ACR Meeting Abstracts

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Abstracts tagged "genetics"

  • Abstract Number: 0426 • ACR Convergence 2020

    T-Cell Receptor (TCR) Sequencing Reveals Decreased Diversity and Clonotypic Expansion of T-cells in Relapsing Polychondritis (RP)

    Emily Rominger1, Sufia Bakshi2, Emily Rose3, Marcela Ferrada3, Peter C. Grayson4, Robert Colbert5 and Keith Sikora6, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 2National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, 5Pediatric Clinical Trials Unit and Office of Clinical Director, NIAMS, NIH, Bethesda, MD, 6National Institutes of Health Clinical Center, Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a rare, systemic inflammatory disease characterized by recurrent inflammation of cartilaginous structures, including the nose/ears, joints, and trachea. The etiology of…
  • Abstract Number: 1669 • ACR Convergence 2020

    Genetics of Age at Diagnosis in Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao2, JingJing Cao2, Dafna Gladman3, Marisa Klein-Gitelman4, Andrea Knight5, Deborah Levy1, Karen Onel6, Andrew Paterson2, Christine Peschken7, Janet Pope8, Zahi Touma9, Murray Urowitz10, Declan Webber1, Joan Wither11, Earl D. Silverman12 and Linda Hiraki13, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 4Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 5Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, 7Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, 8Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 9University of Toronto, Toronto, ON, Canada, 10University Health Network, University of Toronto, Toronto, ON, Canada, 11University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 12Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 13Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Genome wide association studies (GWAS) have identified >90 SNPs associated with systemic lupus erythematosus (SLE) risk. However, there may be additional loci impacting the…
  • Abstract Number: 0471 • ACR Convergence 2020

    Splice Site Variants in IKBKG, Encoding NEMO, Detected by a Customized Analysis of Next-Generation Sequencing Data Cause an Early-onset Autoinflammatory Syndrome of Panniculitis and Cytopenias in Male and Female Patients

    Adriana de Jesus1, Sofia Torreggiani2, Bin Lin2, Jacob Mitchell2, Eric Karlins3, Andrew Oler3, Sara Alehashemi4, Dana Kahle5, Katelin R. Honer2, Gema Souto Adeva2, Eric Hanson6, Gina Montealegre Sanchez7, Amer Khojah8, Timothy Moran9, Eveline Wu9, Chris Scott10, Timothy Ronan Leahy11, Emma Jane MacDermott11, Orla Killeen12, Thaschawee Arkachaisri13, Zoran Gucev14, Kathryn Phillippi15, Vafa Mammadova16, Gulnara Nasrullayeva16 and Raphaela Goldbach-Mansky17, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 3Bioinformatics and Computational Biosciences Branch/NIAID/NIH, Bethesda, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Clarksville, MD, 5Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 6Indiana University School of Medicine, Indianapolis, IN, 7NIAID/NIH, Rockville, MD, 8Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 9UNC Chapel Hill, Chapel Hill, NC, 10University of Cape Town, Cape Town, South Africa, 11Our Lady's Children's Hospital, Dublin, Ireland, 12National Centre for Paediatric Rheumatology, CHI at Crumlin, Dublin, Ireland, 13Duke-NUS Medical School, Singapore, Singapore, 14University Children's Hospital, Medical Faculty Skopje, Skopje, Macedonia, 15Akron Children’s Hospital, Akron, OH, 16Azerbaijan Medical University, Baku, Azerbaijan, 17Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: The Inhibitor of Kappa-B Kinase Regulatory Subunit Gamma (IKBKG) is located on the X chromosome and encodes the NF-κB essential modulator (NEMO). Loss-of-function mutations…
  • Abstract Number: 1671 • ACR Convergence 2020

    Identifying Rare Genetic Variants in Childhood-onset Monogenic Systemic Lupus Erythematosus

    Melissa Misztal1, Fangming Liao2, Sergey Naumenko3, Andrea Knight4, Daniela Dominguez5, JingJing Cao2, Declan Webber6, Bhooma Thiruvahindrapuram7, Deborah Levy6, Andrew Paterson2, Earl D. Silverman8 and Linda Hiraki9, 1Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Oakville, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3The Centre for Computational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 5Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 7The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, 8Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 9Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Among children diagnosed with systemic lupus erythematosus (SLE), there exists monogenic forms of SLE, where rare variants in a single gene lead to disease.…
  • Abstract Number: 0494 • ACR Convergence 2020

    Genetic-epigenetic Interaction and the Relationship Between DNA Methylation Patterns and Disease Activity in a Longitudinal Cohort of Lupus Patients

    Patrick Coit1, Lourdes Ortiz-Fernandez2, Emily Lewis3, W. Joseph McCune3, Kathleen Maksimowicz-McKinnon4 and Amr Sawalha2, 1University of Pittsburgh and University of Michigan, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3University of Michigan, Ann Arbor, MI, 4Henry Ford Hospital, Detroit

    Background/Purpose: Genetic factors and epigenetic dysregulation are implicated in the pathogenesis of lupus. We performed a longitudinal analysis of DNA methylation in lupus patients for…
  • Abstract Number: 1677 • ACR Convergence 2020

    Schizophrenia Genetics and Neuropsychiatric Features in Childhood-Onset Systemic Lupus Erythematosus

    Ana C. Ulloa Baez1, Fangming Liao2, Raffaella Carlomagno3, Talia Diaz3, Daniela Dominguez4, Deborah Levy3, Lawrence Ng5, Earl D. Silverman6, Andrea Knight7 and Linda Hiraki8, 1Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 5Division of Rheumatology, Hospital for Sick Children, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 7Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Prior studies indicate that schizophrenia and systemic lupus erythematosus (SLE) share genetic risk loci. Despite overlapping phenotypic features such as psychosis, little is known…
  • Abstract Number: 164 • 2020 Pediatric Rheumatology Symposium

    The Juvenile Idiopathic Arthritis-Associated IL2RA and IL6R Haplotypes Contain Enhancers Whose Functions Are Altered by JIA-Associated Genetic Variants

    Kaiyu Jiang 1, Yungki Park 2, tao liu 3, Marc Sudman 4, Susan Thompson 5 and James Jarvis6, 1University at Buffalo, Buffalo, 2University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, 3Roswell Park Cancer Institute, Buffalo, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, 6University at Buffalo Jacobs School of Medicine, Buffalo

    Background/Purpose: The JIA risk haplotypes, like those of other autoimmune diseases, are highly enriched for H3K4me1/H3K27ac histone marks, epigenetic features typically associated with functional enhancers.…
  • Abstract Number: 165 • 2020 Pediatric Rheumatology Symposium

    A Massively Parallel Reporter Assay Screen of Genetic Variants on JIA Haplotypes Reveals Variants Associated with Altered Function of an Intergenic Enhancer in the HLA Class II Locus

    Kaiyu Jiang 1, tao liu 2, Ryan Tewhey 3 and James Jarvis4, 1University at Buffalo, Buffalo, 2Roswell Park Cancer Institute, Buffalo, 3Jackson Laboratories, Bar Harbor, 4University at Buffalo Jacobs School of Medicine, Buffalo

    Background/Purpose: While genome-wide association studies have provided valuable information about genetic risk for juvenile idiopathic arthritis (JIA), we are still unable to determine the actual…
  • Abstract Number: 007 • 2020 Pediatric Rheumatology Symposium

    Dense Genotyping of Immunologic Loci Identifies CXCR4 as a Novel Susceptibility Locus for Systemic Juvenile Idiopathic Arthritis

    Emily Shuldiner 1, Elaine Remmers 2, Miranda Marion 3, Marc Sudman 4, Colleen Satorius 5, International Childhood Arthritis Genetics Consortium (INCHARGE), Juvenile Arthritis Consortium for the Immunochip (JACI), Wendy Thomson 6, Michael Ombrello1, Patricia Woo 7, Carl Langefeld 8, Sampath Prahalad 9 and Susan Thompson 10, 1NIAMS, NIH, Bethesda, 2National Human Genome Research Institute, Bethesda, 3Wake Forest University, Winston-Salem, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5NHGRI, NIH, Bethesda, 6Manchester Academic Health Science Centre, Manchester, United Kingdom, 7London, United Kingdom, 8Winston Salem, 9Emory + Children's Pediatric Institute, Atlanta, 10Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe, potentially lethal inflammatory condition. It accounts for a disproportionate share of morbidity and mortality among childhood…
  • Abstract Number: 017 • 2020 Pediatric Rheumatology Symposium

    MyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis

    Sufia Bakshi1, Malika Waschmann 2, Anders Lindstedt 2, Emily Rominger 2, Robert Colbert 3 and Keith Sikora 4, 1National Institutes of Health, Bethesda, Maryland, 2National Institutes of Health, Bethesda, 3NIH/NIAMS, Bethesda, Maryland, 4National Institutes of Health Clinical Center, Bethesda, Maryland

    Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88 (S222R)…
  • Abstract Number: 019 • 2020 Pediatric Rheumatology Symposium

    Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm Syndrome

    Mingce Zhang 1, Remy Cron 1, Devin Absher 2, Prescott Atkinson 1, W. Winn Chatham 1 and Randy Cron1, 1University of Alabama at Birmingham, Birmingham, 2HudsonAlpha Institute for Biotechnology, Huntsville

    Background/Purpose: Cytokine storm syndromes (CSS), such as macrophage activation syndrome (MAS) and secondary hemophagocytic lymphohistiocytosis (HLH), are life threatening conditions that commonly present with unremitting…
  • Abstract Number: 031 • 2020 Pediatric Rheumatology Symposium

    Exome Sequencing for Early Pediatric Systemic Lupus Erythematosus: Standard of Care in 2020?

