ACR Meeting Abstracts

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Abstracts tagged "genetics"

  • Abstract Number: 1954 • ACR Convergence 2020

    Genome-wide Association Study of Sjögren’s Syndrome Identifies Ten New Risk Loci

    Bhuwan Khatri1, Tove Ragna Reksten2, Kandice Tessneer3, Astrid Rasmussen1, R. Scofield1, Simon Bowman4, Joel Guthridge1, Judith James5, Lars Ronnblom6, Blake Warner7, Xavier Mariette8, Roald Omdal9, Javier Martin10, Maria Teruel10, Janicke Liaaen Jensen11, Lara Aqrawi11, Øyvind Palm11, Marie Wahren-Herlenius12, Torsten Witte13, Roland Jonsson14, Maureen Rischmueller15, A Darise Farris1, Marta Alarcon-Riquelme10, Wan-Fai Ng16, Kathy Sivils1, Gunnel Nordmark17 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Bergen, Bergen, Norway, 3Oklahoma Medical Research Foundation, Oklahoma City, 4University Hospitals Birmingham, Birmingham, United Kingdom, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 6Uppsala University, Uppsala, Sweden, 7National Institute of Dental and Craniofacial Research, Bethesda, 8Paris-Sud University, Rueil-Malmaison, France, 9University of Oslo, Stavanger, Norway, 10Center for Genomics and Oncological Research (GENYO), Granada, Spain, 11University of Oslo, Oslo, Norway, 12Karolinska Institute, Stockholm, Sweden, 13Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 14Haukeland University Hospital, Bergen, Norway, 15The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 16Newcastle University, Gateshead, United Kingdom, 17Uppsala University, Copenhagen S, Sweden

    Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with exocrine gland dysfunction leading to substantial morbidity, and 10 published genetic susceptibility loci. Our genome-wide…
  • Abstract Number: 0288 • ACR Convergence 2020

    Targeted Sequencing Revealed Novel Candidate Genetic Contributions to Lupus Nephritis in a Cohort of Swedish Patients with Systemic Lupus Erythematosus

    Sule Yavuz1, Pascal Pucholt2, Dag Leonard2, Juliana Imgenberg-Kreuz2, Matteo Bianchi2, Johanna Sandling2, Iva Gunnarsson3, Swedish Sle Network2 and Lars Ronnblom2, 1Uppsala University Rheumatology, Doral, FL, 2Uppsala University, Uppsala, Sweden, 3Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Lupus nephritis (LN) is a common debilitating manifestation of Systemic Lupus Erythematosus (SLE). Despite improved understanding of underlying mechanisms driving to LN and early…
  • Abstract Number: 1164 • ACR Convergence 2020

    Frequency of Genetic Diagnosis in an Autoinflammatory Disease Natural History Protocol Cohort of Patients

    Katelin R. Honer1, Kim Johnson1, Gema Souto Adeva1, Gina Montealegre Sanchez2, Jenna Wade3, Jacob Mitchell1, Katherine Townsend3, Adriana de Jesus4 and Raphaela Goldbach-Mansky5, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Rockville, MD, 3Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 5Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: Monogenic autoinflammatory diseases (AID) are caused by innate immune dysregulation resulting in systemic inflammation and variable organ-specific clinical manifestations. The Translational Autoinflammatory Disease Section…
  • Abstract Number: 1955 • ACR Convergence 2020

    High-throughput Identification of Functional Regulatory SNPs Associated with Systemic Lupus Erythematosus

    Qiang Wang1, Marta Martínez2, Matthew Weirauch3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, 3Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Systemic lupus erythematosus (SLE) is a disease involves the complex interplay of many genes, reflected in more than one hundred loci linked with disease…
  • Abstract Number: 0295 • ACR Convergence 2020

    CCL3L3–null Status May Predispose to Systemic Lupus Erythematosus and Non-scarring Alopecia

