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Abstracts tagged "Genome Wide Association Studies"

  • Abstract Number: 0301 • ACR Convergence 2020

    Genetic Associations and Polygenic Risk Assessment in Incomplete Lupus Erythematosus

    Matthew Slief1, Jeremy Levin2, Susan Macwana1, Wade DeJager1, Rebecka Bourn3, Swapan Nath3, Melissa Munroe4, Teresa Aberle1, Patrick Gaffney5, Joan Merrill3, Judith James6 and Joel Guthridge1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2OU Medical Center, Oklahoma City, 3Oklahoma Medical Research Foundation, Oklahoma City, 4Oklahoma Medical Research Foundation/Progentec Diagnostics, Inc., Oklahoma City, OK, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Patients with incomplete lupus erythematosus (ILE) have features of lupus, but have insufficient criteria for SLE classification. Some ILE patients transition to classified SLE,…
  • Abstract Number: 0982 • ACR Convergence 2020

    Genetics of Avascular Necrosis in Children and Adults with Systemic Lupus Erythematosus

    Declan Webber1, JingJing Cao2, Daniela Dominguez3, Dafna Gladman4, Andrea Knight5, Deborah Levy1, Lawrence Ng6, Andrew Paterson2, Zahi Touma7, Murray Urowitz8, Joan Wither9, Earl D. Silverman10 and Linda Hiraki11, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 4Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 5Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Division of Rheumatology, Hospital for Sick Children, Toronto, Canada, 7University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network; Krembil Research Institute, Toronto, ON, Canada, 8University Health Network, University of Toronto, Toronto, ON, Canada, 9University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 10Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 11Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Genetics have been shown to contribute to risk of avascular necrosis (AVN), a debilitating complication of systemic lupus erythematosus (SLE). Our aim was to…
  • Abstract Number: 1008 • ACR Convergence 2020

    Assessing Improved Risk Prediction of Seropositive Rheumatoid Arthritis by Environmental, Genetic, and Preclinical Plasma Metabolite Factors

    Karen Costenbader1, Jeffrey Sparks2, Elizabeth Karlson3, Kazuki Yoshida4, Jing Cui5, Susan Malspeis6 and Lilia Bouzit7, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 5Brigham Women's Hospital, Boston, MA, 6Brigham and Women's Hospital, Boston, 7Harvard Chan School of Public Health, Boston, MA

    Background/Purpose: Recent research has advanced the understanding of associations between environmental, genetic, and metabolic factors and rheumatoid arthritis (RA), introducing potential to improve risk prediction.…
  • Abstract Number: 1472 • ACR Convergence 2020

    Assessing Causal Associations of Urate Levels with Type 2 Diabetes and Related Glycemic Traits Using Bidirectional Mendelian Randomization

    Natalie McCormick1, Mark O'Connor1, Shelby Marozoff2, John Choi3, Aaron Leong1 and Hyon Choi4, 1Massachusetts General Hospital, Boston, MA, 2Arthritis Research Canada, Vancouver, Canada, 3Massachusetts General Hospital, Boston, 4Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA

    Background/Purpose: Type 2 diabetes (T2D) and gout/hyperuricemia frequently coexist, but the nature and direction of this relationship is unclear.  Observational studies have reported positive associations…
  • Abstract Number: 1525 • ACR Convergence 2020

    Intergenic HLA Variants in African American Patients with Systemic Sclerosis Regulate Expression of HLA-DRB1

    Urvashi Kaundal1, Julia Hartman2, Chloe Borden2, Janet Wang3, Ami Shah4, Maureen Mayes5, Ayo Doumatey6, Amy Bentley7, Daniel Shriner6, Robyn Domsic8, Thomas Medsger9, Paula Ramos10, Richard Silver11, Virginia Steen12, John Varga13, Vivien Hsu14, Lesley Ann Saketkoo15, Elena Schiopu16, Dinesh Khanna17, Jessica Gordon18, Lindsey Criswell19, Heather Gladue20, Chris Derk21, Elana Bernstein22, S. Louis Bridges23, Victoria Shanmugam24, Kathleen Kolstad25, Lorinda Chung26, Suzanne Kafaja27, Reem Jan28, Marcin Trojanowski29, Avram Goldberg30, Benjamin Korman31, Monique Hinchcliff32, Settara Chandrasekharappa6, Massimo Gadina2, Davide Randazzo2, Stefania Dell'Orso2, Adebowale Adeyemo6, Charles Rotimi6, Elaine Remmers6, Fredrick Wigley33, Rafael Casellas2, Daniel Kastner6, Francesco Boin34 and Pravitt Gourh1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Beachwood, OH, 4Johns Hopkins University School of Medicine, Ellicott City, MD, 5University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, 6National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD, 7National Human Genome Research Institute (NHGRI), NIH, Bethedsa, MD, 8University of Pittsburgh School of Medicine, Pittsburgh, PA, 9University of Pittsburgh School of Medicine, Verona, PA, 10Medical University of South Carolina, Charleston, SC, 11Medical University of South Carolina, Charleston, 12Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 13Northwestern University, Chicago, IL, 14Rutgers-RWJ Medical School, South Plainfield, NJ, 15Scleroderma Patient Care and Research Center, Tulane University, New Orleans, LA, 16Michigan Medicine, Ann Arbor, MI, 17University of Michigan, Ann Arbor, MI, 18Hospital for Special Surgery, New York, NY, 19Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, 20Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, 21University of Pennsylvania, Philadelphia, PA, 22Columbia University, New York, NY, 23University of Alabama at Birmingham, Mountain Brk, AL, 24The George Washington University, Washington, DC, 25Division of Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 26Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA, 27David Geffen School of Medicine, UCLA, Los Angeles, CA, 28Pritzker School of Medicine, University of Chicago, Chicago, IL, 29Boston University Medical Center, BOSTON, MA, 30NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 31Department of Medicine, University of Rochester Medical Center, Rochester, NY, 32Yale School of Medicine, Westport, CT, 33Johns Hopkins University School of Medicine, Baltimore, MD, 34University of California San Francisco, Cedars-Sinai, West Hollywood, CA

    Background/Purpose: Genome-wide association study (GWAS) from the Genome Research in African American Scleroderma Patients (GRASP) cohort has identified the human leukocyte antigen (HLA) region as…
  • Abstract Number: 1669 • ACR Convergence 2020

    Genetics of Age at Diagnosis in Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao2, JingJing Cao2, Dafna Gladman3, Marisa Klein-Gitelman4, Andrea Knight5, Deborah Levy1, Karen Onel6, Andrew Paterson2, Christine Peschken7, Janet Pope8, Zahi Touma9, Murray Urowitz10, Declan Webber1, Joan Wither11, Earl D. Silverman12 and Linda Hiraki13, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 4Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 7Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 8Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 9University of Toronto, Toronto, ON, Canada, 10University Health Network, University of Toronto, Toronto, ON, Canada, 11University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 12Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 13Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Genome wide association studies (GWAS) have identified >90 SNPs associated with systemic lupus erythematosus (SLE) risk. However, there may be additional loci impacting the…
  • Abstract Number: 1860 • ACR Convergence 2020

    An Integrative Approach to Identify Heritable and De Novo Genomic Variations in Psoriatic Arthritis Mutilans and Understand Its Systems Biology

    Sara Rahmati1, Quan Li1, Dafna Gladman2, Proton Rahman3 and Vinod Chandran2, 1University Health Network, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Memorial University of Newfoundland, Department of Medicine, St John's, Canada

    Background/Purpose: Psoriasis is a chronic autoimmune skin disease that burdens ~3% of North Americans. ~24% of psoriatic patients develop psoriasis arthritis (PsA), an inflammatory disease…
  • Abstract Number: 1954 • ACR Convergence 2020

    Genome-wide Association Study of Sjögren’s Syndrome Identifies Ten New Risk Loci

    Bhuwan Khatri1, Tove Ragna Reksten2, Kandice Tessneer3, Astrid Rasmussen1, R. Scofield1, Simon Bowman4, Joel Guthridge1, Judith James5, Lars Ronnblom6, Blake Warner7, Xavier Mariette8, Roald Omdal9, Javier Martin10, Maria Teruel10, Janicke Liaaen Jensen11, Lara Aqrawi11, Øyvind Palm11, Marie Wahren-Herlenius12, Torsten Witte13, Roland Jonsson14, Maureen Rischmueller15, A Darise Farris1, Marta Alarcon-Riquelme10, Wan-Fai Ng16, Kathy Sivils1, Gunnel Nordmark17 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Bergen, Bergen, Norway, 3Oklahoma Medical Research Foundation, Oklahoma City, 4University Hospitals Birmingham, Birmingham, United Kingdom, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 6Uppsala University, Uppsala, Sweden, 7National Institute of Dental and Craniofacial Research, Bethesda, 8Paris-Sud University, Rueil-Malmaison, France, 9University of Oslo, Stavanger, Norway, 10Center for Genomics and Oncological Research (GENYO), Granada, Spain, 11University of Oslo, Oslo, Norway, 12Karolinska Institute, Stockholm, Sweden, 13Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 14Haukeland University Hospital, Bergen, Norway, 15The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 16Newcastle University, Gateshead, United Kingdom, 17Uppsala University, Copenhagen S, Sweden

    Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity, and 10 published genetic susceptibility loci. Our genome-wide…
  • Abstract Number: 1955 • ACR Convergence 2020

    High-throughput Identification of Functional Regulatory SNPs Associated with Systemic Lupus Erythematosus

    Qiang Wang1, Marta Martínez2, Matthew Weirauch3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, 3Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Systemic lupus erythematosus (SLE) is a disease involves the complex interplay of many genes, reflected in more than one hundred loci linked with disease…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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