Abstracts tagged "giant cell arteritis and vasculitis"

Abstract Number: 875 • 2016 ACR/ARHP Annual Meeting
Pericardial Involvement in Biopsy-Proven Giant-Cell Arteritis (GCA) Patients Detected By CT Angiography (CTA): Prevalence at Diagnosis and Outcome with Glucocorticoid (GC) Treatment
Javier Marco-Hernández¹, Sergio Prieto-González², Rosa Gilabert³, Pedro Arguis⁴, Georgina Espígol-Frigolé⁵, Ana García-Martínez⁶, Ester Planas-Rigol⁵, Marc Corbera-Bellalta², Nekane Terrades-Garcia², Jose Hernández-Rodríguez² and Maria C. Cid⁷, ¹Internal Medicine, Hospital Clínic, Barcelona, Spain, ²Vasculitis Research Unit. Department of Autoimmune Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ³Center for Diagnostic Imaging, Hospital Clínic, Barcelona, Spain, ⁴Center for Diagnostic Imaging, Hospital Clínic. IDIBAPS. University of Barcelona, Barcelona, Spain, ⁵Department of Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁶Emergeny Department, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ⁷Autoimmune and Systemic Diseases, Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain
Background/Purpose: In GCA, cranial artery involvement is particularly frequent and underlies the classical manifestations and complications of the disease. Symptomatic pericarditis has been occasionally described…
Abstract Number: 1261 • 2015 ACR/ARHP Annual Meeting
Molecular Analysis of Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis: Targeting Endothelin-1 Receptor to Control Proliferation
Alexis Regent¹, Kim Heang Ly², Matthieu Groh³, Chabha Khifer⁴, Sebastien Lofek⁵, Mathieu Tamby⁶, Guilhem Clary⁷, Philippe Chafey⁷, Véronique Baud⁸, Cédric Broussard⁹, Christian Federici⁷, Francois Labrousse¹⁰, Laura Mesturoux¹¹, Claire Le Jeunne¹², Elisabeth Vidal¹³, Antoine P. Brezin¹⁴, Veronique Witko-Sarsat¹⁵, Loïc Guillevin¹² and Luc Mouthon¹⁵, ¹Service de médecine interne, Hôpital Cochin, Paris, France, ²CHU Dupuytren, Limoges, Limoges, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁴Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵Université Paris Descartes, Paris, France, ⁶Institut Cochin, U1016, Paris, France, ⁷Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁸Institut cochin, U1016, Paris, France, ⁹Inserm U 567, CNRS UMR 8104, Cochin Institute, Paris, France, ¹⁰Department of Pathology, Limoges University Hospital, Limoges, France, ¹¹CHU Limoges, Limoges, France, ¹²Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ¹³Internal Medecine, Limoges hospital, Paris, France, ¹⁴Université Paris Descartes, Hôpital Cochin, Paris, France, ¹⁵Labex Inflamex, Université Sorbonne Paris Cité, Paris, France
Background/Purpose: Vascular remodeling play a major role in the pathophysiology of giant cell arteritis (GCA) and the mechanisms underlying it are poorly understood. Methods: Vascular…
Abstract Number: 1951 • 2015 ACR/ARHP Annual Meeting
The Incidence Rate of Giant Cell Arteritis in Slovenia
Natasa Potocnik¹, Alojzija Hocevar¹, Ziga Rotar¹, Joze Pizem², Marko Hawlina³, Ana Fakin³ and Matija Tomšič¹, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Institute of Pathology, University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia, ³Department of Ophthalmology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults aged 50 years or above. Annual incidence rates vary widely from 6.9–76.6…
Abstract Number: 1955 • 2015 ACR/ARHP Annual Meeting
The Performance of Colour-Doppler Sonography of Temporal Arteries in Patients Suspect of Having Giant Cell Arteritis in Daily Clinical Practice
Alojzija Hocevar, Rok Ješe, Ziga Rotar and Matija Tomšič, Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Background/Purpose: The Colour-Doppler Sonography of temporal arteries (CDS-TA) has recently gained momentum as a potential non-invasive tool for diagnosing GCA. Our aim was to evaluate the…
Abstract Number: 1957 • 2015 ACR/ARHP Annual Meeting
Colour-Doppler Ultrasonography of Epiaortic Arteries in Patients with Giant Cell Arteritis
Alojzija Hocevar, Rok Ješe, Ziga Rotar and Matija Tomšič, Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Background/Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in patients over 50 years of age. Large vessel disease outside temporal arteries is…
Abstract Number: 1786 • 2014 ACR/ARHP Annual Meeting
Vasculitis As Underlying Cause of Death in the United States: 1999 – 2010
Alicia Rodriguez-Pla¹, Paul A. Monach² and Jose Rossello-Urgell³, ¹Rheumatology, Boston University, Boston, MA, ²Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ³Baylor Research Institut, Baylor Institute for Immunology Research, Dallas, TX
Background/Purpose Current data on mortality rates of primary vasculitis, which were tradionally associated with a dreadful prognosis, are limited. Therefore, we aimed to estimate the mortality rates…
Abstract Number: 883 • 2014 ACR/ARHP Annual Meeting
Accuracy of High Resolution MRI of Scalp Arteries for the Diagnosis of Giant Cell Arteritis: Results of a Prospective Study
Maxime Rhéaume¹, Ryan Rebello², Christian Pagnoux³, Simon Carette³, Marie Clements-Baker⁴, Violette Cohen-Hallaleh², David Doucette-Preville², B. Stanley Jackson⁵, Sam Salama⁶, George Ioannidis⁷ and Nader A. Khalidi¹, ¹Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ²Department of Radiology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Queens University, Kingston, ON, Canada, ⁵Department of Surgery, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ⁶Department of Pathology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ⁷St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA). It is invasive and its sensitivity is limited…
Abstract Number: 881 • 2014 ACR/ARHP Annual Meeting
DNA Methylation Analysis of the Temporal Artery Microenvironment Reveals a Robust T Cell Signature and Suggests a Role for TNF-α in Giant Cell Arteritis
Patrick S. Coit¹, Lindsey B. De Lott², Bin Nan³, Victor M. Elner⁴ and Amr H. Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of Michigan, Ann Arbor, MI, ⁴Department of Ophthalmology and Visual Sciences & Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: Giant cell arteritis (GCA) is a systemic large vessel vasculitis of unknown etiology. A hallmark of GCA is the presence of granulomatous inflammation of…
Abstract Number: 803 • 2014 ACR/ARHP Annual Meeting
Corticosteroid-Related Adverse Events in Patients with Giant Cell Arteritis: A Claims-Based Analysis
Gordon H. Sun¹, Khaled Sarsour², Eunice Chang¹, Michael S. Broder¹, Neil Collinson³, Katie Tuckwell³, Pavel Napalkov² and Micki Klearman², ¹Partnership for Health Analytic Research, LLC, Beverly Hills, CA, ²Genentech, Inc., a Member of the Roche Group, South San Francisco, CA, ³Roche Products Ltd., Welwyn Garden City, United Kingdom
Background/Purpose Giant cell arteritis (GCA) is an inflammatory vasculitis preferentially affecting large and medium-sized arteries with an incidence of 1 to 30/100,000. High-dose oral corticosteroids…
Abstract Number: 802 • 2014 ACR/ARHP Annual Meeting
Inpatient Complications in Patients with Giant Cell Arteritis: Increased Risk of Thromboembolism, Delirium and Adrenal Insufficiency
Sebastian Unizony¹, Mariano Menendez², Naina Rastalsky³ and John H. Stone¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose The morbidity and mortality of hospitalized giant cell arteritis (GCA) patients has been largely unexplored. The aim of this study was to analyze inpatient…
Abstract Number: 792 • 2014 ACR/ARHP Annual Meeting
Is Temporal Artery Biopsy the Gold Standard for the Diagnosis of Giant Cell Arteritis?