    Yike Jiang1, Bo Yuan 1, Marietta DeGuzman 1, M. Cecilia Poli 2, Justin Branch 1, Andrea Ramirez 3, Martha Curry 1, Maria Pereira 4, Amanda Brown 1, W. Blaine Lapin 5, Sarah Nicholas 1, Lisa Forbes 1, Nicholas Rider 1, Levi Watkin 1, Jennifer Rammel 6, Ankur Kamdar 7, Melissa Mizesko 8, Juan Carlos Becerra 9, Emilina Lim 10, Eyal Muscal 11, Anaid Reyes 1, Zeynep Coban-Akdemir 1, James Lupski 1, Ivan Chinn 1 and Tiphanie Vogel 1, 1Baylor College of Medicine, Houston, 2Universidad del Desarrollo, Santiago, Chile, 3Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 4Assistant Professor, Section of Rheumatology, Division of Pediatrics, Baylor College of Medicine, Houston, Texas, 5, 6Section of Nephrology and Rheumatology, Department of Pediatrics, University of Florida Health Jacksonville, Jacksonville, Florida, 7Houston, 8Driscoll Children's Hospital, Corpus Christi, 9Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru, 10Children's Hospital Orange County, Orange County, 11Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, houston

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with multifactorial etiology. Identification of monogenic causes of pediatric SLE (pSLE) has yielded important insights…
  • Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium

    Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao 1, JingJing Cao 2, Dafna Gladman 3, Marisa Klein-Gitelman 4, Andrea Knight 5, Deborah Levy 1, Andrew Paterson 2, Zahi Touma 3, Murray Urowitz 3, Declan Webber 1, Joan Wither 3, Earl D. Silverman 6 and Linda Hiraki 7, 1Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, 4Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, 5SickKids Research Institute, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, 7Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada

    Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
  • Abstract Number: 1933 • 2019 ACR/ARP Annual Meeting

    Tumorigenesis Related Gene Identification in Dermatomyositis Using Meta-Analysis

    Jihad Aljabban1, Saad Syed 2, Sharjeel Syed 3, Kalyn Hoffman 4, Laith Hasan 5, Nikhil Adapa 1, Zahir Allarakhia 6, Dexter Hadley 7, Mohamad Aljabban 8 and Wael Jarjour 9, 1Ohio State University College of Medicine, Columbus, 2Stanford School of Medicine, Stanford, 3Stanford School of Medicine, Stanford, CA, 4The Ohio State University College of Medicine, Columbus, OH, 5Tulane School of Medicine, New Orleans, 6Ohio State University College of Medicine, Columbus, OH, 7Institute for Computational Health Sciences, San Francisco, 8Genesys Health Systems, Grand Blanc, MI, 9Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Dermatomyositis (DM) is a progressive, systemic autoimmune disease-causing inflammatory changes in the skin and skeletal muscles.  DM is associated with carcinomas of the ovary,…
  • Abstract Number: 1934 • 2019 ACR/ARP Annual Meeting

    Tripartite Motif (TRIM) Gene Family Expression in Dermatomyositis

    Jihad Aljabban1, Sharjeel Syed 2, Saad Syed 3, Zarife Sahenk 4, Noah Weisleder 5, Kevin McElhanon 5, Kalyn Hoffman 6, Nikhil Adapa 1, Zahir Allarakhia 7, Laith Hasan 8, Dexter Hadley 9, Mohamad Aljabban 10 and Wael Jarjour 11, 1Ohio State University College of Medicine, Columbus, 2Stanford School of Medicine, Stanford, CA, 3Stanford School of Medicine, Stanford, 4Department of Neurology, Research Institute at Nationwide Children’s Hospital, Columbus, OH, 5Dorothy M. Davis Heart and Lung Research Institute & Dept. of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, 6The Ohio State University College of Medicine, Columbus, OH, 7Ohio State University College of Medicine, Columbus, OH, 8Tulane School of Medicine, New Orleans, 9Institute for Computational Health Sciences, San Francisco, 10Genesys Health Systems, Grand Blanc, MI, 11Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Dermatomyositis (DM) is a progressive, systemic autoimmune disease causing inflammatory changes to the skin and skeletal muscles. TRIM family proteins are composed of approximately…
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