    Eunyoung Lee1, Young-Ho Kim2, Hye Won Sim2, Eun-Kyung Kang2, Yoon-Ho Won2, Esther Park2, Yeong-Wook Song3 and Kyeong-Man Hong2, 1Seoul National University Hospital, Seoul, Republic of Korea, 2National Cancer Center, Ilsan, Kyonggi-do, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Seoul, Korea, Republic of Korea

    Background/Purpose: The correlation between the copy number variation of CCL3L1 and susceptibility to systemic lupus erythematosus (SLE), rheumatoid arthritis, Kawasaki disease, and HIV infection has…
  • Abstract Number: 1166 • ACR Convergence 2020

    Use of Rituximab to Treat COPA Syndrome: A Multi-Institutional Cohort

    Leigh Stubbs1, Isabella Osuna2, Tarin Bigley3, Michal Cidon4, Kristen Mengwasser5, Simon Helfgott6, Marietta DeGuzman7, Manuel Silva-Carmona8 and Tiphanie Vogel9, 1Baylor College of Medicine, Houston, TX, 2Department of Pediatrics, Division of Rheumatology, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA, Houston, TX, 3Washington University in St. Louis, Saint Louis, MO, 4CHLA, Los Angeles, CA, 5Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, USA, Boston, MA, 6BWH- HMS, Boston, MA, 7Baylor College of Medicine, Houston, 8Department of Pediatrics, Division of Pulmonology Medicine, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA, Houston, TX, 9Baylor College of Medicine/Texas Children's Hospital, Houston, TX

    Background/Purpose: Coatomer protein complex subunit α (COPA) syndrome is a rare genetic multisystem autoimmune disorder inherited in an autosomal dominant manner. Onset typically occurs in…
  • Abstract Number: 1956 • ACR Convergence 2020

    Dysregulated Expression of the Long Non-coding RNA, LINC01871, Implicated in Sjögren’s Syndrome Pathogenesis

    Michelle Joachims1, Bhuwan Khatri1, Kandice Tessneer2, Anna Stolarczyk1, Graham Wiley1, Astrid Rasmussen1, Joel Guthridge1, Judith James3, R. Scofield1, Kathy Sivils1, Indra Adrianto4 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 4Henry Ford Health System, Detroit, MI

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammatory destruction of the exocrine glands. Long non-coding RNAs (lncRNAs) are a functionally diverse class…
  • Abstract Number: 0298 • ACR Convergence 2020

    Local Genetic Ancestry Associations with Clinical Features of Systemic Lupus Erythematosus

    Olivia Solomon1, Cristina Lanata2, Cameron Adams1, Joanne Nititham3, Kim Taylor3, Sharon Chung3, Bernardo Pons-Estel4, Teresa Tusié-Luna5, Betty Tsao6, Eric Morand7, Marta Alarcón-Riquelme8, Lisa Barcellos1 and Lindsey Criswell9, 1University of California, Berkeley, Berkeley, CA, 2UCSF, San Francisco, CA, 3University of California, San Francisco, San Francisco, CA, 4Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina, 5Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran and Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de Mexico, Mexico City, Mexico, 6Medical University of South Carolina, Charleston, 7Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 8Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica, Granada (GENYO), Granada, Spain, 9Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical manifestations which are known to vary in severity by race. Health disparities in…
  • Abstract Number: 1194 • ACR Convergence 2020

    MUC5B Promoter Variant rs35705950 and Risk Stratification for Rheumatoid Arthritis – Interstitial Lung Disease

    Pierre-Antoine Juge1, Fabienne Louis-Sidney2, Benjamin Granger3, Joanna Kedra4, Marie-Pierre Debray5, Esther Ebstein1, Raphaël Borie6, Arnaud Constantin7, Bernard Combe8, Rene-Marc Flipo9, Xavier Mariette10, Olivier Vittecoq11, Alain Saraux12, Guillermo Carvajal Alegria13, Jean Sibilia14, Francis Berenbaum15, Caroline Kannengiesser16, Bruno Crestani6, Catherine Boileau16, Bruno Fautrel17 and Philippe Dieude18, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2Service de Rhumatologie, CHU de Fort de France, Martinique, France, Fort de France, France, 3Département de Biostatistiques, Santé Publique et Information Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France., Paris, France, 4Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, UMR S1136, Paris, France, Paris, France, 5Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 6Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 7Hospital Pierre Paul Riquet, Toulouse, France, 8University of Montpellier, Montpellier, France, 9Lille University Hospital, Lille, France, 10Paris-Sud University, Rueil-Malmaison, France, 11University Hospital of Rouen, Rouen, France, 12Department of Rheumatology, UBO, CHU, INSERM 1227 (LBAI), Brest, France, 13CHU de Brest, Service de Rhumatologie, Brest, France, 14CHU Strasbourg, Service de Rhumatologie, Strasbourg, France, 15AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 16Université de Paris, Hôpital Bichat, Service de Génétique, AP-HP, Paris, Paris, France, 17Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, 18Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) detected in 20 to 60% of patients with RA on high-resolution computed-tomography…
  • Abstract Number: 0299 • ACR Convergence 2020

    The Minor Protective Allele at rs1876453 Is Associated with Increased Age of Onset of Systemic Lupus Erythematosus

    Ani Oganesyan1, Jennifer Kelly2, Stuart Glenn2, Adam Adler2, Adrienne Williams3, Mary Comeau4, Julia Ziegler5, Miranda Marion5, Marta Alarcón-Riquelme6, Graciela Alarcón7, Juan-Manuel Anaya8, Sang-Cheol Bae9, Dam Kim9, Lee Hye-Soon9, Lindsey Criswell10, Barry Freedman11, Gary Gilkeson12, Joel Guthridge13, Chaim Jacob14, Judith James15, Diane Kamen16, Joan Merrill17, Kathy Moser Silvis18, Timothy Niewold19, Michelle Petri20, Rosalind Ramsey-Goldman21, John Reveille22, Hal Scofield23, Anne Stevens24, Luis Vilá25, Timothy Vyse26, Kenneth Kaufman27, John Harley28, Carl Langefeld5, Patrick Gaffney2, Elizabeth Brown29, Jeffrey Edberg7, Robert Kimberly7, Betty Tsao12, Daniela Ulgiati30, Kenneth Jones31 and Susan Boackle32, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Department of Biostatistical Sciences and Center for Public Health Genomics Wake Forest School of Medicine, Winston-Salem,, NC, 4Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine; MC Analytics, Winston-Salem, NC, 5Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica, Granada (GENYO), Granada, Spain, 7Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 8Center for Autoimmune Diseases Research (CREA), Universidad del Rosario, Bogotá, Colombia, 9Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 10Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, 11Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem,, NC, 12Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 13Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oaklahoma, OK, 14Department of Medicine, University of Southern California, Los Angeles, CA, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 16Medical University of South Carolina, Charleston, SC, 17Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 19Colton Center for Autoimmunity, NYU School of Medicine, New York, NY, 20Johns Hopkins University School of Medicine, Baltimore, 21Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 22Department of Internal Medicine, University of Texas, Houston, TX, 23Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Charleston, SD, 24Janssen Pharmaceuticals, Spring House, PA, 25Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, 26Division of Genetics and Molecular Medicine and Immunology, King’s College, London, United Kingdom, 27Cincinnati Children’s Hospital Medical Center;US Department of Veterans Affairs Medical Center, Cincinnati, OH, 28Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH, 29Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 30School of Pathology and Laboratory Medicine, Centre for Genetic Origins of Health and Disease, The University of Western Australia, Crawley, Australia, 31Harold Hamm Diabetes Center, University of Oklahoma Health Science Center, Oklahoma City, OK, 32Division of Rheumatology, University of Colorado School of Medicine; Denver Veterans Affairs Medical Center, Aurora, CO

    Background/Purpose: Systemic lupus erythematosus (SLE) is a clinically heterogenous autoimmune disease characterized by autoantibody- and complement-mediated inflammatory damage to multiple organ systems. We previously showed…
  • Abstract Number: 1195 • ACR Convergence 2020

    MUC5B rs35705950 and Rheumatoid Arthritis Associated Interstitial Lung Disease Progression

    Pierre-Antoine Juge1, Joshua Solomon2, Romain Garofoli3, Joyce S. Lee4, Fabienne Louis-Sidney5, Esther Ebstein1, Jorge Rojas-Serrano6, Montserrat I. Gonzalez-Perez6, Mayra Mejia6, Ivette Buendia-Roldan6, Ramces Falfan-Valencia7, Enrique Ambrocio-Ortiz7, Effrosyni Manali8, Spyros A. Papiris8, Theofanis Karageorgas9, Dimitrios Boumpas9, Katarina Antoniou10, Coline H.M. van Moorsel11, Joanne van Der Vis11, Yaël A. de Man11, Jan C. Grutters11, Caroline Kannengiesser12, Raphaël Borie13, Lidwine Wemeau-Stervinou14, Rene-Marc Flipo15, Hilario Nunes16, Yurdagul Uzunhan17, Dominique Valeyre18, Nathalie Saidenberg Kermanac'h19, Marie-Christophe Boissier20, Christophe Richez21, Thierry Schaeverbeke22, Tracy J. Doyle23, Paul Wolters24, Marie-Pierre Debray25, Catherine Boileau12, Raphaël Porcher26, Bruno Crestani13, David A. Schwartz4 and Philippe Dieude27, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2National Jewish Health, Denver, CO, 3Hôpital Cochin, Service de Rééducation, Paris, Paris, France, 4Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA, Aurora, CO, 5Service de Rhumatologie, CHU de Fort de France, Martinique, France, Fort de France, France, 6Interstitial Lung Disease & Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México, Mexico, Mexico, 7HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas. Mexico City, Mexico, Mexico, Mexico, 82nd Pulmonary Medicine Department, University Hospital of Athens "Attikon", National and Kapodistrian University of Athens, Greece, Athens, Greece, 9Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, University Hospital of Athens "Attikon", National and Kapodistrian University of Athens, Greece, Athens, Greece, 10PS Department of Respiratory Medicine & Laboratory of Molecular & Cellular Pneumonology, Faculty of Medicine, University of Crete, Crete, Greece, Heraklion, Greece, 11St Antonius ILD center of excellence, St Antonius ziekenhuis, Nieuwegein, The Netherlands, Nieuwegein, Netherlands, 12Université de Paris, Hôpital Bichat, Service de Génétique, AP-HP, Paris, Paris, France, 13Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 14CHRU de Lille, Service de Pneumologie et Immuno-Allergologie, Centre de compétence des maladies pulmonaires rares, FHU IMMINENT, Lille, France, Lille, France, 15Lille University Hospital, Lille, France, 16Department of Pulmonology, Hôpital Avicenne, APHP, Bobigny, France, Bobigny, France, 17Hôpital Avicennes, Service de Pneumologie, AP-HP, Bobigny, Bobigny, France, 18Hôpital Avicenne, Service de pneumologie, AP-HP, Bobigny, Bobigny, France, 19Hôpital Avicennes, Service de Rhumatologie, AP-HP, Bobigny, Bobigny, France, 20Hôpital Avicenne, Service de Rhumatologie, AP-HP, Bobigny, Bobigny, France, 21Rheumatology Hospital, Pelligrin Hospital, Bordeaux University Hospital, Bordeaux, France, 22CHU de Bordeaux, Service de Rhumatologie, Bordeaux, France, 23Brigham and Women's Hospital, West Roxbury, MA, 24University of California, San Francisco, San Francisco, CA, 25Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 26Centre d’Epidémiologie Clinique, AP-HP, Hôpital Hôtel-Dieu, F-75004 Paris, France, Paris, France, 27Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Rheumatoid arthritis (RA) associated interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF) sharephenotypic and genotypic similarities. Recently, in a large international genetic association…
  • Abstract Number: 0301 • ACR Convergence 2020

