ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 883

Accuracy of High Resolution MRI of Scalp Arteries for the Diagnosis of Giant Cell Arteritis: Results of a Prospective Study

Maxime Rhéaume1, Ryan Rebello2, Christian Pagnoux3, Simon Carette3, Marie Clements-Baker4, Violette Cohen-Hallaleh2, David Doucette-Preville2, B. Stanley Jackson5, Sam Salama6, George Ioannidis7 and Nader A. Khalidi1, 1Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 2Department of Radiology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 3Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 4Rheumatology, Queens University, Kingston, ON, Canada, 5Department of Surgery, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 6Department of Pathology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 7St Joseph's Healthcare Hamilton, Hamilton, ON, Canada

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: diagnosis, giant cell arteritis and vasculitis, MRI

  • Tweet
  • Email
  • Print
Session Information

Session Title: Vasculitis I

Session Type: Abstract Submissions (ACR)

Background/Purpose: Temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA). It is invasive and its sensitivity is limited by segmental arterial involvement. We sought to determine the diagnostic accuracy of high-field MRI compared to TAB in patients with suspected GCA.

 

Methods: All patients referred for TAB at our center were approached for this study. A high-resolution 3T MRI of the scalp arteries was obtained before the TAB was performed. Arterial abnormalities on MRI were assessed according to a previously published grading scheme, evaluating mural thickness and enhancement based on multiplanar postcontrast T1-weighted spin-echo images. Diagnostic accuracy of MRI was evaluated by comparison with TAB results as a primary analysis. Secondary analyses included comparison to clinician diagnosis and ACR criteria.

 

Results: 191 patients were screened and 171 were included in the study. Exclusions were based on withdrawal of consent (11), contra-indication to MRI (3), non-diagnostic test (3 MRI, 2 TAB) or failure to obtain MRI (1). ACR criteria were met in 137 patients (80.1%). Physician diagnosis was available for 162 subjects, with 78 (48.2%) considered as GCA. The MRI showed abnormal scalp arteries in 60 patients (35.1%) while biopsy was positive in 31 (18.1%). MRI was positive in 29 of those 31 patients with positive TAB (Sensitivity 93.6%). MRI was normal in 109 of those 140 with negative TAB (Specificity 77.9%). Relative to TAB, the negative predictive value of MRI was 98.2%.

 

Conclusion: High-resolution MRI detects biopsy-positive GCA with high sensitivity. A negative MRI is highly predictive of a negative TAB, such that patients with a negative MRI could safely be spared TAB. The significance of a positive MRI is not as well defined, and this should be the focus of future research.

 

 

MRI: Sensitivity, Specificity, Positive predictive value (PPV) and Negative predictive value (NPV)

Index Test

Reference Test

Sensitivity

(95% CI)

Specificity

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

MRI

Biopsy

0.936 (0.786,0.992)

0.779

(0.701, 0.844)

0.483

(0.352, 0.616)

0.982

(0.936, 0.998)

MRI

ACR (Fulfillment of at least 3/5 ACR criteria)

0.394

(0.311, 0.481)

0.824

(0.655, 0.932)

0.900

(0.795, 0.962)

0.252

(0.175,0.344)

 


Disclosure:

M. Rhéaume,
None;

R. Rebello,
None;

C. Pagnoux,
None;

S. Carette,
None;

M. Clements-Baker,
None;

V. Cohen-Hallaleh,
None;

D. Doucette-Preville,
None;

B. S. Jackson,
None;

S. Salama,
None;

G. Ioannidis,
None;

N. A. Khalidi,
None.

  • Tweet
  • Email
  • Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/accuracy-of-high-resolution-mri-of-scalp-arteries-for-the-diagnosis-of-giant-cell-arteritis-results-of-a-prospective-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies