, Paris, France, ¹³Service De Rhumatologie, CHUV, Lausanne, Switzerland, ¹⁴Department of Rheumatology, CHUV, Lausanne, Switzerland, ¹⁵Surgery, University of Otago, Dunedin, New Zealand, ¹⁶Department of Biochemistry, University of Otago, Dunedin, New Zealand, ¹⁷Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ¹⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Gout is caused by an inflammatory response to monosodium urate (MSU) crystals and is associated with elevated triglyceride and very low density lipoprotein levels.…
Abstract Number: 235 • 2015 ACR/ARHP Annual Meeting
Relationship Between Tissue Stress during Gait and Patterns of Urate Deposition and Bone Erosion in Gout: A Biomechanical Computational Modelling Study
Nicola Dalbeth¹, Michelle Deacon², Gregory Gamble¹, Kumar Mithraratne² and Justin Fernandez², ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand
Background/Purpose: Gout typically presents at characteristic sites such as the 1st metatarsophalangeal joint, midfoot or ankle. A potential explanation for this distribution is that tissue…
Abstract Number: 2237 • 2015 ACR/ARHP Annual Meeting
Effects of Coffee Consumption on Serum Uric Acid. a Systematic Review and Meta-Analysis
Jae-Bum Jun¹, Shin-Young Yim², Hyun Jung Kim³, Kyu Yong Park⁴, Hyeong Sik Ahn³, Sun Hee Kim⁴ and Eun Ji Park⁴, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Suwon, South Korea, ³Department of Preventive Medicine, Korea University College of Medicine, Seoul, South Korea, ⁴Department of Physical Medicine and Rehabilitation, Ajou University Hospital, Suwon, South Korea
Background/Purpose: Findings on the effect of coffee consumption on serum uric acid has been conflicting. The aim of this systematic review and meta-analysis is to analyze…
Abstract Number: 238 • 2015 ACR/ARHP Annual Meeting
Relationship Between Ultrasonographic Synovial Inflammation and Ultrasonographic Urate Deposition Findings in Patients with Gout
Fernando Perez-Ruiz^1,2, Sandra P. Chinchilla-Gallo³, Irati Urionagüena⁴ and Elena Garmendia^3,5, ¹Rheumatology Division, Hospital Universitario Cruces, Barakaldo, Spain, ²BioCruces Health Research Institute, Baracaldo, Spain, ³Rheumatology Division, Hospital Universitario Cruces, Baracaldo, Spain, ⁴Rheumatology Division, Hospital Universitario ruces, Baracaldo, Spain, ⁵Biocruces Helath Research Institute, Baracaldo, Spain
Background/Purpose: urate intra-articular deposits are seen in ultrasound as double contour sign (DCS), and hyperechogenic aggregates and tophi, but the extent of contribution of any…
Abstract Number: 2238 • 2015 ACR/ARHP Annual Meeting
Body Mass Index Modulates the Relationship Between Sugar-Sweetened Beverage Intake and Serum Urate Concentration
Nicola Dalbeth¹, Amanda Phipps-Green², Meaghan House¹, Gregory Gamble¹, Anne Horne¹, Lisa K. Stamp³ and Tony R. Merriman^2,4, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ⁴Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Elevated body mass index (BMI) and intake of sugar-sweetened beverages (SSB) are both modifiable risk factors for hyperuricaemia and gout. BMI can modulate the…
Abstract Number: 239 • 2015 ACR/ARHP Annual Meeting
The Role of Dual Energy Computed Tomography in Diagnosing Acute Gouty Arthritis: Comparison with Ultrasound and Aspiration
Jennifer Lee¹, Ji Yeon Lee², Jung Hee Koh³, Min Kyung Chung⁴, Ji Hun Kim¹, Seung-Ki Kwok⁵, Ji Hyeon Ju⁶ and Sung-Hwan Park⁷, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: The gold standard of acute gouty arthritis diagnosis has been to verify the presence of monosodium urate (MSU) crystal in the aspirated fluid of…
Abstract Number: 2239 • 2015 ACR/ARHP Annual Meeting
Prevalence of Gout and Hyperuricemia and Association with Fat Mass and Fat Free Mass: Results from a Population-Based Study
Tiffany K. Gill¹, Kimberley Ting², Graeme R Tucker¹, E. Michael Shanahan^3,4 and Catherine Hill^5,6, ¹Medicine, The University of Adelaide, Adelaide, Australia, ²Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia, ³Flinders University, Adelaide, Australia, ⁴Repat General Hospital, Flinders University, Adelaide, Australia, ⁵The Health Observatory, The University of Adelaide, Adelaide, Australia, ⁶Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia
Background/Purpose: Gout and hyperuricemia are major co-morbid health issues worldwide, with a known association with metabolic syndrome. Only one previous study based in Vietnam, has…
Abstract Number: 1223 • 2014 ACR/ARHP Annual Meeting
Enhancement of Proinflammatory Cytokine Production By Uric Acid in Human Cells Via Down Regulation of IL-1Ra
Tania Crisan¹, Maartje Cleophas², Heidi Lemmers³, Helga Toenhake-Dijkstra¹, Mihai Netea¹, Tim Jansen⁴ and Leo Joosten¹, ¹Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose Gout is an autoinflammatory disease characterized by the deposition of monosodium urate (MSU) crystals in the joints of hyperuricaemic patients and subsequent attacks of…
Abstract Number: 172 • 2014 ACR/ARHP Annual Meeting
Sleep Apnea and Risk of Incident Gout: A Population-Based Body-Mass Index Matched Cohort Study
Yuqing Zhang¹, Christine Peloquin², Maureen Dubreuil³, Edward Roddy⁴, Na Lu¹, Tuhina Neogi¹ and Hyon K. Choi⁵, ¹Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, ³Rheumatology, Boston University Medical Center, Boston, MA, ⁴Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ⁵Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Sleep apnea is common among obese individuals with comorbidities (up to ~30%), a typical profile of gout patients. Since hypoxia associated with sleep apnea…
Abstract Number: 1206 • 2014 ACR/ARHP Annual Meeting
Low Dose Colchicine Anti-Inflammatory Effects Are Transduced By AMP-Activated Protein Kinase (AMPK)
Ru Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose AMPK is a master metabolic energy regulator, whose tissue activity drops in response to nutritional excesses, alcohol consumption, and in obesity, metabolic syndrome and…
Abstract Number: 158 • 2014 ACR/ARHP Annual Meeting
Performance of Joint Ultrasonography in the Diagnosis of Suspected Acute Crystal Arthritis : Results of a Prospective Study of 112 Patients
Pascal Zufferey¹, Isabelle Fabreguet¹, Roxana Valcov¹, Alexandre Dumusc¹ and Alexander K. So Sr.², ¹DAL, RHU/CHUV, Lausanne, Switzerland, ²Dal/Rhu, CHUV, Lausanne, Switzerland
Background/Purpose The gold standard for diagnosing gout and CCP arthritis is the identification of monosodium urate (MSU) crystals in joint fluid. Ultrasound (US) features of…
Abstract Number: 1219 • 2014 ACR/ARHP Annual Meeting
Lack of Gene-Diuretic Interactions on Risk of Incident Gout: The Nurses’ Health Study and Health Professionals Follow-up Study
Ying Bao¹, Tony R. Merriman², Gary Curhan³, Eli A. Stahl⁴, David B. Mount⁵, Robert M. Plenge⁶, Peter Kraft⁷ and Hyon K. Choi⁸, ¹Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Renal Division, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁸Boston University School of Medicine, Boston, MA
Background/Purpose: Diuretics, particularly thiazide and loop diuretics, increase the risk of gout, likely through urate transporters (e.g., OAT4) and volume depletion promoting urate reabsorption. As…
Abstract Number: 155 • 2014 ACR/ARHP Annual Meeting
Cost-Effectiveness Analysis of HLA-B5801 Genotyping in the Treatment of Gout Patients with Chronic Renal Insufficiency in Korea
Dong-Jin Park¹, Kyung-Eun Lee¹, Sung-Hwan Park² and Shin-Seok Lee³, ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose Allopurinol-induced severe cutaneous adverse reactions (SCARs) are relatively rare, but cause high rates of morbidity and mortality. Studies have shown that the HLA-B5801 allele…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 152 • 2014 ACR/ARHP Annual Meeting
Subclinical Synovial Inflammation in Gout
Priya Chowalloor^1,2, Patrick Cheah³ and Helen I. Keen^1,2, ¹Rheumatology, Royal Perth Hospital, Perth, Australia, ²School of Medicine and Pharmacology, The University of Western Australia, Crawley, Australia, ³Rheumatology, Sir Charles Gairdner Hospital, Nedlands, Australia
Background/Purpose Gout is poorly managed in the community. Long standing poorly controlled gout can lead into progressive destructive arthropathy, decreased quality of life and increased…

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