    Genetic Associations and Polygenic Risk Assessment in Incomplete Lupus Erythematosus

    Matthew Slief1, Jeremy Levin2, Susan Macwana1, Wade DeJager1, Rebecka Bourn3, Swapan Nath3, Melissa Munroe4, Teresa Aberle1, Patrick Gaffney5, Joan Merrill3, Judith James6 and Joel Guthridge1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2OU Medical Center, Oklahoma City, 3Oklahoma Medical Research Foundation, Oklahoma City, 4Oklahoma Medical Research Foundation/Progentec Diagnostics, Inc., Oklahoma City, OK, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Patients with incomplete lupus erythematosus (ILE) have features of lupus, but have insufficient criteria for SLE classification. Some ILE patients transition to classified SLE,…
  • Abstract Number: 1305 • ACR Convergence 2020

    Is the Occurrence of Acute Anterior Uveitis Linked Primarily to Ankylosing Spondylitis (AS) or to HLA-B27? Results of a 35-Year Follow-Up Family Study of a Swiss Cohort of Patients with AS

    Sjef van der Linden1, Peter Villiger2, Zhixiu Li3, Matthew Brown4, Heinz Baumberger5, Hermine Zandwijk6 and Muhammad Khan7, 1Department of Rheumatology, Immunology and Allergology, University of Bern, Inselspital, Bern, Switzerland, Mortroux, Belgium, 2Department of Rheumatology, Immunology and Allergology, University of Bern, Inselspital, Switzerland, Bern, Switzerland, 3Queensland University of Technology (QUT), Translational Genomics Group, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia, Brisbane, Queensland, Australia, 4Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom, 5Retired, Flims, Tajikistan, 6Retired, Mortroux, Belgium, 7Case Western Reserve University, Cleveland OH, Westlake, OH

    Background/Purpose: Approximately 30% of HLA-B27(+) patients with ankylosing spondylitis (AS) have one or more episodes of acute anterior uveitis (AAU), a condition that is also…
  • Abstract Number: 0372 • ACR Convergence 2020

    Tumor Necrosis Factor-α Receptor 2 Polymorphisms and Response to TNF Inhibitor Therapy in Patients with Psoriatic Arthritis

    Sarah Rasheed1, MacKenzie Dunlap1, Jennifer Harvey1, Connery Brennan1, Yuxuan Jin2, Unnikrishnan Chandrasekharan3 and M. Elaine Husni2, 1Cleveland Clinic Foundation, Cleveland, 2Cleveland Clinic, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) have significantly improved the prognosis of patients with psoriatic arthritis (PsA); however, approximately 40% of patients do not achieve…
  • Abstract Number: 1667 • ACR Convergence 2020

    Development of Autoimmune Diseases and HLA Associations in Children with Neonatal Lupus and Their Unaffected Siblings

    Amit Saxena1, Aaron Garza Romero2, Daniel Gratch3, Peter Izmirly4, Hannah Ainsworth5, Miranda Marion5, Carl Langefeld6, Robert Clancy7 and Jill Buyon8, 1NYU School of Medicine, New York, 2Gonzaba Medical Group, San Antonio, 3NYU Langone Health, New York, 4Department of Medicine, New York University School of Medicine, New York, NY, 5Wake Forest School of Medicine, Winston-Salem, 6Wake Forest School of Medicine, Winston Salem, NC, 7New York University School of Medicine, New York, NY, 8Department of Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies with major manifestations being congenital heart block…
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