ACR Meeting Abstracts

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Abstracts tagged "Gene Expression"

  • Abstract Number: 1894 • 2018 ACR/ARHP Annual Meeting

    Baricitinib-Associated Changes in Type l Interferon Gene Signature during a 24-Week Phase-2 Clinical SLE Trial

    Thomas Dörner1, Yoshiya Tanaka2, Michelle Petri3, Josef S. Smolen4, Ernst R. Dow5, Richard E. Higgs5, Robert J. Benschop5, Adam Abel5, Maria E. Silk5, Stephanie de Bono5 and Robert W. Hoffman5, 1Charité Universitätsmedizin Berlin and Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 5Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: In the phase 2 study JAHH (NCT02708095), treatment with baricitinib (bari), an oral selective Janus kinase 1/2 inhibitor approved for the treatment of RA,…
  • Abstract Number: 856 • 2018 ACR/ARHP Annual Meeting

    Integrated mRNA and microRNA Transcriptomes of Monocytes from Antiphospholipid Syndrome Patients Identifies Molecular Networks Related to Their Atherothrombotic Status. Modulatory Effects of In Vivo Ubiquinol Supplementation

    Carlos Perez-Sanchez1, Laura Pérez Sánchez2, Alejandra Maria Patiño-Trives3, María Luque Tevar3, Luca Scudeler4, Alejandro Ibáñez-Costa3, Patricia Ruiz-Limon5, Yolanda Jiménez-Gómez1, Ivan Arias de la Rosa6, Maria Carmen Abalos-Aguilera6, Pedro Segui7, Nuria Barbarroja1, Jose Manuel Villalba8, Eduardo Collantes Estevez3, Maria Jose Cuadrado9, Maria Ángeles Aguirre Zamorano1 and Chary Lopez-Pedrera3, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Università degli Studi di Torino, Turin, Italy, 5Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, 6Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 7Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 8Departamento de Biologia Celular, Fisiologia e Inmunología, University of Córdoba, Cordoba, Spain, 9Clinica Universidad de Navarra, Madrid, Spain

    Background/Purpose: 1. To characterize the mRNAs and microRNAs transcriptomes of monocytes, key immune cells in the atherothrombotic pathology of Antiphospholipid Syndrome patients (APS). 2. To…
  • Abstract Number: 1897 • 2018 ACR/ARHP Annual Meeting

    Single Cell RNA Expression in Lupus Nephritis Comparing African-American and Caucasian Patients Identifies Differential Expression of Interferon Pathway

    Andrea Fava1, Yuji Zhang2, Nir Hacohen3, Arnon Arazi4, Celine C. Berthier5, Deepak Rao6, Michael Brenner7, David Wofsy8, Anne Davidson9, Matthias Kretzler10, David Hildeman11, E. Steve Woodle12, Betty Diamond13 and Michelle Petri14, 1Departement of Medicine - Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 3Harvard Medical School, Boston, MA, 4Broad Institute, Cambridge, MA, 5Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, 6Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 8Rheumatology, University of California, San Francisco, San Francisco, CA, 9Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 10Division of Nephrology, University of Michigan, Ann Arbor, MI, 11University of Cincinnati, Cincinnati, OH, 12University of Cincinnati College of Medicine, Cincinnati, OH, 13The Feinstein Institute for Medical Research, Manhasset, NY, 14Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: African-American (AA) ethnicity is associated with a 3-fold higher risk of developing systemic lupus erythematosus (SLE). In addition, there is an increased risk of…
  • Abstract Number: 899 • 2018 ACR/ARHP Annual Meeting

    Changes in the Systemic Sclerosis Molecular Signatures after Myeloablation Followed By Autologous Hematopoietic Stem Cell Transplantation and Their Clinical Correlates

    Shervin Assassi1, Xuan Wang2, Jun Ying3, Lynette Keyes-Elstein4, Ellen Goldmuntz5, Jacob Turner6, Wenjin Zheng7, Guocai Chen7, Maria Virginia Pascual8, John Varga9, Monique Hinchcliff10, Chiara Bellocchi11, Peter McSweeney12, Daniel E. Furst13, Richard Nash12, Leslie Crofford14, Beverly Welch15, Ashley Pinckney16, Maureen D. Mayes1 and Keith Sullivan17, 1Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 2Baylor Scott & White Health, Dallas, TX, 3Department of Internal Medicine - Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 4Rho, Inc, Chapel Hill, NC, 5NIAID, National Institutes of Health, Bethesda, MD, 6Stephen F Austin University, Nacogdoches, TX, 7University of Texas Health Science Center at Houston, Houston, TX, 8Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 9Northwestern University, Chicago, IL, 10Rheumatology, Northwestern University, Chicago, IL, 11Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, 12Colorado Blood Cancer Institute, Denver, CO, 13University of California Los Angeles, Los Angeles, CA, 14Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 15National Institutes of Health, Bethesda, MD, 16Rho Federal Systems, Inc., Chapel Hill, NC, 17Duke University Medical Center, Durham, NC

    Background/Purpose: Myeloablation followed by autologous hematopoietic stem cell transplantation (HSCT) led to improved clinical outcomes compared to 12 monthly infusions of cyclophosphamide (CYC) in patients…
  • Abstract Number: 1903 • 2018 ACR/ARHP Annual Meeting

    Molecular Analysis of a Skin Equivalent Tissue Culture Model System of Systemic Sclerosis Using RNA Sequencing, Epigenetic Assays, Histology, and Immunoassays

    Diana M. Toledo1, Mengqi Huang2, Yue Wang2, Bhaven K. Mehta2, Tammara A. Wood3, Avi Smith4, Yolanda Nesbeth5, Irena Ivanovska6, Brock Christensen7, Patricia A. Pioli8, Jonathan Garlick4 and Michael L. Whitfield9, 1Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 3Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 4Tufts University School of Medicine, Boston, MA, 5Celdara Medical, LLC, Lebanon, NH, 6Celdara Medical, LLC, Hanover, NH, 7Geisel School of Medicine at Dartmouth, Hanover, NH, 8Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 9Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: The molecular mechanisms of systemic sclerosis (SSc) have been difficult to study outside of patient samples. Mouse models often lack key features of the…
  • Abstract Number: 919 • 2018 ACR/ARHP Annual Meeting

    A Machine Learning Classifier for Assigning Individual Patients with Systemic Sclerosis to Intrinsic Molecular Subsets

    Jennifer Franks1, Viktor Martyanov1, Guoshuai Cai2, Yue Wang3, Tammara A. Wood1 and Michael L. Whitfield4, 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Environmental Health Sciences, Arnold School of Public Health at University of South Carolina, Columbia, SC, 3Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 4Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: High-throughput gene expression profiling of skin biopsies from patients with systemic sclerosis (SSc) has identified four “intrinsic” gene expression subsets conserved across multiple cohorts…
  • Abstract Number: 1958 • 2018 ACR/ARHP Annual Meeting

    Gene Expression Pathways across Multiple Tissues in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Reveal Core Pathways of Disease Pathology

    Marcia Friedman1, Donseok Choi1,2,3,4, Steven Planck1,4, James T. Rosenbaum5 and Cailin Sibley1, 1Oregon Health & Science University, Portland, OR, 2OHSU-PSU School of Public Health, Portland, OR, 3Graduate School of Dentistry, Kyung Hee Universtiy, Seoul, Korea, Republic of (South), 4Casey Eye Institute, Portland, OR, 5Ophthalmology, Oregon Health & Science University and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: In recent years, several studies have characterized the gene expression signatures of different tissues affected by ANCA-associated vasculitis (AAV). The purpose of this study…
  • Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting

    Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis

    Adrià Aterido1, Jesús Tornero2, Francisco J Blanco3, Benjamin Fernandez Gutierrez4, Antonio Gonzalez5, Juan D. Cañete6, Joan Maymó7, Mercedes Alperi-López8, Alejandro Olivé-Marqués9, Hector Corominas10, Víctor Martínez-Taboada11, Isidoro Gonzalez-Alvaro12, Antonio Fernandez-Nebro13, Alba Erra14, Simón Sánchez-Fernández15, María López-Lasanta1, Mireia López-Corbeto1, Raül Tortosa1, Laia Codó16, Sara Marsal1 and Antonio Julià1, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 3Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 4Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, 5Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 6Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, 7Rheumatology Department, Hospital del Mar, Barcelona, Spain, 8Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, 9Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 12Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 13UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, 14Rheumatology Service, Hospital San Rafael, Barcelona, Spain, 15Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, 16Life Sciences Department, Barcelona Supercomputing Centre, Barcelona, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…
  • Abstract Number: 1973 • 2018 ACR/ARHP Annual Meeting

    Leveraging Publicly Available Gene Expression Data and Applying Machine Learning to Identify Novel Biomarkers for Rheumatoid Arthritis

    Dmitry Rychkov1, Marina Sirota2 and Cindy Lin3, 1Institute for Computational Health Sciences, University of Calfornia, San Francisco, San Francisco, CA, 2Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, 3Stanford, Stanford, CA

    Background/Purpose: Diagnosis and monitoring the disease progression of RA is challenging requiring a combination of imaging techniques and blood tests. There is currently no biochemical…
  • Abstract Number: 929 • 2018 ACR/ARHP Annual Meeting

    Transcriptional Profiling of the Subcutaneous Rheumatoid Nodule: An Insight into Pathogenic Mechanisms and Cellular Content

    Judith Marsman1, Melanie J Millier1, John Highton1, Lisa K. Stamp2 and Paul A Hessian1, 1Department of Medicine, University of Otago, Dunedin, New Zealand, 2University of Otago, Christchurch, New Zealand

    Background/Purpose: Rheumatoid nodules are the most common cutaneous manifestation in patients with RA, often associated with longstanding and a more severe disease course. Paradoxically, therapy…
  • Abstract Number: 1974 • 2018 ACR/ARHP Annual Meeting

    Dynamics of Transcriptional Signatures from Synovial Macrophage Subsets during Acute and Chronic Murine Models of Inflammatory Arthritis

    Philip J. Homan1, Anna B Montgomery2, Salina Dominguez3, Carla M. Cuda3, Harris Perlman3 and Deborah R. Winter3, 1Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Macrophages play an integral role in the progression and persistence of rheumatoid arthritis (RA) through production of degradative enzymes, cytokines, and chemokines and recruitment…
  • Abstract Number: 647 • 2017 ACR/ARHP Annual Meeting

    Gene Expression in Cellular Subsets in Psoriatic Disease

    Anastasiya Muntyanu1, Fatima Abji2, Remy Pollock1, Vinod Chandran2 and Dafna D Gladman2, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis is an inflammatory musculoskeletal disease which develops in 30% of patients with psoriasis. Our previous peripheral blood microarray study identified CXCL10, NOTCH2NL,…
  • Abstract Number: 1700 • 2017 ACR/ARHP Annual Meeting

    Focusing on Pulmonary Vascular Disease at Early Stage of Systemic Sclerosis: Exercise-Induced Pulmonary Arterial Hypertension and Gene Co-Expression Networks Involved in Its Pathogenesis

    Yoshinobu Koyama1, Soichiro Fuke2, Yoshiharu Sato3 and Toshie Higuchi1, 1Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, 2Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, 3DNA Chip Research Inc, Yokohama, Japan

    Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement in systemic sclerosis (SSc), which remains a leading cause of death in spite of…
  • Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting

    DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome

    Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…
  • Abstract Number: 756 • 2017 ACR/ARHP Annual Meeting

    Novel Machine Learning Classifier Accurately Predicts Intrinsic Molecular Subsets for Patients with Systemic Sclerosis

    Jennifer Franks1, Viktor Martyanov1, Guoshuai Cai1 and Michael L. Whitfield2, 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: High-throughput gene expression profiling of skin biopsies from patients with systemic sclerosis (SSc) has identified four “intrinsic” gene expression subsets conserved across multiple cohorts…
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