Marina Scolnik¹, Aldo Fabian Ojeda², Valeria Scaglioni³ and Enrique R. Soriano⁴, ¹Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Departamento de Reumatología, Hospital de Clínicas, FCM-UNA, Asuncion, Paraguay, ³Rheumatology Unit, Internal Medical Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina
Background/Purpose: The only test that confirms diagnosis of Giant Cell Arteritis (GCA) is a temporal artery biopsy showing vasculitis with mononuclear cell inflammatory infiltrates, often with…
Abstract Number: 783 • 2014 ACR/ARHP Annual Meeting
Increased Migration and Proliferation Potential Characterize Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis
Alexis Regent^1,2, Kim-Heang Ly³, Matthieu Groh², Chabha Khifer⁴, Sebastien Lofek⁴, Guilhem Clary⁵, Philippe Chafey⁵, Cédric Broussard⁵, Christian Federici⁵, Claire Le Jeunne², Elisabeth Vidal⁶, Antoine Brezin⁷, Veronique witko-Sarsat⁵, Loïc Guillevin² and Luc Mouthon², ¹Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ³Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges;, Limoges, France, ⁴Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁶Laboratoire d’immunologie, EA3842, Faculté de médecine, Limoges, France, ⁷Service d’ophtalmologie, hôpital Cochin, AP-HP, Paris, France
Background/Purpose The pathophysiology of GCA is poorly understood. Questions remain regarding the mechanisms underlying vascular remodeling. Methods Vascular smooth muscle cells (VSMC) were cultured from…
Abstract Number: 1669 • 2013 ACR/ARHP Annual Meeting
The Birmingham Vasculitis Activity Score As a Measure Of Disease Activity In Patients With Giant Cell Arteritis
Tanaz A. Kermani¹, David Cuthbertson², Simon Carette³, Gary S. Hoffman⁴, Nader A. Khalidi⁵, Curry L. Koening⁶, Carol A. Langford⁷, Kathleen McKinnon-Maksimowicz⁸, Carol McAlear⁹, Paul A. Monach¹⁰, Philip Seo¹¹, Kenneth J. Warrington¹², Steven R. Ytterberg¹³, Peter A Merkel¹⁴ and Eric L. Matteson¹⁵, ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²Department of Biostatistics, University of South Florida, Tampa, FL, ³Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁴Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁵Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Internal Medicine, Salt Lake City Veterans Administration, Salt Lake City, UT, ⁷Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Rheumatology, Boston University, Boston, MA, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹³Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁴Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ¹⁵Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS), a validated tool for assessment of vasculitis disease activity, in a cohort…
Abstract Number: 895 • 2013 ACR/ARHP Annual Meeting
The Relative Risk Of Aortic Aneurysm In Patients With Giant Cell Arteritis Compared With The General Population
Joanna Robson¹, Amit Kiran², Joseph Maskell³, Andrew Hutchings⁴, Nigel K. Arden⁵, Bhaskar Dasgupta⁶, William Hamilton⁷, Akan Emin⁸, David Culliford³ and Raashid A. Luqmani², ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, ³Faculty of Medicine, University of Southampton, Southampton, United Kingdom, ⁴Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁵NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁶Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom, ⁷Primary Care Diagnostics, University of Exeter Medical School, Exeter, United Kingdom, ⁸Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, United Kingdom
Background/Purpose: To evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) when compared with age, gender and location matched controls from…
Abstract Number: 857 • 2012 ACR/ARHP Annual Meeting
Impairment of the Inhibitory PD-1-PD-L1 Axis in Giant Cell Arteritis (GCA)
Mazen Nasrallah¹, Augusto Vaglio², Shalini Mohan¹, Bjorn Hartmann³, Joyce Liao⁴, Kenneth J. Warrington⁵, Jorg J. Goronzy³ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Unit of Nephrology, University Hospital of Parma, Parma, Italy, ³Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Giant cell arteritis (GCA) is an autoimmune syndrome characterized by granuloma formation in the media of medium and large arteries. In a healthy immune…

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