Abstracts tagged "gout"

Abstract Number: 1227 • 2019 ACR/ARP Annual Meeting
A Neutrophil Signature Is Strongly Associated with Cardiovascular Risk in Gout
Daisy Vedder ¹, Martijn Gerritsen ¹, Mike Nurmohamed ², Ronald van Vollenhoven ³ and Christian Lood⁴, ¹Amsterdam Rheumatology & immunology Center / Reade, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center location Reade and Amsterdam UMC location VU medical center, Amsterdam, Netherlands, ³Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴University of Washington, Seattle, WA
Background/Purpose: Patients with gout have an increased cardiovascular morbidity and mortality, not fully explained by traditional cardiovascular risk factors. Xanthine oxidase-induced oxidative stress, increased lipid…
Abstract Number: 2077 • 2019 ACR/ARP Annual Meeting
Population Impact Attributable to Modifiable Risk Factors for Hyperuricemia and the Fallacy of the Variance Explained
Natalie McCormick ¹, Na Lu ², Sharan Rai ³, Chio Yokose ⁴, Yuqing Zhang ⁴ and Hyon K. Choi⁴, ¹Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Massachusetts General Hosptial, Boston, MA, ³Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA
Background/Purpose: In a seminal BMJ paper (Prior 1986), the Tokelau Island migrant study for gout and hyperuricemia concluded preventive strategies to modify body mass, diet…
Abstract Number: 324 • 2019 ACR/ARP Annual Meeting
Adherence to Guideline Directed Management of Gout Among VA Providers
Kelly Corbitt ¹, Isis Lopez² and David Dillon ³, ¹University of Miami/Jackson Memorial Hospital, Miami, FL, ²University of Miami/ Jackson Memorial Hospital, Miami, FL, ³University of Miami/Jackson Memorial Hospital, Miami
Background/Purpose: Gout is the most common inflammatory arthritis, affecting about 4% of the adult population in the United States. Management is often costly, with estimates around…
Abstract Number: 349 • 2019 ACR/ARP Annual Meeting
Carotid Atherosclerosis and Sonographic Signs of Urate Crystal Deposits in Patients with Gout: An Association Study
Irene Calabuig¹, Agustín Martínez-Sanchis ² and Mariano Andrés ³, ¹Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain, ²Hospital General Universitario de Alicante, Alicante, Spain, ³Hospital General Universitario de Alicante-ISABIAL, Universidad Miguel Hernández, Alicante, Spain
Background/Purpose: Carotid subclinical atherosclerosis is prevalent in patients with gout, although poorly predicted by cardiovascular risk assessment tools. Gout itself is deemed to contribute to…
Abstract Number: 1228 • 2019 ACR/ARP Annual Meeting
Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) Ameliorates Monosodium Urate Crystals (MSUC)-induced Inflammation in a Mouse Air-pouch Model of Gout
Vitaly Kliminski ¹ and Yair Molad², ¹Laboratory of Inflammation Research, Felsenstein Medical Research Center, Tel Aviv University, Petach Tikva, Israel, ²Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petach Tikva, HaMerkaz, Israel
Background/Purpose: Myeloid cells membrane-bound TREM-1 (mTREM-1) amplifies toll like receptor (TLR)-4-mediated myeloid cells activation, accompanied by release of soluble TREM-1 (sTREM-1) that acts as a…
Abstract Number: 2133 • 2019 ACR/ARP Annual Meeting
Acute Myocardial Infarction in Rheumatoid Arthritis, Gout, and Osteoarthritis: A Retrospective Study Using the National Inpatient Sample from 2002-2016
Rouhin Sen¹, Sarah Aurit ², Luay Sarsam ³, Osman Bhatty ⁴, Mukund Kumar ¹ and Joseph Nahas ¹, ¹Creighton University Medical Center, Omaha, NE, ²Creighton University Medical Center, Omaha, ³Arnot Health, Elmira, NY, ⁴Montefiore Medical Center Wakefield Campus, Bronx, NY
Background/Purpose: Inflammation is a risk factor in the development of cardiovascular disease. The proposed etiology centers around accelerated atherosclerosis involving various cytokines in the TNF…
Abstract Number: 329 • 2019 ACR/ARP Annual Meeting
Excessive Alcohol Intake Is Associated with Tophi Formation in Gout Patients
Qian-Hua Li ¹, Chao Deng ¹, Li-Juan Yang ¹, Jin-Jian Liang ¹, Jian-Zi Lin ¹, Ying-Qian Mo ¹ and Lie Dai¹, ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (People's Republic)
Background/Purpose: Dietary factors have been recognized as risk factors of hyperuricemia and gout. However, their association with tophi formation remain elusive. The aim of this…
Abstract Number: 351 • 2019 ACR/ARP Annual Meeting
Risk Factors for Cutaneous Reactions to Allopurinol in Kinh Vietnameses: Results of a Prospective Study in Ho Chi Minh City
Thomas Bardin¹, Linh Gia Le ², Quang Dinh Nguyen ³, Anh Duy Do ⁴, Hung Le ⁵, Minh Duc Do ², Anh Hoang Vu ², Anh Ngoc Le ⁶, Kim Minh Bui ³, Pascal Richette ⁷, Matthieu Resche-Rigon ⁸ and Thao Phuong Mai ⁹, ¹Vien Gut Medical Center and hopital Lariboisiere, Paris, France, ²Center for Molecular Biomedicine, University of Medicine and Pharmacy HCMC, Vietnam, Ho Chi Minh City, Vietnam, ³Vien Gut Medical Center, Ho Chi Minh City, Vietnam, ⁴Department of Physiology, Pathophysiology and Immunology - Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam, ⁵Department of Tropical Disease - Cho Ray Hospital, Ho Chi Minh City, Vietnam, ⁶Departement of Scientific Research, Cho Ray Hospital, Ho Chi Minh City, Vietnam, ⁷Department of Rheumatology, AP-HP Lariboisiere Hospital, Paris, France, ⁸Departe;ent of Biostatistics Hopital St Louis, Paris, France, ⁹Department of Physiology, Faculty of Medicine, University of Medicine and Pharmacy HCMC, Vietnam, Ho Chi Minh City, Vietnam
Background/Purpose: Allopurinol (ALLO), the leading hypouricemic drug worldwide, exposes to mild (M) and severe (S) cutaneous adverse reactions (CARs). SCARS have been associated with HLA*B-58…
Abstract Number: 1230 • 2019 ACR/ARP Annual Meeting
Do Serum Urate-Associated Genetic Variants Influence Gout Risk in People on Diuretics? Analysis of the UK Biobank
Ravi Narang¹, Greg Gamble ¹, Amanda Phipps-Green ², Ruth Topless ³, Murray Cadzow ³, Lisa Stamp ⁴, Tony Merriman ⁵ and Nicola Dalbeth ¹, ¹University of Auckland, Auckland, New Zealand, ²University of Otago, Otago, Otago, New Zealand, ³University of Otago, Otago, New Zealand, ⁴University of Otago, Christchurch, Christchurch, Canterbury, New Zealand, ⁵University of Otago, Birmingham, AL
Background/Purpose: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with serum urate and gout. An association between diuretic use and gout has also…
Abstract Number: 2755 • 2019 ACR/ARP Annual Meeting
Assessing the Sensitivity to Change of the OMERACT Ultrasound Structural Gout Lesions During Urate-Lowering Therapy
Sara Nysom Christiansen¹, Mikkel Østergaard ², Ole Slot ¹, George A. W. Bruyn ³, Helen Keen ⁴, Maria-Antonietta D’Agostino ⁵ and Lene Terslev ⁶, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Glostrup, Denmark, ²Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ³Department of Rheumatology, MC Groep Hospitals., Lelystad, Netherlands, ⁴School of Medicine and Pharmacology Fiona Stanley Hospital Unit, University of Western Australia, Perth, Australia, ⁵Department of Rheumatology, Ambroise Pare´ Hospital, and Versailles Saint-Quentin-en-Yvelines University, Boulogne-Billancourt, France, ⁶Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark
Background/Purpose: To evaluate the sensitivity to change of ultrasound (US) structural gout lesions, as defined by the OMERACT US group, in gout patients during urate…
Abstract Number: 331 • 2019 ACR/ARP Annual Meeting
Gout Management in the Medical Community: A Claims-Based Analysis
N. Lawrence Edwards¹, Naomi Schlesinger ², Sanders Clark ³, Jeremy Paige ⁴, Theresa Arndt ⁴ and Peter Lipsky ⁵, ¹Department of Medicine, University of Florida, Gainesville, FL, ²Division of Rheumatology, Department of Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, ³HVH Precision Analytics, LLC, Wayne, PA, ⁴HVH Precision Analytics, Wayne, PA, ⁵AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Gout is one of the most common inflammatory arthropathies. Despite available urate lowering therapies (ULT), many patients progress to chronic or advanced gout, characterized…
Abstract Number: 353 • 2019 ACR/ARP Annual Meeting
Allopurinol Use and Type 2 Diabetes Incidence Among Patients with Gout: A VA Cohort Study
Anastasia Slobodnick¹, Michael Toprover ², Courtney Pike ³, Daria Crittenden ⁴, Jeffrey Greenberg ⁵ and Michael Pillinger ², ¹New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, ³Rheumatology Section, NY Harbor VA Healthcare System, New York, ⁴Amgen Inc., Thousand Oaks, CA, ⁵Corrona, LLC; NYU School of Medicine, Waltham, MA
Background/Purpose: Several studies implicate gout and/or xanthine oxidase activity as risk factors for type 2 diabetes. However, no studies have directly evaluated the effect of…
Abstract Number: 1231 • 2019 ACR/ARP Annual Meeting
Improvement in Hepatic Fibrosis Estimated by Fibrosis-4 (FIB-4) Index in Subjects with Chronic Refractory Gout Treated with Pegloticase
Naomi Schlesinger¹, Anthony Yeo ² and Peter Lipsky ³, ¹Division of Rheumatology, Department of Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, ²Horizon Therapeutics plc, Lake Forest, IL, ³AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD) (Yang C et al. PlosOne2017; 12:e0177249; Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017;…
Abstract Number: 2834 • 2019 ACR/ARP Annual Meeting
Assessing the Risk of Gout with Sodium Glucose Co-Transporter-2 Inhibitors: A Population-Based Cohort Study
Michael Fralick¹, Sarah Chen ², Elisabetta Patorno ³ and Seoyoung C. Kim ⁴, ¹Mount Sinai Hospital, University of Toronto, Toronto, ²Brigham and Women's Hospital and Harvard Medical School, Boston, ³Harvard University, Boston, ⁴Brigham and Women’s Hospital and Harvard Medical School, Boston
Background/Purpose: Hyperuricemia is common in patients with type 2 diabetes mellitus and is associated with an increased risk of gout. Sodium-glucose cotransporter 2 (SGLT2) inhibitors,…
Abstract Number: 1006 • 2018 ACR/ARHP Annual Meeting
Physical Activity at Lower Intensities Reduces Localized IL-1b in a Murine Model of Gout By Systemically Down-Regulating TLR2 Expression on Circulating Neutrophils and Suppressing CXCL1 Expression
Kyle Jablonski¹, Nicholas A. Young², Bianca Sandoval³, Ifeoma Okafor⁴, Emily Schwarz³, Caitlin Henry³, Peter Harb³, Anuradha Kalyanasundaram⁵, Wael Jarjour⁶ and Naomi Schlesinger⁷, ¹The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Physiology and Cell Biology, The Ohio State University, Columbus, OH, ⁶Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁷Department of Medicine/Rheumatology Division, Rutgers- Robert Wood Johnson Medical School, New Brunswick, New Brunswick, NY
Background/Purpose: Exercise was originally believed to exacerbate inflammation in rheumatic disease, however, recent studies have shown that regular physical activity is anti-inflammatory. In gout, there…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].